Dr. Francisco G. La Rosa |
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University of Colorado Health Sciences Center School of Medicine Pathology and Immunology Prostate Diagnostic Laboratory Assistant ProfessorAppointed: 1987 TelePathology Consultants, PC PresidentAppointed: 1996 Pathology Consultants, PC Medical DirectorAppointed: 1996 |  |
Mailing AddressUniversity of Colorado, DHSC at Fitzsimons Prostate Cancer Research Laboratories Campus Mail Stop 8104 P.O. Box 6511 Aurora, Colorado 80045-0508United States | Contact InformationPhone: (303) 724-3782 Fax: (413) 410-4489 Mobile: (303) 549-4450 Francisco.LaRosa@UCHSC.edu http://www.telepathology.com |
Qualifications
Fellow in Lung Cancer Patholog, University of Colorado Health Sciences Center, 1996.
University of Colorado Health Sciences Center, Anatomic and Clinical Pathologist, 1995.
Universidad Nacional Mayor de San Marcos, Clinical Pathologist, 1979.
Medical Doctor, Facultad de Medicina 'Hipólito Unánue', Universidad Nacional Federico Villarreal, 1975.
Expertise and Research Interests
I am a very versatile physician, fully bilingual (English-Spanish), Board-Certified in Anatomic Pathology and Clinical Pathology, with more than 25 years of clinical, research and teaching experience in Surgical Pathology, Cytopathology and Immunology.
EARLY BACKGROUND
I received my MD degree in 1975 at the Facultad de Medicina 'Hipólito Unanue' at the Universidad Nacional 'Federico Villarreal' in Lima, Peru. After this, I did a 3-year residency in Clinical Pathology (1977-79) at the Facultad de Medicina 'San Fernando' at the Universidad Mayor de San Marcos in Lima, Peru. Between 1975 and 1981, I created and operated two of my own pathology laboratories in Lima, Peru. I also practiced general medicine, and held the position of Assistant Professor in Microbiology and Immunology at the School of Medicine in Peru. Between 1979 and 1981, I served as a medical consultant for Ortho Pharmaceutical of Peru, traveling across the country and giving seminars and workshops on the diagnosis of hepatitis B. In 1981, Ortho invited me to visit their headquarters in Raritan, New Jersey, an experience that motivated me to further develop my medical career here in the United States. Between 1981 and 1992, I earned a fellowship followed by an appointment towork at the University of Colorado HSC, reaching the rank of Assistant Professor. Between 1992 and 1995 I did a second residency in pathology followed by a 1-year fellowship in lung cancer pathology.
IMMUNOLOGY
In the field of Immunology, I started my teaching activities when I was still a medical student in 1973. I re-organized and gave the first lectures for the Immunology chapters to medical, dental and medical technology students at my alma mater in Lima. In addition to teaching, I did some research in parasitic infections and autoimmunity. After I arrived to Denver in 1981, I did a 5-year fellowship in Immunology at the University of Colorado, HSC under the direction of Dr. David W. Talmage (candidate for the Nobel Prize in Medicine togetherwith Dr. Burnet for his work in the clonal selection theory). With him and later with Dr. Kevin Lafferty, I developed a very exciting line of research in transplantation immunology and Immunobiology of Type I Diabetes. During the next 12 years, I received several research awards plus a RO1-NIH grant for the study of the mechanism of rejection and tolerance of cultured allografts. In 1991, I worked as a medical consultant for a private company in Colorado in the research and development of ELISA testsfor the detection of antinuclear antibodies and IgA anti-cardiolipin antibodies; kits for both of these tests are now commercially available.
CYTOPATHOLOGY
In the field of cytopathology, I started my training in 1978 with Dr. Javier Arias-Stella (who famously described the Arias-Stella reaction in endometrium). With him I did my last year of pathology residency in Lima, which included intensive training in cervical cytology and GYN pathology in Lima's largest woman’s hospital. When I resumed my pathology training in the USA in 1992, I put special emphasis in cytopathology (GYN and non-GYN), having the opportunity to publish a paper describing the first case of breast lymph node pathology diagnosed by FNA in an HIV-1 positive patient. After my residency training, I did a 1-year fellowship in lung cancer pathology under the supervision of Dr. Wilbur A. Franklin, UCHSC through an NCI-SPORE award, with special emphasis on sputum cytology and molecular pathology. This training helped me to further develop my expertise in the field of cytopathology. When I took the Board exams in AP/CP Pathology (which I only had to take once) my highest score was achieved in cytopathology. Between 1996 and 2001 I have accumulated more than 70 hours of CME Category 1 and A1 credits by the College of American Pathologists, through the Inter-laboratory Comparison Program in Gynecological and Non-Gynecologic Cytopathology, achieving more than 98% accuracy in my diagnoses.
