Prof. Gail Pairitz Jarvik

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University of Washington
School of Medicine
Medicine
Medical Genetics
Head, Division of Medical GeneticsAppointed: 2007
University of Washington
Genome Sciences
Professor of Genome SciencesAppointed: 2007
University of Washington
School of Public Health
Epidemiology
Adjunct Professor of EpidemiologyAppointed: 2005
University of Washington
School of Medicine
Medicine
Medical Genetics
ProfessorAppointed: 2005

Mailing Address

University of Washington Medical Center
Medical Genetics
Box 357720
Seattle, Washington 98195-7720
United States

Contact Information

Phone: (206) 685-9069
Fax: (206) 616-7186
pair@u.washington.edu

Qualifications

M.D., University of Iowa, Medicine, 1987.
Ph.D., University of Michigan, Human Genetics, 1986.
M.S., University of Michigan, Human Genetics, 1983.
B.Sc., University of Iowa, Zoology, 1980.

Expertise and Research Interests

Dr. Jarvik's major interest is in the genetics of common disease. She is involved in a number of research projects that address the inheritance of diseases of complex etiology. These projects use statistical genetics methods such as linkage analysis, complex segregation analysis, and association and interaction tests, in large data-sets collected in collaboration with molecular biologists and epidemiologists. She is particularly interested in the analysis of risk factors for coronary artery disease, including lipid disorders. A major focus of research is the study of gene-by-gene interactions in the inheritance of familial combined hyperlipidemia and elevated levels of apolipoprotein B. That study is also directed at mapping genes for heart disease. A second major project involves lipid oxidative and inflammation risk factors in a case-control study of carotid artery disease. Factors that predict neurological outcome in infants that undergo cardiovascular surgery are studied cooperatively with investigators at The Children's Hospital of Philadelphia.

Other Expertise

Clinical breast cancer genetics

Keywords

COS Keywords:

Cancer Genetics, Cardiovascular Diseases, Dementia, Epidemiology, Genetics, Inflammation, Medical Genetics.

Additional Terms:

Cardiovascular Disease, Genetic Epidemiology, Medical Genetics, Statistical Genetics.

Memberships

American Heart Association
American Society of Human Genetics

Honors and Awards

1997-2001, Pew Biomedical Scholar, Pew Charitable Trusts

Previous Positions

2001-2005, Associate Professor of Medicine, University of Washington, Medicine, Medical Genetics
1995-2000, Assistant Professor of Medicine, University of Washington, Medicine, Medical Genetics
1991-1995, Senior Fellow, University of Washington, Medical Genetics
1987-1990, Intern, University of Pennsylvania, University of Pennsylvania Hospital, Internal Medicine
1987-1990, Resident, University of Pennsylvania, University of Pennsylvania Hospital, Internal Medicine

Funding Received

  • National Institutes of Health (NIH): STARNET: Research Experiences for Students and Teachers, , 2005 to 2010.
  • National Institutes of Health (NIH): Inflammatory genomics in human carotid artery disease, , 2003 to 2007.
  • National Institutes of Health (NIH): APOE genotype and sequelae of infant cardiac surgery, , 2003 to 2008.
  • National Institutes of Health (NIH): Prediction and Progression of Carotid Artery Disease, , 2001 to 2010.
  • National Institutes of Health (NIH): Human Lipoprotein Pathophysiology/Genetics of Familial Combined Hyperlipidemia, , 1999 to 2010.

