Dr. Edward J. Novotny

powered by
COS Expertise®
Yale University
School of Medicine
Pediatrics, Neurology and Neurosurgery
Neurology
Associate ProfessorAppointed: 2000
Professional Headshot of Edward J. Novotny

Mailing Address

Department of Pediatrics
Yale University
333 Cedar St., LMP 3089
New Haven, Connecticut 06510
United States

Contact Information

Phone: (203) 785-5730
Fax: (203) 785-7194
edward.novotny@yale.edu
http://www.yalepediatrics.org/neuro/

Qualifications

M.D., Saint Louis University, 1979.
B.S., University of California, Irvine, 1975.

Expertise and Research Interests

Major changes in both metabolism and function of the nervous system occur during development. Nuclear magnetic resonance (NMR) techniques provide non-invasive methods to study the changes in anatomy, metabolism and cerebral function during development in both animals and humans. These NMR methods include MRI for quantitative anatomy, fMRI for measures of function and MRS for measures of metabolism. My research interest invovles the application of NMR methods to the investigation of both normal physiology and pathological disorders in the developing nervous system. Particular interests are investigations of metabolism, anatomy and function in epilepsy and neurogenetic disorders in both animal and humans.

Other Expertise

I wish to be contacted by interested students (medical, graduate or undergraduates) as a potential research mentor/thesis advisor.

Board Certification in Pediatrics; Pediatrics; American Board of Pediatrics; 1986.
Board Certification in Neurology with special qualification in Child Neurology; American Board of Psychiatry and Neurology; 1986.
Board Certification in Neurology with special qualification in Clinical Neurophysiology; American Board of Psychiatry and Neurology; 1994.(Recertified 8/2004)
Residencies: University of California, Davis (Pediatrics); Stanford University (Neurology).
Fellowships: Stanford University and Yale University.

Keywords

COS Keywords:

Epilepsy, Magnetic Resonance, Magnetic Resonance Imaging, Neurology, Neuroscience, Neurosurgery, Nuclear Magnetic Resonance, Pediatrics.

Additional Terms:

Cerebral Metabolism, Development, Epilepsy, Neuroscience, Nuclear Magnetic Resonance.

Memberships

American Academy of Neurology
American Association for the Advancement of Science
American Clinical Neurophysiology Society
American Epilepsy Society
Child Neurology Society
International Child Neurology Association
International Society for Magnetic Resonance in Medicine
Society for Neuroscience
Society for Pediatric Research

Honors and Awards

1990-1995, FIRST Award, NIH/NINDS, Yale University, NMR Spectroscopy of Epilepsy
1987-1989, National Research Service Award, NIH/NINDS, Yale University, NMR Spectroscopy of Epilepsy
1985-1986, S. Weir Mitchell Award, American Acedemy of Neurology, Stanford University, Mitochondrial Neurodegenerative Disorders
1984-1985, William Gowers Fellowship, Epilepsy Foundation of America, Stanford University, Neonatal Seizures/Epilepsy

Previous Positions

1986-1987, Acting Assistant Professor, Stanford University, Neurology, Pediatric Neurology

Funding Received

  • Juvenile Diabetes Foundation: Brain Glucose Transport in Nondiabetic and Insulin Dependent Diabetic Subjects Investigated by In Vivo NMR Spectroscopy, Sep 1, 1991 to Aug 31, 1992.
  • NINDS: In vivo 1H/13C NMR Studies of Neonatal seizures, Sep 1, 1990 to Aug 31, 1995.
  • Epilepsy Foundation of America: Multinuclear NMR studies of the Ketogenic Diet in Children, Jul 1, 1996 to Jun 30, 1997.
  • NINDS: In vivo NMR spectroscopic investigations in epilepsy, Jul 1, 1987 to Jun 30, 1989.
  • NINDS: Cerebral GABA in Cryptogenic Generalized Epilepsy, Jan 4, 1999 to Nov 30, 2004.
  • NIDA: NMR Studies of Brain Glutamate Turnover in Development, , 2002 to 2005.

