Prof. Cornelia Ulrich

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National Center of Tumor Diseases
Heidelberg, Germany
Division of Preventive Oncology
DirectorAppointed: 2009
German Cancer Research Center
Preventive Oncology
HeadAppointed: 2009
University of Washington
Graduate School
Nutritional Sciences
Core Faculty
University of Washington
School of Public Health and Community Medicine
Epidemiology
Professor
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Cancer Prevention Program
Full Member
University of Washington
School of Public Health and Community Medicine
Health Services
Adjunct Research Associate Professor
Professional Headshot of Cornelia Ulrich

Mailing Address

German Cancer Research Center (DKFZ)
Praeventive Onkologie
Im Neuenheimer Feld 581
G110
Heidelberg, 69120
Germany

Contact Information

Phone: +49-6221-42-1661/1660
Fax: +49-6221-42-1669
nulrich@fhcrc.org

Qualifications

Ph.D., University of Washington, Epidemiology (Minor: Health Services Research), 1998.
M.S., Oregon State University, Nutrition (Minor: Public Health), 1992.
Vordiplom, Universitaet Hohenheim, Nutrition Science, 1990.

Expertise and Research Interests

Pharmacogenetics and survivorship: In collaboration with clinicians at multiple institutions in the United States, Canada, and Australia Dr. Ulrich is leading studies of cohorts of cancer patients that investigate how polymorphisms in folate metabolism affect the response to chemotherapy with methotrexate or 5-fluorouracil. Research on biologic aspects of cancer survivorship is important and has received little attention. Dr. Ulrich's research aims to answer questions on pharmacogenetics, the impact of the use of nutritional supplements, and chemoprevention strategies among cancer survivors.

Polymorphisms in prostaglandin synthesis and risk of colorectal polyps: Dr. Ulrich heads interdisciplinary studies investigating genetic variability in prostaglandin/eicosanoid synthesis in relation to colorectal neoplasia. This biologic pathway is critical for the efficacy of aspirin and other NSAIDs in colorectal cancer prevention. In addition to epidemiologic studies of colon and rectal cancer, we will also undertake in vitro evaluation of the functional impact of polymorphisms. This work brings together researchers from the FHCRC, the University of Utah, TGen, and the University of Texas.

Transdisciplinary research in energy balance and cancer (TREC): Together with colleagues at the FHCRC and three other institutions in the United States, Dr. Ulrich is participating in a large interdisciplinary NIH initiative to elucidate the mechanisms linking obesity and energy balance to cancer risk, and explore new prevention strategies. She is leading a project that evaluates as part of a randomized controlled trial the effects of exercise and/or energy restriction on DNA repair capacity, gene expression, proteomics, and biomarkers of inflammation. Dr. Ulrich is also leading the Training and Education Core of the Seattle TREC.

DNA mutagen sensitivity and repair capacity: In addition to the effects of exercise/caloric restriction on this critical biomarker, Dr. Ulrich collaborates with other colleagues at the FHCRC in studies investigating within randomized controlled trials the effects of diets high in specific classes of fruits and vegetables on indicators of DNA damage and repair capacity, and on studies evaluating associations between supplement use and DNA repair capacity.

Folate and DNA repair polymorphisms and risk of colorectal neoplasia: Dr. Ulrich directs studies investigating associations between common genetic variability in folate-metabolizing and DNA-repair enzymes and risk of colorectal polyps or cancer. Gene-environment interactions with respect to relevant exposures are a special emphasis of this work. Collaborators include colleagues at the FHCRC and the University of Utah. We have also recently proposed a whole-genome scan of non-synonymous SNPs, using a two-stage design. This project will address the role of genetic variability in colon cancer risk on a genomic level.

Mathematical modeling of folate-mediated one-carbon metabolism: Dr. Ulrich leads an interdisciplinary investigation to develop a mathematical simulation model of the biochemistry of folate-mediated one-carbon metabolism, including its link to DNA methylation. This model has already shown intriguing insights into folate homeostasis and the relevance of regulatory mechanisms in folate metabolism for preserving methylation capacity. Collaborators include colleagues at Duke University, the University of Florida, the University of Berkeley, the University of Arkansas, and the FHCRC.

Immune function studies: Together with colleagues at the FHCRC and University of Washington Dr. Ulrich investigates the effects of 12-months moderate exercise on immune function as part of a randomized controlled trial of 115 postmenopausal women. This also includes studies exploring how dietary factors and weight-loss relate to measures of immune function in this population. We have recently submitted findings showing that exercise reduces the incidence of colds among postmenopausal women.

Keywords

COS Keywords:

Biomarkers, Bone Marrow Transplantation, Cancer or Carcinogenesis, Cancer Prevention, Clinical Research or Studies, Enzymes, Epidemiology, Exercise, Genetics, Mathematical Modeling (Medical), Medical Genetics, Metabolism, Molecular Epidemiology, Nutrition or Dietetics, Oncology, Pharmacogenetics, Pharmacology, Public Health.

