Dr. Nancy D. Turner

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Texas A&M University
Intercollegiate Faculty of Nutrition
Associate ProfessorAppointed: 2003
Texas A&M University
Intercollegiate Faculty of Nutrition
ChairAppointed: 2003
Professional Headshot of Nancy D. Turner

Mailing Address

Texas A&M University
Department of Nutrition & Food Science, Faculty of Nutrition
2253 TAMU
College Station, Texas 77843-2253
United States

Contact Information

Phone: (979) 845-0850
Fax: (979) 862-1862
n-turner@tamu.edu

Qualifications

Ph.D., Texas A&M University, Nutrition, 1995.
M.S., Texas A&M University, Animal Nutrition, 1984.
B.S., Texas A&M University, Animal Science, 1978.

Expertise and Research Interests

My research program focuses on determining the role of dietary constituents in regulatory mechanisms involved in colon carcinogenesis. We are evaluating the effects of various fiber types, fat sources, and specific phytochemicals contained in them on the tumorigenic process. Aspects of cytokinetics and apoptosis are being measured to determine which of these normal mechanisms are being affected by dietary modifications, and both chemical carcinogens and radiation. Techniques used for these assessments include immunohistochemistry, immunoblotting, real time PCR, and microarray platforms.

Keywords

COS Keywords:

Animal Growth, Animal Nutrition, Cancer Biology, Cancer Or Carcinogenesis, Cell Cycle, Cereals, Cytokinetics, Gastroenterology, Immunohistochemistry, Metabolism, Nutrition Or Dietetics, Phytochemistry, Polymerase Chain Reaction.

Additional Terms:

Animal Metabolism, Colon Cancer, Cytokinetics, Intestinal Physiology, Nutrition, Phytochemical.

Memberships

American Association for Cancer Research
American Association of Cereal Chemists
American Physiological Society
American Society for Nutritional Sciences
American Society of Animal Science
New York Academy of Sciences
Society for Experimental Biology and Medicine

Previous Positions

1998-2003, Research Assistant Professor, Texas A&M University, College of Agriculture and Life Sciences, Animal Science, Human Nutrition
1996-1998, Assistant Research Scientist, Texas A&M University, College of Agriculture and Life Sciences, Animal Science, Human Nutrition
1984-1995, Research Associate, Texas A&M University
1981-1984, Graduate Student Research Technician, Texas A&M University

Funding Received

  • United States Department of Agriculture (USDA): Mechanisms behind the antioxidant properties of quercetin in colon carcinogenesis, $62,801, Sep 2002 to Aug 2004.
  • National Institutes of Health (NIH): Biostatistics, bioinformatics and the biology of nutrition and cancer, $2,469,801, Sep 2001 to Aug 2006.
  • National Space Biomedical Research Institute/NASA: Nutritional countermeasures to radiation exposure, $1,197,063, Mar 2001 to Sept 2004.
  • National Institutes of Health (NIH): Response to DNA damage: Colon vs small intestine, $700,000, Jul 2000 to April 2005.
  • United States Department of Agriculture (USDA): Exploring biological activities of citrus limonoids: A multidisciplinary approach, $1,075,165, Jan 2002 to Dec 2005.
  • Texas Higher Education Coordinating Board: Exploring biological activities of citrus limonoids: A multidisciplinary approach, $249,370, Jan 2002 to Dec 2004.
  • National Institutes of Health (NIH): Diet, apoptosis and colon carcinogensis, $900,000, Feb 2001 to Jan 2005.
  • National Aeronautics and Space Administration (NASA): Gene expression in radiation-enhanced colon cancer, $349,995, 5/15/2003 to 5/30/2004.
  • National Space Biomedical Research Institute/NASA: A graduate education program focusing on space life sciences, $90,661, 2004 to 2005.
  • National Space Biomedical Research Institute/NASA: Nutritional countermeasures to radiation-enhanced colon cancer, $1,352,148, 2004 to 2008.