Publications

  • Pearl P, Capp PK, Novotny EJ, Gibson KM (2005) Inherited disorders of neurotransmitters in children and adults., Clinical Biochemistry, 38 (12), 1051-8
  • McNally KA, Paige AL, Varghese G, Zhang H, Novotny EJ Jr, Spencer SS, Zubal IG, Blumenfeld H (Sep 2005) Localizing value of ictal-interictal SPECT analyzed by SPM (ISAS)., Epilepsia, 46 (9), 1450-64 Abstract
  • Safriel Y, Pol-Rodriguez M, Novotny EJ, Rothman DL, Fulbright RK (2005) Reference values for long echo time MR spectroscopy in healthy adults, Am J Neuroradiology, 26 (6), 1439-45
  • Trubel H, Herman P, Kampmann C, Huth R, Maciejewski PK, Novotny E, Hyder F (Sep 2004) A novel approach for selective brain cooling: implications for hypercapnia and seizure activity., Intensive Care Medicine, 30 (9), 1829-33 Abstract
  • Blumenfeld H, McNally KA, Vanderhill SD, Paige AL, Chung R, Davis K, Norden AD, Stokking R, Studholme C, Novotny EJ Jr, Zubal IG, Spencer SS (Aug 2004) Positive and negative network correlations in temporal lobe epilepsy., Cerebral Cortex (new York, N.y. : 1991), 14 (8), 892-902 Abstract
  • Trubel H, Herman P, Kampmann C, Novotny E, Hyder F, [Selective pharyngeal brain cooling], Biomedizinische Technik. Biomedical Engineering, 48(11), 298-300, November 2003 Abstract
  • Lai JC, White BK, Buerstatte CR, Haddad GG, Novotny EJ Jr, Behar KL, Chronic hypoxia in development selectively alters the activities of key enzymes of glucose oxidative metabolism in brain regions, Neurochemical Research, 28(6), 933-40, June 2003
  • Trubel HK, Novotny E, Lister G, Outcome of coma in children, Current Opinion in Pediatrics, 15(3), 283-7, June 2003 Abstract
  • Nguyen D, Singh S, Zaatreh M, Novotny E, Levy S, Testa F, Spencer SS, Hypothalamic hamartomas: seven cases and review of the literature, Epilepsy Behav, 4(3), 246-58, June 2003 Abstract
  • Pearl PL, Gibson KM, Acosta MT, Vezina LG, Theodore WH, Rogawski MA, Novotny EJ, Gropman A, Conry JA, Berry GT, Tuchman M, Clinical spectrum of succinic semialdehyde dehydrogenase deficiency, Neurology, 60(9), 1413-7, May 2003 Abstract
  • Motamedi M, Nguyen DK, Zaatreh M, Singh SP, Westerveld M, Thompson JL, Mattson R, Blumenfeld H, Novotny E, Spencer SS, Levetiracetam Efficacy in Refractory Partial-onset Seizures, Especially after Failed Epilepsy Surgery, Epilepsia, 44(2), 211-4, February 2003 Abstract
  • Pearl PL, Novotny EJ, Acosta MT, Jakobs C, Gibson KM, Succinic semialdehyde dehydrogenase deficiency in children and adults, Annals of Neurology, 54 Suppl 6, S73-80, 2003 Abstract
  • Novotny EJ Jr, Fulbright RK, Pearl PL, Gibson KM, Rothman DL, Magnetic resonance spectroscopy of neurotransmitters in human brain, Annals of Neurology, 54 Suppl 6, S25-31, 2003 Abstract
  • Zaatreh MM, Spencer DD, Thompson JL, Blumenfeld H, Novotny EJ, Mattson RH, Spencer SS, Frontal lobe tumoral epilepsy: clinical, neurophysiologic features and predictors of surgical outcome, Epilepsia, 43(7), 727-33, July 2002 Abstract
  • Butchko HH, Stargel WW, Comer CP, Mayhew DA, Benninger C, Blackburn GL, de Sonneville LM, Geha RS, Hertelendy Z, Koestner A, Leon AS, Liepa GU, McMartin KE, Mendenhall CL, Munro IC, Novotny EJ, Renwick AG, Schiffman SS, Schomer DL, Shaywitz BA, Trefz FK, Aspartame: review of safety, Regulatory Toxicology and Pharmacology: Rtp, 35(2 Pt 2), S1-93, April 2002
  • de Graaf RA, Pan JW, Telang F, Lee JH, Brown P, Novotny EJ, Hetherington HP, Rothman DL, Differentiation of glucose transport in human brain gray and white matter, Journal of Cerebral Blood Flow and Metabolism, 21(5), 483-92, May 2001 Abstract
  • Studholme C, Novotny E, Zubal IG, Duncan JS, Estimating tissue deformation between functional images induced by intracranial electrode implantation using anatomical MRI, Neuroimage, 13(4), 561-76, April 2001 Abstract
  • Novotny EJ Jr, Ariyan C, Mason GF, O'Reilly J, Haddad GG, Behar KL, Differential increase in cerebral cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitro, Brain Research, 888(2), 193-202, 2001 Abstract
