Dr. Julie Overbaugh

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Fred Hutchinson Cancer Research Center
Human Biology Division
MemberAppointed: 1999
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Professional Headshot of Julie Overbaugh

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N., C3-168
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-3524
joverbau@fhcrc.org

Qualifications

Ph.D., University of Colorado, 1983.
Postdoctoral Fellow, Harvard University, Cancer Biology.

Expertise and Research Interests

Dr. Overbaugh's laboratory has a long-standing interest in understanding the mechanisms of HIV transmission and pathogenesis. A major hypothesis for the studies in her lab is that the variants of HIV-1 that are transmitted are a selected subset of all the viruses that evolve during the course of infection. Thus, a goal of Dr. Overbaugh's research is to determine whether some variants are more transmissible and others are more pathogenic in the host. Her lab has shown that the emergence and replication of particular variants of the virus is central to AIDS pathogenesis. Her research group has also shown that the late stage pathogenic variants have evolved to escape neutralizing antibodies, and they have found that these virus variants are protected by newly acquired sugars that limit access of antibodies. Ongoing studies include defining the patterns of genetic variation during retroviral infection and determining how particular changes in the virus influence replication, immunogenicity and disease outcome. One aspect of this research is defining the interactions of the viral envelope protein and proteins of the host cell, including the viral receptors and coreceptors. Other studies are focused on analyses of how genetic variation alters the efficacy of neutralizing antibodies in controlling virus replication.

Much of the HIV research in the lab is focused on populations in Africa because this is where the AIDS epidemic is most severe. The Overbaugh lab is analyzing HIV variants early in infection in Kenyan cohorts at high risk for HIV infection, including women and infants. These early HIV strains represent critical targets for vaccine design, and provide important insights into how HIV is transmitted. The laboratory is part of a larger team, comprising researchers in both Seattle and Kenya (The Nairobi HIV/STD Project), that is studying the molecular epidemiology of HIV transmission. The project is also examining the efficacy of various intervention strategies to limit the spread of HIV, particularly those that may be practical to implement in Africa and other parts of the developing world.

Other Expertise

Dr. Overbaugh has served as Chair of the NIH study section on HIV Molecular Biology (1998-2000), and as a member of various NIH review panels. She has served as a member of the NIH Office of AIDS Research Advisory Council and as an Editor for the Journal of Virology.

Keywords

COS Keywords:

AIDS, Cancer Biology, Cancer Or Carcinogenesis, Cell Proliferation, Epidemiology, Gene Expression, Genes, HIV, Lymphocytes, Microbiology, Pathobiology.

Additional Terms:

AIDS, Disease Manifestation, Epidemiology, Gene Expression, Genes, HIV/SIV Infection, Microbiology, Regulation, Viral Disease, Viruses.

Honors and Awards

1999, NIH MERIT Award Early Infection in Women Exposed Mucosally to HIV-1
1999-2004, Elizabeth Glaser Scientist, Pediatric AIDS Foundation
1993-1998, Scholar, Leukemia Society of America

Previous Positions

1994-1998, Associate Professor, University of Washington, School of Medicine, Microbiology

