Michael B. Zemel

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University of Tennessee
College of Human Ecology
Nutrition
ProfessorAppointed: 1990
University of Tennessee
The Nutrition Institute
DirectorAppointed: 1994
University of Tennessee
Medicine
ProfessorAppointed: 1990
Professional Headshot of Michael B. Zemel

Mailing Address

1215 W. Cumberland Ave.
Rm. 229
Knoxville, Tennessee 37996-1920
United States

Contact Information

Phone: (865) 974-6238
Fax: (865) 974-3491
mzemel@utk.edu

Qualifications

Ph.D., University of Wisconsin-Madison, Nutritional Sciences, 1980.
M.S., University of Wisconsin-Madison, Nutritional Sciences, 1978.
B.S., University of Wisconsin-Madison, Nutritional Sciences, 1976.

Expertise and Research Interests

Cell calcium regulation
Obesity genetics
Adipocyte metabolism
Mitochondrial function
Adipokines

Keywords

COS Keywords:

Hypertension, Insulin, Metabolism, Nutrition or Dietetics, Obesity.

Additional Terms:

Adipocyte, Cell Calcium, Insulin, Obesity, Obesity Research.

Memberships

American College of Nutrition
American Heart Association
American Society for Clinical Nutrition
American Society for Nutritional Sciences
American Society for the Advancement of Science
American Society of Hypertension
Endocrine Society
North American Association for the Study of Obesity
Society for Experimental Biology and Medicine

Honors and Awards

2005, Lydia J. Roberts Memorial Lecture Award, University of Chicago
2004, Wheeley Award for Excellence in Technology Transfer, University of Tennessee
1995, Chancellor's Citation for Research, University of Tennessee
1990, Fellow, Council on High Blood Pressure Research
1988, Career Development Chair, University of Wisconsin-Madison
Contributing Editor, Nutrition Reviews
Editorial Board, Journal of Nutritional Biochemistry
Fellow, American College of Nutrition
Chair, Membership Committee, American College of Nutrition

Previous Positions

1990-2002, Department Head, University of Tennessee, College of Human Ecology, Nutrition
1987-1991, Research Biochemist, VA Medical Center, Allen Park
1985-1990, Associate Professor, Wayne State University, Nutrition and Food Science
1980-1985, Assistant Professor, Wayne State University, Nutrition and Food Science

Patents

Modulation of the sulfonylurea receptor and calcium in adipocytes for treatment of obesity/diabetes, Patent Number: 6569633, 2003, United States of America.
Materials and Methods for the Treatment and Prevention of Obesity, Patent Number: 6384087, 2002, Institution-owned, United States of America.
Modulation of the sulfoylurea receptor and calcium in adipocytes for treatment of obesity/diabetes, Patent Number: 6492130, 2002, Institution-owned, United States of America.
Screening for SUR1 antagonists using adipocytes, Patent Number: 6242200, 2001, Institution-owned, United States of America.
Modulation of the Sulfonylurea Receptor and Calcium in Adipocytes for Treatment of Obesity/Diabetes, Patent Number: 6100047, 2000, Institution-owned, United States of America.
Calcium Fortification, Patent Number: , 1990, Institution-owned, United States of America.
Method of making calcium fortified soy milk and the calcium fortified soy milk, Patent Number: 04906482, 1990, United States of America.

