Patrick J. Concannon

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Virginia Mason Research Center
Director, Molecular Genetics Program
University of Washington
School of Medicine
Immunology
Affiliate Professor

Mailing Address

1201 Ninth Avenue
Seattle, Washington 98101
United States

Contact Information

Phone: (206) 223-6476
Fax: (206) 625-7213
patcon@u.washington.edu

Expertise and Research Interests

Current research projects ongoing in the laboratory are:

Genetic dissection of the biochemical pathways involved in the mammalian cellular DNA damage response through the study of rare human inherited disorders in which patients are hypersensitive to ionizing radiation. These disorders include ataxia-telangiectasia (A-T), Nijmegen breakage syndrome (NBS) and Ligase IV syndrome (LIG4S).

A multi-center epidemiologic study of the role of DNA damage response genes, such as those involved in A-T or NBS, in second primaryl breast cancers developing following radiation therapy.

Identification of genes that predispose to type 1 diabetes by genetic linkage analysis.

Keywords

COS Keywords:

Diabetes, Genetics, Immunology.

Additional Terms:

Cancer Susceptibility, DNA Double-strand Break Repair, Diabetes, Human Genetics, Linkage Analysis, Radiation Sensitivity.

Publications

  • Resnick IB, Kondratenko I, Togoev O, Vasserman N, Shagina I, Evgrafov O, Tverskaya S, Cerosaletti KM, Gatti RA, Concannon P, Nijmegen breakage syndrome: clinical characteristics and mutation analysis in eight unrelated Russian families, Journal of Pediatrics, 140(3), 355-61, March 2002 Abstract
  • Jeggo PA, Concannon P, Immune diversity and genomic stability: opposite goals but similar paths, Journal of Photochemistry and Photobiology. B, Biology, 65(2-3), 88-96, December 2001 Abstract
  • O'Driscoll M, Cerosaletti KM, Girard PM, Dai Y, Stumm M, Kysela B, Hirsch B, Gennery A, Palmer SE, Seidel J, Gatti RA, Varon R, Oettinger MA, Neitzel H, Jeggo PA, Concannon P, DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency, Molecular Cell, 8(6), 1175-85, December 2001 Abstract
  • Cox NJ, Wapelhorst B, Morrison VA, Johnson L, Pinchuk L, Spielman RS, Todd JA, Concannon P, Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families, American Journal of Human Genetics, 69(4), 820-30, October 2001 Abstract
  • Teraoka SN, Malone KE, Doody DR, Suter NM, Ostrander EA, Daling JR, Concannon P, Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history, Cancer, 92(3), 479-87, August 2001 Abstract
  • Buscemi G, Savio C, Zannini L, Micciche F, Masnada D, Nakanishi M, Tauchi H, Komatsu K, Mizutani S, Khanna K, Chen P, Concannon P, Chessa L, Delia D, Chk2 activation dependence on Nbs1 after DNA damage, Molecular and Cellular Biology, 21(15), 5214-22, August 2001 Abstract
  • Hiel JA, Weemaes CM, van Engelen BG, Smeets D, Ligtenberg M, van Der Burgt I, van Den Heuvel LP, Cerosaletti KM, Gabreels FJ, Concannon P, Nijmegen breakage syndrome in a Dutch patient not resulting from a defect in NBS1, Journal of Medical Genetics, 38(6), E19, June 2001 Abstract
  • Desai-Mehta A, Cerosaletti KM, Concannon P, Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization, Molecular and Cellular Biology, 21(6), 2184-91, March 2001 Abstract
  • Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, et al., Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus, Nature Genetics, 26(2), 163-75, October 2000 Abstract