Additional Terms:

Epidemiology, Folate, Genetic Polymorphism, Genetic Testing, Molecular Epidemiology, Nutrition, Pharmacogenetics.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
German: (Fluent, Fluent, Fluent)

Memberships

American Association for Cancer Research
American College of Epidemiology
American Society of Preventive Oncology
International Society of Exercise Immunology
Women in Cancer Research

Honors and Awards

1999, Student Prize Paper, American College of Epidemiology
1998, Outstanding Student Award, Department of Epidemiology, University of Washington
1998, Pre- and Post-doctoral Award, Association of Health Services Research, 15th Annual Meeting
1998, AACR-Bristol-Myers Squibb Young Investigator Award, AACR-Bristol-Myers Squibb
1993-1995, German Academic Exchange Service (DAAD) Scholarship, Special Program for Epidemiology
1992, Fulbright Professional Enhancement Grant, Fulbright
1991-1992, Fulbright Scholarship, Fulbright
Exzellenzprofessur, Helmholtzgesellschaft

Previous Positions

2005-2009, Associate Professor, University of Washington, School of Public Health and Community Medicine, Epidemiology
2004-2008, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences, Cancer Prevention Research
2000-2004, Research Assistant Professor, University of Washington, School of Public Health and Community Medicine, Epidemiology
1999-2004, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences, Cancer Prevention Research

