Dr. John F. Neumaier

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University of Washington
School of Medicine
Psychiatry and Behavioral Sciences
ProfessorAppointed: 2008
Professional Headshot of John F. Neumaier

Mailing Address

Psychiatry, Box 359911
University of Washington
Harborview Medical Center
325 9th Ave.
Seattle, Washington 98104
United States

Contact Information

Phone: (206) 341-5803
Fax: (206) 341-5804
neumaier@u.washington.edu

Qualifications

M.D., University of Washington, 1990.
Ph.D., University of Washington, 1989.
B.A., Reed College, Biology, 1983.

Expertise and Research Interests

My laboratory is studying the regulation of serotonin receptors in rat brain in animal models of psychiatric illnesses. We use techniques that span molecular to behavioral levels of analysis. Our strategy is to explore the reciprocal relationship between receptor expression and behavior using techniques that focus on discrete brain regions. There are currently three main projects in the laboratory:

1. The role of 5-HT1B autoreceptors in stress related behaviors associated with anxiety and depression. We use viral mediated gene transfer to manipulate 5-HT1B expression in clusters of serotonergic neurons that project to different brain regions and determine the behavioral and physiological outcomes.

2. The role of 5-HT1B and 5-HT6 receptors in drug reward mechanisms. Nucleus accumbens neurons express these receptors heavily, and manipulating their expression with targeted gene transfer alters the rewarding properties of cocaine, amphetamine, and alcohol. We are continuing to evaluate the potential of these receptors to be targets for manipulating the addictive properties of these drugs.

3. The role of 5-HT6 receptors in cognition. Using several behavioral models, we have found that 5-HT6 antagonists enhance memory and overexpression of 5-HT6 receptors in striatum impairs learning. The mechanism for these cognitive effects is not known but likely involves the modulation of other neurotransmitter systems, especially acetylcholine.

These research projects are currently supported by the NIMH, NIDA, the National Alliance for Research in Schizophrenia and Depression.

Other Expertise

Academic Experience:
- 1994 Outstanding Resident, Department of Psychiatry
- 1994 Sandoz Award for Research
- 1993 Society of Biological Psychiatry/Dista Fellowship Award
- 1992 NIMH Outstanding Resident Award
- 1991-1994 Neuroscience track, Department of Psychiatry
- 1990 Margaret H. O'Donnell Prize in Psychiatry

Keywords

COS Keywords:

Animal Models, Behavioral Biology, Cell Culture, Depression, Gene Transfer, Histochemistry, In Situ Hybridization, Nervous System, Neurobiology, Neuropsychopharmacology, Neuroscience, Psychiatry, Psychosis, Schizophrenia.

Additional Terms:

Antidepressant, Autoreceptor, Behavioral Biology, Nervous System, Neurobiology, Psychiatry, Rat, Serotonin, Viral Mediated Gene Transfer.

Memberships

American College of Neuropsychopharmacology
American Psychiatric Association
Serotonin Club
Society for Biological Psychiatry
Society for Neuroscience

Previous Positions

2001-2008, Associate Professor, University of Washington, Psychiatry and Behavioral Sciences
1994-2001, Assistant Professor, University of Washington, School of Medicine, Psychiatry and Behavioral Sciences
1993-1994, Chief Resident, University of Washington, Medical Center, Psychiatry

Funding Received

  • National Institute of Mental Health: 5-HT1B autoreceptors in an animal model of stress, Mar 2001 to 2010.
  • National Institute on Drug Abuse: 5-HT6 Receptors in Reward Motivated Learning, 2008 to 2010.
  • National Institute on Alcohol Abuse and Alcoholism: Regulation of ethanol reward by 5-HT1B receptors, 2006 to 2008.
  • National Institute on Drug Abuse: The role of serotonin receptors in brain reward circuits, 2003 to .