GENERAL PATHOLOGY
In 1992, after too many years of working with mice, I decided to carry on with my original vocation in the practice of medicine; I had to do, for a second time, a pathology residency in order to become eligible for board certification in the USA. Based on my previous experience in the field, the American Board of Pathology granted me two years of credit and I finished my residency in June 1995. In my last year, while working with Dr. Daniel Ambruso at the Belle Bonfils Memorial Blood Center, I received a grant from that institution for a study on platelet transfusions in cancer patients. During my residency, I managed to write a handful of articles on some original pathology cases. Nevertheless, returning to human pathology did not disrupt my focus in the field of basic research. After Dr. Talmage's retirement in 1991, I continued working part time at the Department of Immunology UCHSC and collaborating with Professor Dr. Kedar Prasad in the area of transplantation of neural cell lines. Our current research is focused on the development of neural cell lines for eventual transplantation procedures in humans and for the treatment of Parkinson's disease. My work in this group is specifically oriented to the immunological typification of neuronal cells through different markers. Here, I am able to combine my unique blend of expertise in immunology and cytology (see below) for the study of these cells. During my 20 years of research, I have published 40 papers in referee journals, most of them in the area of transplantation immunology, I have written a review article in transplantation immunology and have 6 book chapters in immunology and transplantation.
As a general pathologist, I have performed more than two hundred bone marrow biopsies and fine needle aspirations from different body sites. I also have performed more than one hundred autopsy procedures, many of them forensic cases. In addition to my expertise in cytopathology and immunopathology, I have special skills in prostate pathology, microbiology, parasitology, molecular pathology, coagulation, and blood banking. I am very familiar with laboratory techniques in cellular and humoral immunology, including immunohistochemistry, ELISA, flow cytometry, cell and tissue culture, electrophoresis of proteins, production of monoclonal antibodies, and DNA analysis, including polymerase chain reaction (PCR), ligase chain reaction (LCR), in-situ hybridization (ISH) and fluorescent in-situ hybridization (FISH). I also have extensive experience in micromanipulation techniques, medical photography, and computing.
As examples of my professional versatility, I have recently taken on some interesting projects. Between Nov. 2000 and Jan. 2001 I had the opportunity to work temporarily as interim Laboratory Director for Quest Diagnostics in Denver. In 2-1/2 months I single-handedly reviewed more than 1,200 abnormal Papanicolaou smears, including more than a hundred non-GYN cases, and more than 2,500 surgical pathology biopsy cases with a degree of accuracy of 98.5%.Since last July 2001, I have collaborated at the Prostate Cancer Prevention Trials at the Department of Pathology, UHSC. Until now, I have screened more than 1,000 prostate biopsy cases with accuracy greater than 99.5%.
As an additional aspect of my experience as a pathologist, in the past four years I have successfully practiced as a locum tenens pathologist in the states of Colorado, Montana, New Mexico, Oregon and Wyoming.
Excellent professional references available
EARLY BACKGROUND
I received my MD degree in 1975 at the Facultad de Medicina 'Hipólito Unanue' at the Universidad Nacional 'Federico Villarreal' in Lima, Peru. After this, I did a 3-year residency in Clinical Pathology (1977-79) at the Facultad de Medicina 'San Fernando' at the Universidad Mayor de San Marcos in Lima, Peru. Between 1975 and 1981, I created and operated two of my own pathology laboratories in Lima, Peru. I also practiced general medicine, and held the position of Assistant Professor in Microbiology and Immunology at the School of Medicine in Peru. Between 1979 and 1981, I served as a medical consultant for Ortho Pharmaceutical of Peru, traveling across the country and giving seminars and workshops on the diagnosis of hepatitis B. In 1981, Ortho invited me to visit their headquarters in Raritan, New Jersey, an experience that motivated me to further develop my medical career here in the United States. Between 1981 and 1992, I earned a fellowship followed by an appointment towork at the University of Colorado HSC, reaching the rank of Assistant Professor. Between 1992 and 1995 I did a second residency in pathology followed by a 1-year fellowship in lung cancer pathology.