Publications

  • Lehman DA, Chung MH, John-Stewart GC, Richardson BA, Kiarie J, Kinuthia J, Overbaugh J (Jul 2008) HIV-1 persists in breast milk cells despite antiretroviral treatment to prevent mother-to-child transmission., AIDS (London, England), 22 (12), 1475-85 Abstract
  • Benki S, Mostad SB, Richardson BA, Mandaliya K, Kreiss JK, Overbaugh J (Apr 2008) Increased levels of HIV-1-infected cells in endocervical secretions after the luteinizing hormone surge., J Acquir Immune Defic Syndr, 47 (5), 529-34 Abstract
  • Blish CA, Nguyen MA, Overbaugh J (Jan 2008) Enhancing exposure of HIV-1 neutralization epitopes through mutations in gp41., PLoS Medicine, 5 (1), e9 Abstract
  • Eastman D, Piantadosi A, Wu X, Forthal DN, Landucci G, Kimata JT, Overbaugh J (2008) Heavily glycosylated, highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent cellular responses but delayed neutralizing antibody responses., Virology J, 5 (1), 90 Abstract
  • Chung MH, Kiarie JN, Richardson BA, Lehman DA, Overbaugh J, Njiri F, John-Stewart GC (Dec 2007) Independent effects of nevirapine prophylaxis and HIV-1 RNA suppression in breast milk on early perinatal HIV-1 transmission., Journal of Acquired Immune Deficiency Syndromes, 46 (4), 472-8 Abstract
  • Piantadosi A, Chohan B, Chohan V, McClelland RS, Overbaugh J (Nov 2007) Chronic HIV-1 infection frequently fails to protect against superinfection., PLoS Pathogens, 3 (11), e177 Abstract
  • Blish CA, Blay WM, Haigwood NL, Overbaugh J (Nov 2007) Transmission of HIV-1 in the face of neutralizing antibodies., Current HIV Research, 5 (6), 578-87 Abstract
  • Voronin Y, Chohan B, Emerman M, Overbaugh J (Oct 2007) Primary isolates of human immunodeficiency virus type 1 are usually dominated by the major variants found in blood., J Virol, 81 (19), 10232-41 Abstract
  • Pineda MJ, Orton BR, Overbaugh J (Jul 2007) A TRIM5alpha-independent post-entry restriction to HIV-1 infection of macaque cells that is dependent on the path of entry., Virology, 363 (2), 310-8 Abstract
  • Baeten JM, Chohan B, Lavreys L, Chohan V, McClelland RS, Certain L, Mandaliya K, Jaoko W, Overbaugh J (Apr 2007) HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads., J Infect Dis, 195 (8), 1177-80 Abstract
  • Rainwater SM, Wu X, Nduati R, Nedellec R, Mosier D, John-Stewart G, Mbori-Ngacha D, Overbaugh J (Mar 2007) Cloning and characterization of functional subtype A HIV-1 envelope variants transmitted through breastfeeding., Current HIV Research, 5 (2), 189-97 Abstract
  • Otieno PA, Brown ER, Mbori-Ngacha DA, Nduati RW, Farquhar C, Obimbo EM, Bosire RK, Emery S, Overbaugh J, Richardson BA, John-Stewart GC (Jan 2007) HIV-1 disease progression in breast-feeding and formula-feeding mothers: A prospective 2-year comparison of T cell subsets, HIV-1 RNA levels, and mortality., J Infect Dis, 195 (2), 220-9 Abstract
  • Benki S, McClelland RS, Emery S, Baeten JM, Richardson BA, Lavreys L, Mandaliya K, Overbaugh J (Dec 2006) Quantification of genital human immunodeficiency virus type 1 (HIV-1) DNA in specimens from women with low plasma HIV-1 RNA levels typical of HIV-1 nontransmitters., J Clin Microbiol, 44 (12), 4357-62 Abstract
  • Sagar M, Wu X, Lee S, Overbaugh J (Oct 2006) Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity, J Virol, 80 (19), 9586-98 Abstract
  • Wu X, Parast AB, Richardson BA, Nduati R, John-Stewart G, Mbori-Ngacha D, Rainwater SMJ, Overbaugh J (2006) Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant., J Virol, 80 (2), 835-844
  • Cheng HH, Anderson MM, Hankenson FC, Johnston L, Kotwaliwale C, Overbaugh J (2006) Envelope determinants for dual-receptor specificity in feline leukemia virus subgroup A and T variants., J Virol, 80 (4), 1619-1628