  • Wilda M, Demuth I, Concannon P, Sperling K, Hameister H, Expression pattern of the Nijmegen breakage syndrome gene, Nbs1, during murine development, Human Molecular Genetics, 9(12), 1739-44, July 2000 Abstract
  • Cerosaletti KM, Desai-Mehta A, Yeo TC, Kraakman-Van Der Zwet M, Zdzienicka MZ, Concannon P, Retroviral expression of the NBS1 gene in cultured Nijmegen breakage syndrome cells restores normal radiation sensitivity and nuclear focus formation, Mutagenesis, 15(3), 281-6, May 2000 Abstract
  • Gatei M, Young D, Cerosaletti KM, Desai-Mehta A, Spring K, Kozlov S, Lavin MF, Gatti RA, Concannon P, Khanna K, ATM-dependent phosphorylation of nibrin in response to radiation exposure, Nature Genetics, 25(1), 115-9, May 2000 Abstract
  • Gatti RA, Tward A, Concannon P, Cancer risk in ATM heterozygotes: a model of phenotypic and mechanistic differences between missense and truncating mutations, Molecular Genetics and Metabolism, 68(4), 419-23, December 1999 Abstract
  • Vanasse GJ, Concannon P, Willerford DM, Regulated genomic instability and neoplasia in the lymphoid lineage, Blood, 94(12), 3997-4010, December 1999 Abstract
  • Teraoka SN, Telatar M, Becker-Catania S, Liang T, Onengut S, Tolun A, Chessa L, Sanal O, Bernatowska E, Gatti RA, Concannon P, Splicing defects in the ataxia-telangiectasia gene, ATM: underlying mutations and consequences, American Journal of Human Genetics, 64(6), 1617-31, June 1999 Abstract
  • Cox NJ, Frigge M, Nicolae DL, Concannon P, Hanis CL, Bell GI, Kong A, Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans, Nature Genetics, 21(2), 213-5, February 1999 Abstract
  • Vissinga CS, Yeo TC, Woessner J, Massa HF, Wilson RK, Trask BJ, Concannon P, Identification, characterization, and mapping of a mouse homolog of the gene mutated in Nijmegen breakage syndrome, Cytogenetics and Cell Genetics, 87(1-2), 80-4, 1999 Abstract
  • Watanabe M, Sugai Y, Concannon P, Koenig M, Schmitt M, Sato M, Shizuka M, Mizushima K, Ikeda Y, Tomidokoro Y, Okamoto K, Shoji M, Familial spinocerebellar ataxia with cerebellar atrophy, peripheral neuropathy, and elevated level of serum creatine kinase, gamma-globulin, and alpha-fetoprotein, Annals of Neurology, 44(2), 265-9, August 1998 Abstract
  • Cerosaletti KM, Lange E, Stringham HM, Weemaes CM, Smeets D, Solder B, Belohradsky BH, Taylor AM, Karnes P, Elliott A, Komatsu K, Gatti RA, Boehnke M, Concannon P, Fine localization of the Nijmegen breakage syndrome gene to 8q21: evidence for a common founder haplotype, American Journal of Human Genetics, 63(1), 125-34, July 1998 Abstract
  • Concannon P, Gogolin-Ewens KJ, Hinds DA, Wapelhorst B, Morrison VA, Stirling B, Mitra M, Farmer J, Williams SR, Cox NJ, Bell GI, Risch N, Spielman RS, A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus, Nature Genetics, 19(3), 292-6, July 1998 Abstract
  • Wright JA, Keegan KS, Herendeen DR, Bentley NJ, Carr AM, Hoekstra MF, Concannon P, Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control, Proceedings of the National Academy of Sciences (USA), 95(13), 7445-50, June 1998 Abstract
  • Varon R, Vissinga C, Platzer M, Cerosaletti KM, Chrzanowska KH, Saar K, Beckmann G, Seemanova E, Cooper PR, Nowak NJ, Stumm M, Weemaes CM, Gatti RA, Wilson RK, Digweed M, Rosenthal A, Sperling K, Concannon P, Reis A, Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome, Cell, 93(3), 467-76, May 1998 Abstract

Profile Details

Last Updated: 7/5/2002

COS Expertise ID #678362
Reference this profile directly: http://myprofile.cos.com/patcon