M. Sue O'Dorisio

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University of Iowa
Carver College of Medicine
Pediatrics
Pediatric Hematology/Oncology
ProfessorAppointed: 1999
Professional Headshot of M. Sue O'Dorisio

Mailing Address

2526 JCP
Iowa City, Iowa 52242
United States

Contact Information

Phone: (319) 356-7873
sue-odorisio@uiowa.edu
http://www.uihealthcare.com/depts/med/pediatrics/pedsmds/odorisio.html

Qualifications

M.D., Ohio State University, Medicine, 1985.
Ph.D., University of Nebraska Medical Center, Biochemistry, 1972.
B.S., Creighton University, Biology/Mathematics, 1967.

Expertise and Research Interests

Research interests include neural crest development, neuropeptide physiology, and nervous system tumors of childhood.

Current projects:
Exploitation of Neuropeptide Receptor in Diagnosis and Therapy of Neural Crest Tumors;
Genetic and Epigenetic Changes in Medulloblastoma.

Other Expertise

Awards:
American Academy of Pediatrics Excellence in Research Award
YWCA Women of Achievement Award in Science & Medicine
Executive Leadership in Academic Medicine

Review Panels:
NCI Program Project Advisory Committee
NIMH Study Section
GCRC Site Visit Team and Program Committee

Keywords

COS Keywords:

Brain Tumors, Cancer Or Carcinogenesis, Children Or Youth, Immunology, Nervous System, Neuroimmunology, Oncology, Pediatrics, Peptides, Tumors.

Additional Terms:

Neuroimmunology, Neuropeptide Biology and Therapeutics, Pediatric Oncology.

Memberships

American Association for Cancer Research
American Association for the Advancement of Science
American Association of Immunologists
American Society of Biological Chemists
Society for Neuroscience
Society for Pediatric Research

Previous Positions

1995-1999, Director, Ohio State University, College of Medicine and Public Health, Pediatrics, Medical Scientist Training Program
1988-1999, Professor, Ohio State University, College of Medicine and Public Health, Pediatrics

Patents

In Vivo, In Vitro Application of Peptide/cell Kinetics Utilizing Radiolabeled Somatostatin Analogs, U.S. Patent No. 5,590,656, 1997, institution-owned
Multi-tyrosinated Somatostatin Analogs, U.S. Patent No. 5,597,894, 1997, institution-owned

Funding Received

  • National Institutes of Health (NIH): Radioreceptor Guided Surgery in Treatment of Neuroblastoma, Sep 1, 2000 to Aug 31, 2004.
  • National Institutes of Health (NIH): Radioreceptor Guided Surgery in Treatment of Neuroblastoma, Sep 1, 2000 to Aug 31, 2004.
  • Somatostatin Receptors: Classification of Neuroblastoma, National Institutes of Health (NIH), 1997-3/1999
  • Neuroblastoma: Biology and Therapeutics, American Cancer Society, 1997-6/1998
  • Pediatric Brain Tumors: Classification and Treatment, Pediatric Brain Tumor Foundation of United States
  • OSU Comprehensive Cancer Center Core Grant, National Institutes of Health (NIH), 1997-6/2001

