Prof. Frederick Gerard Moeller

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University of Texas Health Science Center at Houston
Medical School
Psychiatry and Behavioral Sciences
Mental Sciences Institute
ProfessorAppointed: 2004
University of Texas Health Science Center at Houston
Graduate School of Biomedical Sciences
Member

Mailing Address

Department of Psychiatry and Behavioral Sciences
University of Texas - Houston Health Science Center
1300 Moursund
Houston, Texas 77030
United States

Contact Information

Phone: (713) 500-2858
Fax: (713) 500-2624
Frederick.G.Moeller@uth.tmc.edu

Qualifications

M.D., University of Texas Health Science Center at Houston, Medicine, 1985.

Expertise and Research Interests

The neurobiology of behavior with an emphasis on the role of impulse control in substance abuse. Combining genetics, brain imaging, and behavioral laboratory measures to study substance abuse. Medication development for cocaine dependence. Functional magnetic resonance imaging and diffusion tensor imaging of substance abuse.

Other Expertise

Pharmacotherapy of substance abuse

Member, Houston Chapter of American Foundation for Suicide Prevention

Future Research

Neurobiology of Impulse Control

Industrial Relevance

Pharmacotherapy of alcohol dependence and stimulant dependence

Keywords

COS Keywords:

Behavioral Medicine, Behavioral Pharmacology, Substance Abuse, Violent Behavior.

Additional Terms:

FMRI, Impulsivity, Serotonin, Substance Abuse.

Memberships

American Foundation for Suicide Prevention
American Medical Association
American Psychiatric Association
Argentine Institute for the Study of the Personality and its Disorders
College on Problems of Drug Dependence
International Society for Magnetic Resonance in Medicine
International Society for Research on Impulsivity
International Society of Psychoneuroendocrinology
Organization for Human Brain Mapping
Society for Neuroscience
Society of Biological Psychiatry
World Psychiatric Association

Honors and Awards

President, International Society for Research on Impulsivity
Chair, Scientific Section on Impulsivity and Impulse Control Disorders, World Psychiatric Association
Independent Scientist Award (K02 DA00403), National Institutes of Health (NIH), University of Texas Health Science Center at Houston

Previous Positions

1993-1997, Assistant Professor, University of Texas Health Science Center at Houston, Medical School, Psychiatry, Substance Abuse Research Center
1990-1993, Assistant Professor, University of Texas Southwestern Medical Center at Dallas, Medical School - Departments and Divisions, Psychiatry

Funding Received

  • National Institutes of Health (NIH): Serotonin and Aggression in Cocaine Dependence, Oct 1, 1996 to Aug 30, 2000.
  • National Institutes of Health (NIH): Antisocial Personality and Alcohol Induced Aggression, May 1, 1997 to Apr 30, 2000.
  • National Institutes of Health (NIH): Substance Abuse Research- Medication Development Center, 2007 to 2010.
  • National Institutes of Health (NIH): Serotonin, Impulsivity, and Substance Abuse, 2007 to 2012.
  • National Institutes of Health (NIH): Scientific Meeting of ISRI, 2005 to 2005.
  • National Institutes of Health (NIH): Serotonin, Impulsivity, and Cocaine Dependence Treatment, 2000 to 2006.
  • National Institutes of Health (NIH): Serotonin, Impulse Control and Substance Abuse, 2000 to 2006.
  • National Institutes of Health (NIH): Serotonin, Drug Use and MDMA Induced Deficits, 2000 to 2007.

