Dr. David C. Perry

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George Washington University
Medicine
Pharmacology & Physiology
ProfessorAppointed: 1983
Professional Headshot of David C. Perry

Mailing Address

2300 I St. NW
Washington, District of Columbia 20037
United States

Contact Information

Phone: (202) 994-3544
Fax: (202) 994-2870
phmdcp@gwumc.edu

Qualifications

Ph.D., University of California, San Francisco, Pharmaceutical Chemistry, 1981.
B.A., Harvard University, Biochemical Sciences, 1970.

Expertise and Research Interests

The principal research interest in my lab is neuronal nicotinic receptors. We have pioneered the use of several new radioligands, including [3H]epibatidine, [125I]epibatidine and [125I]A-85380, and have developed a novel quantitative approach using these ligands to measure receptor subtypes with receptor autoradiography and receptor binding. We also measure nicotinic receptor function in vitro by rubidium efflux and neurotransmitter release. We employ these methods to characterize the how chronic nicotine exposure affects expression and function of nicotinic receptor subtypes in rodents. Recent studies have focused on differential responses at differential developmental stages, including nicotine exposure in adolescents and in utero. Furthermore, in collaboration with Dr. Ken Kellar of Georgetown, and Dr. Yousef Tizabi of Howard, we are studying the roles of these subtypes in psychiatric diseases including schizophrenia and depression.

My research skills include:
Receptor binding and autoradiography
Radioiodination
Rubidium efflux
Neurotransmitter release

Other Expertise

Interdisciplinary Descriptor
Neuroscientist
Neuropharmacologist

Keywords

COS Keywords:

Affective Disorders, Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Anxiety Disorders, Brain Injury, Cardiovascular Diseases, Cell Culture, Cell Cycle, Cerebrovascular Disorders, Death Or Mortality, Depression, Diseases and Disorders, Drugs or Drug Abuse, Growth Factors, Molecular Biology, Neurological Disorders, Neurology, Neuropharmacology, Neurotransmitters, Nicotine, Pharmacology, Receptors, Schizophrenia, Stroke, Tourette's Syndrome.

Additional Terms:

Nicotine Addiction, Nicotinic Receptors, Receptor Autoradiography, Schizophrenia.

Memberships

American Association for the Advancement of Science
American Association of Pharmaceutical Scientists
American Society for Pharmacology and Experimental Therapeutics
Society for Neuroscience
Society for Research in Nicotine and Tobacco

Previous Positions

1988-1998, Associate Professor, George Washington University, School of Medicine and Health Sciences, Pharmacology and Neuroscience
1983-1988, Assistant Professor, George Washington University, School of Medicine and Health Sciences, Pharmacology
1981-1983, Postdoctoral Fellow, Johns Hopkins University, School of Medicine, Neuroscience, Laboratory of Dr. Solomon H. Snyder
1973-1976, Chemist, PharmChem Labs

Funding Received

  • National Institutes of Health (NIH): Chronic nicotine effects on nicotinic receptor subtypes, 2004 to 2008.
  • National Institutes of Health (NIH): Reduction of Tobacco Exposure in Pregnancy and Infancy. (Ayman El-Mohandes, PI), 2004 to 2009.

