Dr. Narayanan Parameswaran

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Michigan State University
College of Human Medicine
Pathology
Assistant Professor

Mailing Address

Department of Physiology
3175 Biomedical Physical Sciences
East Lansing, Michigan 48824
United States

Contact Information

Phone: (517) 355-6475, ext. 1134
Fax: (517) 355-5125
paramesw@msu.edu

Qualifications

Ph.D., Michigan State University, Physiology, 1999.
M.S., Ohio State University, Veterinary Physiology and Pharmacology, 1995.
B.V.Sc. (eq. to DVM), Madras Veterinary College, Veterinary Medicine, 1994.

Expertise and Research Interests

Cellular and molecular signaling including mechanisms controlling growth, apoptosis and differentiation
Receptor pharmacology including molecular mechanisms affecting receptor activation and deactivation
System physiology and pharmacology
Molecular mechanisms of diseases including macrophage biology

Keywords

COS Keywords:

Apoptosis, Cardiovascular Diseases, Growth Factor Receptors, Kidney Disease, Pathology, Pharmacology, Physiology, Veterinary Medicine.

Additional Terms:

Adrenomedullin, CGRP, Cardiovascular Disease, G-protein Coupled Receptor, Growth Factor Receptor, Macrophage, Renal Disease, TLR, TNF Receptor.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Tamil: (Fluent, Fluent, Fluent)
Hindi: (Basic, None, Basic)

Memberships

Federation of American Societies for Experimental Biology

Honors and Awards

2007, Young Faculty Travel Award, American Association of Immunology
2002, James A. Bain Young Scientist Travel Award, IUPHAR XIVth World Congress of Pharmacology, San Francisco
2000, Young Investigator Award, Second International Symposium on Adrenomedullin and PAMP, Japan
1994-1995, Graduate Fellowship, Ohio State University Graduate School, Ohio State University
1994, Gold Medal for Physiology, Society of Animal Physiologists of India, Madras Veterinary College
1994, Sir Dorabji Tata Prize for Veterinary Medicine, Sir Dorabji Tata, Madras Veterinary College
1994, Outstanding Medal for Veterinary Medicine, TANUVAS Alumni Association Medal, Madras Veterinary College
1994, Obstetrics and Gynecology, Indian Society for Study of Animal Reproduction, Tamil Nadu Chapter, Madras Veterinary College
1994, Best Performance Medal for BVSc (DVM) Animal Health Exam, Dr. O.P. Gautam, Madras Veterinary College
1994, Medal for Best Performance in BVSc., Poultry Science Exam, Thru S.K. Mylasamy Gounder Prize, Madras Veterinary College
1994, Medal For Best Performance in BVSc., Animal Nutrition, Dr. G. Venkatachalam, Madras Veterinary College
1994, Medal For Best Performance in BVSc., Animal Genetics and Breeding, Obstetrics and Gynecology Exam, Dr. C.G. Basker, Madras Veterinary College
1994, Medal For Best Performance in BVSc. Examination, Sri Karumathil Narayanan Menon Award, Madras Veterinary College
1994, Medal For Best Performance in BVSc. Obstetrics and Gynecology Examination, Dr. B. Neduncheralathan Memorial Award, Madras Veterinary College
1994, Gold Medal for Best Performance in BVSc., Animal Husbandry Examination, Rao Sahib Dr. T. Vinayaka Mudaliar, Madras Veterinary College
1994, Gold Medal for Best Performance in BVSc., Examination, SKM Animal Feeds and Foods (India) Ltd., Madras Veterinary College
1994, Best Performance Medal for BVSc (DVM) Obstetrics and Gynecology Examination, Sri Vallam Varadiah Naidu Memorial Prize, Madras Veterinary College
1994, Best Student Award, M.R.V. Panikkar Prize, Madras Veterinary College
1994, Best Student in Microbiology, Dr. R. Eswaran Memorial Prize, Madras Veterinary College
1994, Best Student Award, Dr. A. Srinivasan Prize, Madras Veterinary College
1988-1994, Tamil Nadu Agriculture University Scholarship, Tamil Nadu Agricultural University, Madras Veterinary College

Previous Positions

2003-2005, NIH Research Fellow (Under Dr. Jeff Benovic), Kimmel Cancer Center, Medicine, Biochemistry
1999-2003, Research Associate (Under Dr. Bill Spielman), Michigan State University, College of Human Medicine
1997-1998, Visiting Scientist, Smith-Kline Beecham Pharmaceuticals, Renal Pharmacology
1995-1999, Graduate Research Assistant, Michigan State University, College of Veterinary Medicine, Physiology
1994-1995, Graduate Research Fellow, Ohio State University, College of Veterinary Medicine, Veterinary Physiology and Pharmacology

Funding Received

  • National Institutes of Health (NIH): Novel GPCR kinase interactions in macrophages and Role in arthritis, $242,000, 2008 to 2010.