Publications

  • Schmitz JM, Mooney ME, Moeller FG, Stotts AL, Green C, Grabowski J (Apr 2008) Levodopa pharmacotherapy for cocaine dependence: Choosing the optimal behavioral therapy platform., Drug and alcohol dependence, 94 (1-3), 142-50 Abstract
  • Swann AC, Steinberg JL, Lijffijt M, Moeller FG (Sep 2007) Impulsivity: Differential relationship to depression and mania in bipolar disorder. Abstract
  • Mathias CW, Stanford MS, Marsh DM, Frick PJ, Moeller FG, Swann AC, Dougherty DM (Jun 2007) Characterizing aggressive behavior with the Impulsive/Premeditated Aggression Scale among adolescents with conduct disorder., Psychiatry research, 151 (3), 231-42 Abstract
  • Mooney ME, Schmitz JM, Moeller FG, Grabowski J (May 2007) Safety, tolerability and efficacy of levodopa-carbidopa treatment for cocaine dependence: two double-blind, randomized, clinical trials., Drug and alcohol dependence, 88 (2-3), 214-23 Abstract
  • Moeller FG, Hasan KM, Steinberg JL, Kramer LA, Valdes I, Lai LY, Swann AC, Narayana PA (Apr 2007) Diffusion tensor imaging eigenvalues: preliminary evidence for altered myelin in cocaine dependence., Psychiatry research, 154 (3), 253-8 Abstract
  • Lane SD, Moeller FG, Steinberg JL, Buzby M, Kosten TR (2007) Performance of cocaine dependent individuals and controls on a response inhibition task with varying levels of difficulty., The American journal of drug and alcohol abuse, 33 (5), 717-26 Abstract
  • Moeller FG, Steinberg JL, Lane SD, Buzby M, Swann AC, Hasan KM, Kramer LA, Narayana PA (2007) Diffusion tensor imaging in MDMA users and controls: association with decision making., The American journal of drug and alcohol abuse, 33 (6), 777-89 Abstract
  • Moeller FG, Schmitz JM, Steinberg JL, Green CM, Reist C, Lai LY, Swann AC, Grabowski J (2007) Citalopram combined with behavioral therapy reduces cocaine use: a double-blind, placebo-controlled trial., The American journal of drug and alcohol abuse, 33 (3), 367-78 Abstract
  • Lane SD, Moeller FG, Steinberg JL, Buzby M, Kosten TR (2007) Performance of cocaine dependent individuals and controls on a response inhibition task with varying levels of difficulty., The American journal of drug and alcohol abuse, 33 (5), 717-26 Abstract
  • Moeller FG, Steinberg JL, Lane SD, Buzby M, Swann AC, Hasan KM, Kramer LA, Narayana PA (2007) Diffusion tensor imaging in MDMA users and controls: association with decision making., The American journal of drug and alcohol abuse, 33 (6), 777-89 Abstract
  • Swann AC, Birnbaum D, Jagar AA, Dougherty DM, Moeller FG (May 2005) Acute yohimbine increases laboratory-measured impulsivity in normal subjects, Biological Psychiatry, 57 (10), 1209-11
  • Moeller FG, Hasan KM, Steinberg JL, Kramer LA, Dougherty DM, Santos RM, Valdes I, Swann AC, Barratt ES, Narayana PA (Mar 2005) Reduced anterior corpus callosum white matter integrity is related to increased impulsivity and reduced discriminability in cocaine-dependent subjects: diffusion tensor imaging, Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 30 (3), 610-7
  • Stein DJ, Moeller FG (Feb 2005) The man who turned bad, Cns Spectrums, 10 (2), 88-90
  • Moeller FG, Steinberg JL, Dougherty DM, Narayana PA, Kramer LA, Renshaw PF, Functional MRI study of working memory in MDMA users, Psychopharmacology, 18 Jun 2004
  • Swann AC, Dougherty DM, Pazzaglia PJ, Pham M, Moeller FG, Impulsivity: a link between bipolar disorder and substance abuse, Bipolar Disorders, 6(3), 204-12, 2004 Abstract