Publications

  • Leyk, M., D.V. Nguyen, S.N. Attoor, E.R. Dougherty, N.D. Turner, L.K. Bancroft, R.S. Chapkin, J.R. Lupton, and R.J. Carroll, Comparing Automatic and Manual Image Processing in FLARE Assay Analysis for Colon Carcinogenesis, Statistical Applications in Genetics and Molecular Biology, online, 4, Article 5, 2005
  • Zhou, G.-D., N. Popovic, J.R. Lupton, N.D. Turner, R.S. Chapkin, and K.C. Donnelly, Tissue-specific Attenuation of Endogenous DNA I-compounds in Rats By Carcinogen Azoxymethane: Possible Role of Dietary Fish Oil in Colon Cancer Prevention, Cancer Epidemiology, Biomarkers & Prevention, 14, 1230-1235, 2005
  • Vanamala, J., G. Cobb, N.D. Turner, J.R. Lupton, K.S. Yoo, L.M. Pike, and B.S. Patil, Bioactive Compounds of Grapefruit (Citrus Paradises Cv Rio Red) Respond Differently to Postharvest Irradiation, Storage and Freeze Drying, Journal of Agricultural and Food Chemistry, 53, 3980-3985, 2005
  • Hong, M.Y., N.D. Turner, R.J. Carroll, R.S. Chapkin, and J.R. Lupton, Differential Response to Oxidative DNA Damage May Explain Aspects of the Cancer Susceptibility Between Small and Large Intestine, Experimental Biology and Medicine, In Press, 2005
  • Hong, M.Y., L.K. Bancroft, N.D. Turner, L.A. Davidson, M.E. Murphy, R.J. Carroll, R.S. Chapkin, and J.R. Lupton, Fish Oil Decreases Oxidative DNA Damage By Enhancing Apoptosis in Rat Colon, Nutrition and Cancer, In Press, 2005
  • Sanders LS, Henderson CE, Hong MY, Barhoumi R, Burghardt RC, Carroll RJ, Turner ND, Chapkin RS, Lupton JR, Pro-oxidant Environment of the Colon Compared to the Small Intestine May Contribute to Greater Cancer Susceptibility, Cancer Letters, 208, 155-161, 2004
  • Wu G, Fang Y-Z, Yang S, Lupton JR, Turner ND, Glutathione metabolism and its implications for health, Journal of Nutrition, 134, 489-492, 2004
  • Davidson LA, Nguyen DV, Hokanson RM, Callaway ES, Isett RB, Turner ND, Dougherty ER, Lupton JR, Carroll RJ, Chapkin RS, Chemopreventive N-3 Polyunsaturated Fatty Acids Reprogram Genetic Signatures During Colon Cancer Initiation and Progression in the Rat, Cancer Research, 64, 6797-6804, 2004
  • Sanders, L.M., C.E. Henderson, M.Y. Hong, R. Barhoumi, R.C. Burghardt, N. Wang, C.M. Spinka, R.J. Carroll, N.D. Turner, R.S. Chapkin, and J.R. Lupton, An Increase in Reactive Oxygen Species By Dietary Fish Oil Coupled With the Attenuation of Antioxidant Defenses By Dietary Pectin Enhances Rat Colonocyte Apoptosis, Journal of Nutrition, 134, 3233-3238, 2004
  • Hong MY, Chapkin RS, Davidson LA, Turner ND, Morris JS, Carroll RJ, Lupton JR, Fish oil enhances targeted apoptosis during colon tumor initiation in part by down regulating bcl-2, Nutrition and Cancer, 46, 44-51, 2003
  • Lupton JR, Turner ND, Dietary fiber and coronary disease: Does the evidence support an association?, Current Atherosclerosis Reports, 5, 500-505, 2003
  • Apanasovich TV, Sheather S, Lupton JR, Popovic N, Turner ND, Chapkin RS, Carroll RJ, Testing for spatial correlation in binary data with application to aberrant crypt foci in colon carcinogenesis, Biometrics, 59, 752-761, 2003
  • Hong MY, Chapkin RS, Barhoumi R, Burghardt RC, Turner ND, Henderson CE, Sanders LM, Fan YY, Davidson LA, Murphy ME, Spinka CM, Carroll RJ, Lupton JR, Fish oil increases mitochondrial phospholipid unsaturation, upregulating reactive oxygen species and apoptosis in rat colonocytes, Carcinogenesis, 23(11), 1919-26, November 2002 Abstract
  • Chapkin RS, Hong MY, Fan YY, Davidson LA, Sanders LM, Henderson CE, Barhoumi R, Burghardt RC, Turner ND, Lupton JR, Dietary n-3 PUFA alter colonocyte mitochondrial membrane composition and function, Lipids, 37(2), 193-9, February 2002 Abstract