  • Lavreys L, Baeten JM, Chohan V, McClelland RS, Hassan WM, Richardson BA, Mandaliya K, Ndinya-Achola JO, Overbaugh J (2006) Higher set point plasma viral load and more-severe acute HIV type 1 (HIV-1) illness predict mortality among high-risk HIV-1-infected African women., Clin Infect Dis, 42, 1333-1339
  • McClelland RS, Baeten JM, Richardson BA, Lavreys L, Emery S, Mandaliya K, Ndinya-Achola JO, Overbaugh J (2006) A comparison of genital HIV-1 shedding and sexual risk behavior among Kenyan women based on eligibility for initiation of HAART according to WHO guidelines., J Acquir Immune Defic Syndr, 41, 611-615
  • Sagar M, Kirkegaard E, Lavreys L, Overbaugh J (2006) Diversity in HIV-1 envelope V1-V3 sequences early in infection reflects sequence diversity throughout the HIV-1 genome but does not predict the extent of sequence diversity during chronic infection, AIDS Research and Human Retroviruses, 22, 430-437
  • Drain PK, Baeten JM, Overbaugh J, Wener MH, Bankson DD, Lavreys L, Mandaliya K, Ndinya-Achola JO, McClelland RS (2006) Effects of low serum albumin and the acute phase response on serum selenium in HIV-1 infected women, BMC Infectious Dis, 6, 85
  • Mendoza R, Anderson MM, Overbaugh J (2006) A putative thiamine transport protein is a receptor for feline leukemia virus subgroup A., J Virol, 80 (7), 3378-3385
  • Farquhar C, Mbori-Ngacha DA, Redman MW, Bosire RK, Lohman BL, Piantadosi AL, Goodman RB, Ruzinski JT, Emery SR, Crudder CH, Overbaugh JM, John-Stewart GC (Oct 2005) CC and CXC chemokines in breastmilk are associated with mother-to-child HIV-1 transmission., Current HIV Research, 3 (4), 361-369 Abstract
  • Chung MH, Kiarie JN, Richardson BA, Lehman DA, Overbaugh J, John-Stewart GC (Sep 2005) Breast milk HIV-1 suppression and decreased transmission: A randomized trial comparing HIVNET 012 nevirapine versus short-course zidovudine., AIDS (London, England), 19 (13), 1415-1422 Abstract
  • John-Stewart GC, Nduati RW, Rousseau CM, Mbori-Ngacha DA, Richardson BA, Rainwater S, Panteleeff DD, Overbaugh J (Aug 2005) Subtype C is associated with increased vaginal shedding of HIV-1., The Journal of Infectious Diseases, 192 (3), 492-496 Abstract
  • Chohan B, Lavreys L, Rainwater SM, Overbaugh J (Aug 2005) Evidence for frequent reinfection with human immunodeficiency virus type 1 of a different subtype., J Virol, 79 (16), 10701-10708 Abstract
  • Lohman BL, Slyker JA, Richardson BA, Farquhar C, Mabuka JM, Crudder C, Dong T, Obimbo E, Mbori-Ngacha D, Overbaugh J, Rowland-Jones S, John-Stewart G (Jul 2005) Longitudinal assessment of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon responses during the first year of life in HIV-1-infected infants., Journal of Virology, 79 (13), 8121-8130 Abstract
  • Quinn TC, Overbaugh J (Jun 2005) HIV/AIDS in women: An expanding epidemic., Science, 308 (5728), 1582-1583 Abstract
  • Chohan B, Lang D, Sagar M, Korber B, Lavreys L, Richardson B, Overbaugh J (May 2005) Selection for human immunodeficiency virus type 1 (HIV-1) envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levels., Journal of Virology, 79 (10), 6528-6531 Abstract
  • Baeten JM, Lavreys L, Sagar M, Kreiss JK, Richardson BA, Chohan B, Panteleeff D, Mandaliya K, Ndinya-Achola JO, Overbaugh J, Farley T, Mwachari C, Cohen C, Chipato T, Jaisamrarn U, Kiriwat O, Duerr A (Mar 2005) Effect of contraceptive methods on natural history of HIV: Studies from the Mombasa cohort., Journal of Acquired Immune Deficiency Syndromes (1999), 38 Suppl 1, S18-21 Abstract
  • Martin HL Jr, Richardson BA, Mandaliya K, Achola JO, Overbaugh J, Kreiss JK (Mar 2005) The early work on hormonal contraceptive use and HIV acquisition., Journal of Acquired Immune Deficiency Syndromes (1999), 38 Suppl 1, S12-4 Abstract