Publications

  • Mitchell ES, Neumaier JF (Jan 2008) 5-HT6 receptor antagonist reversal of emotional learning and prepulse inhibition deficits induced by apomorphine or scopolamine., Pharmacology, biochemistry, and behavior, 88 (3), 291-8 Abstract
  • Ferguson SM, Mitchell ES, Neumaier JF (Jan 2008) Increased expression of 5-HT6 receptors in the nucleus accumbens blocks the rewarding but not psychomotor activating properties of cocaine., Biological psychiatry, 63 (2), 207-13 Abstract
  • Suzuki S, Zhou H, Neumaier JF, Pham TA (Aug 2007) Opposing functions of CREB and MKK1 synergistically regulate the geometry of dendritic spines in visual cortex., The Journal of comparative neurology, 503 (5), 605-17 Abstract
  • Mitchell ES, Sexton T, Neumaier JF (Jul 2007) Increased expression of 5-HT6 receptors in the rat dorsomedial striatum impairs instrumental learning., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 32 (7), 1520-30 Abstract
  • Clark MS, McDevitt RA, Hoplight BJ, Neumaier JF (Jun 2007) Chronic low dose ovine corticotropin releasing factor or urocortin II into the rostral dorsal raphe alters exploratory behavior and serotonergic gene expression in specific subregions of the dorsal raphe., Neuroscience, 146 (4), 1888-905 Abstract
  • Barot SK, Ferguson SM, Neumaier JF (May 2007) 5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine., The European journal of neuroscience, 25 (10), 3125-31 Abstract
  • Avery DH, Holtzheimer PE, Fawaz W, Russo J, Neumaier J, Dunner DL, Haynor DR, Claypoole KH, Wajdik C, Roy-Byrne P (May 2007) Transcranial magnetic stimulation reduces pain in patients with major depression: a sham-controlled study., The Journal of nervous and mental disease, 195 (5), 378-81 Abstract
  • Hoplight BJ, Vincow ES, Neumaier JF (Feb 2007) Cocaine increases 5-HT1B mRNA in rat nucleus accumbens shell neurons., Neuropharmacology, 52 (2), 444-9 Abstract
  • Clark MS, McDevitt RA, Neumaier JF (Oct 2006) Quantitative mapping of tryptophan hydroxylase-2, 5-HT1A, 5-HT1B, and serotonin transporter expression across the anteroposterior axis of the rat dorsal and median raphe nuclei., The Journal of comparative neurology, 498 (5), 611-23 Abstract
  • Hiroi R, McDevitt RA, Neumaier JF (Aug 2006) Estrogen selectively increases tryptophan hydroxylase-2 mRNA expression in distinct subregions of rat midbrain raphe nucleus: association between gene expression and anxiety behavior in the open field., Biological psychiatry, 60 (3), 288-95 Abstract
  • Mitchell ES, Hoplight BJ, Lear SP, Neumaier JF (Mar 2006) BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism., Neuropharmacology, 50 (4), 412-20 Abstract
  • Hoplight BJ, Sandygren NA, Neumaier JF (Feb 2006) Increased expression of 5-HT1B receptors in rat nucleus accumbens via virally mediated gene transfer increases voluntary alcohol consumption., Alcohol (Fayetteville, N.Y.), 38 (2), 73-9 Abstract
  • Hiroi R, Neumaier JF (Jan 2006) Differential effects of ovarian steroids on anxiety versus fear as measured by open field test and fear-potentiated startle., Behavioural brain research, 166 (1), 93-100 Abstract
  • Hoplight BJ, Vincow ES, Neumaier JF, The Effects of SB 224289 on Anxiety and Cocaine-related Behaviors in A Novel Object Task., Physiology & Behavior, 84(5), 707-14, Apr 2005 Abstract
  • Kohen R, Kirov S, Navaja GP, Happe HK, Hamblin MW, Snoddy JR, Neumaier JF, Petty F (2005) Gene expression profiling in the hippocampus of learned helpless and nonhelpless rats., The Pharmacogenomics Journal, 5 (5), 278-91 Abstract
  • Bakewell CJ, Russo J, Tanner C, Avery DH, Neumaier JF, Comparison of Clinical Efficacy and Side Effects for Bitemporal And Bifrontal Electrode Placement in Electroconvulsive Therapy., The Journal of Ect, 20(3), 145-53, Sep 2004 Abstract
  • Figlewicz DP, Zavosh A, Sexton T, Neumaier JF, Catabolic action of insulin in rat arcuate nucleus is not enhanced by exogenous 'tub' expression, American Journal of Physiology. Endocrinology and Metabolism, 286(6), E1004-10, June 2004