Funding Received

  • National Dairy Council: Role of Dairy Products in Weight Loss: A Multi-Center Trial, $941,202, Jul 1, 2002 to Jun 30, 2004.
  • National Diary Council: Role of Dairy Products in Weight Maintenance (Extented Studies), $395,000, 2005 to 2006.
  • Mead Johnson and Company: Effects of Diet on Metabolism and Gene Expression, $77,760, 2005 to 2006.
  • Mead Johnson and Company: Role of Dairy Proteins in Modulating Body Composition and Metabolic Programming in Mice, $189,143, 2005 to 2006.
  • National Dairy Council: Role of dairy components in enhancing the anti-obesity effects of dietary calcium, $157,000, 2004 to 2005.
  • Centers for Disease Control and Prevention: Obesity Prevention, $500,000, 2004 to 2005.
  • National Dairy Council: Role of Dairy Products in Weight Maintenance, $239,635, 2003 to 2005.
  • Quaker, Inc.: Role of Dietary Glycemic Index on the Modulation of Adiposity in a Rodent Model of Obesity, $145,403, 2001 to 2002.
  • General Mills, Inc.: Effects of Calicum-Fortified Breakfast Cereal on Body Composition and Weight Loss in Obese Adults, $150,000, 2001 to 2003.
  • National Dairy Council: Interaction Between Calcium-Rich Dairy Products and Dietary Macronutrients in Modulating Weight Loss in Obese Mice, $190,425, 2001 to 2002.
  • General Mills, Inc.: Effects of Fermented Dairy Products on Body Composition and Weight Loss in Obese Adults, $149,835, 2001 to 2003.
  • National Dairy Council: Effects of Calcium-Rich Dairy Products on Body Composition and Weight Loss in African-American Adults, $289,500, 2000 to 2003.
  • Pharmacia-Upjohn: Effects of Low Glycemic Index Diets on the Insulin Resistance Syndrome (Syndrome X) in Heterozygous (Fa/fa) Zucker Rats, $23,660, 2000 to .
  • General Mills: Effects of Calcium-Fortified Breakfast Cereal on Body Composition and Weight Control in a Transgenic Model of Human Obesity, $125,457, 2000 to 2002.
  • General Mills: Effects of Fermented Dairy Products on Body Composition and Weight Control in Transgenic Mice, $125,457, 2000 to 2002.
  • Quaker Oats Company: Role of Dietary Glycemic Index on the Modulation of Adiposity in a Rodent Model of Obesity, $145,403, 2000 to 2001.
  • National Dairy Council: The Effects of Calcium-Rich Dairy Products on Weight Loss in Obese Adults, $103,360, 2000 to 2001.
  • Roche Laboratories: A 52-Week Double Blind, Randomized, Placebo Controlled Study to Evaluate the Efficacy of Orlistat Treatment in Obese Patients with Type 2 Diabetes Inadequately Controlled with Insulin, $77,733, 1999 to 2000.
  • National Diary Council: Effect of Calcium on Lipogenic Gene Expression, Adipocyte Metabolism and Weight Loss in Obese Agouti-Transgenic Mice, $86,230, 1999 to 2000.
  • National Dairy Council: Calcium-Rich Dairy Products Improve Body Composition and Insulin Sensitivity, $69,919, 1998 to 1999.
  • Knoll Pharmaceutical Company: Agouti-Insulin Interactions in Obesity, $97,903, 1997 to 1999.
  • American Heart Association (AHA): Interactions Between Insulin and Tissue-Specific Agouti Expression in Agouti-Induced Obesity, $259,000, 1997 to 2000.