  • McClelland RS, Lavreys L, Katingima C, Overbaugh J, Chohan V, Mandaliya K, Ndinya-Achola J, Baeten JM (Feb 2005) Contribution of HIV-1 infection to acquisition of sexually transmitted disease: A 10-year prospective study., The Journal of Infectious Diseases, 191 (3), 333-338 Abstract
  • Veronin Y, Overbaugh J, Emerman M (2005) SIV variants that differ in pathogenicity differ in fitness under rapid cell-turnover conditions., J Virol, 79 (24), 15091-15098
  • Rainwater SJ, DeVange S, Sagar M, Mandaliya K, Ndinya-Achola JO, Overbaugh J (2005) No evidence for rapid subtype C spread within an epidemic in which multiple subtypes and intersubtype recombinants circulate., AIDS Research and Human Retroviruses, 21, 1060-1065
  • Benki S, McClelland RS, Overbaugh J (2005) Risk factors for human immunodeficiency virus type-1 acquisition in women in Africa., Journal of Neurovirology, 11 Suppl 1, 58-65 Abstract
  • Richardson BA, Overbaugh J (Jan 2005) Basic statistical considerations in virological experiments., Journal of Virology, 79 (2), 669-676 Abstract
  • Rousseau CM, Nduati RW, Richardson BA, John-Stewart GC, Mbori-Ngacha DA, Kreiss JK, Overbaugh J (Nov 2004) Association of levels of HIV-1-infected breast milk cells and risk of mother-to-child transmission., The Journal of Infectious Diseases, 190 (10), 1880-1888 Abstract
  • Sagar M, Kirkegaard E, Long EM, Celum C, Buchbinder S, Daar ES, Overbaugh J, Human immunodeficiency virus type 1 (HIV-1) diversity at time of infection is not restricted to certain risk groups or specific HIV-1 subtypes, Journal of Virology, 78(13), 7279-83, Jul 2004 Abstract
  • Sagar M, Kirkegaard E, Long EM, Celum C, Buchbinder S, Daar ES, Overbaugh J (Jul 2004) Human immunodeficiency virus type 1 (HIV-1) diversity at time of infection is not restricted to certain risk groups or specific HIV-1 subtypes., Journal of Virology, 78 (13), 7279-7283 Abstract
  • Benki S, Mostad SB, Richardson BA, Mandaliya K, Kreiss JK, Overbaugh J, Cyclic shedding of HIV-1 RNA in cervical secretions during the menstrual cycle, The Journal of Infectious Diseases, 189(12), 2192-201, Jun 2004 Abstract
  • Obimbo EM, Mbori-Ngacha DA, Ochieng JO, Richardson BA, Otieno PA, Bosire R, Farquhar C, Overbaugh J, John-Stewart GC, Predictors of early mortality in a cohort of human immunodeficiency virus type 1-infected african children, The Pediatric Infectious Disease Journal, 23(6), 536-43, Jun 2004 Abstract
  • Benki S, Mostad SB, Richardson BA, Mandaliya K, Kreiss JK, Overbaugh J (Jun 2004) Cyclic shedding of HIV-1 RNA in cervical secretions during the menstrual cycle., The Journal of Infectious Diseases, 189 (12), 2192-2201 Abstract
  • Baeten JM, McClelland RS, Corey L, Overbaugh J, Lavreys L, Richardson BA, Wald A, Mandaliya K, Bwayo JJ, Kreiss JK, Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trial, The Journal of Infectious Diseases, 189(8), 1466-71, Apr 2004 Abstract
  • Baeten JM, McClelland RS, Corey L, Overbaugh J, Lavreys L, Richardson BA, Wald A, Mandaliya K, Bwayo JJ, Kreiss JK (Apr 2004) Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: A randomized clinical trial., The Journal of Infectious Diseases, 189 (8), 1466-1471 Abstract
  • Lavreys L, Baeten JM, Martin HL Jr, Overbaugh J, Mandaliya K, Ndinya-Achola J, Kreiss JK, Hormonal contraception and risk of HIV-1 acquisition: results of a 10-year prospective study, AIDS (London, England), 18(4), 695-7, Mar 2004 Abstract
  • Sagar M, Lavreys L, Baeten JM, Richardson BA, Mandaliya K, Ndinya-Achola JO, Kreiss JK, Overbaugh J (Mar 2004) Identification of modifiable factors that affect the genetic diversity of the transmitted HIV-1 population., AIDS (London, England), 18 (4), 615-619 Abstract