Publications

  • Rasmussen BA (2008) Effects of nicotine on sensorimotor gating impairment induced by long-term treatment with neurotoxic NMDA antagonism., Neurotoxicity Research, In Press
  • Mao D (2008) The a4b2a5 nicotinic cholinergic receptor in rat brain is resistant to up-regulation by nicotine in vivo., J. Pharmacol. Exp. Therap., 104, 446-456
  • Rasmussen BA (2007) Long-term effects of developmental PCP administration on auditory gating in male and female rats., Psychopharmacology (Berl.),, 190, 43-49
  • Rasmussen BA (2006) An autoradiographic analysis of [125I]alpha-bungarotoxin binding in rat brain after chronic nicotine exposure., Neurosci. Lett, 404, 9-14
  • Nguyen HN, Rasmussen BE, Perry DC (2004) Binding and functional activity of nicotinic cholinergic receptors in selected rat brain regions are increased following long-term but not short-term nicotine treatment., J. Neurochem, 90, 40-49
  • Perry DC, Xiao Y, Nguyen HN, Musachio JL, Dávila-García MI, Kellar KJ (2003) Measuring nicotinic receptors with characteristics of a4b2, a3b2 and a3b4 subtypes in rat tissues by autoradiography, J. Neurochem, 82, 468-481
  • Nguyen HN, Rasmussen BE, Perry DC (2003) Subtype-selective upregulation by chronic nicotine of high affinity nicotinic receptors in rat brain demonstrated by receptor autoradiography., J. Pharmacol. Exp. Therap, 307, 1090-1097
  • Nguyen HN, Wang C, Bui M & Perry DC, Depletion of intracellular calcium stores is toxic to SH-SY5Y neuronal cells, Brain Research, 924, 159-166, 2002
  • Wang C, Nguyen HN, Maguire JL & Perry DC, Oxygen-glucose deprivation in neuronal cell lines: Evidence that cell death is induced by depletion of endoplasmic reticulum calcium stores, Journal of Cerebral Blood Flow and Metabolism, 22, 206-214, 2002
  • Perry DC, Xiao Y, Nguyen HN, Musachio JL, Dávila-García MI & Kellar KJ, Measuring nicotinic receptors with characteristics of a4b2, a3b2 and a3b4 subtypes in rat tissues by autoradiography, Journal of Neurochemistry, in press, 2002
  • Ferreira M, Ebert SN, Perry DC, Yasuda RP, Baker C, Dávila-García MI, Kellar KJ & Gillis, RA, Evidence of a functional alpha7 neuronal nicotinic receptor subtype located on motoneurons of the dorsal motor nucleus of the vagus, Journal of Pharmacology and Experimental Therapeutics, 296, 260-269, 2001
  • Tizabi Y, Russell, LT, Nespor SM, Perry DC & Grunberg NE, Prenatal nicotine exposure: Effects on locomotor activity and central [125I]alpha-BT binding in rats, Pharmacology, Biochemistry and Behavior, 66, 495-500, 2000
  • Tizabi Y & Perry D, Effects on [125I]epibatidine binding in rat brain, Pharmacology, Biochemistry and Behavior, 67, 319-323, 2000
  • Perry DC, Davila-Garcia MI, Stockmeier CA, Kellar KJ, Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies., Journal of Pharmacology and Experimental Therapeutics, 289(3), 1545-52, June 1999 Abstract
  • Wei H, Wei W, Bredesen DE, Perry DC, Bcl-2 protects against apoptosis in neuronal cell line caused by thapsigargin-induced depletion of intracellular calcium stores., Journal of Neurochemistry, 70(6), 2305-14, 1998 Abstract
  • H. Wei, W. Wei, D.E. Bredesen & D.C. Perry, Bcl-2 protects against apoptosis in neuronal cell line caused by thapsigargin-induced depletion of intracellular calcium stores, Journal of Neurochemistry, 70, 2305-11, 1998
  • Dávila-García, M.I., Musachio, J.L., Perry, D.C., Xiao, Y., Horti, A., London, E.D., Dannals, R.F. and Kellar, K.J., [125I]IPH, an epibatidine analog, binds with high affinity to neuronal nicotinic cholinergic receptors, Journal of Pharmacology and Experimental Therapeutics, 282, 445-451, 1997
  • Wei H, Fiskum G, Rosenthal R E, Perry D C, Global cerebral ischemia and reperfusion alters NMDA receptor binding in canine brain., Molecular and Chemical Neuropathology, 30(1-2), 25-39, January 1997 Abstract
  • Wei H, Fiskum G, Rosenthal R E, Perry D C, Non-NMDA glutamate receptor binding in canine brain after global cerebral ischemia and reperfusion., Molecular and Chemical Neuropathology, 29(1), 37-52, September 1996 Abstract
  • H. Wei & D.C. Perry, Dantrolene is cytoprotective in two models of neuronal cell death, Journal of Neurochemistry, 67, 2390-8, 1996
  • Perry D C, Kellar K J, [3H]epibatidine labels nicotinic receptors in rat brain: an autoradiographic study., Journal of Pharmacology and Experimental Therapeutics, 275(2), 1030-4, November 1995 Abstract
  • D.C. Perry & K.J. Kellar, [3H]Epibatidine labels nicotinic receptors in rat brain: an autoradiographic study, Journal of Pharmacology and Experimental Therapeutics, 275, 1030-4, 1995
  • Perry D C, Wei H, Rosenthal R E, Fiskum G, Autoradiographic analysis of L- and N-type voltage-dependent calcium channel binding in canine brain after global cerebral ischemia/reperfusion., Brain Research, 657(1-2), 65-72, 19 Sep 1994 Abstract
  • Perry D C, Getz R, Lee I Y, Panchison D, Okuda Y, Miller L P, Forebrain ischemia in the gerbil increases lambda opiate binding in hippocampal mossy fibers., Brain Research, 617(2), 296-302, 23 Jul 1993 Abstract
  • Grimm L J, Blendy J A, Kellar K J, Perry D C, Chronic reserpine administration selectively up-regulates beta 1- and alpha 1b-adrenergic receptors in rat brain: an autoradiographic study., Neuroscience, 47(1), 77-86, 1992 Abstract
  • Blendy J A, Perry D C, Pabreza L A, Kellar K J, Electroconvulsive shock increases alpha 1b- but not alpha 1a-adrenoceptor binding sites in rat cerebral cortex., Journal of Neurochemistry, 57(5), 1548-55, November 1991 Abstract
  • Perry D C, Autoradiography of [3H]quipazine in rodent brain., European Journal of Pharmacology, 187(1), 75-85, 2 Oct 1990 Abstract
  • Blendy J A, Grimm L J, Perry D C, West-Johnsrud L, Kellar K J, Electroconvulsive shock differentially increases binding to alpha-1 adrenergic receptor subtypes in discrete regions of rat brain., Journal of Neuroscience, 10(8), 2580-6, August 1990 Abstract

Profile Details

Last Verified: 1/22/2008

COS Expertise ID #329972
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