Publications

  • Carlson CS, Heagerty PJ, Nord AS, Pritchard DK, Ranchalis J, Boguch JM, Duan H, Hatsukami TS, Schwartz SM, Rieder MJ, Nickerson DA, Jarvik GP (2007) TagSNP evaluation for the association of 42 inflammation loci and vascular disease: Evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects, Human Genetics, 121 (1), 65-75
  • Gaynor JW, Wernovsky G, Jarvik GP, Bernbaum J, Gerdes M, Zackai E, Nord AS, Clancy RR, Nicolson SC, Spray TL (2007) Patient characteristics are important determinants of neurodevelopmental outcome at one year of age after neonatal and infant cardiac surgery, J Thorac Cardiovasc Surg, In Press
  • Carty CL, Heagerty P, Nakayama K, McClung EC, Lewis J, Lum D, Boespflug E, McCloud-Gehring C, Soleimani BR, Ranchalis J, Bacus TJ, Furlong CE, Jarvik GP (2006) Inflammatory response following influenza vaccination in men with and without carotid artery disease, Arterioscler Thromb Vasc Biol, 26 (12), 2738-44
  • Bookman EB, Langehome AA, Eckfeldt JH, Glass KC, Jarvik GP, Klag M, Koski G, Motulsky A, Wilfond B, Manolio TA, Fabsitz RR, Luepker RV (2006) Reporting genetic results in research studies: Summary and recommendations of an NHLBI working group, Am J Med Gen, 140A (10), 1033-40
  • Carlson CS, Heagerty PJ, Hatsukami TS, Richter RJ, Ranchalis J, Lewis J, Bacus TJ, McKinstry LA, Schellenberg GD, Rieder M, Nickerson D, Furlong CE, Chait A, Jarvik GP (2006) TagSNP analyses of the PON gene cluster: effects on PON1 activity, LDL oxidative susceptibility, and vascular disease, J Lipid Res, 47 (5), 1014-24
  • Kaltman JR, Jarvik GP, Bernbaum J, Wernovsky G, Gerdes M, Zackai E, Clancy RR, Nicolson SC, Spray TL, Gaynor JW (2006) Neurodevelopmental outcome after early repair of a ventricular septal defect with or without aortic arch obstruction, J Thorac Cardiovasc Surg, 131 (4), 792-798
  • Saam T, Yuan C, Chu B, Takaya N, Underhill H, Cai J, Tran N, Polissar NL, Neradilek B, Jarvik GP, Isaac C, Garden GA, Maravilla KR, Hashimoto B, Hatsukami TS (2006) Predictors of carotid atherosclerotic plaque progression as measured by noninvasive magnetic resonance imaging, Atherosclerosis, In Press
  • Gaynor JW, Jarvik GP, Bernbaum J, Gerdes M, Wernovsky G, Burnham NB, D'Agostino JA, Zackai E, McDonald-McGinn DM, Nicolson SC, Spray TL, Clancy RR (2006) The relationship of postoperative electrographic seizures to neurodevelopmental outcome at 1 year of age after neonatal and infant cardiac surgery, J Thorac Cardiovasc Surg, 131 (1), 181-9
  • Badzioch MB, Goode EL, Jarvik GP (2005) The role of parametric linkage methods in complex trait analyses using microsatellites, BMC Genetics, 6 (Suppl1), S48
  • Bailey-Wilson JE, Almasy L, de Andrade M, Bailey J, Bickeboller H, Cordell HJ, Daw EW, Goldin L, Goode EL, Gray-McGuire C, Hening W, Jarvik GP, Maher BS, Mendell N, Paterson AD, Rice J, Satten G, Suarez B, Vieland V, Wilcox M, Zhang H, Ziegler A, Maccluer JW (2005) Genetic Analysis Workshop 14: microsatellite and single-nucleotide polymorphism marker loci for genome-wide scans, BMC Genetics, 6 (Suppl 1), S1
  • Schultz AH, Jarvik GP, Wernovsky G, Bernbaum J, Clancy RR, D'Agostino JA, Gerdes M, McDonald-McGinn D, Nicolson SC, Spray TL, Zackai E, Gaynor JW (2005) Effect of congenital heart disease on neurodevelopmental outcomes within multiple-gestation births, J Thorac Cardiovasc Surg, 130 (6), 1511-1516
  • Goode EL, Badzioch MB, Jarvik GP (2005) Bias of allele-sharing linkage statistics in the presence of intermarker linkage disequilibrium, BMC Genetics, 6 (Suppl 1), S82
  • Gaynor JW, Nicolson SC, Jarvik GP, Wernovsky G, Montenegro LM, Burnham NB, Hartman DM, Louie A, Spray TL, Clancy RR (2005) Increasing duration of deep hypothermic circulatory arrest is associated with an increased incidence of postoperative electroencephalographic siezures, J Thorac Cardiovasc Surg, 130 (5), 1278-86