  • Buerstatte CR, Behar KL, Novotny EJ, Lai JC, Brain regional development of the activity of alpha-ketoglutarate dehydrogenase complex in the rat, Brain Research. Developmental Brain Research, 125(1-2), 139-45, 2000 Abstract
  • Boles RG, Seashore MR, Mitchell WG, Kollros PR, Mofidi S, Novotny EJ, Glucose transporter type 1 deficiency: a study of two cases with video-EEG, European Journal of Pediatrics, 158(12), 978-83, December 1999 Abstract
  • Masuoka LK, Anderson AW, Gore JC, McCarthy G, Spencer DD, Novotny EJ, Functional magnetic resonance imaging identifies abnormal visual cortical function in patients with occipital lobe epilepsy, Epilepsia, 40(9), 1248-53, September 1999 Abstract
  • Shevell MI, Ashwal S, Novotny E, Proton magnetic resonance spectroscopy: clinical applications in children with nervous system diseases, Seminars in Pediatric Neurology, 6(2), 68-77, June 1999 Abstract
  • Novotny EJ Jr, Hyder F, Shevell M, Rothman DL, GABA changes with vigabatrin in the developing human brain, Epilepsia, 40(4), 462-6, April 1999 Abstract
  • Shen J, Novotny EJ, Rothman DL, In vivo lactate and beta-hydroxybutyrate editing using a pure-phase refocusing pulse train, Magnetic Resonance In Medicine, 40(5), 783-8, November 1998
  • Levy SR, Berg AT, Testa FM, Novotny EJ Jr, Chiappa KH, Comparison of digital and conventional EEG interpretation, Journal of Clinical Neurophysiology, 15(6), 476-80, November 1998 Abstract
  • Novotny E, Ashwal S, Shevell M, Proton magnetic resonance spectroscopy: an emerging technology in pediatric neurology research, Pediatric Research, 44(1), 1-10, July 1998
  • Novotny E J Jr, The role of clinical neurophysiology in the management of epilepsy, Journal of Clinical Neurophysiology, 15(2), 96-108, March 1998
  • Kang P B, Novotny E J Jr, A two-year-old girl with acute onset of seizures and progressive encephalopathy, Current Opinion In Pediatrics, 9(6), 558-64, December 1997
  • Gruetter R, Novotny E J, Boulware S D, Rothman D L, Shulman R G, 1H NMR studies of glucose transport in the human brain, Journal of Cerebral Blood Flow and Metabolism, 16(3), 427-38, May 1996
  • Berg AT, Levy SR, Novotny EJ, Shinnar S, Predictors of intractable epilepsy in childhood: a case-control study, Epilepsia, 37(1), 24-30, January 1996 Abstract
  • Novotny E J Jr, Avison M J, Herschkowitz N, Petroff O A, Prichard J W, Seashore M R, Rothman D L, In vivo measurement of phenylalanine in human brain by proton nuclear magnetic resonance spectroscopy, Pediatric Research, 37(2), 244-9, February 1995
  • Mason G F, Gruetter R, Rothman D L, Behar K L, Shulman R G, Novotny E J, Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR, Journal of Cerebral Blood Flow and Metabolism, 15(1), 12-25, January 1995
  • Novotny E J Jr, Overview--the role of NMR spectroscopy in epilepsy, Magnetic Resonance Imaging, 13(8), 1171-3, 1995
  • Gruetter R, Novotny E J, Boulware S D, Mason G F, Rothman D L, Shulman G I, Prichard J W, Shulman R G, Localized 13C NMR spectroscopy in the human brain of amino acid labeling from D-[1-13C]glucose, Journal of Neurochemistry, 63(4), 1377-85, October 1994
  • Shaywitz B A, Anderson G M, Novotny E J, Ebersole J S, Sullivan C M, Gillespie S M, Aspartame has no effect on seizures or epileptiform discharges in epileptic children, Annals of Neurology, 35(1), 98-103, January 1994
  • Chen W, Novotny E J, Zhu X H, Rothman D L, Shulman R G, Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation, Proceedings of the National Academy of Sciences (USA), 90(21), 9896-900, 1 Nov 1993
  • Novotny E J Jr, Neonatal seizures, Seminars In Perinatology, 17(5), 351-6, October 1993
  • Spencer S S, Katz A, Ebersole J, Novotny E, Mattson R, Ictal EEG changes with corpus callosum section., Epilepsia, 34(3), 568-73, May 1993 Abstract
  • Shaywitz B A, Novotny E J Jr, Aspartame and seizures, Neurology, 43(3 Pt 1), 630-1, March 1993 Abstract