  • Lavreys L, Baeten JM, Martin HL Jr, Overbaugh J, Mandaliya K, Ndinya-Achola J, Kreiss JK (Mar 2004) Hormonal contraception and risk of HIV-1 acquisition: Results of a 10-year prospective study., AIDS (London, England), 18 (4), 695-697 Abstract
  • Overbaugh J, HTLV-1 sweet-talks its way into cells, Nature Medicine, 10(1), 20-1, Jan 2004 Abstract
  • Lavreys L, Baeten JM, Kreiss JK, Richardson BA, Chohan BH, Hassan W, Panteleeff DD, Mandaliya K, Ndinya-Achola JO, Overbaugh J, Injectable contraceptive use and genital ulcer disease during the early phase of HIV-1 infection increase plasma virus load in women, The Journal of Infectious Diseases, 189(2), 303-11, Jan 2004 Abstract
  • Wang CC, McClelland RS, Overbaugh J, Reilly M, Panteleeff DD, Mandaliya K, Chohan B, Lavreys L, Ndinya-Achola J, Kreiss JK, The effect of hormonal contraception on genital tract shedding of HIV-1, Aids (london, England), 18(2), 205-9, Jan 2004 Abstract
  • Overbaugh J, HTLV-1 sweet-talks its way into cells., Nature Medicine, 10(1), 20-1, Jan 2004 Abstract
  • Overbaugh J (2004) HTLV-1 sweet-talks its way into cells., Nature Medicine, 10, 20-21
  • Lavreys L, Baeten JM, Kreiss JK, Richardson BA, Chohan BH, Hassan W, Panteleeff DD, Mandaliya K, Ndinya-Achola JO, Overbaugh J (Jan 2004) Injectable contraceptive use and genital ulcer disease during the early phase of HIV-1 infection increase plasma virus load in women., The Journal of Infectious Diseases, 189 (2), 303-311 Abstract
  • Wang CC, McClelland RS, Overbaugh J, Reilly M, Panteleeff DD, Mandaliya K, Chohan B, Lavreys L, Ndinya-Achola J, Kreiss JK (Jan 2004) The effect of hormonal contraception on genital tract shedding of HIV-1., AIDS (London, England), 18 (2), 205-209 Abstract
  • Sagar M, Lavreys L, Baeten JM, Richardson BA, Mandaliya K, Chohan BH, Kreiss JK, Overbaugh J, Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progression, Journal of Virology, 77(23), 12921-6, Dec 2003 Abstract
  • Sagar M, Lavreys L, Baeten JM, Richardson BA, Mandaliya K, Chohan BH, Kreiss JK, Overbaugh J (Dec 2003) Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progression., Journal of Virology, 77 (23), 12921-12926 Abstract
  • Forte S, Harmon ME, Pineda MJ, Overbaugh J, Early- and intermediate-stage variants of simian immunodeficiency virus replicate efficiently in cells lacking CCR5, Journal of Virology, 77(17), 9723-7, Sep 2003 Abstract
  • Mbori-Ngacha D, Richardson BA, Overbaugh J, Panteleeff DD, Nduati R, Steele M, John-Stewart G, Short-term effect of zidovudine on plasma and genital human immunodeficiency virus type 1 and viral turnover in these compartments, Journal of Virology, 77(13), 7702-5, Jul 2003 Abstract
  • Richardson BA, Mbori-Ngacha D, Lavreys L, John-Stewart GC, Nduati R, Panteleeff DD, Emery S, Kreiss JK, Overbaugh J, Comparison of human immunodeficiency virus type 1 viral loads in Kenyan women, men, and infants during primary and early infection, Journal of Virology, 77(12), 7120-3, Jun 2003 Abstract
  • Richardson BA, Mbori-Ngacha D, Lavreys L, John-Stewart GC, Nduati R, Panteleeff DD, Emery S, Kreiss JK, Overbaugh J (Jun 2003) Comparison of human immunodeficiency virus type 1 viral loads in Kenyan women, men, and infants during primary and early infection., Journal of Virology, 77 (12), 7120-7123 Abstract
  • Richardson BA, John-Stewart GC, Hughes JP, Nduati R, Mbori-Ngacha D, Overbaugh J, Kreiss JK, Breast-milk infectivity in human immunodeficiency virus type 1-infected mothers, The Journal of Infectious Diseases, 187(5), 736-40, Mar 2003 Abstract
  • Rousseau CM, Nduati RW, Richardson BA, Steele MS, John-Stewart GC, Mbori-Ngacha DA, Kreiss JK, Overbaugh J, Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease, The Journal of Infectious Diseases, 187(5), 741-7, Mar 2003 Abstract