Publications

  • Sun X, Zemel MB (Sep 2007) Calcitriol and calcium regulate cytokine production and adipocyte-macrophage cross-talk. Abstract
  • Sun X, Zemel MB (Aug 2007) 1Alpha,25-dihydroxyvitamin D3 modulation of adipocyte reactive oxygen species production., Obesity (Silver Spring, Md.), 15 (8), 1944-53 Abstract
  • Sun X, Zemel MB (Apr 2007) Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells., Lipids, 42 (4), 297-305 Abstract
  • Sun X, Zemel MB (Feb 2007) Calcium and 1,25-dihydroxyvitamin D3 regulation of adipokine expression., Obesity (Silver Spring, Md.), 15 (2), 340-8 Abstract
  • Ding S, McEntee MF, Whelan J, Zemel M (2007) Adiposity-related protection of intestinal tumorigenesis: interaction with dietary calcium., Nutrition and cancer, 58 (2), 153-61 Abstract
  • Sun X, Zemel MB (Sep 2006) Dietary calcium regulates ROS production in aP2-agouti transgenic mice on high-fat/high-sucrose diets., International journal of obesity (2005), 30 (9), 1341-6 Abstract
  • Melanson EL, Donahoo WT, Dong F, Ida T, Zemel MB (Dec 2005) Effect of low- and high-calcium dairy-based diets on macronutrient oxidation in humans., Obesity research, 13 (12), 2102-12 Abstract
  • Zemel MB (Dec 2005) The role of dairy foods in weight management., Journal of the American College of Nutrition, 24 (6 Suppl), 537S-46S Abstract
  • Thompson WG, Rostad Holdman N, Janzow DJ, Slezak JM, Morris KL, Zemel MB (Aug 2005) Effect of energy-reduced diets high in dairy products and fiber on weight loss in obese adults., Obesity research, 13 (8), 1344-53 Abstract
  • Zemel MB, Richards J, Milstead A, Campbell P (Jul 2005) Effects of calcium and dairy on body composition and weight loss in African-American adults., Obesity research, 13 (7), 1218-25 Abstract
  • Morris KL, Zemel MB (Apr 2005) 1,25-dihydroxyvitamin D3 modulation of adipocyte glucocorticoid function., Obesity research, 13 (4), 670-7 Abstract
  • Zemel MB, Richards J, Mathis S, Milstead A, Gebhardt L, Silva E (Apr 2005) Dairy augmentation of total and central fat loss in obese subjects., International journal of obesity (2005), 29 (4), 391-7 Abstract
  • Morris, K.L., Zemel, M. B., Effect of Dietary Carbohydrate Source on the Development of Obesity in Agouti Transgenic Mice, Obesity Research, 13, 21-25, 2005
  • Zemel, M.B., Richards, J., Mathis, S., Milstead, A., Gebhardt, L., Silva, E., Dairy Augmentation of Total and Central Fat Loss in Obese Subjects, International Journal of Obesity, 29, 391-397, 2005
  • Morris, K.L., Zemel, M.B., 1,25-dihydroxyvitamin D-3 Modulation of Adipocyte Glucocorticoid Function, Obesity Research, 13, 670-677, 2005
  • Zemel, M.B., Calcium Regulation of Adiposity, Obesity Research, 13, 192-193, 2005
  • Zemel, M.B., Richards, J., Milstead, A., Campbell, P., Effects of Calcium and Diary on Body Composition and Weight Loss in African-American Adults, Obesity Research, 13, 1218-1225, 2005
  • Thompson, W.G., Holdman, N.R., Janzow, D.J., Slezak, J.M., Morris, K.L., Zemel, M.B., Effect of Energy-reduced Diets High in Dairy Products and Fiber on Weight Loss in Obese Adults, Obesity Research, 13, 1344-1353, 2005
  • Zemel, M.B., Role of Dairy in Weight Management, J. Am. Coll. Nutr., In Press, 2005
  • Zemel MB (Jan 2005) Calcium and dairy modulation of obesity risk., Obesity research, 13 (1), 192-3 Abstract
  • Morris KL, Zemel MB (Jan 2005) Effect of dietary carbohydrate source on the development of obesity in agouti transgenic mice., Obesity research, 13 (1), 21-35 Abstract
  • Sun X and Zemel MB, Calcium and dairy inhibit weight and fat regain during ad libitum consumption following energy restriction in aP2-agouti transgenic mice, Journal of Nutrition, 134, 3054-3060, Nov 2004