  • Gagnon F, Jarvik GP, Badzioch MD, Motulsky AG, Brunzell JD, Wijsman EM (Sep 2005) Genome scan for quantitative trait loci influencing HDL levels: evidence for multilocus inheritance in familial combined hyperlipidemia., Human Genetics, 117 (5), 494-505 Abstract
  • Rozek LS, Hatsukami TS, Richter RJ, Ranchalis J, Nakayama K, McKinstry LA, Gortner DA, Boyko E, Schellenberg GD, Furlong CE, Jarvik GP (Sep 2005) The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status., Journal of Lipid Research, 46 (9), 1888-95 Abstract
  • Furlong CE, Cole TB, Jarvik GP, Pettan-Brewer C, Geiss GK, Richter RJ, Shih DM, Tward AD, Lusis AJ, Costa LG (Aug 2005) Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants., Neurotoxicology, 26 (4), 651-9 Abstract
  • Xu J, Dimitrov L, Chang BL, Adams TS, Turner AR, Meyers DA, Eeles RA, Easton DF, Foulkes WD, Simard J, Giles GG, Hopper JL, Mahle L, Moller P, Bishop T, Evans C, Edwards S, Meitz J, Bullock S, Hope Q, Hsieh CL, Halpern J, Balise RN, Oakley-Girvan I, Whittemore AS, Ewing CM, Gielzak M, Isaacs SD, Walsh PC, Wiley KE, Isaacs WB, Thibodeau SN, McDonnell SK, Cunningham JM, Zarfas KE, Hebbring S, Schaid DJ, Friedrichsen DM, Deutsch K, Kolb S, Badzioch M, Jarvik GP, Janer M, Hood L, Ostrander EA, Stanford JL, Lange EM, Beebe-Dimmer JL, Mohai CE, Cooney KA, Ikonen T, Baffoe-Bonnie A, Fredriksson H, Matikainen MP, Tammela TLj, Bailey-Wilson J, Schleutker J, Maier C, Herkommer K, Hoegel JJ, Vogel W, Paiss T, Wiklund F, Emanuelsson M, Stenman E, Jonsson BA, Gronberg H, Camp NJ, Farnham J, Cannon-Albright LA, Seminara D, The ACTANE Consortium (Aug 2005) A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics., American Journal of Human Genetics, 77 (2), 219-29 Abstract
  • Takaya N, Yuan C, Chu B, Saam T, Polissar NL, Jarvik GP, Isaac C, McDonough J, Natiello C, Small R, Ferguson MS, Hatsukami TS (2005) Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution megnetic resonance imaging study, Circulation, 111 (21), 2768-75
  • Hendrickson A, McKinstry LA, Lewis JK, Lum J, Louie A, Schellenberg GD, Hatsukami TS, Chait A, Jarvik GP (2005) Ex vivo measures of LDL oxidative susceptibility predict carotid artery disease, Atherosclerosis, 179 (1), 147-153
  • Schaid DJ, Chang BI, The International Consortium for Prostate Cancer Genetics (2005) Description of the International Consortium for Prostate Cancer Genetics, and Failure to Replicate Linkage of Hereditary Prostate Cancer to 20q13, The Prostate, 63 (3), 276-290
  • Goode EL, Jarvik GP (2005) Genetic Analysis Workshop 14 Group Summary: assessment and implications of linkage disequilibrium in genome-wide single-nucleotide polymorphism and microsatellite panels, Genetic Epidemiology, 8 (29(Suppl 1)), S72-S76
  • Badzioch MD, Igo RP Jr, Gagnon F, Brunzell JD, Krauss RM, Motulsky AG, Wijsman EM, Jarvik GP (Oct 2004) Low-density lipoprotein particle size loci in familial combined hyperlipidemia: evidence for multiple loci from a genome scan., Arteriosclerosis, Thrombosis, and Vascular Biology, 24 (10), 1942-50 Abstract
  • Gaynor JW, Gerdes M, Zackai EH, Bernbaum J, Wernovsky G, Clancy RR, Newman MF, Saunders AM, Heagerty PJ, D'Agostino JA, McDonald-McGinn D, Nicolson SC, Spray TL, Jarvik GP (2003) Apolipoprotein E genotype and neurodevelopmental sequelae of infanct cardiac surgery, J Thorac Cardiovasc Surg, 126 (6), 1736-1745
  • Jarvik GP, Jampsa R, Richter RJ, Carlson CS, Rieder MJ, Nickerson DA, Furlong CE (2003) Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease, Arterioscler Thromb Vasc Biol, 23 (8), 1465-1471