  • McClelland RS, Wang CC, Overbaugh J, Richardson BA, Corey L, Ashley RL, Mandaliya K, Ndinya-Achola J, Bwayo JJ, Kreiss JK (Dec 2002) Association between cervical shedding of herpes simplex virus and HIV-1., AIDS (London, England), 16 (18), 2425-2430 Abstract
  • Long EM, Rainwater SM, Lavreys L, Mandaliya K, Overbaugh J (May 2002) HIV type 1 variants transmitted to women in Kenya require the CCR5 coreceptor for entry, regardless of the genetic complexity of the infecting virus., AIDS Research and Human Retroviruses, 18 (8), 567-576 Abstract
  • Baeten J, McClelland RS, Overbaugh J, Richardson BA, Emery S, Lavreys L, Mandaliya K, Bankson DD, Ndinya-Achola JO, Bwayo JJ, Kreiss JK, Vitamin A Supplementation and Human Immunodeficiency Virus Type 1 Shedding in Women: Results of a Randomized Clinical Trial, Journal of Infectious Diseases, 185, 1187-1191, 2002
  • Overbaugh J, Bangham CR (May 2001) Selection forces and constraints on retroviral sequence variation., Science, 292 (5519), 1106-1109 Abstract
  • John GC, Nduati RW, Mbori-Ngacha DA, Richardson BA, Panteleeff DD, Mwatha A, Overbaugh J, Bwayo JJ, Ndinya-Achola JO, Kreiss JK, Correlates of Mother-to-Child Transmission of HIV-1 in the Kenya Breastfeeding Clinical Trial, Journal of Infectious Diseases, 183, 206-212, 2001
  • Overbaugh J, Bangham CRM., Selection Forces and Constraints on Retroviral Sequence Variation, Science, 292, 1106-1109, 2001
  • Gwynn SR, Hankenson FC, Lauring AS, Rohn JL, Overbaugh J, Feline leukemia virus envelope sequences that affect T-cell tropism and syncytium formation are not part of known receptor-binding domains, Journal of Virology, 74(13), 5754-61, July 2000 Abstract
  • Emery S, Bodrug S, Richardson BA, Giachetti C, Bott MA, Panteleeff D, Jagodzinski LL, Michael NL, Nduati R, Bwayo J, Kreiss JK, Overbaugh J, Evaluation of performance of the Gen-Probe human immunodeficiency virus type 1 viral load assay using primary subtype A, C, and D isolates from Kenya, Journal of Clinical Microbiology, 38(7), 2688-95, July 2000 Abstract
  • John GC, Rousseau C, Dong T, Rowland-Jones S, Nduati R, Mbori-Ngacha D, Rostron T, Kreiss JK, Richardson BA, Overbaugh J, Maternal SDF1 3'A polymorphism is associated with increased perinatal human immunodeficiency virus type 1 transmission, Journal of Virology, 74(12), 5736-9, June 2000 Abstract
  • Jagodzinski LL, Wiggins DL, McManis JL, Emery S, Overbaugh J, Robb M, Bodrug S, Michael NL, Use of calibrated viral load standards for group M subtypes of human immunodeficiency virus type 1 to assess the performance of viral RNA quantitation tests, Journal of Clinical Microbiology, 38(3), 1247-9, March 2000 Abstract
  • Anderson MM, Lauring AS, Burns CC, Overbaugh J, Identification of a Cellular Cofactor Required for Infection by Feline Leukemia Virus, Science, 287(5459), 1828-1830, March 2000
  • Nduati R, John G, Mbori-Ngacha D, Richardson B, Overbaugh J, Mwatha A, Ndinya-Achola J, Bwayo J, Onyango FE, Hughes J, Kreiss J, Effect of breastfeeding and formula feeding on transmission of HIV-1: A randomized clinical trial, Jama, 283(9), 1167-1174, March 2000
  • Nduati R, John G, Mbori-Ngacha D, Richardson B, Overbaugh J, Mwatha A, Ndinya-Achola J, Bwayo J, Onyango FE, Hughes J, Kreiss J (Mar 2000) Effect of breastfeeding and formula feeding on transmission of HIV-1: a randomized clinical trial., JAMA: The Journal of the American Medical Association, 283 (9), 1167-1174 Abstract
  • Anderson MM, Lauring AS, Burns CC, Overbaugh J (Mar 2000) Identification of a cellular cofactor required for infection by feline leukemia virus., Science, 287 (5459), 1828-1830 Abstract
  • Quigley JG, Burns CC, Anderson MM, Lynch ED, Sabo KM, Overbaugh J, Abkowitz JL, Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia, Blood, 95(3), 1093-9, February 2000 Abstract