Publications

  • Curtin K (2009) MSH6 G39E polymorphisms and CpG island methylator phenotype in colon cancer, Molecular Carginogenesis
  • Trobridge P (2009) TGF-ß receptor inactivation cooperates with mutant Kras in vivo to induce intestinal neoplasms through a ß-catenin independent pathway, Gastroenterology, 136, 1680-88
  • Nijhout HF (2009) A mathematical model gives insights into the effects of vitamin B-6 deficiency on one-carbon and glutathione metabolism, Journal of Nutrition, 139 (4), 784-91
  • Williams L (2009) Proximity to traffic, inflammation and immune function among women in the Seattle area, Environmental Health Perspectives, 117, 373-78
  • Maruti SS (2009) Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk, American Journal of Clinical Nutrition, 89, 624-33
  • Wayne SJ (2008) Breast cancer survivors who use estrogenic botanical supplements have lower serum estrogen levels than non users, Breast Cancer Research and Treatment
  • Wayne SJ, Neuhouser ML, Koprowski C, Ulrich CM, Wiggins C, Gilliland F, Baumgartner KB, Baumgartner RN, McTiernan A, Bernstein L, Ballard-Barbash R (Oct 2008) Breast cancer survivors who use estrogenic botanical supplements have lower serum estrogen levels than non users., Breast cancer research and treatment Abstract
  • Meyers JA, Liu AY, McTiernan A, Wener MH, Wood B, Weigle DS, Sorensen B, Chen-Levy Z, Yasui Y, Boynton A, Potter JD, Ulrich CM (Oct 2008) Serum leptin concentrations and markers of immune function in overweight or obese postmenopausal women., The Journal of endocrinology, 199 (1), 51-60 Abstract
  • Dong LM, Ulrich CM, Hsu L, Duggan DJ, Benitez DS, White E, Slattery ML, Caan BJ, Potter JD, Peters U (Oct 2008) Genetic variation in calcium-sensing receptor and risk for colon cancer., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17 (10), 2755-65 Abstract
  • Samowitz WS, Curtin K, Wolff RK, Albertsen H, Sweeney C, Caan BJ, Ulrich CM, Potter JD, Slattery ML (Oct 2008) The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer., Genes, chromosomes & cancer, 47 (10), 835-44 Abstract
  • Ulrich CM (Sep 2008) Folate and cancer prevention--where to next? Counterpoint., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17 (9), 2226-30 Abstract
  • Ulrich CM, Reed MC, Nijhout HF (Aug 2008) Modeling folate, one-carbon metabolism, and DNA methylation., Nutrition reviews, 66 Suppl 1, S27-30 Abstract
  • Neuhouser ML, Sorensen B, Hollis BW, Ambs A, Ulrich CM, McTiernan A, Bernstein L, Wayne S, Gilliland F, Baumgartner K, Baumgartner R, Ballard-Barbash R (Jul 2008) Vitamin D insufficiency in a multiethnic cohort of breast cancer survivors., The American journal of clinical nutrition, 88 (1), 133-9 Abstract
  • Ulrich CM, Neuhouser M, Liu AY, Boynton A, Gregory JF, Shane B, James SJ, Reed MC, Nijhout HF (Jul 2008) Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17 (7), 1822-31 Abstract
  • Campbell KL, Campbell PT, Ulrich CM, Wener M, Alfano CM, Foster-Schubert K, Rudolph RE, Potter JD, McTiernan A (Jul 2008) No reduction in C-reactive protein following a 12-month randomized controlled trial of exercise in men and women., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17 (7), 1714-8 Abstract
  • Luebeck EG, Moolgavkar SH, Liu AY, Boynton A, Ulrich CM (Jun 2008) Does folic acid supplementation prevent or promote colorectal cancer? Results from model-based predictions., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17 (6), 1360-7 Abstract
  • Ulrich CM, Holmes RS (Jun 2008) Shedding light on colorectal cancer prognosis: vitamin d and beyond., Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 26 (18), 2937-9 Abstract
  • Campbell PT, Curtin K, Ulrich C, Samowitz W, Bigler J, Velicer C, Caan B, Potter J, Slattery M (Jun 2008) Mismatch repair polymorphisms and risk of colon cancer, tumor microsatellite instability, and interactions with lifestyle factors., Gut Abstract
  • Campbell PT, Wener MH, Sorensen B, Wood B, Chen-Levy Z, Potter JD, McTiernan A, Ulrich CM (Jun 2008) Effect of exercise on in vitro immune function: a 12-month randomized, controlled trial among postmenopausal women., Journal of applied physiology (Bethesda, Md. : 1985), 104 (6), 1648-55 Abstract
  • Dong LM, Potter JD, White E, Ulrich CM, Cardon LR, Peters U (May 2008) Genetic susceptibility to cancer: the role of polymorphisms in candidate genes., JAMA : the journal of the American Medical Association, 299 (20), 2423-36 Abstract
  • Pierce BL, Neuhouser ML, Wener MH, Bernstein L, Baumgartner RN, Ballard-Barbash R, Gilliland FD, Baumgartner KB, Sorensen B, McTiernan A, Ulrich CM (Apr 2008) Correlates of circulating C-reactive protein and serum amyloid A concentrations in breast cancer survivors., Breast cancer research and treatment Abstract
  • Jung AY, Poole EM, Bigler J, Whitton J, Potter JD, Ulrich CM (Feb 2008) DNA methyltransferase and alcohol dehydrogenase: gene-nutrient interactions in relation to risk of colorectal polyps., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17 (2), 330-8 Abstract
  • Hawkins VN, Foster-Schubert K, Chubak J, Sorensen B, Ulrich CM, Stancyzk FZ, Plymate S, Stanford J, White E, Potter JD, McTiernan A (Feb 2008) Effect of Exercise on Serum Sex Hormones in Men: A 12-Month Randomized Clinical Trial., 40 (2), 223-233 Abstract
  • Velicer CM, Ulrich CM (Feb 2008) Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review., Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 26 (4), 665-73 Abstract