  • Turner, ND, J Zhang, LA Davidson, JR Lupton, and RS Chapkin, Oncogenic ras alters sensitivity of colonocytes to butyrate and fatty acid mediated growth arrest and apoptosis, Cancer Letters, 186, 29-35, 2002
  • Turner, ND, LA Braby, J Ford, and JR Lupton, Opportunities for nutritional amelioration of radiation-induced cellular damage, Nutrition, 18, 904-912, 2002
  • Morris JS, Wang N, Lupton JR, Chapkin RS, Turner ND, Hong MY, Carroll RJ, A Bayesian analysis of colonic crypt structure and coordinated response to carcinogen exposure incorporating missing crypts, Biostatistics, 3, 529-546, 2002
  • Turner ND, Knapp JR, Byers FM, Kopchick JJ, Physical and mechanical characteristics of tibias from transgenic mice expressing mutated bovine growth hormone genes, Experimental Biology and Medicine, 226(2), 133-9, February 2001
  • Hong, MH, RS Chapkin, JS Morris, N Wang, RJ Carroll, ND Turner, W-CL Chang, LA Davidson, and JR Lupton, Anatomical site-specific response to DNA damage is related to later tumor development in the rat azoxymethane colon carcinogenesis model, Carcinogenesis, 22, 1831-1835, 2001
  • Morris, JS, N Wang, JR Lupton, RS Chapkin, ND Turner, MY Hong, and RJ Carroll, Parametric and nonparametric methods for understanding the relationship between carcinogen-induced DNA adduct levels in distal and proximal regions of the colon, Journal of the American Statistical Association, 96, 816-826, 2001
  • Davidson LA, Brown RE, Chang WC, Morris JS, Wang N, Carroll RJ, Turner ND, Lupton JR, Chapkin RS, Morphodensitometric analysis of protein kinase C beta(II) expression in rat colon: modulation by diet and relation to in situ cell proliferation and apoptosis, Carcinogenesis, 21(8), 1513-9, August 2000 Abstract
  • Maier, S.M., N.D. Turner, and J.R. Lupton, Serum lipids in hypercholesterolemic men and women consuming oat bran and amaranth products, Cereal Chemistry, 77, 297-302, 2000
  • Hong MY, Chapkin RS, Wild CP, Morris JS, Wang N, Carroll RJ, Turner ND, Lupton JR, Relationship between DNA adduct levels, repair enzyme, and apoptosis as a function of DNA methylation by azoxymethane., Cell Growth and Differentiation, 10(11), 749-58, November 1999 Abstract
  • Fan YY, Zhang J, Barhoumi R, Burghardt RC, Turner ND, Lupton JR, Chapkin RS, Antagonism of CD95 signaling blocks butyrate induction of apoptosis in young adult mouse colonic cells, American Journal of Physiology, 277(2 Pt 1), C310-9, August 1999 Abstract
  • Lupton JR, Turner ND, Potential protective mechanisms of wheat bran fiber, American Journal of Medicine, 106(1A), 24S-27S, 1999 Abstract
  • Turner ND, Knapp JR, Byers FM, Kopchick JJ, Expression of mutant bovine growth hormone genes in mice perturbs age-related nutrient utilization patterns, Journal of Nutrition, 128(3), 520-4, March 1998 Abstract
  • Davidson LA, Aymond CM, Jiang YH, Turner ND, Lupton JR, Chapkin RS, Non-invasive detection of fecal protein kinase C betaII and zeta messenger RNA: putative biomarkers for colon cancer, Carcinogenesis, 19(2), 253-7, February 1998 Abstract
  • Maciorowski, K. G., N. D. Turner, J. R. Lupton, R. S. Chapkin, C. L. Shermer, S. D. Ha, and S. C. Ricke, Diet and carcinogen alter the fecal microbial populations of rats, Journal of Nutrition, 127, 449-457, 1997
  • Zoran, D.L., N.D. Turner, S.S. Taddeo, R.S. Chapkin, and J.R. Lupton, Wheat bran diet reduces tumor incidence in a rat model of colon cancer independent of effects on distal luminal butyrate concentrations, Journal of Nutrition, 127, 2217-2225, 1997
  • Turner, N. D., McDonough, C. M., Byers, F. M., and Dale, B. E., Nutrient and Microstructural Indices of Maize and Sorghum Responses to Ammonia Pressurization/depressurization, Cereal Chem., 72, 589, 1995

Profile Details

Last Updated: 6/9/2005

COS Expertise ID #405888
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