  • Long EM, Martin HL Jr, Kreiss JK, Rainwater SM, Lavreys L, Jackson DJ, Rakwar J, Mandaliya K, Overbaugh J., Gender differences in HIV-1 diversity at time of infection, Nature Medicine, 6, 71-75, 2000
  • Long EM, Martin HL Jr, Kreiss JK, Rainwater SM, Lavreys L, Jackson DJ, Rakwar J, Mandaliya K, Overbaugh J (Jan 2000) Gender differences in HIV-1 diversity at time of infection., Nature Medicine, 6 (1), 71-75 Abstract
  • Mostad SB, Kreiss JK, Ryncarz AJ, Overbaugh J, Mandaliya K, Chohan B, Ndinya-Achola J, Bwayo JJ, Corey L, Cervical shedding of cytomegalovirus in human immunodeficiency virus type 1-infected women, Journal of Medical Virology, 59(4), 469-73, December 1999 Abstract
  • Richardson BA, Morrison CS, Sekadde-Kigondu C, Sinei SK, Overbaugh J, Panteleeff DD, Weiner DH, Kreiss JK, Effect of intrauterine device use on cervical shedding of HIV-1 DNA, Aids, 13(15), 2091-7, October 1999 Abstract
  • Linenberger ML, Rohn JL, Deng T, Ellis-Smith S, Ingber R, Overbaugh J, Lymphokines modulate the growth and survival of thymic tumor cells containing a novel feline leukemia virus/Notch2 variant, Veterinary Immunology and Immunopathology, 70(3-4), 223-43, September 1999 Abstract
  • Poss M, Overbaugh J, Variants from the diverse virus population identified at seroconversion of a clade A human immunodeficiency virus type 1-infected woman have distinct biological properties, Journal of Virology, 73(7), 5255-64, July 1999 Abstract
  • Neilson JR, John GC, Carr JK, Lewis P, Kreiss JK, Jackson S, Nduati RW, Mbori-Ngacha D, Panteleeff DD, Bodrug S, Giachetti C, Bott MA, Richardson BA, Bwayo J, Ndinya-Achola J, Overbaugh J, Subtypes of human immunodeficiency virus type 1 and disease stage among women in Nairobi, Kenya, Journal of Virology, 73(5), 4393-403, May 1999 Abstract
  • Kimata JT, Kuller L, Anderson DB, Dailey P, Overbaugh J, Emerging cytopathic and antigenic simian immunodeficiency virus variants influence AIDS progression [see comments], Nature Medicine, 5(5), 535-41, May 1999 Abstract
  • Neilson JR, John GC, Carr JK, Lewis P, Kreiss JK, Jackson S, Nduati RW, Mbori-Ngacha D, Panteleeff DD, Bodrug S, Giachetti C, Bott MA, Richardson BA, Bwayo J, Ndinya-Achola J, Overbaugh J (May 1999) Subtypes of human immunodeficiency virus type 1 and disease stage among women in Nairobi, Kenya., Journal of Virology, 73 (5), 4393-4403 Abstract
  • Kimata JT, Kuller L, Anderson DB, Dailey P, Overbaugh J (May 1999) Emerging cytopathic and antigenic simian immunodeficiency virus variants influence AIDS progression., Nature Medicine, 5 (5), 535-541 Abstract
  • Kimata JT, Gosink JJ, KewalRamani VN, Rudensey LM, Littman DR, Overbaugh J, Coreceptor specificity of temporal variants of simian immunodeficiency virus Mne, Journal of Virology, 73(2), 1655-60, February 1999 Abstract
  • Panteleeff DD, John G, Nduati R, Mbori-Ngacha D, Richardson B, Kreiss J, Overbaugh J, Rapid method for screening dried blood samples on filter paper for human immunodeficiency virus type 1 DNA, Journal of Clinical Microbiology, 37(2), 350-3, February 1999 Abstract
  • Polacino P, Stallard V, Klaniecki JE, Montefiori DC, Langlois AJ, Richardson BA, Overbaugh J, Morton WR, Benveniste RE, Hu SL, Limited breadth of the protective immunity elicited by simian immunodeficiency virus SIVmne gp160 vaccines in a combination immunization regimen, Journal of Virology, 73(1), 618-30, Jan 1999 Abstract
  • Overbaugh J, et al., Studies of HIV-1 Mucosal Shedding and Transmission in Kenya, Journal of Infectious Diseases, 179, s410-404, 1999
  • Rohn JL, Overbaugh J., Pathogenic Feline Retroviruses: Feline Leukemia Virus and Feline Immunodeficiency Virus, In: Persistent Viral Infections (Eds: R. Ahmed and I.S.Y. Chen, Wiley & Sons), 1999
