Lyle F. Mockros

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Northwestern University
Robert R. McCormick School of Engineering and Applied Sciences
Biomedical Engineering
ProfessorAppointed: 1985
Northwestern University
Robert R. McCormick School of Engineering and Applied Sciences
Chemical and Biological Engineering
ProfessorAppointed: 1991

Mailing Address

Department of Biomedical Engineering
Northwestern University
2145 Sheridan Road
Evanston, Illinois 60208-3107
United States

Contact Information

Phone: (847) 491-3172
Fax: (847) 491-4928
lmockros@northwestern.edu
http://www.bme.northwestern.edu/faculty/fac_core_mockros.shtml

Qualifications

Ph.D., University of California, Berkeley, Fluid Mechanics, 1962.
M.S., Northwestern University, Civil Engineering, 1957.
B.S., Northwestern University, Civil Engineering, 1956.

Expertise and Research Interests

Our current research focuses on the fluid mechanics and mass transfer processes of blood in medical devices. We are specifically interested in the engineering analysis and design of cross-flow bioprocessing equipment and artificial lungs.

Many blood processing devices involve the flow of suspensions through porous-walled tubes. Our research focuses on theoretical and experimental investigations of both general suspensions and certain
specific suspensions, e.g., blood. Applications include cell separations, cell washing, and the removal or addition of specific molecules or groups of molecules.

Artificial lungs are widely used as the lung part of the heart-lung machines needed during open-heart surgery. This is a short-term application, a matter of hours. Our current work focuses on the
development of devices for the intermediate term (weeks) for the treatment of acute but reversible respiratory distress and for the long term (years) as a permanent implant. The basic engineering problems involve optimizing gas transfer to flowing blood while minimizing trauma to blood components.

Other Expertise

Civil Engineering: Open Channel Flows

Keywords

COS Keywords:

Biomedical Engineering, Fluid Mechanics, Mass Transfer.

Additional Terms:

Biomedical Engineering, Blood Processing Equipment, Development of Artificial Lungs, Fluid Mechanics and Mass Transfer Processes, Thrombogenesis in Prosthetic Devices.

Memberships

American Institute for Medical and Biological Engineering
American Society for Artificial Internal Organs
American Society of Civil Engineers
American Society of Mechanical Engineers - Bioengineering Division
Biomedical Engineering Society

Honors and Awards

1993, Founding Fellow, American Institute for Medical and Biological Engineering
1992-1996, Program Committee, American Society for Artificial Internal Organs
1992-1996, Editorial Board, ASAIO Transactions, American Society for Artificial Internal Organs
1986-1990, Editorial Board, ASAIO Transactions, American Society for Artificial Internal Organs
1985-1988, Program Committee, American Society for Artificial Internal Organs
1984, Outstanding Teacher in Engineering, Northwestern University
1983-1984, Nominations Committee, Biomedical Engineering Society
1983-1984, Membership Committee, Biomedical Engineering Society
1982, Honorable Mention, Tech Teaching Award, Northwestern University
1982, Civil Engineering Teacher of the Year, Northwestern University
1982-1990, Editorial Board, Annals of Biomedical Engineering
1979, Honorable Mention, Tech Teaching Award, Northwestern University
1977, Nightingale Prize, Journal of Medical and Biological Engineering, Best Paper for the Two Years: 1975-1976
1976, Honorable Mention, Tech Teaching Award, Northwestern University
1968, Founding Member, Biomedical Engineering Society

Previous Positions

1978-1980, Associate Chairman, Northwestern University, Robert R. McCormick School of Engineering and Applied Sciences, Civil Engineering
1976-1983, Chairman, Northwestern University, Biomedical Engineering Council and Biomedical Engineering
1970-1991, Professor, Northwestern University, Civil Engineering and Engineering Sciences
1966-1970, Associate Professor, Northwestern University
1962-1966, Assistant Professor, Northwestern University
1959-1962, Assistant Research Engineer, University of California, Berkeley, Institute of Engineering Research
1957-1959, Teaching Associate, University of California, Berkeley, Civil Engineering

Patents

Vascular Acoustic Emission Analysis in a Balloon Angioplasty System, Patent Number: 5,957,950, 1999, Northwestern University, United States.
Intravascular Lung Assist Device and Method., Patent Number: 5037383, 1991, Northwestern University, .

Publications

  • Boschetti F, Cook KE, Perlman CE and Mockros LF, Blood Flow Pulsatility Effects upon Oxygen Transfer in Artificial Lungs, ASAIO Journal, 49(6), 678-687, 2003
  • Mockros LF and Cook KE, Engineering Design of Thoracic Artificial Lungs, Landes Biosciences Publishers, Austin, Texas, pp. 33-64, 2002., 33-64, 2002
  • Cook KE, Maxhimer J, Leonard DJ, Mavroudis C, Backer CL, Mockros LF, Platelet and leukocyte activation and design consequences for thoracic artificial lungs, ASAIO Journal (American Society for Artificial Internal Organs), 48(6), 620-30, 2002
  • Cook KE and Mockros LF, Biocompatibility of Artificial Lungs, Landes Biosciences Publishers, 65-97, 2002
  • Zwischenberger JB, Anderson CM, Cook KE, Lick SD, Mockros LF, Bartlett RH, Development of an implantable artificial lung: challenges and progress, Asaio Journal (american Society for Artificial Internal Organs : 1992), 47(4), 316-20, 2001 Abstract
  • Boschetti F, Perlman CE, Cook KE, Mockros LF, Hemodynamic effects of attachment modes and device design of a thoracic artificial lung, Asaio Journal (american Society for Artificial Internal Organs : 1992), 46(1), 42-8, 2000 Abstract
  • Liu SQ, Moore MM, Glucksberg MR, Mockros LF, Grotberg JB, Mok AP, Partial prevention of monocyte and granulocyte activation in experimental vein grafts by using a biomechanical engineering approach, Journal of Biomechanics, 32(11), 1165-75, November 1999 Abstract
  • Ryan EA, Mockros LF, Stern AM, and Lorand L, Influence of a Natural and Synthetic Inhibitor of Factor XIIIa on Fibrin Clot Rheology, Biophysical Journal, 77, 2827-2839, 1999
  • Ryan EA, Mockros LF, Weisel JW, and Lorand L, Structural Origins of Fibrin Clot Rheology, Biophysical Journal, 77, 2813-2826, 1999
  • Vonesh MJ, Mockros LF, Davidson CJ, Chandran KB, McPherson DD, A hypothesis regarding vascular acoustic emission accompanying arterial injury induced by balloon angioplasty, Annals of Biomedical Engineering, 25(5), 882-95, 1997 Abstract
  • Vonesh MJ, Mockros LF, Davidson CJ, Chandran KB, McPherson DD, In vitro identification of angioplasty-induced injury by use of vascular acoustic emissions, Circulation, 95(4), 1022-9, February 1997 Abstract
  • Cook KE, Makarewicz AJ, Backer CL, Mockros LF, Przybylo HJ, Crawford SE, Hernandez JM, Leonard RJ, Mavroudis C, Testing of an intrathoracic artificial lung in a pig model, Asaio Journal (american Society for Artificial Internal Organs : 1992), 42(5), M604-9, 1996 Abstract
  • Makarewicz AJ, Mockros LF, Mavroudis C, New design for a pumping artificial lung, Asaio Journal (american Society for Artificial Internal Organs : 1992), 42(5), M615-9, 1996 Abstract

Profile Details

Last Updated: 9/2/2004

COS Expertise ID #418395
Reference this profile directly: http://myprofile.cos.com/mock88