  • Grabowski J, Rhoades H, Stotts A, Cowan K, Kopecky C, Dougherty A, Moeller FG, Hassan S, Schmitz J, Agonist-like or antagonist-like treatment for cocaine dependence with methadone for heroin dependence: two double-blind randomized clinical trials, Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology., 29(5), 969-81, 2004 Abstract
  • Moeller FG, Barratt ES, Fischer CJ, Dougherty DM, Reilly EL, Mathias CW, Swann AC, P300 event-related potential amplitude and impulsivity in cocaine-dependent subjects, Neuropsychobiology, 50(2), 167-73, 2004 Abstract
  • Swann AC, Pazzalia P, Nicholls A, Dougherty DM, Moeller FG, Impulsivity and phase of illness in bipolar disorder, Journal of Affective Disorders, 75, 105-111, 2003
  • Swann AC, Bjork JM, Moeller FG, Dougherty DM, Two models of impulsivity: relationship to personality traits and psychopathology, Biological Psychiatry, 51(12), 988-94, June 2002 Abstract
  • Schmitz JM, Averill P, Sayre S, McCleary P, Moeller FG, Swann A, Cognitive-behavioral treatment of bipolar disorder and substance abuse: A preliminary randomized study, Journal of Addictive Disorders and Their Treatment, 1, 17-24, 2002
  • Moeller FG, Dougherty DM, Steinberg JL, Swann AC, Silverman PB, Ruiz P, Barratt ES, Heavy 'ecstacy' use is associated with increased impulsivity, Journal of Addictive Disorders and Their Treatment, 1, 47-52, 2002
  • Moeller FG, Dougherty DM, Barratt ES, Oderinde V, Mathias CW, Harper RA, Swann AC, Increased impulsivity in cocaine dependent subjects independent of antisocial personality disorder and aggression, Drug and Alcohol Dependence, 68, 105-111, 2002
  • Dougherty DM, Bjork JM, Marsh DM, Moeller FG, Influence of trait hostility on tryptophan depletion-induced laboratory aggression., Psychiatry Res, 88(3), 227-32, 29 Nov 1999 Abstract
  • Dougherty DM, Bjork JM, Bennett RH, Moeller FG, The effects of a cumulative alcohol dosing procedure on laboratory aggression in women and men, Journal of Studies On Alcohol, 60(3), 322-9, May 1999 Abstract
  • Davis LL, Clark DM, Kramer GL, Moeller FG, Petty F, D-fenfluramine challenge in posttraumatic stress disorder, Biological Psychiatry, 45(7), 928-30, April 1999 Abstract
  • Dougherty DM, Bjork JM, Huckabee HC, Moeller FG, Swann AC, Laboratory measures of aggression and impulsivity in women with borderline personality disorder., Psychiatry Res, 85(3), 315-26, 22 Mar 1999 Abstract
  • Dougherty DM, Bjork JM, Huckabee HC, Moeller FG, Swann AC, Laboratory measures of aggression and impulsivity in women with borderline personality disorder, Psychiatry Research, 85(3), 315-26, March 1999 Abstract
  • Bjork JM, Dougherty DM, Moeller FG, Symptomatology of depression and anxiety in female 'social drinkers', American Journal of Drug and Alcohol Abuse, 25(1), 173-82, February 1999 Abstract
  • Cherek DR, Moeller FG, Khan-Dawood F, Swann A, Lane SD, Prolactin response to buspirone was reduced in violent compared to nonviolent parolees, Psychopharmacology, 142(2), 144-8, February 1999 Abstract
  • Bjork JM, Dougherty DM, Moeller FG, Cherek DR, Swann AC, The effects of tryptophan depletion and loading on laboratory aggression in men: time course and a food-restricted control, Psychopharmacology, 142(1), 24-30, February 1999 Abstract
  • Cherek DR, Moeller FG, Khan-Dawood F, Swann A, Lane SD, Prolactin response to buspirone was reduced in violent compared to nonviolent parolees., Psychopharmacology \(Berl\), 142(2), 144-8, February 1999 Abstract