  • Gruetter R, Novotny E J, Boulware S D, Rothman D L, Mason G F, Shulman G I, Tamborlane W V, Shulman R G, Non-invasive measurements of the cerebral steady-state glucose concentration and transport in humans by 13C nuclear magnetic resonance, Advances In Experimental Medicine and Biology, 331, 35-40, 1993
  • Petroff O A, Novotny E J, Avison M, Rothman D L, Alger J R, Ogino T, Shulman G I, Prichard J W, Cerebral lactate turnover after electroshock: in vivo measurements by 1H/13C magnetic resonance spectroscopy, Journal of Cerebral Blood Flow and Metabolism, 12(6), 1022-9, November 1992
  • Rothman D L, Novotny E J, Shulman G I, Howseman A M, Petroff O A, Mason G, Nixon T, Hanstock C C, Prichard J W, Shulman R G, 1H-[13C] NMR measurements of [4-13C]glutamate turnover in human brain, Proceedings of the National Academy of Sciences (USA), 89(20), 9603-6, 15 Oct 1992
  • Gruetter R, Rothman D L, Novotny E J, Shulman G I, Prichard J W, Shulman R G, Detection and assignment of the glucose signal in 1H NMR difference spectra of the human brain, Magnetic Resonance In Medicine, 27(1), 183-8, September 1992
  • Rothman D L, Hanstock C C, Petroff O A, Novotny E J, Prichard J W, Shulman R G, Localized 1H NMR spectra of glutamate in the human brain, Magnetic Resonance In Medicine, 25(1), 94-106, May 1992
  • Gruetter R, Rothman D L, Novotny E J, Shulman R G, Localized 13C NMR spectroscopy of myo-inositol in the human brain in vivo, Magnetic Resonance In Medicine, 25(1), 204-10, May 1992
  • Gruetter R, Novotny E J, Boulware S D, Rothman D L, Mason G F, Shulman G I, Shulman R G, Tamborlane W V, Direct measurement of brain glucose concentrations in humans by 13C NMR spectroscopy [published erratum appears in Proc Natl Acad Sci U S A 1992 Dec 15;89(24):12208], Proceedings of the National Academy of Sciences (USA), 89(3), 1109-12, 1 Feb 1992 Abstract
  • Prichard J, Rothman D, Novotny E, Petroff O, Kuwabara T, Avison M, Howseman A, Hanstock C, Shulman R, Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation, Proceedings of the National Academy of Sciences (USA), 88(13), 5829-31, 1 Jul 1991
  • Novotny E J Jr, Ogino T, Rothman D L, Petroff O A, Prichard J W, Shulman R G, Direct carbon versus proton heteronuclear editing of 2-13C ethanol in rabbit brain in vivo: a sensitivity comparison., Magnetic Resonance In Medicine, 16(3), 431-43, December 1990 Abstract
  • Novotny E J Jr, Epileptic syndromes and seizures in infants, Seminars In Neurology, 10(4), 366-79, December 1990
  • Avison M J, Herschkowitz N, Novotny E J, Petroff O A, Rothman D L, Colombo J P, Bachmann C, Shulman R G, Prichard J W, Proton NMR observation of phenylalanine and an aromatic metabolite in the rabbit brain in vivo, Pediatric Research, 27(6), 566-70, June 1990
  • Petroff O A, Novotny E J, Ogino T, Avison M, Prichard J W, In vivo measurements of ethanol concentration in rabbit brain by 1H magnetic resonance spectroscopy, Journal of Neurochemistry, 54(4), 1188-95, April 1990
  • Hanstock C C, Rothman D L, Shulman R G, Novotny E J Jr, Petroff O A, Prichard J W, Measurement of ethanol in the human brain using NMR spectroscopy, Journal of Studies On Alcohol, 51(2), 104-7, March 1990
  • Young R S, Petroff O A, Novotny E J Jr, Wong M, Neonatal excitotoxic brain injury. Physiologic, metabolic, and pathologic findings, Developmental Neuroscience, 12(3), 210-20, 1990
  • Gruetter R, Novotny EJ, Boulware SD, Rothman DL, Mason GF, Shulman GI, Shulman RG, Tamborlane WT. (1992) Direct measurement of brain glucose concentrations in humans by 13C NMR spectroscopy. Proc Natl Acad Sci USA 89:1109-11
  • Chen W, Novotny EJ, Zhu -xH, Rothman DL, Shulman RG. (1993) Localised 1H NMR Measurement of Glucose Consumption in the Human Brain During Visual Stimulation. Proc Natl Acad Sci USA 90:9896-9900

Profile Details

Last Updated: 3/31/2006

COS Expertise ID #900526
Reference this profile directly: http://myprofile.cos.com/novotny3