Dr. Matt Kaeberlein

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University of Washington
School of Medicine
Pathology
Assistant ProfessorAppointed: 2006

Mailing Address

1959 NE Pacific Street
HSB D-514
Box 357470
Seattle, 98195-7470 98195-7470
United States

Contact Information

Phone: (206) 543-4849
Fax: (206) 543-3644
kaeber@u.washington.edu
http://www.kaeberleinlab.org

Qualifications

Ph.D., Massachusetts Institute of Technology, Biology, 2002.
B.A., Western Washington University, Mathematics, 1997.
B.S., Western Washington University, Biochemistry, 1997.

Keywords

COS Keywords:

Genetics, Pathology.

Additional Terms:

Aging, Biogerontology, Genetics.

Publications

  • Kaeberlein M, Hu D, Kerr EO, Tsuchiya M, Westman EA, Dang N, Fields S, Kennedy BK (2005) Increased life span due to calorie restriction in respiratory-deficient yeast, PLoS Genetics, 1 (5), e69
  • Kaeberlein M, Steffen KK, Hu D, Dang N, Kerr EO, Tsuchiya M, Fields S, Kennedy BK (2006) Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction"., Science, 312 (5778), 1312
  • Kaeberlein M, Hu D, Kerr EO, Tsuchiya M, Westman EA, Dang N, Fields S, Kennedy BK (2006) Author's Reply., PLoS Genetics, 2 (3), e34
  • Powers RW 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S (2006) Extension of chronological life span in yeast by decreased TOR pathway signaling., Genes and Development, 20 (2), 174-84
  • Kaeberlein M (2006) Longevity and aging in the budding yeast, Handbook of Models for Human Aging, 1 Edition, Boston, Academic Press, ISBN=0-12-369391-8 (bookchapter)
  • Kaeberlein M (2006) Application of high-throughput technologies to aging-related research, Handbook of Models for Human Aging, 1 Edition, Boston, Academic Press, ISBN=0-12-369391-8 (bookchapter)
  • Kennedy BK, Smith ED, Kaeberlein M (2005) The enigmatic role of Sir2 in aging., Cell, 123 (4), 655-67
  • Kaeberlein M, Powers RW 3rd, Stefffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK (2005) Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients., Science, 310 (5751), 1193-6
  • Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK (Apr 2005) Substrate-specific activation of sirtuins by resveratrol., The Journal of Biological Chemistry, 280 (17), 17038-45 Abstract
  • Kaeberlein M, Kirkland KT, Fields S, Kennedy BK (Apr 2005) Genes determining yeast replicative life span in a long-lived genetic background., Mechanisms of Ageing and Development, 126 (4), 491-504 Abstract
  • Kaeberlein M, Kennedy BK (Jan 2005) Large-scale identification in yeast of conserved ageing genes., Mechanisms of Ageing and Development, 126 (1), 17-21 Abstract
  • Hudson FN, Kaeberlein M, Linford M, Pritchard D, Beyer P, Rabinovitch P (2005) Microarray analysis of gene expression changes in aging, Handbook of the Biology of Aging, 6 Edition, Boston, Academic Press, ISBN=0-12-088387-2 (bookchapter)
  • Kaeberlein M (Oct 2004) Aging-related research in the "-omics" age., Science of Aging Knowledge Environment [electronic Resource] : Sage Ke, 2004 (42), pe39 Abstract
  • Kaeberlein M, Kirkland KT, Fields S, Kennedy BK (Sep 2004) Sir2-independent life span extension by calorie restriction in yeast., Plos Biology, 2 (9), E296 Abstract
  • Kaeberlein M, Andalis AA, Liszt GB, Fink GR, Guarente L (Apr 2004) Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism., Genetics, 166 (4), 1661-72 Abstract
  • Kaeberlein M, Andalis AA, Liszt GB, Fink GR, Guarente L (Apr 2004) Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism., Genetics, 166 (4), 1661-72 Abstract
  • Kaeberlein M, Andalis AA, Fink GR, Guarente L (Nov 2002) High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction., Molecular and Cellular Biology, 22 (22), 8056-66 Abstract
  • Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, Fink GR, Guarente L (Jul 2002) Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration., Nature, 418 (6895), 344-8 Abstract
  • Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, Fink GR, Guarente L (Jul 2002) Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration., Nature, 418 (6895), 344-8 Abstract
  • Armstrong CM, Kaeberlein M, Imai SI, Guarente L (Apr 2002) Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity., Molecular Biology of the Cell, 13 (4), 1427-38 Abstract
  • Kaeberlein M, Jegalian B, McVey M (Apr 2002) AGEID: a database of aging genes and interventions., Mechanisms of Ageing and Development, 123 (8), 1115-9 Abstract
  • Kaeberlein M, Guarente L (Jan 2002) Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity., Genetics, 160 (1), 83-95 Abstract
  • Kaeberlein M, McVey M, Guarente L (Oct 2001) Using yeast to discover the fountain of youth., Science of Aging Knowledge Environment [electronic Resource] : Sage Ke, 2001 (1), pe1 Abstract
  • McVey M, Kaeberlein M, Tissenbaum HA, Guarente L (Apr 2001) The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination., Genetics, 157 (4), 1531-42 Abstract
  • Pultz MA, Zimmerman KK, Alto NM, Kaeberlein M, Lange SK, Pitt JN, Reeves NL, Zehrung DL (Mar 2000) A genetic screen for zygotic embryonic lethal mutations affecting cuticular morphology in the wasp Nasonia vitripennis., Genetics, 154 (3), 1213-29 Abstract
  • Imai S, Armstrong CM, Kaeberlein M, Guarente L (Feb 2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase., Nature, 403 (6771), 795-800 Abstract
  • Kaeberlein M, McVey M, Guarente L (Oct 1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms., Genes & Development, 13 (19), 2570-80 Abstract
  • Defossez PA, Prusty R, Kaeberlein M, Lin SJ, Ferrigno P, Silver PA, Keil RL, Guarente L (Apr 1999) Elimination of replication block protein Fob1 extends the life span of yeast mother cells., Molecular Cell, 3 (4), 447-55 Abstract

Profile Details

Last Updated: 7/16/2007

COS Expertise ID #1234830
Reference this profile directly: http://myprofile.cos.com/mkaeberlein