  • Moeller FG, Dougherty DM, Lane SD, Steinberg JL, Cherek DR, Antisocial personality disorder and alcohol-induced aggression, Alcoholism, Clinical and Experimental Research, 22(9), 1898-902, December 1998 Abstract
  • Moeller FG, Allen T, Cherek DR, Dougherty DM, Lane S, Swann AC, Ipsapirone neuroendocrine challenge: relationship to aggression as measured in the human laboratory., Psychiatry Res, 81(1), 31-8, 19 Oct 1998 Abstract
  • Moeller FG, Allen T, Cherek DR, Dougherty DM, Lane S, Swann AC, Ipsapirone neuroendocrine challenge: relationship to aggression as measured in the human laboratory, Psychiatry Research, 81(1), 31-8, October 1998 Abstract
  • Lane SD, Cherek DR, Dougherty DM, Moeller FG, Laboratory measurement of adaptive behavior change in humans with a history of substance dependence, Drug and Alcohol Dependence, 51(3), 239-52, August 1998 Abstract
  • Lane SD, Cherek DR, Dougherty DM, Moeller FG, Laboratory measurement of adaptive behavior change in humans with a history of substance dependence., Drug and Alcohol Dependence, 51(3), 239-52, 1 Aug 1998 Abstract
  • Dougherty DM, Steinberg JL, Wassef AA, Medearis D, Cherek DR, Moeller FG, Immediate versus delayed visual memory task performance among schizophrenic patients and normal control subjects, Psychiatry Research, 79(3), 255-65, July 1998 Abstract
  • Allen TJ, Moeller FG, Rhoades HM, Cherek DR, Impulsivity and history of drug dependence, Drug and Alcohol Dependence, 50(2), 137-45, April 1998 Abstract
  • Doughterty DM Bjork JM Cherek DR Moeller FG and Huang D, The effects of menstrual cycle phase on aggression measured in men and women, Aggressive Behavior, 24, 9-26, 1998
  • Dougherty DM, Bjork JM, Moeller FG, Swann AC, The influence of menstrual-cycle phase on the relationship between testosterone and aggression, Physiology and Behavior, 62(2), 431-5, August 1997 Abstract
  • Allen TJ, Moeller FG, Rhoades HM, Cherek DR, Subjects with a history of drug dependence are more aggressive than subjects with no drug use history, Drug and Alcohol Dependence, 46(1-2), 95-103, June 1997 Abstract
  • Bjork JM, Dougherty DM, Moeller FG, A positive correlation between self-ratings of depression and laboratory-measured aggression, Psychiatry Research, 69(1), 33-8, March 1997 Abstract
  • Cherek DR, Moeller FG, Schnapp W, Dougherty DM, Studies of violent and nonviolent male parolees: I. Laboratory and psychometric measurements of aggression, Biological Psychiatry, 41(5), 514-22, March 1997 Abstract
  • Cherek DR, Moeller FG, Dougherty DM, Rhoades H, Studies of violent and nonviolent male parolees: II. Laboratory and psychometric measurements of impulsivity, Biological Psychiatry, 41(5), 523-9, March 1997 Abstract
  • Moeller FG, Dougherty DM, Rustin T, Swann AC, Allen TJ, Shah N, Cherek DR, Antisocial personality disorder and aggression in recently abstinent cocaine dependent subjects, Drug and Alcohol Dependence, 44(2-3), 175-82, March 1997 Abstract
  • Dougherty DM Bjork JM Huang D and Moeller FG, The relationship between self-reported menstrual symptomatology and aggression measured in the laboratory, Personality and Individual Differenences, 44, 175-182, 1997
  • Moeller FG, Dougherty DM, Swann AC, Collins D, Davis CM, Cherek DR, Tryptophan depletion and aggressive responding in healthy males, Psychopharmacology, 126(2), 97-103, July 1996 Abstract
  • Waller DA, Sheinberg Al, Gullion C, Moeller FG, Cannon DS, Petty F, Hardy BW, Orsulak P, Rush AJ, Impulsivity and neuroendocrine response to buspirone in bulimia nervosa, Biological Psychiatry, 39(5), 371-4, March 1996 Abstract