Publications

  • Balster DA, O'Dorisio MS, Albers AR, Park SK, Qualman SJ, Suppression of tumorigenicity in neuroblastoma cells by upregulation of human vasoactive intestinal peptide receptor type 1, Regulatory Peptides, 109(1-3), 155-65, November 2002 Abstract
  • Juweid ME, Menda Y, O'Dorisio MS, Bushnell D, Blake M, Madsen M, Johnson J, Graham MM, 111In-pentreotide versus bone scintigraphy in the detection of bony metastases of neuroblastoma, Nuclear Medicine Communications, 23, 983-989, 2002
  • O'Dorisio MS, Hauger M, O'Dorisio TM, Age-dependent levels of plasma neuropeptides in normal children, Regulatory Peptides, 109(1-3), 189-192, 2002
  • Karacay B, O'Dorisio MS, Kasow K, Hollenback C, Krahe R, Expression and fine mapping of murine vasoactive intestinal peptide receptor 1, Journal of Molecular Neuroscience : Mn, 17(3), 311-24, December 2001 Abstract
  • Klisovic DD, O'Dorisio MS, Katz SE, Sall JW, Balster D, O'Dorisio TM, Craig E, Lubow M, Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study, Investigative Ophthalmology and Visual Science, 42(10), 2193-201, September 2001 Abstract
  • Watson JC, Balster DA, Gebhardt BM, O'Dorisio TM, O'Dorisio MS, Espenan GD, Drouant GJ, Woltering EA, Growing vascular endothelial cells express somatostatin subtype 2 receptors, British Journal of Cancer, 85(2), 266-72, July 2001 Abstract
  • Lum SS, Fletcher WS, O'Dorisio MS, Nance RW, Pommier RF, Caprara M, Distribution and functional significance of somatostatin receptors in malignant melanoma, World Journal of Surgery, 25(4), 407-12, April 2001 Abstract
  • Balster DA, O'Dorisio MS, Summers MA, Turman MA, Segmental expression of somatostatin receptor subtypes sst(1) and sst(2) in tubules and glomeruli of human kidney, American Journal of Physiology. Renal Physiology, 280(3), F457-65, March 2001 Abstract
  • Lara-Marquez M, O'Dorisio M, O'Dorisio T, Shah M, Karacay B, Selective gene expression and activation-dependent regulation of vasoactive intestinal peptide receptor type 1 and type 2 in human T cells, Journal of Immunology (baltimore, Md. : 1950), 166(4), 2522-30, February 2001 Abstract
  • Fruhwald MC, O'Dorisio MS, Dai Z, Rush LJ, Krahe R, Smiraglia DJ, Pietsch T, Elsea SH, Plass C, Aberrant hypermethylation of the major breakpoint cluster region in 17p11.2 in medulloblastomas but not supratentorial PNETs, Genes, Chromosomes and Cancer, 30(1), 38-47, Jan 2001 Abstract
  • Fruhwald MC, O'Dorisio MS, Rush LJ, Reiter JL, Smiraglia DJ, Wenger G, Costello JF, White PS, Krahe R, Brodeur GM, Plass C, Gene amplification in PNETs/medulloblastomas: mapping of a novel amplified gene within the MYCN amplicon, Journal of Medical Genetics, 37(7), 501-9, July 2000 Abstract
  • Albers AR, O'Dorisio MS, Balster DA, Caprara M, Gosh P, Chen F, Hoeger C, Rivier J, Wenger GD, O'Dorisio TM, Qualman SJ, Somatostatin receptor gene expression in neuroblastoma, Regulatory Peptides, 88(1-3), 61-73, March 2000 Abstract
  • Costello JF, Fruhwald MC, Smiraglia DJ, Rush LJ, Robertson GP, Gao X, Wright FA, Feramisco JD, Peltomaki P, Lang JC, Schuller DE, Yu L, Bloomfield CD, Caligiuri MA, Yates A, Nishikawa R, Su Huang H, Petrelli NJ, Zhang X, O'Dorisio MS, Aberrant CpG-island methylation has non-random and tumour-type-specific patterns, Nature Genetics, 24(2), 132-8, February 2000 Abstract
  • Lara-Marquez ML, O'Dorisio MS, Karacay B, Vasoactive intestinal peptide (VIP) receptor type 2 (VPAC2) is the predominant receptor expressed in human thymocytes, Annals of the New York Academy of Sciences, 921, 45-54, 2000 Abstract
  • Karacay B, O'Dorisio MS, Summers M, Bruce J, Regulation of vasoactive intestinal peptide receptor expression in developing nervous systems, Annals of the New York Academy of Sciences, 921, 165-74, 2000 Abstract
  • Cuntz MC, Levine EA, O'Dorisio TM, Watson JC, Wray DA, Espenan GD, McKnight C, Meier JR, Weber LJ, Mera R, O'Dorisio MS, Woltering EA, Intraoperative gamma detection of 125I-lanreotide in women with primary breast cancer, Annals of Surgical Oncology : the Official Journal of the Society of Surgical Oncology, 6(4), 367-72, June 1999 Abstract
  • Smiraglia DJ, Fruhwald MC, Costello JF, McCormick SP, Dai Z, Peltomaki P, O'Dorisio MS, Cavenee WK, Plass C, A new tool for the rapid cloning of amplified and hypermethylated human DNA sequences from restriction landmark genome scanning gels, Genomics, 58(3), 254-62, June 1999 Abstract
  • Fruhwald MC, O'Dorisio MS, Fleitz J, Pietsch T, Reubi JC, Vasoactive intestinal peptide (VIP) and VIP receptors: gene expression and growth modulation in medulloblastoma and other central primitive neuroectodermal tumors of childhood, International Journal of Cancer. Journal International Du Cancer, 81(2), 165-73, April 1999 Abstract
  • Woltering EA, O'Dorisio MS, Murphy WA, Chen F, Drouant GJ, Espenan GD, Fisher DR, Sharma C, Diaco DS, Maloney TM, Fuselier JA, Nelson JA, O'Dorisio TM, Coy DH, Synthesis and characterization of multiply-tyrosinated, multiply-iodinated somatostatin analogs, The Journal of Peptide Research : Official Journal of the American Peptide Society, 53(2), 201-13, February 1999 Abstract
  • Fruhwald MC, O'Dorisio MS, Pietsch T, Reubi J-C, Somatostatin and somatostatin receptor expression in primitive neuroectodermal tumors of childhood, Pediatric Research, 45, 1-11, 1999
  • Fruhwald MC, O'Dorisio MS, Cottingham SL, Qualman SJ, O'Dorisio TM, Neuropeptides in developmental tumors of the central and peripheral nervous system, Annals of the New York Academy of Sciences, 865, 420-6, December 1998 Abstract
  • Turman MA, O'Dorisio MS, O'Dorisio TM, Apple CA, Albers AR, Somatostatin expression in human renal cortex and mesangial cells, Regulatory Peptides, 68(1), 15-21, January 1997 Abstract
  • Fletcher WS, Lum SS, Nance RW, Pommier RF, O'Dorisio MS, The current status of somatostatin receptors in malignant melanoma, Yale Journal of Biology and Medicine, 70(5-6), 561-563, 1997

Profile Details

Last Verified: 11/17/2006

COS Expertise ID #413344
Reference this profile directly: http://myprofile.cos.com/msodorisio