  • Ulrich CM (2008) Folate and cancer prevention: where to next?, Cancer Epidemiology, Biomarkers and Prevention, 17, 2226-30
  • Ulrich CM (2008) Modeling folate, one-carbon metabolism, and DNA methylation, Nutrition Reviews, 66, 27-30
  • Poole EM, Bigler J, Whitton J, Sibert JG, Carlson CS, Potter JD, Ulrich CM (2008) C-reactive protein genotypes and haplotypes, polymorphisms in NSAID-metabolizing enzymes, and risk of colorectal polyps, Pharmacogenetics and Pharmacogenomics, In Press
  • Wayne S, Neuhouser ML, Ulrich CM, Koprowski C, Wiggins C, Baumgartner KB, Bernstein L, Baumgartner RN, Gilliland F, McTiernan A, Ballard-Barbash R (2008) The association between alcohol intake and serum sex hormones and peptides differs by tamoxifen use in breast cancer survivors, Cancer Epidemiology, Biomarkers and Prevention, In Press
  • Campbell KL, Foster-Schubert K, Kratz M, Makar K, McTiernan A, Ulrich CM (2008) Biomarkers of cancer risk in subcutaneous adipose tissue: A pilot study, Cancer Prevention Research, In Press
  • Reed MC, Thomas RL, Pavisic J, James SJ, Ulrich CM, Nijhout HF (2008) A mathematical model of glutathione metabolism., Theoretical biology & medical modelling, 5, 8 Abstract
  • Boynton A, Neuhouser ML, Sorensen B, McTiernan A, Ulrich CM (Jan 2008) Predictors of diet quality among overweight and obese postmenopausal women., Journal of the American Dietetic Association, 108 (1), 125-30 Abstract
  • Cross JT, Poole EM, Ulrich CM (Jan 2008) A review of gene-drug interactions for nonsteroidal anti-inflammatory drug use in preventing colorectal neoplasia. Abstract
  • Nijhout HF (2008) Mathematical models for folate-mediated one-carbon metabolism, Vitamins and Hormones: Folic Acids and Folates, 45-82 pages, ISBN=0123742323 (bookchapter)
  • Wayne SJ, Neuhouser ML, Ulrich CM, Koprowski C, Baumgartner KB, Baumgartner RN, McTiernan A, Bernstein L, Ballard-Barbash R (Dec 2007) Dietary fiber is associated with serum sex hormones and insulin-related peptides in postmenopausal breast cancer survivors. Abstract
  • Boynton A, Neuhouser ML, Wener MH, Wood B, Sorensen B, Chen-Levy Z, Kirk EA, Yasui Y, Lacroix K, McTiernan A, Ulrich CM (Nov 2007) Associations between healthy eating patterns and immune function or inflammation in overweight or obese postmenopausal women., The American journal of clinical nutrition, 86 (5), 1445-55 Abstract
  • Abrahamson PE, King IB, Ulrich CM, Rudolph RE, Irwin ML, Yasui Y, Surawicz C, Lampe JW, Lampe PD, Morgan A, Sorensen BE, Ayub K, Potter JD, McTiernan A (Nov 2007) No effect of exercise on colon mucosal prostaglandin concentrations: a 12-month randomized controlled trial., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 16 (11), 2351-6 Abstract
  • Nijhout HF, Reed MC, Ulrich CM (2007) A day in the life of cell metabolism, Biological Theory 2007, In Press
  • Abrahamson PE, Tworoger SS, Aiello EJ, Bernstein L, Ulrich CM, Gilliland FD, Stanczyk FZ, Baumgartner R, Baumgartner K, Sorensen B, Ballard-Barbash R, McTiernan A (Sep 2007) Associations between the CYP17, CYPIB1, COMT and SHBG polymorphisms and serum sex hormones in post-menopausal breast cancer survivors., Breast cancer research and treatment, 105 (1), 45-54 Abstract
  • Campbell KL, McTiernan A, Li SS, Sorensen BE, Yasui Y, Lampe JW, King IB, Ulrich CM, Rudolph RE, Irwin ML, Surawicz C, Ayub K, Potter JD, Lampe PD (Sep 2007) Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 16 (9), 1767-74 Abstract
  • Curtin K, Slattery ML, Ulrich CM, Bigler J, Levin TR, Wolff RK, Albertsen H, Potter JD, Samowitz WS (Aug 2007) Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet., Carcinogenesis, 28 (8), 1672-9 Abstract
  • Ulrich CM (Aug 2007) Folate and cancer prevention: a closer look at a complex picture., The American journal of clinical nutrition, 86 (2), 271-3 Abstract
  • Rhew I, Yasui Y, Sorensen B, Ulrich CM, Neuhouser ML, Tworoger SS, Chubak J, Bowen DJ, McTiernan A (Jul 2007) Effects of an exercise intervention on other health behaviors in overweight/obese post-menopausal women., Contemporary clinical trials, 28 (4), 472-81 Abstract
  • Ulrich CM, Potter JD (Jun 2007) Folate and cancer--timing is everything., JAMA : the journal of the American Medical Association, 297 (21), 2408-9 Abstract
  • Poole EM, Bigler J, Whitton J, Sibert JG, Kulmacz RJ, Potter JD, Ulrich CM (Jun 2007) Genetic variability in prostaglandin synthesis, fish intake and risk of colorectal polyps., Carcinogenesis, 28 (6), 1259-63 Abstract
  • Curtin K, Ulrich CM, Samowitz WS, Bigler J, Caan B, Potter JD, Slattery ML (May 2007) Thymidylate synthase polymorphisms and colon cancer: associations with tumor stage, tumor characteristics and survival., International journal of cancer. Journal international du cancer, 120 (10), 2226-32 Abstract
  • Tworoger SS, Sorensen B, Chubak J, Irwin M, Stanczyk FZ, Ulrich CM, Potter J, McTiernan A (May 2007) Effect of a 12-month randomized clinical trial of exercise on serum prolactin concentrations in postmenopausal women., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 16 (5), 895-9 Abstract
  • Bigler J, Sibert JG, Poole EM, Carlson CS, Potter JD, Ulrich CM (Mar 2007) Polymorphisms predicted to alter function in prostaglandin E2 synthase and prostaglandin E2 receptors., Pharmacogenetics and genomics, 17 (3), 221-7 Abstract
