Dr. Michael P. LaValley

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Boston University
School of Public Health
Biostatistics
ProfessorAppointed: 2008
Professional Headshot of Michael P. LaValley

Mailing Address

Department of Biostatistics
Crosstown Center, Room 322
801 Mass Ave
Boston, Massachusetts 02118
United States

Contact Information

Phone: (617) 638-5186
Fax: (617) 638-6484
mlava@bu.edu

Qualifications

Ph.D., Pennsylvania State University, Statistics, 1993.
M.A., Ohio State University, Mathematics, 1985.

Expertise and Research Interests

Meta-analysis
Survival analysis
Ordinal response data
Correlated data
Statistical computing
Arthritis research

Keywords

COS Keywords:

Arthritis, Biostatistics, Epidemiology, Mathematics, Regression, Rheumatic Diseases, Statistics, Survival Probability.

Memberships

American Statistical Association
Association of Rheumatology Health Professionals
International Biometric Society

Honors and Awards

2007, Excellence in Teaching Award, School of Public Health, Boston University, Meta-analysis for Public Health and Medical Research
2006, First Place Research Award, American Rehabilitation Counseling Association
2006, Excellence in Teaching Award, School of Public Health, Boston University, Logistic Regression and Survival Analysis
2004, Excellence in Teaching Award, School of Public Health, Boston University, Logistic Regression and Survival Analysis
2004, Excellence in Teaching Award, School of Public Health, Boston University, Meta-Analysis for Public Health and Medical Research
2003, Health Professional Investigator Award, Research and Education Foundation, American College of Rheumatology
2002, Excellence in Teaching Award, School of Public Health, Boston University, Topics in Biostatistics: Meta-Analysis

Previous Positions

2001-2008, Associate Professor, Boston University, School of Public Health, Biostatistics
1995-2000, Assistant Professor, Boston University, School of Public Health, Epidemiology and Biostatistics
1995-2005, Statistician, Boston University, School of Medicine, Clinical Epidemiology Research and Training Unit
1993-1995, Post-Doctoral Fellow, Harvard University, School of Public Health, Biostatistics

