Margaret Pepe

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Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Program in Biostatistics and Biomathematics
Full MemberAppointed: 1996
University of Washington
School of Public Health and Community Medicine
Biostatistics
ProfessorAppointed: 2000

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave N
M2-B500
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-7398
Fax: (206) 667-7004
mspepe@u.washington.edu

Qualifications

Ph.D., University of Washington, Biomathematics, 1986.
M.S., University of Washington, Statistics, 1984.
B.S., University College, Cork, Mathematical Science, 1981.

Keywords

COS Keywords:

Public Health.

Honors and Awards

1999-2000, Genontech Professor, University of Washington, Department of Biostatistics
1997, Mortimer Spiegelman Award, American Public Health Association
1981, Fullbright Scholar, University of Washington

Previous Positions

1991-1996, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Department of Biostatistics
1988-1991, Staff Scientist, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Department of Biostatistics
1988-1991, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Department of Biostatistics

Publications

  • Moskowitz CS, Pepe MS, Sample size and analysis for paired study designs comparing the predictive values of binary diagnostic tests, Clinical Trials, In Press, 2006
  • Janes H, Pepe MS, The optimal ratio of cases to controls in a case-control biomarker study, Biostatistics, In Press, 2006
  • Zheng Y, Pepe MS, A practical multifaceted approach to selecting differentially expressed genes, Cancer Informatics, In Press, 2006
  • Pepe MS, Cai T, Longton G, Combining predictors for classification using the area under the ROC curve, Biometrics, 62(1), 221-229, 2006
  • Cai T, Pepe MS, Zheng Y Lumley T, Jenny NS, sensitivity and specificity of markers for event times, Biostatistics, 7(2), 182-197, 2006
  • Brumback LC, Pepe MS, Alonzo TA, Using the ROC curve for gauging treatment effects in clinical trials, Statistics in Medicine, 25, 575-590, 2006
  • Pepe MS, Longton G (Sep 2005) Standardizing diagnostic markers to evaluate and compare their performance., Epidemiology (cambridge, Mass.), 16 (5), 598-603 Abstract
  • Janes H, Pepe M, Kooperberg C, Newcomb P (May 2005) Identifying target populations for screening or not screening using logic regression., Statistics in Medicine, 24 (9), 1321-38 Abstract
  • Pepe MS, Evaluating technologies for classification and prediction in medicine, Statistics in Medicine, 24(24), 3687-3696, 2005
  • Alonzo TA and Pepe MS, Assessing accuracy of a continuous screening test in the presence of verification bias, JRSS (c) Applied Statistics, 54, 173-190, 2005
  • Song X, Pepe MS (Dec 2004) Evaluating markers for selecting a patient's treatment., Biometrics, 60 (4), 874-83 Abstract
  • Pepe MS, Cai T (Jun 2004) The analysis of placement values for evaluating discriminatory measures., Biometrics, 60 (2), 528-35 Abstract
  • Moskowitz CS, Pepe MS (May 2004) Quantifying and comparing the accuracy of binary biomarkers when predicting a failure time outcome., Statistics in Medicine, 23 (10), 1555-70 Abstract
  • Pepe MS, Janes H, Longton G, Leisenring W, Newcomb P (May 2004) Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker., American Journal of Epidemiology, 159 (9), 882-90 Abstract
  • Callahan HS, Cummings DE, Pepe MS, Breen PA, Matthys CC, Weigle DS (Mar 2004) Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humans., The Journal of Clinical Endocrinology and Metabolism, 89 (3), 1319-24 Abstract
  • Yasui Y, Pepe MS, Hsu L, Feng Z, Partially supervised learning using an EM-boosting algorithm, Biometrics, 60, 199-206, 2004
  • Moskowitz CS, Pepe MS (Jan 2004) Quantifying and comparing the predictive accuracy of continuous prognostic factors for binary outcomes., Biostatistics (oxford, England), 5 (1), 113-27 Abstract
  • Fritscher-Ravens A, Davidson BL, Hauber HP, Bohuslavizki KH, Bobrowski C, Lund C, Knofel WT, Soehendra N, Brandt L, Pepe MS, Pforte A (Dec 2003) Endoscopic ultrasound, positron emission tomography, and computerized tomography for lung cancer., American Journal of Respiratory and Critical Care Medicine, 168 (11), 1293-7 Abstract
  • Etzioni R, Kooperberg C, Pepe M, Smith R, Gann PH (Oct 2003) Combining biomarkers to detect disease with application to prostate cancer., Biostatistics (oxford, England), 4 (4), 523-38 Abstract
  • Dodd LE, Pepe MS (Sep 2003) Partial AUC estimation and regression., Biometrics, 59 (3), 614-23 Abstract
