Dr. Pablo C. Okhuysen

(Reading, Writing, Speaking)

National Institutes of Health: A Randomized, Open Label, Phase III, International Study of Subcutaneous Recombinant Interleukin-2 (Proleukin) in Patients with HIV-1 Infection and CD4+ cell counts >300/mm3:Evaluation of Subcutaneous Proleukin in a Randomized International Trial (ESPRIT), Sept. 2000 to Oct. 2005.
Food and Drug Administration: Establish a Correlative Dose Response for human cryptosporidiosis, Subcontract, Sep 1, 1998 to Aug 31, 2002.
National Institutes of Health (NIH): Intestinal Cytokines in Human Cryptosporidiosis, Subcontract, Sep 1, 1997 to Aug 31, 2005.
Environmental Protection Agency: Infectivity and Virulence of Cryptosporidium genotype 1/H oocysts in Healthy Adults, March 2000 to Feb. 2003.
National Institutes of Health - NIAID: Evaluation of Control Measures Against Diseases Other Than AIDS: Part C - Enteric Challenges Studies, Jun 1, 2002 to May 31, 2007.
Environmental Protection Agency: Infectivity and virulence of Cryptosporidium non-parvum species in health adult volunteers, Jan. 2002 to Dec. 2004.
National Institutes of Health (NIH): Evaluation of Control Measures Against Diseases Other Than AIDS: Part C - Enteric Challenges Studies, $1,408,381, 2002 to 2007.
National Institutes of Health (NIH): Intestinal Cytokines in Human Cryptosporidiosis, $302,692, 1997 to 2006.