Publications

  • Allaire S, Wolfe F, Niu J, LaValley MP, Zhang B, Reisine S (Mar 2009) Current risk factors for work disability associated with rheumatoid arthritis: recent data from a US national cohort., Arthritis and rheumatism, 61 (3), 321-8 Abstract
  • Hernández-Molina G, Reichenbach S, Zhang B, LaValley M, Felson DT (Sep 2008) Effect of therapeutic exercise for hip osteoarthritis pain: results of a meta-analysis., Arthritis and rheumatism, 59 (9), 1221-8 Abstract
  • Amin S, Guermazi A, LaValley MP, Niu J, Clancy M, Hunter DJ, Grigoryan M, Felson DT (Aug 2008) Complete anterior cruciate ligament tear and the risk for cartilage loss and progression of symptoms in men and women with knee osteoarthritis., Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, 16 (8), 897-902 Abstract
  • Allaire S, Wolfe F, Niu J, Zhang Y, Zhang B, LaValley M (Aug 2008) Evaluation of the effect of anti-tumor necrosis factor agent use on rheumatoid arthritis work disability: the jury is still out., Arthritis and rheumatism, 59 (8), 1082-9 Abstract
  • Zhang B, LaValley M, Felson DT (Aug 2008) The sensitivity to change for Lower Disease Activity is greater than for Higher Disease Activity in rheumatoid arthritis trials., Annals of the rheumatic diseases Abstract
  • Knapp PE, Storer TW, Herbst KL, Singh AB, Dzekov C, Dzekov J, LaValley M, Zhang A, Ulloor J, Bhasin S (Jun 2008) Effects of a supraphysiological dose of testosterone on physical function, muscle performance, mood, and fatigue in men with HIV-associated weight loss., American journal of physiology. Endocrinology and metabolism, 294 (6), E1135-43 Abstract
  • Mahr AD, Neogi T, LaValley MP, Davis JC, Hoffman GS, McCune WJ, Specks U, Spiera RF, St Clair EW, Stone JH, Merkel PA (Jun 2008) Assessment of the item selection and weighting in the Birmingham vasculitis activity score for Wegener's granulomatosis., Arthritis and rheumatism, 59 (6), 884-91 Abstract
  • Vlad SC, LaValley MP (Jun 2008) Intention-to-treat analysis may better represent the actual efficacy., Archives of internal medicine, 168 (11), 1228 Abstract
  • LaValley MP (May 2008) Logistic regression., Circulation, 117 (18), 2395-9 Abstract
  • Allaire S, Wolfe F, Niu J, LaValley MP (Apr 2008) Contemporary prevalence and incidence of work disability associated with rheumatoid arthritis in the US., Arthritis and rheumatism, 59 (4), 474-80 Abstract
  • Hunter DJ, LaValley M, Li J, Bauer DC, Nevitt M, DeGroot J, Poole R, Eyre D, Guermazi A, Gale D, Totterman S, Felson DT (2008) Biochemical markers of bone turnover and their association with bone marrow lesions., Arthritis research & therapy, 10 (4), R102 Abstract
  • Mahr AD, Jover JA, Spiera RF, Hernández-García C, Fernández-Gutiérrez B, LaValley MP, Merkel PA (Aug 2007) Adjunctive methotrexate for treatment of giant cell arteritis: an individual patient data meta-analysis., Arthritis and rheumatism, 56 (8), 2789-97 Abstract
  • Vlad SC, LaValley MP, McAlindon TE, Felson DT (Jul 2007) Glucosamine for pain in osteoarthritis: why do trial results differ?, Arthritis and rheumatism, 56 (7), 2267-77 Abstract
  • Baker K, Goggins J, Xie H, Szumowski K, LaValley M, Hunter DJ, Felson DT (Apr 2007) A randomized crossover trial of a wedged insole for treatment of knee osteoarthritis., Arthritis and rheumatism, 56 (4), 1198-203 Abstract
  • Hunter DJ, Li J, LaValley M, Bauer DC, Nevitt M, DeGroot J, Poole R, Eyre D, Guermazi A, Gale D, Felson DT (2007) Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study., Arthritis research & therapy, 9 (5), R108 Abstract
  • Kapoor A, Page S, LaValley M, Gale D, Felson DT (2007) MRI for diagnosing foot osteomyelitis: a meta-analysis, Archives of Internal Medicine, 167 (2), 125-132
  • Amin S, Niu J, Guermazi A, Grigorian M, Hunter DJ, Clancy M, LaValley MP, Genant HK, Felson DT (2007) Cigarette smoking and the risk of cartilage loss and knee pain in men with knee osteoarthritis, Annals of the Rheumatic Diseases, 66 (1), 18-22
