Dr. Lawrence Karl Olson

(Reading, Writing, Speaking)

Juvenile Diabetes Foundation International: Regulation of beta cell line growth and differentiation by expression of cyclin-dependent kinase inhibitors, $90,000, May 1, 1998 to Apr 31, 2000.
American Diabetes Association: Glucose toxicity and insulin gene expression, $50,000, Jan 1, 1997 to Dec 31, 2000.

• Tai, MH (2007) Cigarette smoke components inhibit intercellular communication and differentiation in human pancreatic ductal epithelial cells., International Journal of Cancer, 120 (9), 1855-1862
• Wang, Y (2006) Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity., Journal of Lipid Research, 47 (9), 2028-2041
• Jayaprakasam B, Olson LK, Schutzki RE, Tai MH, Nair MG (2006) Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic Acid in cornelian cherry (cornus MAS)., J Agric Food Chem, 54 (1), 243-248
• Ye, DZ, Tai, M-H, Linning, KD, Szabo, C, Olson, LK (2006) MafA expression and insulin promoter activity are induced by nicotinamide and related compounds in INS-1 pancreatic b cells, Diabetes, 55 (3), 742-750
• Jayaprakasam, B, Vareed, SK, Olson, LK, Nair, M (2005) Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits, Journal of Agriculture and Food Chemistry, 53, 28-31
• Tai, M-H, Chang, CC, Olson, LK, Trosko, JE (2005) Oct4 expression in adult human stem cells: Evidence in support of the stem cell theory of carcinogenesis., Carcinogenesis, 26, 495-520
• Pino, MF, Ye, D, Linning, KD, Green, C, Wicksteed, B, Poitout, V, Olson, LK (2005) Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic ß cells via reduced nuclear factor binding to the A5/core and Z element, Molecular Endocrinology, 19, 1343-1360
• Francis, JA, Jayaprakasam, B, Olson, LK, Nair, MG (2004) Insulin secretagogues from Moringa oleifera with cyclooxygenase enzyme and lipid peroxidation inhibitory activities, Helvetica Acta Chimica, 87, 317-326
• Zhang, Y, Jayaprakasam, Seeram, NP, Olson, LK, DeWitt, D, Nair, MG (2004) Insulin secretion and cyclooxygenase enzyme inhibition by Cabernet Sauvignon grape skin compounds., Journal of Agriculture and Food Chemistry, 52, 228-233
• Linning, KD, Tai, M-H, Madhukar, BV, Chang, CC, Reed, DN, Ferber, S, Trosko, JE, Olson, LK (2004) Redox-mediated enrichment of self-renewing adult human pancreatic cells that possess endocrine differentiation potential, Pancreas, 29, e64-e76
• Tai, M-H, Olson, LK, Madhukar, BV, Linning, KD, Van Camp, L, Tsao, M-S, Trosko (2003) Characterization of gap junctional intercellular communication in immortalized human pancreatic ductal epithelial cells with stem cell characteristics, Pancreas, 26, e18-e26
• Luo, M, Hess, MC, Fink, GD, Olson, LK, Rogers, J, Kreulen, DL, Dai, X, Galligan, JJ (2003) Differential alterations in sympathetic neurotransmission in mesenteric arteries and veins in DOCA-salt hypertensive rats, Autonomic Neuroscience: Basic and Clinical, 104, 47-57
• Luckie, DB, Wiltering, JH, Maleszewski, JJ, Hobbs, EC, Olson, LK (2002) Extracellular acidification parallels insulin secretion in INS-1 and HIT-T15 ß-cell lines, Biochemical and Biophysical Research Communications, 293, 1168-1173
• Busik, JV, Olson, LK, Grant, MB, Henry, DN (2002) Glucose-induced activation of glucose uptake in cells from the inner and outer blood retinal barrier, Invest. Ophthalamol. Vis. Sci, 43, 2356-2363
• Wells, WW, Xu, DP, Washburn, MP, Cirrito, H, Olson, LK (2001) Polyhydroxy benzoates inhibit ascorbic acid activation of mitochondrial glycerol-3-phosphate dehydrogenase: Implications for glucose metabolism and insulin secretion, J. Biol. Chem, 276, 2404-2410