IMMUNOLOGY
In the field of Immunology, I started my teaching activities when I was still a medical student in 1973. I re-organized and gave the first lectures for the Immunology chapters to medical, dental and medical technology students at my alma mater in Lima. In addition to teaching, I did some research in parasitic infections and autoimmunity. After I arrived to Denver in 1981, I did a 5-year fellowship in Immunology at the University of Colorado, HSC under the direction of Dr. David W. Talmage (candidate for the Nobel Prize in Medicine togetherwith Dr. Burnet for his work in the clonal selection theory). With him and later with Dr. Kevin Lafferty, I developed a very exciting line of research in transplantation immunology and Immunobiology of Type I Diabetes. During the next 12 years, I received several research awards plus a RO1-NIH grant for the study of the mechanism of rejection and tolerance of cultured allografts. In 1991, I worked as a medical consultant for a private company in Colorado in the research and development of ELISA testsfor the detection of antinuclear antibodies and IgA anti-cardiolipin antibodies; kits for both of these tests are now commercially available.
CYTOPATHOLOGY
In the field of cytopathology, I started my training in 1978 with Dr. Javier Arias-Stella (who famously described the Arias-Stella reaction in endometrium). With him I did my last year of pathology residency in Lima, which included intensive training in cervical cytology and GYN pathology in Lima's largest woman’s hospital. When I resumed my pathology training in the USA in 1992, I put special emphasis in cytopathology (GYN and non-GYN), having the opportunity to publish a paper describing the first case of breast lymph node pathology diagnosed by FNA in an HIV-1 positive patient. After my residency training, I did a 1-year fellowship in lung cancer pathology under the supervision of Dr. Wilbur A. Franklin, UCHSC through an NCI-SPORE award, with special emphasis on sputum cytology and molecular pathology. This training helped me to further develop my expertise in the field of cytopathology. When I took the Board exams in AP/CP Pathology (which I only had to take once) my highest score was achieved in cytopathology. Between 1996 and 2001 I have accumulated more than 70 hours of CME Category 1 and A1 credits by the College of American Pathologists, through the Inter-laboratory Comparison Program in Gynecological and Non-Gynecologic Cytopathology, achieving more than 98% accuracy in my diagnoses.
GENERAL PATHOLOGY
In 1992, after too many years of working with mice, I decided to carry on with my original vocation in the practice of medicine; I had to do, for a second time, a pathology residency in order to become eligible for board certification in the USA. Based on my previous experience in the field, the American Board of Pathology granted me two years of credit and I finished my residency in June 1995. In my last year, while working with Dr. Daniel Ambruso at the Belle Bonfils Memorial Blood Center, I received a grant from that institution for a study on platelet transfusions in cancer patients. During my residency, I managed to write a handful of articles on some original pathology cases. Nevertheless, returning to human pathology did not disrupt my focus in the field of basic research. After Dr. Talmage's retirement in 1991, I continued working part time at the Department of Immunology UCHSC and collaborating with Professor Dr. Kedar Prasad in the area of transplantation of neural cell lines. Our current research is focused on the development of neural cell lines for eventual transplantation procedures in humans and for the treatment of Parkinson's disease. My work in this group is specifically oriented to the immunological typification of neuronal cells through different markers. Here, I am able to combine my unique blend of expertise in immunology and cytology (see below) for the study of these cells. During my 20 years of research, I have published 40 papers in referee journals, most of them in the area of transplantation immunology, I have written a review article in transplantation immunology and have 6 book chapters in immunology and transplantation.