  • Hunter DJ, LaValley M, Li J, Zhang Y, Bauer D, Nevitt M, Guermazi A, Degroot J, Sakkee N, Gale D, Felson DT (2007) Urinary pentosidine does not predict cartilage loss among subjects with symptomatic knee OA: the BOKS study, Osteoarthritis and Cartilage, 15 (1), 93-97
  • Hunter DJ, Zhang Y, Tu X, LaValley M, Niu J, Amin S, Guermazi A, Genant H, Gale D, Felson DT (2006) Change in joint space witdth: hyaline articular cartilage or alteration in the meniscus?, Arthritis & Rheumatism, 54, 2488-2495
  • Hunter DJ, Zhang Y, Niu J, Goggins J, Amin S, LaValley MP, Guermazi A, Genant H, Gale D, Felson DT (2006) Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis, Arthritis & Rheumatism, 54, 1529-1535
  • Neogi T, Nevitt M, Niu J, LaValley MP, Hunter DJ, Terkeltaub R, Carbone L, Chen H, Harris T, Kwoh K, Guermazi A, Felson DT (2006) Lack of association between chondrocalcinosis and increased risk of cartilage loss in knees with osteoarthritis, Arthritis & Rheumatism, 54, 1822-1828
  • Allaire S, Wolfe F, Niu J, Baker N, Michaud K, LaValley M (2006) The physical demand of jobs held by employed persons with rheumatoid arthritis is characterized by extensive hand use, Arthritis & Rheumatism (Arthritis Care & Research), 55, 294-299
  • Gao X, LaValley MP, Tucker KL (2005) Prospective studies of dairy product and calcium intakes and prostate cancer risk: a meta-analysis, Journal of the National Cancer Institute, 97, 1768-1777
  • Hunter DJ, Zhang Y, Niu J, Tu X, Amin S, Goggins J, LaValley M, Guermazi A, Gale D, Felson DT (2005) Structural factors associated with malalignment in knee osteoarthritis: the Boston osteoarthritis of the knee study, Journal of Rheumatology, 32, 2192-2199
  • LaValley MP, McLaughlin S, Goggins J, Gail D, Nevitt MC, Felson DT (2005) The lateral view radiograph for assessment of the tibiofemoral joint space in knee osteoarthritis: its reliability, sensitivity to change and longitudinal validity, Arthritis and Rheumatism, 52, 3542-3547
  • Amin S, LaValley MP, Guermazi A, Grigoryan M, Hunter DJ, Clancy M, Niu J, Gale DR, Felson DT (Oct 2005) The relationship between cartilage loss on magnetic resonance imaging and radiographic progression in men and women with knee osteoarthritis., Arthritis and Rheumatism, 52 (10), 3152-9 Abstract
  • Akritas M, LaValley MP (2005) A generalized product-limit estimator for truncated data, Journal of Nonparametric Statistics, 17, 643-663
  • Lo GH, Hunter DJ, Zhang Y, McLennan CE, LaValley MP, Kiel DP, McLean RR, Genant HK, Guermazi A, Felson DT (Sep 2005) Bone marrow lesions in the knee are associated with increased local bone density, Arthritis and Rheumatism, 52 (9), 2814-21 Abstract
  • Allaire S, Wolfe F, Niu J, LaValley M, Michaud K (Aug 2005) Work disability and its economic effect on 55-64-year-old adults with rheumatoid arthritis, Arthritis and Rheumatism, 53 (4), 603-8 Abstract
  • Oran B, Malek K, Sanchorawala V, Wright DG, Quillen K, Finn KT, LaValley M, Skinner M, Seldin DC (Mar 2005) Predictive factors for hematopoietic engraftment after autologous, Bone Marrow Transplantation, 35 (6), 567-75 Abstract
  • Alliaire SH, Niu J, LaValley MP, Employment and satisfaction outcomes from a job retention intervention delivered to persons with chronic diseases, Rehabilitation Counseling Bulletin, 48(2), 100-9, 15 Jan 2005
  • Felson DT, Gale DR, Elon Gale M, Niu J, Hunter DJ, Goggins J, LaValley MP (Jan 2005) Osteophytes and progression of knee osteoarthritis., Rheumatology (oxford, England), 44 (1), 100-4 Abstract
  • McAlindon T, Formica M, LaValley M, Lehmer M, Kabbara K, Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial, The American Journal of Medicine, 117(9), 643-9, Nov 2004 Abstract
  • Warsi A, Wang PS, LaValley MP, Avorn J, Solomon DH, Self-management education programs in chronic disease: a systematic review and methodological critique of the literature, Archives of Internal Medicine, 164(15), 1641-9, Aug 2004 Abstract
  • Amin S, Luepongsak N, McGibbon CA, LaValley MP, Krebs DE, Felson DT, Knee adduction moment and development of chronic knee pain in elders, Arthritis and Rheumatism, 51(3), 371-6, Jun 2004 Abstract