  • Poss M, Rodrigo AG, Gosink JJ, Learn GH, de Vange Panteleeff D, Martin HL Jr, Bwayo J, Kreiss JK, Overbaugh J, Evolution of envelope sequences from the genital tract and peripheral blood of women infected with clade A human immunodeficiency virus type 1, Journal of Virology, 72(10), 8240-51, October 1998 Abstract
  • Mertz KJ, Weiss JB, Webb RM, Levine WC, Lewis JS, Orle KA, Totten PA, Overbaugh J, Morse SA, Currier MM, Fishbein M, St. Louis ME, An investigation of genital ulcers in Jackson, Mississippi, with use of a multiplex polymerase chain reaction assay: high prevalence of chancroid and human immunodeficiency virus infection, Journal of Infectious Diseases, 178(4), 1060-6, October 1998 Abstract
  • Mostad SB, Jackson S, Overbaugh J, Reilly M, Chohan B, Mandaliya K, Nyange P, Ndinya-Achola J, Bwayo JJ, Kreiss JK, Cervical and vaginal shedding of human immunodeficiency virus type 1-infected cells throughout the menstrual cycle, Journal of Infectious Diseases, 178(4), 983-91, October 1998 Abstract
  • Hajjar AM, Lewis PF, Endeshaw Y, Ndinya-Achola J, Kreiss JK, Overbaugh J, Efficient isolation of human immunodeficiency virus type 1 RNA from cervical swabs, Journal of Clinical Microbiology, 36(8), 2349-52, August 1998 Abstract
  • Rohn JL, Moser MS, Gwynn SR, Baldwin DN, Overbaugh J, In vivo evolution of a novel, syncytium-inducing and cytopathic feline leukemia virus variant, Journal of Virology, 72(4), 2686-96, April 1998 Abstract
  • Moser M, Burns CC, Boomer S, Overbaugh J, The host range and interference properties of two closely related feline leukemia variants suggest that they use distinct receptors, Virology, 242(2), 366-77, March 1998 Abstract
  • Kimata JT, Mozaffarian A, Overbaugh J, A lymph node-derived cytopathic simian immunodeficiency virus Mne variant replicates in nonstimulated peripheral blood mononuclear cells, Journal of Virology, 72(1), 245-56, Jan 1998 Abstract
  • Lewis P, Nduati R, Kreiss JK, John GC, Richardson BA, Mbori-Ngacha D, Ndinya-Achola J, Overbaugh J, Cell-free human immunodeficiency virus type 1 in breast milk, Journal of Infectious Diseases, 177(1), 34-9, Jan 1998 Abstract
  • Rudensey LM, Kimata JT, Long EM, Chackerian B, Overbaugh J, Changes in the Extracellular Envelope Glycoprotein of Variants that Evolve during the Course of SIVMne Infection Affect Neutralizing Antibody Recognition, Syncytia Formation and Macrophage Tropism, bu, Journal of Virology, 72, 209-217, 1998
  • Chackerian B, Rudensey LM, Overbaugh J (Oct 1997) Specific N-linked and O-linked glycosylation modifications in the envelope V1 domain of simian immunodeficiency virus variants that evolve in the host alter recognition by neutralizing antibodies., Journal of Virology, 71 (10), 7719-7727 Abstract
  • Poss M, Martin HL, Kreiss JK, Granville L, Chohan B, Nyange P, Mandaliya K, Overbaugh J (Dec 1995) Diversity in virus populations from genital secretions and peripheral blood from women recently infected with human immunodeficiency virus type 1., Journal of Virology, 69 (12), 8118-8122 Abstract
  • Cairns J, Overbaugh J, Miller S (Sep 1988) The origin of mutants., Nature, 335 (6186), 142-145 Abstract
  • Overbaugh J, Riedel N, Hoover EA, Mullins JI (Apr 1988) Transduction of endogenous envelope genes by feline leukaemia virus in vitro., Nature, 332 (6166), 731-734 Abstract
  • Overbaugh J, Donahue PR, Quackenbush SL, Hoover EA, Mullins JI (Feb 1988) Molecular cloning of a feline leukemia virus that induces fatal immunodeficiency disease in cats., Science, 239 (4842), 906-910 Abstract

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Last Updated: 9/18/2008

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