Neeraj Vij

powered by
COS Expertise®
Johns Hopkins University
School of Medicine
Pediatrics
Pulmonary Medicine
Assistant Professor
Johns Hopkins University
Center for Global Health
Johns Hopkins University
Institute of Nano Biotechnology
Johns Hopkins University
Institute of Clinical and Translational Research
Professional Headshot of Neeraj Vij

Mailing Address

600 N. Wolfe Street
CMSC 3-122
Baltimore, Maryland 21287
United States

Contact Information

Phone: (410) 955-9783
Fax: (410) 502-8007
nvij1@jhmi.edu

Qualifications

Postdoctoral Fellow, Johns Hopkins University, Molecular Biology & Functional Genomics, 2006.
Scientific Research Associate, University of Heidelberg, Molecular Immunology, 2002.
Ph.D., Indian Institute of Technology, Roorkee, Biotechnology, 2001.
Research Fellow, Institute of Genetics, BRC, Szeged, Molecular Biology and Genetics, 2001.

Honors and Awards

2001-2002, Postdoctoral Fellowship, German Research Council, University of Heidelberg, Germany, Molecular Immunology
2000-2001, ITC Fellowship, UNESCO and EMBO, Institute of Genetics, BRC, Hungary, Molecular Biology and Genetics
1996-1998, University Topper, MS (Microbiology)

Expertise and Research Interests

1. Protein processing of misfolded dF508 CFTR, alpha-1-antitrypsin Z mutant and other conformational mutant proteins.
2. Functional role of VCP/p97 (AAA ATP chaperone) in ERAD, protein aggregation and forward trafficking pathways, and identification of sites for selective interaction and/or post translational modification for therapeutic intervention.
3. Mechanisms of ubiquitination and deubiquitination of misfolded proteins, and identification of substarte specific ubuitinating ligases (E1/E2/E3s) and deubiquitinating enzymes (DUBs like Ub C-terminal hydrolases, UCHs or ubiquitin specific proteases, USPs).
4. Chronic airway inflammation with emphasis on the role of PGE-2, IL8 and neutrophil chemotaxis.
5. Immune privilege and wound healing.
6. Identification of novel therapeutic strategies including design of small molecules and nano- drug delivery systems.

Memberships

American Association for the Advancement of Science
American Society for Gene Therapy
American Society of Physiology
American Thoracic Society
Association for Research in Vision and Ophthalmology

Publications

  • Vij N, Mazur S, Zeitlin PL (2009) CFTR is a negative regulator of NFkappaB mediated innate immune response., PLoS ONE, 4 (2), e4664 Abstract
  • MacDonald KD, McKenzie KR, Henderson MJ, Hawkins CE, Vij N, Zeitlin PL (Nov 2008) Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice., American journal of physiology. Lung cellular and molecular physiology, 295 (5), L933-40 Abstract
  • Cebotaru L, Vij N, Ciobanu I, Wright J, Flotte T, Guggino WB (Aug 2008) Cystic fibrosis transmembrane regulator missing the first four transmembrane segments increases wild type and DeltaF508 processing., The Journal of biological chemistry, 283 (32), 21926-33 Abstract
  • Vij N (Aug 2008) AAA ATPase p97/VCP: cellular functions, disease and therapeutic potential., Journal of cellular and molecular medicine Abstract
  • Vij N, Amoako MO, Mazur S, Zeitlin PL (Feb 2008) CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells., American journal of respiratory cell and molecular biology, 38 (2), 176-84 Abstract
  • Vij N, Sharma A, Thakkar M, Sinha S, Mohan RR (2008) PDGF-driven proliferation, migration, and IL8 chemokine secretion in human corneal fibroblasts involve JAK2-STAT3 signaling pathway., Molecular vision, 14, 1020-7 Abstract
  • Wu F, Vij N, Roberts L, Lopez-Briones S, Joyce S, Chakravarti S (Sep 2007) A novel role of the lumican core protein in bacterial lipopolysaccharide-induced innate immune response., The Journal of biological chemistry, 282 (36), 26409-17 Abstract
  • Vij N, Fang S, Zeitlin PL (Jun 2006) Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications., The Journal of biological chemistry, 281 (25), 17369-78 Abstract
  • Vij N, Zeitlin PL (Jun 2006) Regulation of the ClC-2 lung epithelial chloride channel by glycosylation of SP1., American journal of respiratory cell and molecular biology, 34 (6), 754-9 Abstract
  • Singh OV, Vij N, Mogayzel PJ, Jozwik C, Pollard HB, Zeitlin PL (Mar 2006) Pharmacoproteomics of 4-phenylbutyrate-treated IB3-1 cystic fibrosis bronchial epithelial cells., Journal of proteome research, 5 (3), 562-71 Abstract
  • Vij N, Roberts L, Joyce S, Chakravarti S (Jan 2005) Lumican regulates corneal inflammatory responses by modulating Fas-Fas ligand signaling., Investigative ophthalmology & visual science, 46 (1), 88-95 Abstract
  • Chakravarti S, Wu F, Vij N, Roberts L, Joyce S (Oct 2004) Microarray studies reveal macrophage-like function of stromal keratocytes in the cornea., Investigative ophthalmology & visual science, 45 (10), 3475-84 Abstract
  • Vij N, Roberts L, Joyce S, Chakravarti S, Lumican suppresses cell proliferation and aids Fas-Fas ligand mediated apoptosis: implications in the cornea, Experimental Eye Research, 78(5), 957-71, May 2004 Abstract
  • Kumar A, Vij N, Randhawa GS, Isolation and symbiotic characterization of transposon Tn5-induced arginine auxotrophs of Sinorhizobium meliloti, Indian Journal of Experimental Biology, 41(10), 1198-204, 2003 Abstract
  • Vij N, Proteomics: a novel approach to explore signal exchanges in Rhizobium-legume symbiosis, Indian Journal of Experimental Biology, 41(10), 1133-5, October 2003 Abstract
  • Abbas BA, Vineetha KE, Prasad CK, Vij N, Hassani R, Randhawa GS, Symbiotic characteristics of cysteine and methionine auxotrophs of Sinorhizobium meliloti, Indian Journal of Experimental Biology, 40(10), 1121-30, 2002 Abstract
  • Hassani R, Prasad CK, Vineetha KE, Vij N, Singh P, Sud R, Yadav S, Randhawa GS, Symbiotic characterization of isoleucine+valine and leucine auxotrophs of Sinorhizobium meliloti, Indian Journal of Experimental Biology, 40(10), 1110-20, 2002 Abstract
  • Vineetha KE, Vij N, Prasad CK, Hassani R, Randhawa GS, Ultrastructural studies on nodules induced by pyrimidine auxotrophs of Sinorhizobium meliloti, Indian Journal of Experimental Biology, 39(4), 371-7, 2001 Abstract

Profile Details

Last Verified: 3/20/2009

COS Expertise ID #1098124
Reference this profile directly: http://myprofile.cos.com/neerajvij