Michael P. Terns

We are investigating the mechanisms controlling the intracellular trafficking of RNA molecules in eukaryotic cells. Our interest in RNA transport and localization stems from the fact that these processes are essential for: 1) eukaryotic gene expression, 2) animal development, and 3) viral production and are relevant to gene therapy strategies being explored to treat human diseases. We employ a combination of molecular, biochemical, genetic, and cell biological techniques in these studies and use microinjection into living frog (Xenopus laevis) oocytes as our primary experimental system. Currently, the laboratory is analyzing the molecular and subcellular determinants of transport and localization of small nuclear RNAs (snRNAs).

Specifically, we are examining the roles of specific RNA sequences, RNA binding proteins, and subcellular structures in the functional localization of these RNAs. We are also investigating the transport and action of small catalytic RNAs called ribozymesin living cells. Ribozymes have tremendous potential as gene therapy agents to treat viral infections and combat genetic diseases such as cancer.

Academic Experience:
Honors and Awards:
1985 Graduation with Distinction, University of Michigan;
1985 Competitive Undergraduate Summer Research Fellowship Department of Biochemistry, Wayne State University, Detroit, MI;
1988 Julius Axelrod Prize in Pharmacology Topic: Role of Poly(A) Polymerase in mRNA Processing;
1988 Graduate Student Research Forum Second Place Oral Presentation Pennsylvania State University;
1991-94 NIH Postdoctoral Fellowship (NRSA);
1994-95 American Cancer Society Postdoctoral Fellowship (National Award);
1995 Grant from the University of Wisconsin Graduate School:
Purpose: To support a collaborative effort to study the structure, function and assembly of nuclear pore complexes in Xenopus laevis oocyte nuclear envelopes byelectron microscopy;
1996 University of Georgia Research Foundation Faculty Research Grants Award