  • Sun X and Zemel MB, Role of Uncoupling Protein 2 (UCP2) Expression and 1alpha, 25-Dihydroxyvitamin D3 in Modulating Adipocyte Apoptosis, FASEB Journal, 18, 1430-1432, Oct 2004
  • Zemel MB, Role of calcium and dairy products in energy partitioning and weight management, The American Journal of Clinical Nutrition, 79(5), 907S-912S, May 2004 Abstract
  • Zemel MB, Miller SL, Dietary calcium and dairy modulation of adiposity and obesity risk, Nutrition Reviews, 62(4), 125-31, Apr 2004 Abstract
  • Zemel MB, Thompson W, Milstead A, Morris K, Campbell P, Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults, Obesity Research, 12(4), 582-90, Apr 2004 Abstract
  • Ha E, Zemel MB, Functional properties of whey, whey components, and essential amino acids: mechanisms underlying health benefits for active people (review), The Journal of Nutritional Biochemistry, 14(5), 251-8, May 2003 Abstract
  • Banz WJ, Maher MA, Thompson WG, Bassett DR, Moore W, Ashraf M, Keefer DJ, Zemel MB, Effects of resistance versus aerobic training on coronary artery disease risk factors, Experimental Biology and Medicine (maywood, N.j.), 228(4), 434-40, April 2003 Abstract
  • Sun X, Zemel MB, Effects of mitochondrial uncoupling on adipocyte intracellular Ca(2+) and lipid metabolism, The Journal of Nutritional Biochemistry, 14(4), 219-26, Apr 2003 Abstract
  • Zemel M, Calcium modulation of adiposity, Obesity Research, 11(3), 375-6, Mar 2003 Abstract
  • Zemel MB, Role of dietary calcium and dairy products in modulating adiposity, Lipids, 38(2), 139-46, Feb 2003 Abstract
  • Michael B. Zemel, Mechanisms of dairy modulation of adiposity, Journal of Nutrition, 133(1), 252S-256S, January 2003
  • Zemel MB, Mechanisms of dairy modulation of adiposity, The Journal of Nutrition, 133(1), 252S-256S, Jan 2003 Abstract
  • Morris KL, Namey TC, Zemel MB, Effects of dietary carbohydrate on the development of obesity in heterozygous Zucker rats, The Journal of Nutritional Biochemistry, 14(1), 32-9, Jan 2003 Abstract
  • Shi H, Norman AW, Okamura WH, Sen A, Zemel MB, 1,25-dihydroxyvitamin D3 inhibits uncoupling protein 2 expression in human adipocytes, FASEB Journal, 16, 1808-1810, November 2002
  • Zemel MB, Regulation of adiposity and obesity risk by dietary calcium: mechanisms and implications, Journal of the American College of Nutrition, 21(2), 146S-151S, April 2002 Abstract
  • Hansen-Petrik MB, McEntee MF, Jull B, Shi H, Zemel MB, Whelan J, Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice, Cancer Research, 62(2), 403-8, January 2002 Abstract
  • Shi, H., Norman, A.W., Okamura, W.H., Sen, A., Zemel, M.B, 1á,25-dihyroxyvitamin D3 modulates human adipocyte metabolism via nongenomic action, FASEB Journal, 15, 2751-2753, December 2001
  • Xue, B., Greenberg, A.G., Kraemer, F.B. and Zemel, M.B, Mechanism of Intracellular Calcium Inhibition of Lipolysis in Human Adipocytes, FASEB Journal, 15, 2527-2529, November 2001
  • Zemel MB, Calcium modulation of hypertension and obesity: Mechanisms and implications, Journal of The American College of Nutrition, 20, 428S-435S, October 2001
  • Xue B, Zemel MB, Agouti signaling protein stimulates islet amyloid polypeptide (amylin) secretion in pancreatic beta-cells, 226(6), 565-9, June 2001 Abstract
  • Shi H, DiRienzo D, Zemel MB, Effects of dietary calcium on adipocyte lipid metabolism and body weight regulation in energy-restricted aP2-agouti transgenic mice, FASEB Journal, 15, 291-93, 2001
  • Zemel MB, Shi H, Pro-opiomelanocortin (POMC) deficiency and peripheral melanocortins in obesity, Nutrition Reviews, 58(6), 177-80, June 2000 Abstract