  • Grady WM, Ulrich CM (Mar 2007) DNA alkylation and DNA methylation: cooperating mechanisms driving the formation of colorectal adenomas and adenocarcinomas?, Gut, 56 (3), 318-20 Abstract
  • Littman AJ, Vitiello MV, Foster-Schubert K, Ulrich CM, Tworoger SS, Potter JD, Weigle DS, McTiernan A (Mar 2007) Sleep, ghrelin, leptin and changes in body weight during a 1-year moderate-intensity physical activity intervention., International journal of obesity (2005), 31 (3), 466-75 Abstract
  • Weiss JM, Weiss NS, Ulrich CM, Doherty JA, Chen C (Dec 2006) Nucleotide excision repair genotype and the incidence of endometrial cancer: effect of other risk factors on the association., Gynecologic oncology, 103 (3), 891-6 Abstract
  • Chubak J, McTiernan A, Sorensen B, Wener MH, Yasui Y, Velasquez M, Wood B, Rajan KB, Wetmore CM, Potter JD, Ulrich CM (Nov 2006) Moderate-intensity exercise reduces the incidence of colds among postmenopausal women., The American journal of medicine, 119 (11), 937-42 Abstract
  • Ambrosone CB, Rebbeck TR, Morgan GJ, Albain KS, Calle EE, Evans WE, Hayes DF, Kushi LH, McLeod HL, Rowland JH, Ulrich CM (Nov 2006) New developments in the epidemiology of cancer prognosis: traditional and molecular predictors of treatment response and survival., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 15 (11), 2042-6 Abstract
  • Reed MC, Nijhout HF, Neuhouser ML, Gregory JF, Shane B, James SJ, Boynton A, Ulrich CM (Oct 2006) A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism., The Journal of nutrition, 136 (10), 2653-61 Abstract
  • Robien K, Bigler J, Yasui Y, Potter JD, Martin P, Storb R, Ulrich CM (Sep 2006) Methylenetetrahydrofolate reductase and thymidylate synthase genotypes and risk of acute graft-versus-host disease following hematopoietic cell transplantation for chronic myelogenous leukemia., Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 12 (9), 973-80 Abstract
  • Chang JL, Chen G, Lampe JW, Ulrich CM (Aug 2006) DNA damage and repair measurements from cryopreserved lymphocytes without cell culture--a reproducible assay for intervention studies., Environmental and molecular mutagenesis, 47 (7), 503-8 Abstract
  • Chubak J, Ulrich CM, Tworoger SS, Sorensen B, Yasui Y, Irwin ML, Stanczyk FZ, Potter JD, McTiernan A (Jul 2006) Effect of exercise on bone mineral density and lean mass in postmenopausal women., Medicine and science in sports and exercise, 38 (7), 1236-44 Abstract
  • Potter JD, Ulrich CM (Jun 2006) COX-2 and gastric cancer: More on inflammation and neoplasia., Gastroenterology, 130 (7), 2198-200 Abstract
  • Yu JH, Bigler J, Whitton J, Potter JD, Ulrich CM (Jun 2006) Mismatch repair polymorphisms and colorectal polyps: hMLH1-93G>A variant modifies risk associated with smoking., The American journal of gastroenterology, 101 (6), 1313-9 Abstract
  • Ulrich CM, Nijhout HF, Reed MC (May 2006) Mathematical modeling: epidemiology meets systems biology., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 15 (5), 827-9 Abstract
  • Ulrich CM, Bigler J, Potter JD (Apr 2006) Genetic tools to tailor cancer prevention by NSAIDs., Discovery medicine, 6 (32), 71-4 Abstract
  • Robien K, Schubert MM, Chay T, Bigler J, Storb R, Yasui Y, Potter JD, Ulrich CM (Apr 2006) Methylenetetrahydrofolate reductase and thymidylate synthase genotypes modify oral mucositis severity following hematopoietic stem cell transplantation., Bone marrow transplantation, 37 (8), 799-800 Abstract
  • Robien K, Schubert MM, Yasui Y, Martin P, Storb R, Potter JD, Ulrich CM (Apr 2006) Folic acid supplementation during methotrexate immunosuppression is not associated with early toxicity, risk of acute graft-versus-host disease or relapse following hematopoietic transplantation., Bone marrow transplantation, 37 (7), 687-92 Abstract
  • Poole EM, Bigler J, Whitton J, Sibert JG, Potter JD, Ulrich CM (Mar 2006) Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 15 (3), 502-8 Abstract
  • Mohanka M, Irwin M, Heckbert SR, Yasui Y, Sorensen B, Chubak J, Tworoger SS, Ulrich CM, McTiernan A (Feb 2006) Serum lipoproteins in overweight/obese postmenopausal women: a one-year exercise trial., Medicine and science in sports and exercise, 38 (2), 231-9 Abstract
  • Ulrich CM, Potter JD (Feb 2006) Folate supplementation: too much of a good thing?, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 15 (2), 189-93 Abstract
  • Ulrich CM, Bigler J, Potter JD (Feb 2006) Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics., Nature reviews. Cancer, 6 (2), 130-40 Abstract
  • Bowen DJ, Fesinmeyer MD, Yasui Y, Tworoger S, Ulrich CM, Irwin ML, Rudolph RE, LaCroix KL, Schwartz RR, McTiernan A (2006) Randomized trial of exercise in sedentary middle aged women: effects on quality of life., The international journal of behavioral nutrition and physical activity, 3, 34 Abstract
  • Nijhout HF, Reed MC, Lam SL, Shane B, Gregory JF, Ulrich CM (2006) In silico experimentation with a model of hepatic mitochondrial folate metabolism., Theoretical biology & medical modelling, 3, 40 Abstract
  • Troen AM, Mitchell B, Sorensen B, Wener MH, Johnston A, Wood B, Selhub J, McTiernan A, Yasui Y, Oral E, Potter JD, Ulrich CM (Jan 2006) Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women., The Journal of nutrition, 136 (1), 189-94 Abstract