As a general pathologist, I have performed more than two hundred bone marrow biopsies and fine needle aspirations from different body sites. I also have performed more than one hundred autopsy procedures, many of them forensic cases. In addition to my expertise in cytopathology and immunopathology, I have special skills in prostate pathology, microbiology, parasitology, molecular pathology, coagulation, and blood banking. I am very familiar with laboratory techniques in cellular and humoral immunology, including immunohistochemistry, ELISA, flow cytometry, cell and tissue culture, electrophoresis of proteins, production of monoclonal antibodies, and DNA analysis, including polymerase chain reaction (PCR), ligase chain reaction (LCR), in-situ hybridization (ISH) and fluorescent in-situ hybridization (FISH). I also have extensive experience in micromanipulation techniques, medical photography, and computing.
As examples of my professional versatility, I have recently taken on some interesting projects. Between Nov. 2000 and Jan. 2001 I had the opportunity to work temporarily as interim Laboratory Director for Quest Diagnostics in Denver. In 2-1/2 months I single-handedly reviewed more than 1,200 abnormal Papanicolaou smears, including more than a hundred non-GYN cases, and more than 2,500 surgical pathology biopsy cases with a degree of accuracy of 98.5%.Since last July 2001, I have collaborated at the Prostate Cancer Prevention Trials at the Department of Pathology, UHSC. Until now, I have screened more than 1,000 prostate biopsy cases with accuracy greater than 99.5%.
As an additional aspect of my experience as a pathologist, in the past four years I have successfully practiced as a locum tenens pathologist in the states of Colorado, Montana, New Mexico, Oregon and Wyoming.
Excellent professional references available
Other Expertise
- Co-investigator in the Prostate Cancer Prevention Trials, Department of Pathology, UHSC (07/2001 to 12/01)
- Member of the Pathology Informatics Committee Department of Pathology, UHSC (07/2000 to date).
- Interim Lab Director, Anatomic PathologyLab Quest Diagnostics of Colorado (11/01/00-01/10/01).
- President Pathology Consultants, PC, Locum tenens in pathology (CO, MT, NM, OR, WY) (07/1996 to date).
- Laboratory Director at Miners' Colfax Medical Center, Raton, NM 87740 (07/01/96-06/30/00).
- Member of the Pathology Informatics Committee Department of Pathology, UHSC (07/2000 to date).
- Interim Lab Director, Anatomic PathologyLab Quest Diagnostics of Colorado (11/01/00-01/10/01).
- President Pathology Consultants, PC, Locum tenens in pathology (CO, MT, NM, OR, WY) (07/1996 to date).
- Laboratory Director at Miners' Colfax Medical Center, Raton, NM 87740 (07/01/96-06/30/00).
Future Research
My future research is oriented to the study of telepathology as a fast mean of consultation between pathologists and other physicians via the Internet. Telepathology includes the study of images from gross surgical pathology specimens as well as histopathology and cytology specimens.
Industrial Relevance
My last enterprise has been the incorporation in the States of Colorado, New Mexico, Wyoming and Montana of the professional corporation TelePathology Consultants, PC. The final goal of this corporation is to provide clinical, research and educational consultation in human pathology through the World Wide Web (telepathology).
Keywords
COS Keywords:
Cytopathology, Family Medicine, Pathology, Telemedicine, Transplantation Immunology.Additional Terms:
Pathology, Telemedicine, Telepathology.Languages
(Reading, Writing, Speaking)
English: (Fluent, Fluent, Fluent)
Italian: (Basic, Basic, Basic)
Portuguese: (Basic, Basic, Basic)
Spanish: (Fluent, Fluent, Fluent)
Memberships
American Association of Immunologists
American Medical Association
American Society of Clinical Pathologists
American Telemedicine Association (www.atmeda.org)