Publications

  • Loniewski K, Shi Y, Pestka J, Parameswaran N (Apr 2008) Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages., Molecular immunology, 45 (8), 2312-22 Abstract
  • Loniewski KJ, Patial S, Parameswaran N (Jul 2007) Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages., Molecular immunology, 44 (15), 3715-23 Abstract
  • Parameswaran N, Spielman WS (Nov 2006) RAMPs: The past, present and future., Trends in biochemical sciences, 31 (11), 631-8 Abstract
  • Parameswaran N, Pao CS, Leonhard KS, Kang DS, Kratz M, Ley SC, Benovic JL (Nov 2006) Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages., The Journal of biological chemistry, 281 (45), 34159-70 Abstract
  • Bomberger JM, Spielman WS, Hall CS, Weinman EJ, Parameswaran N (Jun 2005) Receptor activity-modifying protein (RAMP) isoform-specific regulation of adrenomedullin receptor trafficking by NHERF-1., The Journal of biological chemistry, 280 (25), 23926-35 Abstract
  • Bomberger JM, Parameswaran N, Hall CS, Aiyar N, Spielman WS (Mar 2005) Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking., The Journal of biological chemistry, 280 (10), 9297-307 Abstract
  • Parameswaran N, Spielman WS, Brooks DP, Nambi P (May 2004) Okadaic acid stimulates caspase-like activities and induces apoptosis of cultured rat mesangial cells., Molecular and cellular biochemistry, 260 (1-2), 7-11 Abstract
  • Parameswaran N, Hall CC, Bomberger JM, Spielman WS (2003) Regulation of adrenomedullin signaling in kidney interstitial fibroblasts., Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 13 (6), 391-400 Abstract
  • Parameswaran N, Hall CS, McCabe LR, Spielman WS (2003) Adrenomedullin increases AP-1 expression in rat mesangial cells via activation of protein kinase-A and p38 MAPK., Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 13 (6), 367-74 Abstract
  • Parameswaran N, Hall CS, Bomberger JM, Sparks HV, Jump DB, Spielman WS (2003) Negative growth effects of ciglitazone on kidney interstitial fibroblasts: role of PPAR-gamma., Kidney & blood pressure research, 26 (1), 2-9 Abstract
  • Parameswaran N, Hall CS, Bock BC, Sparks HV, Gallo KA, Spielman WS (Dec 2002) Mixed lineage kinase 3 inhibits phorbol myristoyl acetate-induced DNA synthesis but not osteopontin expression in rat mesangial cells., Molecular and cellular biochemistry, 241 (1-2), 37-43 Abstract
  • Aiyar N, Disa J, Ao Z, Xu D, Surya A, Pillarisetti K, Parameswaran N, Gupta SK, Douglas SA, Nambi P (Jun 2002) Molecular cloning and pharmacological characterization of bovine calcitonin receptor-like receptor from bovine aortic endothelial cells., Biochemical pharmacology, 63 (11), 1949-59 Abstract
  • Nowak W, Parameswaran N, Hall CS, Aiyar N, Sparks HV, Spielman WS (Jun 2002) Novel regulation of adrenomedullin receptor by PDGF: role of receptor activity modifying protein-3., American journal of physiology. Cell physiology, 282 (6), C1322-31 Abstract
  • Parameswaran N, Hall CS, Böck BC, Sparks HV, Gallo KA, Spielman WS (2002) Mixed lineage kinase 3 inhibits platelet-derived growth factor-stimulated DNA synthesis and matrix mRNA expression in mesangial cells., Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 12 (5-6), 325-34 Abstract
  • Parameswaran N, Nowak W, Hall CS, Sparks HV, Spielman WS (Nov 2001) Cellular and molecular actions of adrenomedullin in glomerular mesangial cells., Peptides, 22 (11), 1919-24 Abstract
  • Filippatos GS, Gangopadhyay N, Lalude O, Parameswaran N, Said SI, Spielman W, Uhal BD (Oct 2001) Regulation of apoptosis by vasoactive peptides., American journal of physiology. Lung cellular and molecular physiology, 281 (4), L749-61 Abstract
  • Parameswaran N, Aiyar N, Wu H, Brooks DP, Nambi P, Spielman WS (Nov 2000) Desensitization and resensitization of adrenomedullin-sensitive receptor in rat mesangial cells., European journal of pharmacology, 407 (3), 205-10 Abstract
  • Parameswaran N, Disa J, Spielman WS, Brooks DP, Nambi P, Aiyar N (Feb 2000) Activation of multiple mitogen-activated protein kinases by recombinant calcitonin gene-related peptide receptor., European journal of pharmacology, 389 (2-3), 125-30 Abstract
  • W.S. Spielman, N. Parameswaran, H.V. Sparks (2000) Adenosine: an intrarenal mediator of renal function In D.W. Seldin and G. Giebisch (eds), The Kidney: Physiology and Pathophysiology, 3rd Edition (bookchapter)
  • Disa J, Parameswaran N, Nambi P, Aiyar N (2000) Involvement of cAMP-dependent protein kinase and pertussis toxin-sensitive G-proteins in CGRP mediated JNK activation in human neuroblastoma cell line., Neuropeptides, 34 (3-4), 229-33 Abstract
  • Parameswaran N, Nambi P, Hall CS, Brooks DP, Spielman WS (Jan 2000) Adrenomedullin decreases extracellular signal-regulated kinase activity through an increase in protein phosphatase-2A activity in mesangial cells., European journal of pharmacology, 388 (2), 133-8 Abstract
  • Parameswaran N, Nambi P, Brooks DP, Spielman WS (May 1999) Regulation of glomerular mesangial cell proliferation in culture by adrenomedullin., European journal of pharmacology, 372 (1), 85-95 Abstract
  • Parameswaran N, Spielman WS, Brooks DP, Nambi P (Apr 1999) SB203580 reverses adrenomedullin's effect on proliferation and apoptosis in cultured mesangial cells., European journal of pharmacology, 371 (1), 75-82 Abstract
  • Parameswaran N, Spielman WS, Pullen M, Francis J, Brooks DP, Nambi P (Apr 1999) Mechanism of adrenomedullin-stimulated hyaluronic acid release in rat mesangial cells., European journal of pharmacology, 370 (3), 313-8 Abstract
  • Parameswaran N, Hamlin RL, Nakayama T, Rao SS, Increased splenic capacity in response to transdermal application of nitroglycerine in the dog., Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, 13 (1), 44-6 Abstract

Profile Details

Last Updated: 5/9/2008

COS Expertise ID #1057353
Reference this profile directly: http://myprofile.cos.com/paramesw