  • Cherek DR Schnapp W Moeller FG and Dougherty DM, Aggressive responding of violent and nonviolent male parolees and laboratory conditions, Aggressive Behavior, 22, 27-36, 1996
  • Moeller FG, Chen YW, Steinberg JL, Petty F, Ripper GW, Shah N, Garver DL, Risk factors for clozapine discontinuation among 805 patients in the VA hospital system, Annals of Clinical Psychiatry, 7(4), 167-73, December 1995 Abstract
  • Fulton MK, Kramer G, Moeller FG, Chae Y, Isbell PG, Petty F, Low plasma homovanillic acid levels in recently abstinent alcoholic men, American Journal of Psychiatry, 152(12), 1819-20, December 1995 Abstract
  • Fulton MK, Kramer G, Moeller FG, Chae Y, Isbell PG, Petty F, Low plasma homovanillic acid levels in recently abstinent alcoholic men [see comments], American Journal of Psychiatry, 152(12), 1819-20, December 1995 Abstract
  • Steinberg JL, Devous MD Sr, Moeller FG, Paulman RG, Raese JD, Gregory RR, Cerebellar blood flow in schizophrenic patients and normal control subjects, Psychiatry Research, 61(1), 15-31, May 1995 Abstract
  • Moeller FG, Steinberg JL, Petty F, Fulton M, Cherek DR, Kramer G, Garver DL, Serotonin and impulsive/aggressive behavior in cocaine dependent subjects, Progress in Neuro-psychopharmacology and Biological Psychiatry, 18(6), 1027-35, October 1994 Abstract
  • Moeller FG, Garver DL, Neutropenia in a patient receiving clozapine [letter], American Journal of Psychiatry, 151(4), 619, April 1994 Abstract
  • Petty F, Kramer GL, Fulton M, Moeller FG, Rush AJ, Low plasma GABA is a trait-like marker for bipolar illness, Neuropsychopharmacology, 9(2), 125-32, September 1993 Abstract
  • Petty F, Steinberg J, Kramer GL, Fulton M, Moeller FG, Desipramine does not alter plasma GABA in patients with major depression, Journal of Affective Disorders, 29(1), 53-6, September 1993 Abstract
  • Steinberg JL, Garver DL, Moeller FG, Raese JD, Orsulak PJ, Serum homovanillic acid levels in schizophrenic patients and normal control subjects, Psychiatry Research, 48(2), 93-106, August 1993 Abstract
  • Moeller FG, Gillin JC, Irwin M, Golshan S, Kripke DF, Schuckit M, A comparison of sleep EEGs in patients with primary major depression and major depression secondary to alcoholism, Journal of Affective Disorders, 27(1), 39-42, January 1993 Abstract
  • Petty F, Fulton M, Moeller FG, Kramer G, Wilson L, Fraser K, Isbell P, Plasma gamma-aminobutyric acid (GABA) is low in alcoholics, Psychopharmacology Bulletin, 29(2), 277-81, 1993 Abstract
  • Rausch JL, Moeller FG, Kinetic effects of desmethylimipramine treatment on platelet serotonin uptake in depressed patients: a comparison with imipramine, Psychiatry Research, 36(3), 299-305, March 1991 Abstract
  • Rausch JL, Ruegg R, Moeller FG, Gepirone as a 5-HT1A agonist in the treatment of major depression, Psychopharmacology Bulletin, 26(2), 169-71, 1990 Abstract
  • Marcus MT, Liehr PR, Schmitz J, Moeller FG, Swank P, Fine M, Cron S, Granmayeh LK, Carroll DD, Behavioral therapies trials: a case example., Nursing research, 56 (3), 210-6 Abstract
  • Cherek DR Lane SD Dougherty DM Moeller FG White S, Laboratory and self-report measures of aggression among female parolees with violent and non-violent histories, Aggressive Behavior, In Press

Profile Details

Last Updated: 4/7/2008

COS Expertise ID #387492
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