  • Clark MS, Vincow ES, Sexton TJ, Neumaier JF, Increased expression of 5-HT1B receptor in dorsal raphe nucleus decreases fear-potentiated startle in a stress dependent manner, Brain Research, 1007(1-2), 86-97, May 2004 Abstract
  • Holtzheimer PE, Neumaier JF, Treatment of acute mania, Cns Spectrums, 8(12), 917-20, 924-8, 2003 Abstract
  • Kaiyala KJ, Vincow ES, Sexton TJ, Neumaier JF, 5-HT1B receptor mRNA levels in dorsal raphe nucleus: inverse association with anxiety behavior in the elevated plus maze, Pharmacology, Biochemistry, and Behavior, 75(4), 769-76, 2003 Abstract
  • Kohen R, Neumaier JF, Hamblin MW, Edwards E, Congenitally learned helpless rats show abnormalities in intracellular signaling, Biological Psychiatry, 53(6), 520-9, March 2003 Abstract
  • Neumaier JF, Gene therapy in psychiatric disorders: too early, too complex?, Current Opinion in Pharmacology, 3(1), 68-72, February 2003 Abstract
  • Neumaier JF, Vincow ES, Arvanitogiannis A, Wise RA, Carlezon WA Jr, Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine, 22(24), 10856-63, December 2002
  • Neumaier JF, Edwards E, Plotsky PM, 5-HT(1B) mrna regulation in two animal models of altered stress reactivity, Biological Psychiatry, 51(11), 902-8, June 2002 Abstract
  • Clark MS, Sexton TJ, McClain M, Root D, Kohen R, Neumaier JF, Overexpression of 5-HT1B receptor in dorsal raphe nucleus using Herpes Simplex Virus gene transfer increases anxiety behavior after inescapable stress, 22(11), 4550-62, June 2002
  • Neumaier JF, Sexton TJ, Hamblin MW, Beck SG, Corticosteroids regulate 5-HT(1A) but not 5-HT(1B) receptor mRNA in rat hippocampus, Brain Research. Molecular Brain Research, 82(1-2), 65-73, October 2000 Abstract
  • Anthony JP, Sexton TJ, Neumaier JF, Antidepressant-induced regulation of 5-HT(1b) mRNA in rat dorsal raphe nucleus reverses rapidly after drug discontinuation, Journal of Neuroscience Research, 61(1), 82-7, July 2000 Abstract
  • Zhukovskaya NL, Neumaier JF, Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells, Neuroscience Letters, 288(3), 236-40, July 2000 Abstract
  • Stanness KA, Neumaier JF, Sexton TJ, Grant GA, Emmi A, Maris DO, Janigro D, A new model of the blood-brain barrier: Co-culture of neuronal, endothelial and glial cells under dynamic conditions, Neuroreport, 10(18), 3725-31, December 1999
  • Avery DH, Claypoole K, Robinson L, Neumaier JF, Dunner DL, Scheele L, Wilson L, Roy-Byrne P, Repetitive transcranial magnetic stimulation in the treatment of medication-resistant depression: preliminary data, Journal of Nervous and Mental Disease, 187(2), 114-7, February 1999 Abstract
  • Sexton, TJ, McEvoy, CJ, Neumaier, JF, (+) 3,4-Methylenedioxymethamphetamine ('Ecstasy') transiently increases striatal 5-HT1B binding sites without altering 5-HT1B mRNA in rat brain, Molecular Psychiatry, 4, 572-579., 1999
  • Neumaier J F, Petty F, Kramer G L, Szot P, Hamblin M W, Learned helplessness increases 5-hydroxytryptamine1B receptor mRNA levels in the rat dorsal raphe nucleus, Biological Psychiatry, 41(6), 668-74, 15 Mar 1997
  • Neumaier J F, Root D C, Hamblin M W, Chronic fluoxetine reduces serotonin transporter mRNA and 5-HT1B mRNA in a sequential manner in the rat dorsal raphe nucleus, Neuropsychopharmacology, 15(5), 515-22, November 1996
  • Neumaier J F, Szot P, Peskind E R, Dorsa D M, Hamblin M W, Serotonergic lesioning differentially affects presynaptic and postsynaptic 5-HT1B receptor mRNA levels in rat brain, Brain Research, 722(1-2), 50-8, 25 May 1996
  • Wagner J J, Caudle R M, Neumaier J F, Chavkin C, Stimulation of endogenous opioid release displaces mu receptor binding in rat hippocampus, Neuroscience, 37(1), 45-53, 1990
  • Neumaier J F, Chavkin C, Calcium-dependent displacement of haloperidol-sensitive sigma receptor binding in rat hippocampal slices following tissue depolarization, Brain Research, 500(1-2), 215-22, 23 Oct 1989

Profile Details

Last Updated: 5/15/2008

COS Expertise ID #926996
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