  • Weiss JM, Weiss NS, Ulrich CM, Doherty JA, Voigt LF, Chen C (Nov 2005) Interindividual variation in nucleotide excision repair genes and risk of endometrial cancer., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 14 (11 Pt 1), 2524-30 Abstract
  • Bigler J, Ulrich CM, Kawashima T, Whitton J, Potter JD (Nov 2005) DNA repair polymorphisms and risk of colorectal adenomatous or hyperplastic polyps., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 14 (11 Pt 1), 2501-8 Abstract
  • Ulrich CM, Curtin K, Potter JD, Bigler J, Caan B, Slattery ML (Nov 2005) Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 14 (11 Pt 1), 2509-16 Abstract
  • Ulrich CM (Nov 2005) Nutrigenetics in cancer research--folate metabolism and colorectal cancer., The Journal of nutrition, 135 (11), 2698-702 Abstract
  • Bigler J, Ulrich CM, Kawashima T, Whitton J, Potter JD (2005) Nucleotide excision repair and risk of colorectal adenomatous or hyperplastic polyps, Cancer Epidemiology, Biomarkers, and Prevention, 14 (11), 2501-8
  • Meyers JA, McTiernan A, Ulrich CM (2005) Leptin and immune function - integrating the evidence, Nutrition Research, 25, 791-803
  • Robien K, Boynton A, Ulrich CM (Oct 2005) Pharmacogenetics of folate-related drug targets in cancer treatment., Pharmacogenomics, 6 (7), 673-89 Abstract
  • Ulrich CM, Curtin K, Samowitz W, Bigler J, Potter JD, Caan B, Slattery ML (Oct 2005) MTHFR variants reduce the risk of G:C->A:T transition mutations within the p53 tumor suppressor gene in colon tumors., The Journal of nutrition, 135 (10), 2462-7 Abstract
  • Ulrich CM, Carlson CS, Sibert J, Poole EM, Yu JH, Wang LH, Sparks R, Potter JD, Bigler J (Oct 2005) Thromboxane synthase (TBXAS1) polymorphisms in African-American and Caucasian populations: evidence for selective pressure?, Human Mutation, 26 (4), 394-5 Abstract
  • Chubak J, Tworoger SS, Yasui Y, Ulrich CM, Stanczyk FZ, McTiernan A (2005) Associations between reproductive and menstrual factors and postmenopausal androgen concentrations., Journal of Women's Health, 14 (8), 704-12 Abstract
  • Tien JH, Hazelton WD, Sparks R, Ulrich CM (Jul 2005) A Michaelis-Menten-style model for the autocatalytic enzyme prostaglandin H synthase., Bulletin of Mathematical Biology, 67 (4), 683-700 Abstract
  • Aiello EJ, Tworoger SS, Yasui Y, Stanczyk FZ, Potter J, Ulrich CM, Irwin M, McTiernan A (Jun 2005) Associations among circulating sex hormones, insulin-like growth factor, lipids, and mammographic density in postmenopausal women., Cancer Epidemiology, Biomarkers & Prevention, 14 (6), 1411-7 Abstract
  • Robien K, Curtin K, Ulrich CM, Bigler J, Samowitz W, Caan B, Potter JD, Slattery ML (May 2005) Microsomal epoxide hydrolase polymorphisms are not associated with colon cancer risk., Cancer Epidemiology, Biomarkers & Prevention, 14 (5), 1350-2 Abstract
  • McTiernan A, Sorensen B, Yasui Y, Tworoger SS, Ulrich CM, Irwin ML, Rudolph RE, Stanczyk FZ, Schwartz RS, Potter JD (Apr 2005) No effect of exercise on insulin-like growth factor 1 and insulin-like growth factor binding protein 3 in postmenopausal women: a 12-month randomized clinical trial., Cancer Epidemiology, Biomarkers & Prevention, 14 (4), 1020-1 Abstract
  • Frank LL, Sorensen BE, Yasui Y, Tworoger SS, Schwartz RS, Ulrich CM, Irwin ML, Rudolph RE, Rajan KB, Stanczyk F, Bowen D, Weigle DS, Potter JD, McTiernan A (Mar 2005) Effects of exercise on metabolic risk variables in overweight postmenopausal women: a randomized clinical trial., Obesity Research, 13 (3), 615-25 Abstract
  • Ulrich CM, Whitton J, Yu JH, Sibert J, Sparks R, Potter JD, Bigler J (Mar 2005) PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs., Cancer Epidemiology, Biomarkers & Prevention, 14 (3), 616-9 Abstract
  • Weiss JM, Goode EL, Ladiges WC, Ulrich CM (Mar 2005) Polymorphic variation in hOGG1 and risk of cancer: a review of the functional and epidemiologic literature, Molecular Carcinogenesis, 42 (3), 127-41 Abstract
  • Irwin ML, Tworoger SS, Yasui Y, Rajan B, McVarish L, LaCroix K, Ulrich CM, Bowen D, Schwartz RS, Potter JD, McTiernan A (Dec 2004) Influence of demographic, physiologic, and psychosocial variables on adherence to a yearlong moderate-intensity exercise trial in postmenopausal women., Preventive medicine, 39 (6), 1080-6 Abstract
  • Nijhout HF, Reed MC, Budu P, Ulrich CM (Dec 2004) A mathematical model of the folate cycle: New insights into folate homeostasis., The Journal of Biological Chemistry, 279 (53), 55008-16 Abstract
  • Robien K, Ulrich CM, Bigler J, Yasui Y, Gooley T, Bruemmer B, Potter JD, Radich JP (Nov 2004) Methylenetetrahydrofolate reductase genotype affects risk of relapse after hematopoietic cell transplantation for chronic myelogenous leukemia, Clinical Cancer Research, 10 (22), 7592-8 Abstract
  • Sparks R, Bigler J, Sibert JG, Potter JD, Yasui Y, Ulrich CM (Oct 2004) TGFbeta1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps., International Journal of Epidemiology, 33 (5), 955-61 Abstract
  • Chubak J, Tworoger SS, Yasui Y, Ulrich CM, Stanczyk FZ, McTiernan A (Aug 2004) Associations between reproductive and menstrual factors and postmenopausal sex hormone concentrations, Cancer Epidemiology, Biomarkers & Prevention, 13 (8), 1296-301 Abstract
  • Hazelton WD, Tien JH, Donato VW, Sparks R, Ulrich CM (August 2004) Prostaglandin H synthases: members of a class of quasi-linear threshold switches, Biochemical Pharmacology, 68 (3), 423-32 Abstract