College of American Pathologists
Colorado Medical Society
Colorado Society of Clinical Pathologists
Denver Medical Society
New Mexico Medical Society
Peruvian American Medical Association - USA
Peruvian Society of Clinical Pathology - Peru
Peruvian Society of Immunology and Allergy - Peru
Peruvian Society of Microbiology
Spanish Society of Immunology - Spain
The Transplantation Society
Honors and Awards
1996-1997,
'Ligase Chain Reaction to Detect K-ras and p53 Mutations in Lung Cancer',
National Cancer Institute,
Molecular Pathology of Lung Cancer
1994-1994,
'Concepts of Molecular Pathology',
College of American Pathology,
Molecular Pathology
1994-1995,
Excellence in Teaching Award,
University of Colorado, HSC Medical School Class 1997,
Teaching
1987-1988,
'Tolerance and Rejection of Pancreatic Islet Allografts in NOD Mice',
Diabetes Research and Education Foundation,
Transplantation and Diabetes
1986-1987,
'Graft Tolerance to Cultured Endocrine Allografts',
Juvenile Diabetes Foundation,
Transplantation and Diabetes
1983-1984,
'Rejection of Cultured Endocrine Allografts',
Krock Foundation Fellowship Awards (2 years),
Transplantation
1975-1975,
'Enrique Leon García Award',
Peruvian Pediatrics Society,
Best Thesis in Pediatrics
Previous Positions
1987-1992, Assistant Professor,
University of Colorado Health Sciences Center,
Medicine,
Microbiology and Immunology
1981-1987, Instructor,
University of Colorado Health Sciences Center,
School of Medicine,
Microbiology,
Immunology
1979-1981, Assistant Professor,
Universidad Nacional Federico Villarreal,
School of Medicine,
Microbiology and Immunology
1973-1979, Instructor,
Universidad Nacional Federico Villarreal,
School of Medicine,
Microbiology and Immunology
Funding Received
- Diabetes Research and Education Foundation: Study on Tolerance and Rejection of Pancreatic Islet Allografts in NOD Mice, $20,000, Jul 1988 to Jun 1989.
- Co-investigator (PI: Dr. Kedar N. Prasad): Neuronal Degenerative Disease and Cell Transplantation, $1,883,496, Jan 1996 to Dec 2001.
- Belle Bonfils Memorial Blood Center: Non-HLA Mediated, Immune Refractoriness to Platelet Transfusions in Cancer Patients, $15,000, Jan 1995 to Dec 1995.
- National Institutes of Health (NIH): Role of MHC Antigen Induction in Graft Rejection, $287,525, Feb 1988 to Jan 1991.
Publications
- Alfaro Ferreres L, García Rojo M, Puras Gil A (eds), collaborators, ... La Rosa, FG ... ., Manual de Telepatología, 2002
- Baruah, MKR, Jayaram N, Prasad SR, Bedi S, Johnson JM, La Rosa, FG, Telepathology in India, Indian Journal of Pathology and Microbiology, 44((3)), :381-383, 2001
- Campbell A, Kumar A, La Rosa FG, Prasad KN, Bondy SC., Aluminum increases levels of beta-amyloid and ubiquitin in neuroblastoma but not in glioma cells, Proceedings of the Society for Experimental Biology and Medicine, 223((4)), :397-402, April 2000
- Kumar A, Hovland AR, Cole WC, La Rosa FG, Edwards-Prasad J, Prasad KN, Relative sensitivity of undifferentiated and cyclic adenosine 3’, 5’-monophosphate-induced differentiated neuroblastoma cells to cyclosporine A: potential role of beta- amyloid and ubiquitin in neurot, In Vitro Cellular and Developmental Biology. Animal, 36, :81-87, February 2000
- Kumar A, La Rosa FG, Hovland AR, Cole WC, Edwards-Prasad J, Prasad KN, Adenosine 3'',5''-cyclic monophosphate increases processing of amyloid precursor protein \(APP\) to beta-amyloid in neuroblastoma cells without changing APP levels or expression of APP mRNA., Neurochemical Research, 24(10), 1209-15, October 1999
- Hovland AR, La Rosa FG, Hovland PG, Cole WC, Kumar A, Prasad JE, Prasad KN, Cyclosporin A regulates the levels of cyclophilin A in neuroblastoma cells in culture., Neurochemistry International, 35(3), 229-35, September 1999
- Prasad KN, La Rosa FG, Prasad JE, Prostaglandins act as neurotoxin for differentiated neuroblastoma cells in culture and increase levels of ubiquitin and beta-amyloid, In Vitro Cellular and Developmental Biology. Animal, 34(3), 265-74, March 1998