  • Jarvik GP, Hatsukami TS, Carlson CS, Richter RJ, Jampsa R, Brophy VH, Margolin S, Rieder MJ, Nickerson DA, Schellenberg GD, Heagerty PJ, Furlong CE (2003) Novel paraoxonase (PON1) nonsense and missense mutations predicted by functional genomic assay of PON1 status, Pharmacogenetics, 13 (5), 291-295
  • Jarvik GP, Tsai NT, McKinstry LA, Wani R, Brophy VH, Richter RJ, Schellenberg GD, Heagerty PJ, Hatsukami TS, Furlong CE (2002) Vitamin C and E intake is associated with increased paraoxonase activity, Arterioscler Thromb Vasc Biol, 22 (8), 1329-1333
  • Peters MA, Jarvik GP, Janer M, Chakrabarti L, Kolb S, Goode EL, Gibbs M, DuBois CC, Shuster EF, Hood L, Ostrander EA, Stanford JL (2001) Genetic linkage analysis of prostate cancer families to Xq27-28, Human Heredity, 51 (1-2), 107-113
  • Jarvik GP, Rozek LS, Brophy VH, Hatsukami TS, Richter RJ, Schellenberg GD, Furlong CE (2000) Paraoxonase phenotype is a better predictor of vascular disease than PON1192 or PON155 genotype, Arterioscler Thromb Vasc Biol, 20 (11), 2441-2447
  • Ko CW, Beresford SA, Alderman B, Jarvik GP, Schulte SJ, Calhoun B, Tsuchida AM, Koepsell TD, Lee SP, Apolipoprotein E genotype and the risk of gallbladder disease in pregnancy., Hepatology, 31(1), 18-23, 2000 Abstract
  • Gibbs M, Chakrabarti L, Stanford JL, Goode EL, Kolb S, Schuster EF, Buckley VA, Shook M, Hood L, Jarvik GP, Ostrander EA (1999) Analysis of chromosome 1q42.2-43 in 152 families with high risk prostate cancer, Am J Hum Genet, 64 (4), 1087-1095
  • Gibbs M, Stanford JL, McIndoe RA, Jarvik GP, Kolb S, Goode EL, Chakrabarti L, Schuster EF, Buckley VA, Miller EL, Brandzel S, Li S, Hood L, Ostrander EA, Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36., American Journal of Human Genetics, 64(3), 776-87, March 1999 Abstract
  • Hokanson JE, Brunzell JD, Jarvik GP, Wijsman EM, Austin MA, Linkage of low-density lipoprotein size to the lipoprotein lipase gene in heterozygous lipoprotein lipase deficiency., American Journal of Human Genetics, 64(2), 608-18, February 1999 Abstract
  • Goddard KA, Goode EL, Rozek LS, Jarvik GP, Impact of family structure on the power of linkage tests using sib-pair methods., Genetic Epidemiology, 17 Suppl 1, S575-9, 1999 Abstract
  • Carmelli D, Swan G E, Reed T, Miller B, Wolf P A, Jarvik G P, Schellenberg G D, Midlife cardiovascular risk factors, ApoE, and cognitive decline in elderly male twins., Neurology, 50(6), 1580-5, June 1998 Abstract
  • Breitner J C, Jarvik G P, Plassman B L, Saunders A M, Welsh K A, Risk of Alzheimer disease with the epsilon4 allele for apolipoprotein E in a population-based study of men aged 62-73 years., Alzheimer Disease and Associated Disorders, 12(1), 40-4, March 1998 Abstract
  • Wijsman E M, Brunzell J D, Jarvik G P, Austin M A, Motulsky A G, Deeb S S, Evidence against linkage of familial combined hyperlipidemia to the apolipoprotein AI-CIII-AIV gene complex., Arteriosclerosis, Thrombosis, and Vascular Biology, 18(2), 215-26, February 1998 Abstract
  • McIndoe R A, Stanford J L, Gibbs M, Jarvik G P, Brandzel S, Neal C L, Li S, Gammack J T, Gay A A, Goode E L, Hood L, Ostrander E A, Linkage analysis of 49 high-risk families does not support a common familial prostate cancer-susceptibility gene at 1q24-25., American Journal of Human Genetics, 61(2), 347-53, August 1997 Abstract
  • Jarvik G P, Genetic predictors of common disease: apolipoprotein E genotype as a paradigm., Annals of Epidemiology, 7(5), 357-62, July 1997 Abstract
  • Jarvik G P, Goode E L, Austin M A, Auwerx J, Deeb S, Schellenberg G D, Reed T, Evidence that the apolipoprotein E-genotype effects on lipid levels can change with age in males: a longitudinal analysis., American Journal of Human Genetics, 61(1), 171-81, July 1997 Abstract