  • Aiello EJ, Yasui Y, Tworoger SS, Ulrich CM, Irwin ML, Bowen D, Schwartz RS, Kumai C, Potter JD, McTiernan A (Jul-A 2004) Effect of a yearlong, moderate-intensity exercise intervention on the occurrence and severity of menopause symptoms in postmenopausal women, Menopause (new York, N.y.), 11 (4), 382-8 Abstract
  • McTiernan A, Tworoger SS, Rajan KB, Yasui Y, Sorenson B, Ulrich CM, Chubak J, Stanczyk FZ, Bowen D, Irwin ML, Rudolph RE, Potter JD, Schwartz RS (Jul 2004) Effect of exercise on serum androgens in postmenopausal women: a 12-month randomized clinical trial., Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology., 13 (7), 1099-105 Abstract
  • Tworoger SS, Chubak J, Aiello EJ, Yasui Y, Ulrich CM, Farin FM, Stapleton PL, Irwin ML, Potter JD, Schwartz RS, McTiernan A (Jun 2004) The effect of CYP19 and COMT polymorphisms on exercise-induced fat loss in postmenopausal women, Obesity Research, 12 (6), 972-81 Abstract
  • Shade ED, Ulrich CM, Wener MH, Wood B, Yasui Y, Lacroix K, Potter JD, McTiernan A (2004) Frequent intentional weight loss is associated with lower natural killer cell cytotoxicity in postmenopausal women: possible long-term immune effects, Journal of the American Dietetic Association, 104 (6), 903-12 Abstract
  • Ulrich CM, Bigler J, Sparks R, Whitton J, Sibert JG, Goode EL, Yasui Y, Potter JD (May 2004) Polymorphisms in PTGS1 (=COX-1) and risk of colorectal polyps, Cancer Epidemiology, Biomarkers & Prevention, 13 (5), 889-93 Abstract
  • Atkinson C, Lampe JW, Tworoger SS, Ulrich CM, Bowen D, Irwin ML, Schwartz RS, Rajan BK, Yasui Y, Potter JD, McTiernan A (May 2004) Effects of a moderate intensity exercise intervention on estrogen metabolism in postmenopausal women, Cancer Epidemiology, Biomarkers & Prevention, 13 (5), 868-74 Abstract
  • Robien K, Schubert MM, Bruemmer B, Lloid ME, Potter JD, Ulrich CM (Apr 2004) Predictors of oral mucositis in patients receiving hematopoietic cell transplants for chronic myelogenous leukemia, Journal of Clinical Oncology, 22 (7), 1268-75 Abstract
  • McTiernan A, Tworoger SS, Ulrich CM, Yasui Y, Irwin ML, Rajan KB, Sorensen B, Rudolph RE, Bowen D, Stanczyk FZ, Potter JD, Schwartz RS (2004) Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial, Cancer Research, 64 (8), 2923-8 Abstract
  • Curtin K, Bigler J, Slattery ML, Caan B, Potter JD, Ulrich CM (Feb 2004) MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer, Cancer Epidemiology, Biomarkers & Prevention, 13 (2), 285-92 Abstract
  • Sparks R, Ulrich CM, Bigler J, Tworoger SS, Yasui Y, Rajan KB, Porter P, Stanczyk FZ, Ballard-Barbash R, Yuan X, Lin MG, McVarish L, Aiello EJ, McTiernan A (2004) UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients, Breast Cancer Research : Bcr, 6 (5), R488-98 Abstract
  • Goode EL, Potter JD, Bigler J, Ulrich CM (Jan 2004) Methionine synthase D919G polymorphism, folate metabolism, and colorectal adenoma risk, Cancer Epidemiology, Biomarkers & Prevention, 13 (1), 157-62 Abstract
  • Tworoger SS, Chubak J, Aiello EJ, Ulrich CM, Atkinson C, Potter JD, Yasui Y, Stapleton PL, Lampe JW, Farin FM, Stanczyk FZ, McTiernan A (Jan 2004) Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women, Cancer Epidemiology, Biomarkers & Prevention, 13 (1), 94-101 Abstract
  • Reed MC, Nijhout HF, Sparks R, Ulrich CM (2004) A mathematical model of the methionine cycle, Journal of Theoretical Biology, 226 (1), 33-43 Abstract
  • Ulrich CM, Robien K, McLeod HL (Dec 2003) Cancer pharmacogenetics: polymorphisms, pathways and beyond, Nature Reviews. Cancer, 3 (12), 912-20 Abstract
  • Tworoger SS, Yasui Y, Vitiello MV, Schwartz RS, Ulrich CM, Aiello EJ, Irwin ML, Bowen D, Potter JD, McTiernan A (Nov 2003) Effects of a yearlong moderate-intensity exercise and a stretching intervention on sleep quality in postmenopausal women., Sleep, 26 (7), 830-6 Abstract
  • Grembowski D, Ulrich CM, Paschane D, Diehr P, Katon W, Martin D, Patrick DL, Velicer C (Sep-O 2003) Managed care and primary physician satisfaction, The Journal of the American Board of Family Practice / American Board of Family Practice., 16 (5), 383-93 Abstract
  • Mitchell BL, Ulrich CM, McTiernan A (August 2003) Supplementation with vitamins or minerals and immune function: can the elderly benefit? (review), Nutrition Research, 23 (8), 1117-1139
  • Chang CK, Ulrich CM (May 2003) Hyperinsulinaemia and hyperglycaemia: possible risk factors of colorectal cancer among diabetic patients., Diabetologia, 46 (5), 595-607 Abstract
  • Robien K, Ulrich CM (April 2003) 5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview, American Journal of Epidemiology, 157 (7), 571-82 Abstract
  • Irwin ML, Yasui Y, Ulrich CM, Bowen D, Rudolph RE, Schwartz RS, Yukawa M, Aiello E, Potter JD, McTiernan A (January 2003) Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial, Jama : the Journal of the American Medical Association, 289 (3), 323-30 Abstract
  • Goode EL, Ulrich CM, Potter JD (Dec 2002) Polymorphisms in DNA repair genes and associations with cancer risk., Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology., 11 (12), 1513-30 Abstract
  • Ulrich CM, Bigler J, Sibert J, Greene EA, Sparks R, Carlson CS, Potter JD (November 2002) Cyclooxygenase 1 (COX1) polymorphisms in African-American and Caucasian populations, Human Mutation, 20 (5), 409-10 Abstract
  • Morimoto LM, Newcomb PA, Ulrich CM, Bostick RM, Lais CJ, Potter JD (Oct 2002) Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential?, Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology., 11 (10 Pt 1), 1012-8 Abstract