- Prasad KN, La Rosa FG, Prasad JE, Prostaglandins act as neurotoxin for differentiated neuroblastoma cells in culture and increase levels of ubiquitin and beta-amyloid., In Vitro Cellular and Developmental Biology. Animal, 34(3), 265-74, 1998
- Clarkson ED, Rosa FGL, Edwards-Prasad J, Weiland DA, Witta SE, Freed CR, Prasad KN, Improvement of neurological deficits in 6-hydroxydopamine-lesioned rats after transplantation with allogeneic simian virus 40 large tumor antigen gene-induced immortalized dopamine cells, Proceedings of the National Academy of Sciences (USA), 95(3), 1265-70, February 1998
- Clarkson ED, La Rosa FG, Edwards-Prasad J, Kumar S, Kumar A, Cole W, Freed CR, Prasad KN, Brain contains inhibiting factors specific to the large T-antigen gene, Cancer Letters, 122(1-2), 31-6, Jan 1998
- Franklin WA, Gazdar AF, Haney J, Wistuba II, La Rosa FG, Kennedy T, Ritchey DM, Miller YE, Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis [published erratum appears in J Clin Invest 1997 Nov 15;100\(10\):2639, Journal of Clinical Investigation, 100(8), 2133-7, 15 Oct 1997
- Franklin WA, Gazdar AF, Haney J, Wistuba II, La Rosa FG, Kennedy T, Ritchey DM, Miller YE, Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis, Journal of Clinical Investigation, 100(8), 2133-7, October 1997
- La Rosa FG, Nawaz S, Fine needle aspiration cytology of intramammary lymph nodes in an HIV-1-positive patient. A case report, Acta Cytologica, 41(3), 849-51, 1997
- La Rosa FG, Adams FS, Krause GE, Meyers AD, Edwards-Prasad J, Kumar R, Freed CR, Prasad KN, Inhibition of proliferation and expression of T-antigen in SV40 large T-antigen gene-induced immortalized cells following transplantations, Cancer Letters, 113(1-2), 55-60, February 1997
- La Rosa FG, Clarke SH, Lefkowitz JB, Brodifacoum intoxication with marijuana smoking, Archives of Pathology and Laboratory Medicine, 121(1), 67-9, January 1997
- Davidson SA, Gottesfeld J, La Rosa FG, Molar pregnancy in a 60-year-old woman, International Journal of Gynaecology and Obstetrics, 56(1), 53-5, January 1997
- Krause GE, La Rosa FG, Meyers AD, Kumar R, Prasad KN, Transplantation of immortalized, nontumorigenic parotid acinar cells into the allogeneic rat parotid gland and oral submucosa, Proceedings of the Society for Experimental Biology and Medicine, 212(2), 160-4, June 1996
- La Rosa FG, Kumar S, Prasad KN, Increased expression of ubiquitin during adenosine 3',5'-cyclic monophosphate-induced differentiation of neuroblastoma cells in culture, Journal of Neurochemistry, 66(5), 1845-50, May 1996
- Adams FS, La Rosa FG, Kumar S, Edwards-Prasad J, Kentroti S, Vernadakis A, Freed CR, Prasad KN, Characterization and transplantation of two neuronal cell lines with dopaminergic properties, Neurochemical Research, 21(5), 619-27, May 1996
- Prasad KN, Kumar S, Carvalho E, Edwards-Prasad J, Kumar R, La Rosa FG, Larsen BB, Ann D, Characterization of human and rat immortalized clones parotid acinar cells with respect to specific proteins and their mRNAs, and receptor-linked adenylate cyclase, In Vitro Cellular and Developmental Biology. Animal, 31(10), 767-72, November 1995
- Prasad KN, Carvalho E, Edwards-Prasad J, La Rosa FG, Kumar R, Kumar S, Establishment and characterization of immortalized cell lines from rat parotid glands, In Vitro Cellular and Developmental Biology. Animal, 30A(5), 321-8, May 1994
- Prasad KN, Carvalho E, Edwards-Prasad J, La Rosa FG, Kumar S, Kim JH, Meyers A, Kentroti S, Establishment of human parotid pleomorphic adenoma cells in culture: morphological and biochemical characterization, In Vitro Cellular and Developmental Biology. Animal, 30A(5), 312-20, May 1994
- Prasad KN, Carvalho E, Kumar S, Edwards-Prasad J, La Rosa FG, Relationship between adenosine 3',5'-cyclic monophosphate level, cell proliferation, and alpha-amylase in rat parotid, Biochemistry and Cell Biology, 71(7-8), 355-60, 1993