  • Zemel MB, Shi H, Greer B, Dirienzo D, Zemel PC, Regulation of adiposity by dietary calcium, FASEB Journal, 14(9), 1132-8, June 2000 Abstract
  • Standridge M, Alemzadeh R, Zemel M, Koontz J, Moustaid-Moussa N, Diazoxide down-regulates leptin and lipid metabolizing enzymes in adipose tissue of Zucker rats, FASEB Journal, 14(3), 455-60, March 2000 Abstract
  • Claycombe KJ, Mynatt RL, Zemel MB, Wilkison WO, Moustaid-Moussa N, Regulation of leptin by agouti, Physiological Genomics, 2, 101-05, 2000
  • Claycombe KJ, Wang Y, Jones BH, Kim S, Wilkison WO, Zemel MB, Chun J, Moustaid-Moussa N, Transcriptional regulation of the adipocyte fatty acid synthase gene by the agouti gene product: interaction with insulin, Physiological Genomics, 3, 157-62, 2000
  • Xue B, Zemel MB, Relationship between human adipose tissue agouti and fatty acid synthase (FAS), Journal of Nutrition, 130, 2478-81, 2000
  • Shi H, Halvorson Y-D, Ellis PN, Wilkison WO, Zemel MB, Role of intracellular calcium ([Ca2+]i) in human adipocyte differentiation, Physiological Genomics, 3, 75-82, 2000
  • Shi H, Moustaid-Moussa N, Wilkison WO, Zemel MB, Role of the sulfonylurea receptor in regulating human adipocyte metabolism, Faseb Journal, 13(13), 1833-8, October 1999 Abstract
  • Morris KL, Zemel MB, Glycemic index, cardiovascular disease, and obesity, Nutrition Reviews, 57(9 Pt 1), 273-6, September 1999 Abstract
  • Xue B, Wilkison WO, Mynatt RL, Moustaid N, Goldman M, Zemel MB, The agouti gene product stimulates pancreatic B-cell Ca2+ signaling and insulin release, Physiological Genomics, 1, 11-19, 1999
  • Zemel MB, Nutritional and endocrine modulation of intracellular calcium: implications in obesity, insulin resistance and hypertension, Molecular and Cellular Biochemistry, 188(1-2), 129-36, November 1998 Abstract
  • Xue B, Moustaid-N, Wilkison WO, Zemel MB, The agouti gene product inhibits lipolysis in human adipocytes via a Ca2 -dependent mechanism, Faseb Journal, 12(13), 1391-6, October 1998 Abstract
  • Zemel MB, Agouti/melanocortin interactions with leptin pathways in obesity, Nutrition Reviews, 56(9), 271-4, September 1998 Abstract
  • Zemel MB, Moore JW, Moustaid N, Kim JH, Nichols JS, Blanchard SG, Parks DJ, Harris C, Lee FW, Grizzle M, James M, Wilkison WO, Effects of a potent melanocortin agonist on the diabetic/obese phenotype in yellow mice, International Journal of Obesity and Related Metabolic Disorders, 22(7), 678-83, July 1998 Abstract
  • Moore JW, Maher MA, Banz WJ, Zemel MB, Chromium picolinate modulates rat vascular smooth muscle cell intracellular calcium metabolism, Journal of Nutrition, 128(2), 180-4, February 1998 Abstract
  • Zemel MB, Xue B, Agouti/melanocortin interactions with leptin pathways in obesity, Nutrition Reviews, 56, 271-81, 1998
  • Michaud EJ, Mynatt RL, Miltenberger RJ, Klebig ML, Wilkinson JE, Zemel MB, Wilkison WO, Woychik RP, Role of the agouti gene in obesity, Journal of Endocrinology, 155(2), 207-9, November 1997 Abstract
  • Zemel MB, Dietary pattern and hypertension: the DASH study. Dietary Approaches to Stop Hypertension, Nutrition Reviews, 55(8), 303-5, August 1997 Abstract
  • Kim JH, Kiefer LL, Woychik RP, Wilkison WO, Truesdale A, Ittoop O, Willard D, Nichols J, Zemel MB, Agouti regulation of intracellular calcium: role of melanocortin receptors., American Journal of Physiology, 272(3 Pt 1), E379-84, 1997 Abstract
  • Mynatt RL, Miltenberger RJ, Klebig ML, Zemel MB, Wilkinson JE, Wilkinson WO, Woychik RP, Combined effects of insulin treatment and adipose tissue-specific agouti expression on the development of obesity, Proceedings of the National Academy of Sciences (USA), 94(3), 919-22, February 1997 Abstract