  • Graham J, Chapman N H, Goddard K A, Goode E L, Wijsman E M, Jarvik G P, Segregation and linkage analysis of a quantitative versus a qualitative trait in large pedigrees., Genetic Epidemiology, 14(6), 999-1004, 1997 Abstract
  • Horwitz M, Goode E L, Jarvik G P, Anticipation in familial leukemia [see comments], American Journal of Human Genetics, 59(5), 990-8, November 1996 Abstract
  • Jarvik G, Larson E B, Goddard K, Schellenberg G D, Wijsman E M, Influence of apolipoprotein E genotype on the transmission of Alzheimer disease in a community-based sample [published erratum appears in Am J Hum Genet 1996 Mar;58(3):648], American Journal of Human Genetics, 58(1), 191-200, January 1996 Abstract
  • Jarvik et al., Influence of Apolipoprotein E Genotype on Transmission of Alzheimer Disease, American Journal of Human Genetics, 1996
  • Jarvik G P, Wijsman E M, Kukull W A, Schellenberg G D, Yu C, Larson E B, Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study., Neurology, 45(6), 1092-6, June 1995 Abstract
  • Edwards K L, Austin M A, Jarvik G P, Evidence for genetic influences on smoking in adult women twins., Clinical Genetics, 47(5), 236-44, May 1995 Abstract
  • Goddard K A, Jarvik G P, Graham J, McNeney B, Hsu L, Siegmund K, Grosser S, Olson J, Wijsman E M, Analysis of quantitative risk factors for a common oligogenic disease., Genetic Epidemiology, 12(6), 759-64, 1995 Abstract
  • Reed T, Carmelli D, Swan G E, Breitner J C, Welsh K A, Jarvik G P, Deeb S, Auwerx J, Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele., Archives of Neurology, 51(12), 1189-92, December 1994 Abstract
  • Jarvik G P, Brunzell J D, Austin M A, Krauss R M, Motulsky A G, Wijsman E, Genetic predictors of FCHL in four large pedigrees. Influence of ApoB level major locus predicted genotype and LDL subclass phenotype., Arteriosclerosis and Thrombosis, 14(11), 1687-94, November 1994 Abstract
  • Jarvik G P, Patton M A, Homfray T, Evans J P, Non-Mendelian transmission in a human developmental disorder: split hand/split foot., American Journal of Human Genetics, 55(4), 710-3, October 1994 Abstract
  • Jarvik G P, Wijsman E M, Alzheimer's disease and the family effect [letter; comment], Nature Genetics, 8(2), 115, October 1994 Abstract
  • Cortner J A, Coates P M, Liacouras C A, Jarvik G P, Familial combined hyperlipidemia in children: clinical expression, metabolic defects, and management., Current Problems In Pediatrics, 24(9), 295-305, October 1994 Abstract
  • Jarvik G P, Austin M A, Fabsitz R R, Auwerx J, Reed T, Christian J C, Deeb S, Genetic influences on age-related change in total cholesterol, low density lipoprotein-cholesterol, and triglyceride levels: longitudinal apolipoprotein E genotype effects., Genetic Epidemiology, 11(4), 375-84, 1994 Abstract
  • Jarvik et al., Genetic Predictors of Familial Combined Hyperlipidemia in Four Large Pedigrees, Arteriosclerosis and Thrombosis, 14, 1687-94, 1994
  • Jarvik G P, Wijsman E, Little R E, Albers J J, Motulsky A G, Brunzell J D, Host and environmental effects on plasma apolipoprotein B., International Journal of Clinical and Laboratory Research, 23(4), 215-20, 1993 Abstract
  • Jarvik G P, Beaty T H, Gallagher P R, Coates P M, Cortner J A, Genotype at a major locus with large effects on apolipoprotein B levels predicts familial combined hyperlipidemia., Genetic Epidemiology, 10(4), 257-70, 1993 Abstract
  • Austin M A, Jarvik G P, Hokanson J E, Edwards K, Complex segregation analysis of LDL peak particle diameter., Genetic Epidemiology, 10(6), 599-604, 1993 Abstract

Profile Details

Last Updated: 4/3/2007

COS Expertise ID #403016
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