  • Lo GH, LaValley M, McAlindon T, Felson DT, Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis, Jama : the Journal of the American Medical Association, 290(23), 3115-21, Dec 2003 Abstract
  • Allaire SH, Li W, LaValley MP, Reduction of job loss in persons with rheumatic diseases receiving vocational rehabilitation: A randomized controlled trial, Arthritis and Rheumatism, 48(11), 3212-8, November 2003 Abstract
  • Felson DT, McLaughlin S, Goggins J, LaValley MP, Gale ME, Totterman S, Li W, Hill C, Gale D, Bone marrow edema and its relation to progression of knee osteoarthritis, Annals of Internal Medicine, 139(5 Pt 1), 330-6, September 2003 Abstract
  • Warsi A, LaValley MP, Wang PS, Avorn J, Solomon DH, Arthritis self-management education programs: a meta-analysis of the effect on pain and disability, Arthritis and Rheumatism, 48(8), 2207-13, August 2003 Abstract
  • McAlindon T, Formica M, Kabbara K, LaValley M, Lehmer M, Conducting clinical trials over the internet: feasibility study, Bmj (clinical Research Ed.), 327(7413), 484-7, Aug 2003 Abstract
  • Demissie S, LaValley MP, Horton NJ, Glynn RJ, Cupples LA, Bias due to missing exposure data using complete-case analysis in the proportional hazards regression model, Statistics in Medicine, 22(4), 545-57, February 2003 Abstract
  • LaValley MP, Felson DT, Truth survival [comment], Annals of Internal Medicine, 137, 932, December 2002
  • Amin S, Lavalley MP, Simms RW, Felson DT, The comparative efficacy of drug therapies used for the management of corticosteroid-induced osteoporosis: a meta-regression, Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research., 17(8), 1512-26, Aug 2002 Abstract
  • Hill CL, LaValley MP, Felson DT, Discrepancy between published report and actual conduct of randomized clinical trials, Journal of Clinical Epidemiology, 55(8), 783-6, Aug 2002 Abstract
  • LaValley MP, Felson DT, Statistical presentation and analysis of ordered categorical outcome data in rheumatology journals, Arthritis and Rheumatism, 47(3), 255-9, June 2002 Abstract
  • Hill CL, LaValley MP, Felson DT, Secular changes in the quality of published randomized clinical trials in rheumatology, Arthritis and Rheumatism, 46(3), 779-84, March 2002 Abstract
  • LaValley M, McAlindon TE, Evans S, Chaisson CE, Felson DT, Problems in the development and validation of questionnaire-based screening instruments for ascertaining cases with symptomatic knee osteoarthritis: the Framingham Study, Arthritis and Rheumatism, 44(5), 1105-13, May 2001 Abstract
  • Allaire SH, Evans SR, LaValley MP, Merrigan DM, Use of the Americans with Disabilities Act by persons with rheumatic diseases and factors associated with use, Arthritis and Rheumatism, 45(2), 174-82, April 2001 Abstract
  • LaValley MP, McAlindon TE, Chaisson CE, Levy D, Felson DT, The validity of different definitions of radiographic worsening for longitudinal studies of knee osteoarthritis, Journal of Clinical Epidemiology, 54(1), 30-9, Jan 2001 Abstract
  • McAlindon TE, LaValley MP, Gulin JP, Felson DT, Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis, JAMA, 283(11), 1469-75, March 2000 Abstract
  • Fraenkel L, Shearer P, Mitchell P, LaValley M, Feldman J, Felson DT, Improving the selective use of plain radiographs in the initial evaluation of shoulder pain, Journal of Rheumatology, 27(1), 200-4, Jan 2000 Abstract
  • Allaire SH, LaValley MP, Evans SR, O'Connor GT, Kelly-Hayes M, Meenan RF, Levy D, Felson DT, Evidence for decline in disability and improved health among persons aged 55 to 70 years: the Framingham Heart Study, American Journal of Public Health, 89(11), 1678-83, November 1999 Abstract
  • Felson DT, LaValley MP, Baldassare AR, Block JA, Caldwell JR, Cannon GW, Deal C, Evans S, Fleischmann R, Gendreau RM, Harris ER, Matteson EL, Roth SH, Schumacher HR, Weisman MH, Furst DE, The Prosorba column for treatment of refractory rheumatoid arthritis: a randomized, double-blind, sham-controlled trial, Arthritis and Rheumatism, 42(10), 2153-9, October 1999 Abstract
