Mario Kratz

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Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Cancer Prevention Program
Assistant MemberAppointed: 2007
University of Washington
School of Public Health and Community Medicine
Department of Epidemiology
Research Assistant ProfessorAppointed: 2008
Professional Headshot of Mario Kratz

Mailing Address

Mail Stop M4-B402
1100 Fairview Ave N
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-7362
Fax: (206) 667-5977
mkratz@fhcrc.org

Qualifications

Ph.D., University of Bonn, Nutrition Sciences, 2001.
M.Sc., University of Bonn, Nutrition Sciences, 1996.

Expertise and Research Interests

I am interested in the molecular and metabolic relationship of dietary and genetic factors to obesity and to the development of diseases that are associated with excess body fat mass such as type 2 diabetes mellitus, cardiovascular disease, and certain types of cancer.

Currently ongoing studies investigate the effect of the fatty acid and carbohydrate composition of the diet on different aspects of energy balance. In one recently completed study, we investigated the effect of dietary n-3-fatty acids on adipose tissue expression and plasma concentration of hormones involved in regulating energy balance and body weight. In another, currently ongoing pilot study, we are comparing the effect of different sugars on plasma concentrations of adiposity hormones and satiety signals as well as the blood oxygen level dependent (BOLD)-response of brain areas involved in food reward and energy homeostasis regulation using functional magnetic resonance imaging.

Another current project involves studying adipose tissue macrophage infiltration and inflammation, and the factors that regulate these processes. We are currently establishing the methods to characterize the phenotype of macrophages in adipose tissue, as well as to collect different cell types in adipose tissue for subsequent separate analyses. The longer-term goal of this line of research will be to perform lifestyle intervention studies to identify modifiable factors that affect the infiltration of adipose tissue with macrophages as well as their activation.

Keywords

COS Keywords:

Cancer Prevention, Diabetes, Nutrition Or Dietetics, Obesity.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
German: (Fluent, Fluent, Fluent)

Memberships

American Diabetes Association
American Society for Nutrition
North American Association for the Study of Obesity

Previous Positions

2003-2007, Post-doctoral fellow, University of Washington, Medicine, Metabolism, Endocrinology & Nutrition
2001-2003, Post-doctoral fellow, Leibnitz-Institute of Arteriosclerosis Research
1997-2001, Ph.D. student, Leibnitz-Institute of Arteriosclerosis Research, Muenster, Germany

Publications

  • Kratz M, Purnell JQ, Breen PA, Thomas KK, Utzschneider KM, Carr DB, Kahn SE, Hughes JP, Rutledge EA, Van Yserloo B, Yukawa M, Weigle DS (Mar 2008) Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophy, The Journal of Clinical Endocrinology and Metabolism, 93 (3), 959-66 Abstract
  • Kratz M, Swarbrick MM, Callahan HS, Matthys CC, Havel PJ, Weigle DS (Feb 2008) Effect of dietary n-3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and women., The American Journal of Clinical Nutrition, 87 (2), 347-53 Abstract
  • Kratz M, Kannenberg F, Gramenz E, Berning B, Trautwein E, Assmann G, Rust S (Jul 2007) Similar serum plant sterol responses of human subjects heterozygous for a mutation causing sitosterolemia and controls to diets enriched in plant sterols or stanols., European Journal of Clinical Nutrition, 61 (7), 896-905 Abstract
  • Cignarella A, Engel T, von Eckardstein A, Kratz M, Lorkowski S, Lueken A, Assmann G, Cullen P (Apr 2005) Pharmacological regulation of cholesterol efflux in human monocyte-derived macrophages in the absence of exogenous cholesterol acceptors., Atherosclerosis, 179 (2), 229-36 Abstract
  • Kratz M (2005) Dietary cholesterol, atherosclerosis and coronary heart disease., Handbook of Experimental Pharmacology (170), 195-213 Abstract
  • Jacobs B, De Angelis-Schierbaum G, Egert S, Assmann G, Kratz M (Jun 2004) Individual serum triglyceride responses to high-fat and low-fat diets differ in men with modest and severe hypertriglyceridemia., The Journal of Nutrition, 134 (6), 1400-5 Abstract
  • Kratz M, Wahrburg U, von Eckardstein A, Ezeh B, Assmann G, Kronenberg F (Jun 2003) Dietary mono- and polyunsaturated fatty acids similarly increase plasma apolipoprotein A-IV concentrations in healthy men and women., The Journal of Nutrition, 133 (6), 1821-5 Abstract
  • Kratz M, von Eckardstein A, Fobker M, Buyken A, Posny N, Schulte H, Assmann G, Wahrburg U (Nov 2002) The impact of dietary fat composition on serum leptin concentrations in healthy nonobese men and women., The Journal of Clinical Endocrinology and Metabolism, 87 (11), 5008-14 Abstract
  • Kratz M, Gulbahe E, von Eckardstein A, Cullen P, Cignarella A, Assmann G, Wahrburg U (Apr 2002) Dietary mono- and polyunsaturated fatty acids similarly affect LDL size in healthy men and women., The Journal of Nutrition, 132 (4), 715-8 Abstract
  • Wahrburg U, Kratz M, Cullen P (2002) Olive oil, Mediterranean diet, and health, European Journal of Lipid Science and Technology, 9-10, 698-705
  • Kratz M, Cullen P, Wahrburg U (2002) The impact of dietary mono- and polyunsaturated fatty acids on risk factors for atherosclerosis in humans, European Journal of Lipid Science and Technology, 104, 300-11
  • Kratz M, Cullen P, Kannenberg F, Kassner A, Fobker M, Abuja PM, Assmann G, Wahrburg U (Jan 2002) Effects of dietary fatty acids on the composition and oxidizability of low-density lipoprotein., European Journal of Clinical Nutrition, 56 (1), 72-81 Abstract
  • Kratz M (2002) Basics of transcription and translation in the cell, Analysing gene expression, 1st Edition, Weinheim, Germany, VHC-Wiley (bookchapter)
  • Lorkowski S, Kratz M, Wenner C, Schmidt R, Weitkamp B, Fobker M, Reinhardt J, Rauterberg J, Gallinski EA, Cullen P (2001) Expression of the ATP-binding Cassette transporter gene ABCG1 (ABC8) in Tangier Disease, Biomedical and Biophysical Research Communications, 283, 821-30
  • Junker R, Kratz M, Neufeld M, Erren M, Nofer JR, Schulte H, Nowak-Gottl U, Assmann G, Wahrburg U (Feb 2001) Effects of diets containing olive oil, sunflower oil, or rapeseed oil on the hemostatic system., Thrombosis and Haemostasis, 85 (2), 280-6 Abstract

Profile Details

Last Verified: 5/5/2008

COS Expertise ID #1280504
Reference this profile directly: http://myprofile.cos.com/mkratz