• Deeg, MA, Bowen, RF, Williams, MD, Olson, LK, Kirk, EA, LeBoeuf, RC (2001) Increased expression of GPI-specific phospholipase D in mouse models of Type 1 diabetes, Am. J. of Physiol. Endocrinol. Metab, 281, E147-E154
• Bowen, RF, Raikwar, NK, Olson, LK, Deeg, MA (2001) Glucose and insulin regulate glycosylphosphatidylinositol-specific phospholipase D expression in islet ß cells, Metabolism, 50 (12), 1489-1492
• Ryu, J-R, Olson, LK, Arnosti, DN (2001) Cell-type specificity of chimeric transcriptional repressors in the Tet regulatory system, Proc. Natl. Acad. Sci. U.S.A., 98 (23), 12960-12965
• Newburg-Kaytor, E, Qian, J, Towle, HC, Olson, LK (2000) An indirect role for upstream stimulatory factor in glucose-mediated induction of pyruvate kinase and S14 gene expression, Molecular and Cellular Biochemistry, 210, 13-21
• Dillon, PF, Root-Bernstein, RS, Sears, PR, Olson, LK (2000) Natural electrophoresis of norepinephrine and ascorbic acid, Biophysical Journal, 79, 370-376
• Qian, J, Newburg-Kaytor, E, Towle, HC, Olson, LK (1999) Functional regulation of Pdx-1 gene expression by upstream stimulatory factor, USF, Biochemical J., 341 (2), 315-322
• Harmon JS, Tanaka Y, Olson LK, Robertson RP, Reconstitution of glucotoxic HIT-T15 cells with somatostatin transcription factor-1 partially restores insulin promoter activity, Diabetes, 47(6), 900-4, June 1998
• Olson LK, Qian J, Poitout V, Glucose rapidly and reversibly decreases INS-1 cell insulin gene transcription via decrements in STF-1 and C1 activator transcription factor activity, Molecular Endocrinology, 12(2), 207-19, February 1998
• LeBoeuf, RC, Caldwell, M, Guo, Y, Metz, C, Davitz, Olson, LK, Deeg, MA, Mouse glycosylphosphatidylinositol-specific phospholipase D (Gpld1) characterization, Mammalian Genome, 9, 710-714, 1998
• Moran A, Zhang HJ, Olson LK, Harmon JS, Poitout V, Robertson RP, Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15, Journal of Clinical Investigation, 99(3), 534-9, February 1997
• Redmon JB, Olson LK, Armstrong MB, Greene MJ, Robertson RP, Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells, Journal of Clinical Investigation, 98(12), 2786-93, December 1996
• Olson LK, Schroeder W, Robertson RP, Goldberg ND, Walseth TF, Suppression of adenylate kinase catalyzed phosphotransfer precedes and is associated with glucose-induced insulin secretion in intact HIT-T15 cells, Journal of Biological Chemistry, 271(28), 16544-52, July 1996
• Poitout V, Olson LK, Robertson RP, Insulin-secreting cell lines: classification, characteristics and potential applications, Diabetes and Metabolism, 22(1), 7-14, February 1996
• Poitout V, Olson LK, Robertson RP, Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator, Journal of Clinical Investigation, 97(4), 1041-6, February 1996
• Kendall DM, Poitout V, Olson LK, Sorenson RL, Robertson RP, Somatostatin coordinately regulates glucagon gene expression and exocytosis in HIT-T15 cells, Journal of Clinical Investigation, 96(5), 2496-502, November 1995
• Sharma A, Olson LK, Robertson RP, Stein R, The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression, Molecular Endocrinology, 9(9), 1127-34, September 1995
• Robertson RP, Olson LK, Zhang HJ, Differentiating glucose toxicity from glucose desensitization: a new message from the insulin gene, Diabetes, 43(9), 1085-9, September 1994
• Olson LK, Redmon JB, Towle HC, Robertson RP, Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein [see comments], Journal of Clinical Investigation, 92(1), 514-9, July 1993
• Walseth TF, Zhang HJ, Olson LK, Schroeder WA, Robertson RP, Increase in Gs and cyclic AMP generation in HIT cells. Evidence that the 45-kDa alpha-subunit of Gs has greater functional activity than the 52-kDa alpha-subunit, Journal of Biological Chemistry, 264(35), 21106-11, December 1989