  • Kim, J-H, Mynatt, RL, Moore, JW, Woychik, RP, Moustaid, N and Zemel, MB, The effects of calcium channel blockade on agouti-induced obesity, FASEB, 10, 1646-52, 1996
  • Maher M, Banz W, Truett G, Zemel MB, Dietary fat and gender modify the heterozygote effects of the rat fatty (fa) allele, Journal of Nutrition, 126, 2487-93, 1996
  • Maher MA, Banz WJ, Zemel MB, Variations of blood pressures in lean Zucker rats fed low or high fat diets, Journal of Nutrition, 125(10), 2618-22, October 1995 Abstract
  • Zemel MB, Insulin resistance vs. hyperinsulinemia in hypertension: insulin regulation of Ca2+ transport and Ca(2+)-regulation of insulin sensitivity, Journal of Nutrition, 125(6 Suppl), 1738S-1743S, June 1995 Abstract
  • Daily JW, Zemel MB, Antioxidants: research vs rhetoric, American Journal of Clinical Nutrition, 61(4), 866-8, April 1995 Abstract
  • Kim YC, Zemel MB, Insulin increases vascular smooth muscle recovery from intracellular calcium loads, Hypertension, 22(1), 74-7, July 1993 Abstract
  • Abel MA, Zemel MB, Impaired recovery of vascular smooth muscle intracellular calcium following agonist stimulation in insulin resistant (Zucker obese) rats, American Journal of Hypertension, 6(6 Pt 1), 500-4, June 1993 Abstract
  • Zemel MB, Johnson BA, Ambrozy SA, Insulin-stimulated vascular relaxation. Role of Ca(2+)-ATPase, American Journal of Hypertension, 5(9), 637-41, September 1992 Abstract
  • Ambrozy SL, Shehin SE, Chiou CY, Sowers JR, Zemel MB, Effects of dietary calcium on blood pressure, vascular reactivity and vascular smooth muscle calcium efflux rate in Zucker rats, American Journal of Hypertension, 4(7 Pt 1), 592-6, July 1991 Abstract
  • Saunders E, Weir MR, Kong BW, Hollifield J, Gray J, Vertes V, Sowers JR, Zemel MB, Curry C, Schoenberger J, A comparison of the efficacy and safety of a beta-blocker, a calcium channel blocker, and a converting enzyme inhibitor in hypertensive blacks, Archives of Internal Medicine, 150(8), 1707-13, August 1990 Abstract
  • Luft FC, Zemel MB, Sowers JA, Fineberg NS, Weinberger MH, Sodium bicarbonate and sodium chloride: effects on blood pressure and electrolyte homeostasis in normal and hypertensive man, Journal of Hypertension, 8(7), 663-70, July 1990 Abstract
  • Sowers JR, Zemel MB, Bronsteen RA, Zemel PC, Walsh MF, Standley PR, Sokol RJ, Erythrocyte cation metabolism in preeclampsia, American Journal of Obstetrics and Gynecology, 161(2), 441-5, August 1989 Abstract
  • Sowers JR, Zemel MB, Zemel P, Beck FW, Walsh MF, Zawada ET, Salt sensitivity in blacks. Salt intake and natriuretic substances, Hypertension, 12(5), 485-90, November 1988 Abstract
  • Zemel MB, Kraniak J, Standley PR, Sowers JR, Erythrocyte cation metabolism in salt-sensitive hypertensive blacks as affected by dietary sodium and calcium, American Journal of Hypertension, 1(4 Pt 1), 386-92, October 1988 Abstract
  • Zemel MB, Gualdoni SM, Sowers JR, Reductions in total and extracellular water associated with calcium-induced natriuresis and the antihypertensive effect of calcium in blacks, American Journal of Hypertension, 1(1), 70-2, January 1988 Abstract
  • Linkswiler HM, Zemel MB, Hegsted M, Schuette S, Protein-induced hypercalciuria, Federation Proceedings, 40(9), 2429-33, July 1981 Abstract
  • Zemel MB, Linkswiler HM, Calcium metabolism in the young adult male as affected by level and form of phosphorus intake and level of calcium intake, Journal of Nutrition, 111(2), 315-24, February 1981 Abstract

Profile Details

Last Updated: 2/8/2008

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