  • Ulrich CM, Bigler J, Bostick R, Fosdick L, Potter JD (June 2002) Thymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas, Cancer Research, 62 (12), 3361-4 Abstract
  • Ulrich CM, Robien K, Sparks R (May 2002) Pharmacogenetics and folate metabolism -- a promising direction, Pharmacogenomics, 3 (3), 299-313 Abstract
  • Ulrich CM, Potter JD (April 2002) Thymidylate synthase polymorphism and survival of colorectal cancer patients treated with 5-fluorouracil, British Journal of Cancer, 86 (8), 1365; discussion 136 Abstract
  • Ulrich CM, Potter JD (2002) Diet, genes, and cancer risk, German Senate Commission on Food Safety (SKLM) Proceedings 2002
  • Tworoger SS, Yasui Y, Ulrich CM, Nakamura H, LaCroix K, Johnston R, McTiernan A (Jan 2002) Mailing strategies and recruitment into an intervention trial of the exercise effect on breast cancer biomarkers., Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology., 11 (1), 73-7 Abstract
  • Ulrich CM, Potter JD (October 2001) Testing for colon neoplasia susceptibility variants at the human Cox2 locus, Journal of the National Cancer Institute, 93 (20), 1572-4 Abstract
  • Kim HS, Newcomb PA, Ulrich CM, Keener CL, Bigler J, Farin FM, Bostick RM, Potter JD (August 2001) Vitamin D receptor polymorphism and the risk of colorectal adenomas: evidence of interaction with dietary vitamin D and calcium, Cancer Epidemiology, Biomarkers and Prevention, 10 (8), 869-74 Abstract
  • Ulrich CM, Bigler J, Whitton JA, Bostick R, Fosdick L, Potter JD (August 2001) Epoxide hydrolase Tyr113His polymorphism is associated with elevated risk of colorectal polyps in the presence of smoking and high meat intake, Cancer Epidemiology, Biomarkers and Prevention, 10 (8), 875-82 Abstract
  • Ulrich CM, Yasui Y, Storb R, Schubert MM, Wagner JL, Bigler J, Ariail KS, Keener CL, Li S, Liu H, Farin FM, Potter JD (2001) Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism, Blood, 98 (1), 231-4 Abstract
  • Ulrich CM, Bigler J, Velicer CM, Greene EA, Farin FM, Potter JD (Dec 2000) Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene., Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology., 9 (12), 1381-5 Abstract
  • Grembowski DE, Diehr P, Novak LC, Roussel AE, Martin DP, Patrick DL, Williams B, Ulrich CM (August 2000) Measuring the 'managedness' and covered benefits of health plans, Health Services Research, 35 (3), 707-34 Abstract
  • Ulrich CM, Kampman E, Bigler J, Schwartz SM, Chen C, Bostick R, Fosdick L, Beresford SA, Yasui Y, Potter JD (Apr 2000) Lack of association between the C677T MTHFR polymorphism and colorectal hyperplastic polyps., Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology., 9 (4), 427-33 Abstract
  • McTiernan A, Ulrich CM, Yancey D, Slate S, Nakamura H, Oestreicher N, Bowen D, Yasui Y, Potter J, Schwartz R (September 1999) The Physical Activity for Total Health (PATH) Study: rationale and design, Medicine and Science in Sports and Exercise, 31 (9), 1307-12 Abstract
  • Ulrich CM, Kampman E, Bigler J, Schwartz SM, Chen C, Bostick R, Fosdick L, Beresford SA, Yasui Y, Potter JD (Aug 1999) Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction?, Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology., 8 (8), 659-68 Abstract
  • Ulrich CM, Georgiou CC, Gillis DE, Snow CM (April 1999) Lifetime physical activity is associated with bone mineral density in premenopausal women, Journal of Womens Health, 8 (3), 365-75 Abstract
  • McTiernan A, Ulrich C, Slate S, Potter J (October 1998) Physical activity and cancer etiology: associations and mechanisms, Cancer Causes and Control, 9 (5), 487-509 Abstract
  • McTiernan A, Ulrich C, Kumai C, Bean D, Schwartz R, Mahloch J, Hastings R, Gralow J, Potter JD (Jun 1998) Anthropometric and hormone effects of an eight-week exercise-diet intervention in breast cancer patients: results of a pilot study., Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology., 7 (6), 477-81 Abstract
  • Roettger-Liepmann B, Ulrich C, Laaser U (1998) Telefonische Befragung zu genetischen Tests fur Brust- und Prostatakrebsrisiko, Fortschritte der Medizin, 116 (suppl 3), 95-99
  • Roettger-Liepmann B, Ulrich C, Laaser U (1998) Akzeptanz genetischer Tests in der Bevolkerung, Fortschritte der Medizin, 116 (27), 43
  • Ulrich CM, Kristal AR, White E, Hunt JR, Durfy SJ, Potter JD (1998) Genetic testing for cancer risk: a population survey on attitudes and intention., Community Genetics, 1 (4), 213-22 Abstract
  • Ulrich CM, Georgiou CC, Snow-Harter CM, Gillis DE (January 1996) Bone mineral density in mother-daughter pairs: relations to lifetime exercise, lifetime milk consumption, and calcium supplements, American Journal of Clinical Nutrition, 63 (1), 72-9 Abstract
  • Ulrich CM (1994) WHO - An internship experience, Zeitschrift fur Gesundheitswissenschaften (German Journal of Public Health), 3, 275-282
  • Nijhout HF, Reed MC, Anderson DF, Mattingly JC, James SJ, Ulrich CM, Long-range allosteric interactions between the folate and methionine cycles stabilize DNA methylation reaction rate., Epigenetics : official journal of the DNA Methylation Society, 1 (2), 81-7 Abstract

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Last Updated: 11/17/2009

COS Expertise ID #830272
Reference this profile directly: http://myprofile.cos.com/nulrich