• Alcantara CA, Steiner T, Barret L, Guerrant RL, Yang CH, Lima A, Chappell CL, Okhuysen PC, White AC, IL-8,TNF -a and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosproidiosis, American Journal of Tropical Medicine and Hygiene, 68(3), 325-328, 2003
• Jiang Z-D, Okhuysen PC, Guo D-C, He R, King TM, DuPont HL, Milewicz DM, Genetic Susceptibility to Enteroaggregative Escherichia coli Diarrhea-Polymorphism in intereleukin-8 Promoter Region, JID, 188(15 August), 506-511, 2003
• Padda R, Tsai A, Chappell CL, Okhuysen PC, Molecular cloning and analysis of the Cryptosporidium parvum aminopeptidase N gene, Int J Parasitol, 187-197, 2002
• Okhuysen PC, Rich SM, Chappell CL, Grimes KA, Widmer G, Feng X, Tzipori S, Infectivity of a Cryptosporidium parvum Isolate of Cervine Origin for Heatlhy Adults and Gamma Interferon-y Knock out Mice, J. Infect. Dis., 1320-1325, 2002
• Teunis PF, Chappell CL, Okhuysen PC, Cryptosporidium Dose-Response Studies: Variation Between Hosts, Risk Analysis, 475-485, 2002
• Teunis PF, Chappell CL, Okhuysen PC, Cryptosporidium Dose-Response Studies: Variation Between Isolates, Risk Analysis, 175-183, 2002
• Nannini EC, Okhuysen PC, HIV1 and the Gut in the Era of Highly Active Antiretroviral Therapy, Curr. Gastroenteral Rep., 392-398, 2002
• Millership JJ, Chappell CL, Okhuysen PC, Snowden KF, Characterization of aminopeptidase activity from three species of microsporidia: Encephalitozoon cuniculi, Encephalitozoon hellem, and Vittaforma corneae, Journal of Parasitology, 843-848, 2002
• Robinson P, Okhuysen PC, Chappell CL, Lewis DE, Shahab I, Janecki A, White AC, Jr., Expression of Tumor Necrosis Factor Alpha and Interleukin1 {beta} in Jejuna of Volunteers after Experimental Challenge with Cryptosporidium parvum Correlates with Exposure but Not with Symptoms, Infection and Immunity, 69, 1172-1174, 2001
• Robinson P, Okhuysen PC, Chappell CL, Lewis DE, Shahab I, Lahoti S, White AC, Jr., Expression of IL-15 and IL-4 in IFn-gamma-Independent Control of Experimental Human Cryptosporidium parvum Infection, Cytokine, 15, 39-46, 2001
• Okhuysen PC, Robinson P, Nguyen MT, Ninnini EC, Lewis DE, Janecki A, Chappell CL, White AC, Jr., Jejunal Cytokine Response in AIDS Patients with Chronic Crytosporidiosis and During Immune Reconstitution, AIDS, 15, 802-804, 2001
• Messner MJ, Chappell CL, Okhuysen PC., Risk Assessment for Cryptosporidium: A Hierarchical Bayesian Analysis of Human Dose Response Data, Water Research, 35, 3934-3940, 2001
• Millership JJ, Didier ES, Okhuysen PC, Maddry JA, Kwong CD, Chen X, Snowden, KF, In Vitro and in vivo Evaluation of aminopeptidase inhibitors as antimicrosporidial therapies, Journal of Eukaryotic Microbiology, 95S-98S, 2001
• Dasgupta A, Okhuysen PC, Pharmacokinetic and other drug interactions in patients with AIDS, Ther Drug Monit, 591-605, 2001
• White AC, Robinson P, Okhuysen PC, Lewis DE, Shahab I, Lahoti S, DuPont HL, Chappell CL, Interferon-gamma Expression in Jejunal Biopsies in Experimental Human Cryptosporidiosis Correlates with Prior Sensitization and Control of Oocyst Excretion, Journal of Infectious Diseases, 181, 701-709, 2000
• Robinson P, Okhuysen PC, Chappell CL, Lewis DE, Shahab I, Lahoti S, White Jr. AC, TGF-Beta 1 is Expressed in the Jejunum After Experiments Human Cryptosporidium, Infection and Immunity, 68, 5405-5407, 2000
• Dann MS, Okhuysen PC, DuPont HL, Chappell CL., Fecal Antibody Response to Cryptosporidium Parvum in Healthy Volunteers, Infection and Immunity, 68, 5068-5074, 2000
• Chappell CL, Okhuysen PC, Sterling CR, Wang C. Jakubowski W, DuPont HL., Infectivity of Cryptosporidium parvum in Healthy Adults with Pre-Existing Anti-C. parvum IgG, American Journal of Tropical Medicine and Hygiene, 60, 157-64, 1999
• Okhuysen PC, Chappell CL, Crabb JH, Sterling CR, DuPont HL, Virulence of Three Distinct Cryptosporidium parvum Isolates for Healthy Adults, Journal of Infectious Diseases, 180, 1275-1281, 1999
• Moss DM, Chappell CL, Okhuysen PC, DuPont HL, Arrowood MJ, Hightower AW, Lammie PJ, The antibody response to 27-, 17-, and 15-kDa Cryptosporidium antigens following experimental infection in humans, Journal of Infectious Diseases, 178(3), 827-33, September 1998
• Okhuysen PC, Chappell CL, Crabb J, Valdez LM, Douglass ET, DuPont HL, Prophylactic effect of bovine anti-Cryptosporidium hyperimmune colostrum immunoglobulin in healthy volunteers challenged with Cryptosporidium parvum, Clinical Infectious Diseases, 26(6), 1324-9, June 1998
• Okhuysen PC, Chappell CL, Sterling CR, Jakubowski W, DuPont HL, Susceptibility and serologic response of healthy adults to reinfection with Cryptosporidium parvum, Infection and Immunity, 66(2), 441-3, February 1998
• Okhuysen PC, Chappell CL, Sterling CR, Jakubowski W, DuPont HL, Susceptibility and serologic response of healthy adults to reinfection with Cryptosporidium parvum., Infection and Immunity, 66(2), 441-3, 1998
• Valdez LM, Dang H, Okhuysen PC, Chappell CL, Flow cytometric detection of Cryptosporidium oocysts in human stool samples, Journal of Clinical Microbiology, 35(8), 2013-7, August 1997
• Valdez LM, Schwab P, Okhuysen PC, Rakita RM, Paradoxical subcutaneous tuberculous abscess, Clinical Infectious Diseases, 24(4), 734, April 1997
• Okhuysen PC, Chappell CL, Kettner C, Sterling CR, Cryptosporidium parvum metalloaminopeptidase inhibitors prevent in vitro excystation, Antimicrobial Agents and Chemotherapy, 40(12), 2781-4, December 1996
• Chappell CL, Okhuysen PC, Sterling CR, DuPont HL, Cryptosporidium parvum: intensity of infection and oocyst excretion patterns in healthy volunteers, Journal of Infectious Diseases, 173(1), 232-6, January 1996
• Okhuysen PC, DuPont HL, Ericsson CD, Marani S, Martinez-Sandoval FG, Olesen MA, Ravelli GP, Zaldaride maleate (a new calmodulin antagonist) versus loperamide in the treatment of traveler's diarrhea: randomized, placebo-controlled trial, Clinical Infectious Diseases, 21(2), 341-4, August 1995
• Okhuysen PC, Jiang X, Ye L, Johnson PC, Estes MK, Viral shedding and fecal IgA response after Norwalk virus infection, Journal of Infectious Diseases, 171(3), 566-9, March 1995
• DuPont HL, Chappell CL, Sterling CR, Okhuysen PC, Rose JB, Jakubowski W, The infectivity of Cryptosporidium parvum in healthy volunteers, New England Journal of Medicine, 332(13), 855-9, March 1995
• Okhuysen PC, DuPont HL, Sterling CR, Chappell CL, Arginine aminopeptidase, an integral membrane protein of the Cryptosporidium parvum sporozoite, Infection and Immunity, 62(10), 4667-70, October 1994
• Okhuysen PC, Rex JH, Kapusta M, Fife C, Successful treatment of extensive posttraumatic soft-tissue and renal infections due to Apophysomyces elegans, Clinical Infectious Diseases, 19(2), 329-31, August 1994
• Okhuysen PC, Singh KV, Murray BE, Susceptibility of beta-lactamase-producing enterococci to piperacillin with tazobactam, Diagnostic Microbiology and Infectious Disease, 17(3), 219-24, October 1993
• Okhuysen PC, Crane JK, Pappas J, St. Louis encephalitis in patients with human immunodeficiency virus infection [letter], Clinical Infectious Diseases, 17(1), 140-1, July 1993
• Okhuysen PC, Ericsson CD, Travelers' diarrhea. Prevention and treatment, Medical Clinics of North America, 76(6), 1357-73, November 1992
• Okhuysen PC, DuPont HL, Flores Lopez JF, Perez Castell J, Mathewson JJ, A comparative study of furazolidone and placebo in addition to oral rehydration in the treatment of acute infantile diarrhea, Scandinavian Journal of Gastroenterology. Supplement, 169, 39-46, 1989