  • Amin S, LaValley MP, Simms RW, Felson DT, The role of vitamin D in corticosteroid-induced osteoporosis: a meta-analytic approach, Arthritis and Rheumatism, 42(8), 1740-51, August 1999 Abstract
  • LaValley MP, Felson DT, Early stopping of clinical trials in lupus and other uncommon rheumatologic diseases, Lupus, 8(8), 698-703, 1999 Abstract
  • Fraenkel L, Lavalley M, Felson D, The use of radiographs to evaluate shoulder pain in the ED, American Journal of Emergency Medicine, 16(6), 560-3, October 1998 Abstract
  • Fraenkel L, Roubenoff R, LaValley M, McAlindon T, Chaisson C, Evans S, Harris T, Dinarello CA, Felson DT, The association of peripheral monocyte derived interleukin 1beta (IL-1beta), IL-1 receptor antagonist, and tumor necrosis factor-alpha with osteoarthritis in the elderly, Journal of Rheumatology, 25(9), 1820-6, September 1998 Abstract
  • Felson DT, Couropmitree NN, Chaisson CE, Hannan MT, Zhang Y, McAlindon TE, LaValley M, Levy D, Myers RH, Evidence for a Mendelian gene in a segregation analysis of generalized radiographic osteoarthritis: the Framingham Study, Arthritis and Rheumatism, 41(6), 1064-71, June 1998 Abstract
  • Comenzo RL, Vosburgh E, Falk RH, Sanchorawala V, Reisinger J, Dubrey S, Dember LM, Berk JL, Akpek G, LaValley M, O'hara C, Arkin CF, Wright DG, Skinner M, Dose-intensive melphalan with blood stem-cell support for the treatment of AL (amyloid light-chain) amyloidosis: survival and responses in 25 patients, Blood, 91(10), 3662-70, May 1998 Abstract
  • Felson DT, Anderson JJ, Lange ML, Wells G, LaValley MP, Should Improvement in Rheumatoid Arthritis Clinical Trials be Defined as Fifty Percent or Seventy Percent Improvement in Core Set Measures, Rather than Twenty Percent?, Arthritis and Rheumatism, 41, 1564-70, 1998
  • Fraenkel L, Zhang Y, Trippel SB, McAlindon TE, LaValley MP, Assif A, Adams KE, Evans SR, Felson DT, Longitudinal Analysis of the Relationship Between Serum Insulin-like Growth Factor-I and Radiographic Knee Osteoarthritis, Osteoarthritis and Cartilage, 6, 362-7, 1998
  • Dubrey SW, Bilazarian S, LaValley M, Reisinger J, Skinner M, Falk RH, Signal-averaged electrocardiography in patients with AL (primary) amyloidosis, American Heart Journal, 134(6), 994-1001, December 1997 Abstract
  • Reisinger J, Dubrey SW, Lavalley M, Skinner M, Falk RH, Electrophysiologic abnormalities in AL (primary) amyloidosis with cardiac involvement, Journal of the American College of Cardiology, 30(4), 1046-51, October 1997 Abstract
  • Felson DT, McAlindon TE, Anderson JJ, Naimark A, Weissman BW, Aliabadi P, Evans S, Levy D, LaValley MP, Defining radiographic osteoarthritis for the whole knee, Osteoarthritis and Cartilage, 5(4), 241-50, July 1997 Abstract
  • Dubrey SW, Cha K, Skinner M, LaValley M, Falk RH, Familial and primary (AL) cardiac amyloidosis: echocardiographically similar diseases with distinctly different clinical outcomes [see comments], Heart, 78(1), 74-82, July 1997 Abstract
  • LaValley M, A consumer's guide to meta-analysis, Arthritis Care and Research, 10(3), 208-13, June 1997 Abstract
  • Akritas MG, LaValley MP, Statistical Analysis with Incomplete Data: A Selective Review, Handbook of Statistics, 15, 551-632, 1997
  • LaValley MP, Anderson JJ, Statistical and Study Design Issues in Assessing the Quality and Outcomes of Care in Rheumatic Diseases, Arthritis Care and Research, 10, 431-40, 1997
  • LaValley MP, DeGruttola V, Models for empirical Bayes estimators of longitudinal CD4 counts, Statistics in Medicine, 15(21-22), 2289-305; discussion, November 1996 Abstract
  • Akritas MG, LaValley MP, Nonparametric inference in factorial designs with censored data, Biometrics, 52(3), 913-24, September 1996 Abstract
  • Akritas MG, Murphy SA, LaValley MP, The Theil-Sen Estimator with Doubly Censored Data and Applications to Astronomy, Journal of the American Statistical Association, 90, 170-77, 1995

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