  • Yasui Y, Pepe M, Thompson ML, Adam BL, Wright GL Jr, Qu Y, Potter JD, Winget M, Thornquist M, Feng Z (Jul 2003) A data-analytic strategy for protein biomarker discovery: profiling of high-dimensional proteomic data for cancer detection., Biostatistics (oxford, England), 4 (3), 449-63 Abstract
  • Alonzo TA, Pepe MS, Lumley T (Apr 2003) Estimating disease prevalence in two-phase studies., Biostatistics (oxford, England), 4 (2), 313-26 Abstract
  • Pepe MS, Longton G, Anderson GL, Schummer M (Mar 2003) Selecting differentially expressed genes from microarray experiments., Biometrics, 59 (1), 133-42 Abstract
  • Dodd L, Pepe MS, Semi-parametric regression for the area under the Receiver Operating Characteristic Curve, Journal of the American Statistical Association, 98, 409-417, 2003
  • McIntosh MW, Pepe MS (Sep 2002) Combining several screening tests: optimality of the risk score., Biometrics, 58 (3), 657-64 Abstract
  • Alonzo TA, Pepe MS, Moskowitz CS (Mar 2002) Sample size calculations for comparative studies of medical tests for detecting presence of disease., Statistics in Medicine, 21 (6), 835-52 Abstract
  • Cai T and Pepe MS, Semi-parametric ROC analysis to evaluate biomarkers for disease, Journal of the American Statistical Association, 97, 1099-1107, 2002
  • Sullivan Pepe M, Etzioni R, Feng Z, Potter JD, Thompson ML, Thornquist M, Winget M, Yasui Y (Jul 2001) Phases of biomarker development for early detection of cancer., Journal of the National Cancer Institute, 93 (14), 1054-61 Abstract
  • Rosenfeld M, Pepe MS, Longton G, Emerson J, FitzSimmons S, Morgan W (Mar 2001) Effect of choice of reference equation on analysis of pulmonary function in cystic fibrosis patients., Pediatric Pulmonology, 31 (3), 227-37 Abstract
  • Lumley T, Pepe MS, Heagerty P, Comment on AA comparison of population average and random-effect models for the analysis of longitudinal count data with baseline information," by Crouchley R and Davies R, Journal of the Royal Statistical Society, Series A, 164, 209-210, 2001
  • Pepe MS and Alonzo TA, Comparing disease screening tests when true disease status is ascertained only for screen positives, Biostatistics, 2, 1-12, 2001
  • Rosenfeld M, Emerson J, Williams-Warren J, Pepe MS, Smith A, Montgomery AB, Ramsey B, Definining a pulmonary exacerbation in cystic fibrosis, Journal of Pediatrics, 139(3), 359-365, 2001
  • Pepe MS and Alonzo TA, Reply to Letter to Editor regarding AAlonzo TA and Pepe MS, Assessing the accuracy of a new diagnostic test when a gold standard does not exist, Statistics in Medicine, 20, 656-660, 2001
  • Nelson JC, Pepe MS (Oct 2000) Statistical description of interrater variability in ordinal ratings., Statistical Methods in Medical Research, 9 (5), 475-96 Abstract
  • Pepe MS (Jun 2000) An interpretation for the ROC curve and inference using GLM procedures., Biometrics, 56 (2), 352-9 Abstract
  • Heagerty PJ, Lumley T, Pepe MS (Jun 2000) Time-dependent ROC curves for censored survival data and a diagnostic marker., Biometrics, 56 (2), 337-44 Abstract
  • Leisenring W, Alonzo T, Pepe MS (Jun 2000) Comparisons of predictive values of binary medical diagnostic tests for paired designs., Biometrics, 56 (2), 345-51 Abstract
  • Alonzo TA, Pepe MS (Nov 1999) Using a combination of reference tests to assess the accuracy of a new diagnostic test., Statistics in Medicine, 18 (22), 2987-3003 Abstract
  • Pepe MS, Heagerty P, Whitaker R (Sep 1999) Prediction using partly conditional time-varying coefficients regression models., Biometrics, 55 (3), 944-50 Abstract
  • Pepe MS, Whitaker RC, Seidel K (Jan 1999) Estimating and comparing univariate associations with application to the prediction of adult obesity., Statistics in Medicine, 18 (2), 163-73 Abstract
  • Ramsey BW, Pepe MS, Quan JM, Otto KL, Montgomery AB, Williams-Warren J, Vasiljev-K M, Borowitz D, Bowman CM, Marshall BC, Marshall S, Smith AL (Jan 1999) Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic Fibrosis Inhaled Tobramycin Study Group., The New England Journal of Medicine, 340 (1), 23-30 Abstract
  • Leisenring W, Pepe MS (Jun 1998) Regression modelling of diagnostic likelihood ratios for the evaluation of medical diagnostic tests., Biometrics, 54 (2), 444-52 Abstract
  • Pepe MS, Three approaches to regression analysis of receiver operating characteristic curves for continuous test results., Biometrics, 54(1), 124-35, 1998 Abstract

Profile Details

Last Updated: 8/10/2006

COS Expertise ID #675786
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