- Shehadeh NN, LaRosa F, Lafferty KJ, Altered cytokine activity in adjuvant inhibition of autoimmune diabetes, Journal of Autoimmunity, 6(3), 291-300, June 1993
- Bradley BJ, Haskins K, La Rosa FG, Lafferty KJ, CD8 T cells are not required for islet destruction induced by a CD4 islet-specific T-cell clone, Diabetes, 41(12), 1603-8, December 1992
- Lopez LR, Santos ME, Espinoza LR, La Rosa FG, Clinical significance of immunoglobulin A versus immunoglobulins G and M anti-cardiolipin antibodies in patients with systemic lupus erythematosus. Correlation with thrombosis, thrombocytopenia, and r, American Journal of Clinical Pathology, 98(4), 449-54, October 1992
- Prasad KN, Edwards-Prasad J, Carvalho E, La Rosa FG, Balbinder E, Meyers A, Quissell D, Establishment of primary cultures of rat and human parotid epithelial cells for transfection experiments, In Vitro Cellular and Developmental Biology, 28A(7-8), 493-9, 1992
- La Rosa FG, Smilek D, Talmage DW, Lafferty KJ, Bauling P, Ammons TJ, Evidence that tolerance to cultured thyroid allografts is an active immunological process. Protection of third-party grafts bearing new antigens when associated with tolerogenic antigens, Transplantation, 53(4), 903-13, April 1992
- Wang Y, Pontesilli O, Gill RG, La Rosa FG, Lafferty KJ, The role of CD4 and CD8 T cells in the destruction of islet grafts by spontaneously diabetic mice, Proceedings of the National Academy of Sciences (USA), 88(2), 527-31, January 1991
- La Rosa FG, Talmage DW, Major histocompatibility complex antigen expression of parenchymal cells of thyroid allografts is not by itself sufficient to induce rejection, Transplantation, 49(3), 605-9, March 1990
- Hao LM, Wang Y, Gill RG, La Rosa FG, Talmage DW, Lafferty KJ, Role of lymphokine in islet allograft rejection, Transplantation, 49(3), 609-14, March 1990
- Hao LM, Wang Y, Gill RG, La Rosa FG, Talmage DW, Lafferty KJ, Role of gamma-interferon in islet allograft rejection: class I MHC antigen induction, Transplantation Proceedings, 21(1 Pt 3), 2697-9, February 1989
- La Rosa FG, Abrogation of mouse pancreatic islet allograft rejection by a four-day culture, Transplantation, 46(2), 330-3, August 1988
- La Rosa FG, Talmage DW, Zlotnik A, Duke RC, Cellular and molecular immunology of tissue transplantation, Revisiones Sobre Biologia Celular, 17, 1-114, 1988
- La Rosa FG, Talmage DW, The abrogation of thyroid allograft rejection by culture in acid medium, Transplantation, 44(4), 592, October 1987
- La Rosa FG, Talmage DW, Tolerance to cultured allografts protects third-party grafts containing new MHC and common minor antigens [published erratum appears in Transplantation 1987 Apr;43(4):608], Transplantation, 43(2), 314-6, February 1987
- Talmage DW, La Rosa FG, Smilek D, Ammons TJ, The tolerance that develops in recipients of cultured allografts is an active process that affects both the activation and effector function of cytotoxic T cells, Progress in Clinical and Biological Research, 224, 187-94, 1986
- La Rosa FG, Talmage DW, Synergism between minor and major histocompatibility antigens in the rejection of cultured allografts, Transplantation, 39(5), 480-5, May 1985
- Zlotnik A, Roberts WK, Vasil A, Blumenthal E, Larosa F, Leibson HJ, Endres RO, Graham SD Jr, White J, Hill J, Henson P, Klein JR, Bevan MJ, Marrack P, Kappler JW, Coordinate production by a T cell hybridoma of gamma interferon and three other lymphokine activities: multiple activities of a single lymphokine?, Journal of Immunology, 131(2), 794-800, August 1983
- La Rosa FG, Talmage DW, The failure of a major histocompatibility antigen to stimulate a thyroid allograft reaction after culture in oxygen, Journal of Experimental Medicine, 157(3), 898-906, March 1983
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COS Expertise ID #431492
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