Dr. James J. Pestka

(Reading, Writing, Speaking)

National Institutes of Health (NIH): Immunotoxic effects of trichothecenes, $1,044,604, 2001 to 2005.
National Institutes of Health (NIH): Dietary lipids and experimental IgA nephropathy, $807,240, 2001 to 2005.
National Institutes of Health (NIH): Endotoxin susceptibility and trichothecene mycotoxins, $780,000, 1999 to 2004.
USDA National Fusarium Head Blight Initiative: Human susceptibility to trichothecene mycotoxins, $300,000, 1999 to 2004.
MSU National Food Safety and Toxicology Center: Rapid detection of staphylococcus thermonuclease, $15,000, 1998 to 1999.
United States Department of Agriculture (USDA): Recombinant antibodies to natural toxicants, $118,000, 1997 to 2000.
MSU Crop and Food Bioprocessing Center: Immunologic approaches to food safety, $180,000, 1996 to 2000.
NIEHS: Effect of trichothecene mycotoxinis on IgA production, $770,000, 1996 to 2001.
National Dairy Council: Effect of Bifidobacterium yogurts on gastrointestinal immunity, $150,000, 1995 to 1998.
United States Department of Agriculture (USDA): Effect of lactic acid bacteria on gastrointestinal immune function, $150,000, 1994 to 1997.
United States Department of Agriculture (USDA): Recombinant antibodies for natural toxicants, $221,000, 1994 to 1997.
National Institute for Environmental Health: Effect of trichothecene mycotoxins on IgA production, $760,000, 1992 to 1996.
MSU Food and Crop Bioprocessing Center Research Excellence Fund: Computer-Aided Multicontaminant Analysis System, $253,000, 1992 to 1996.
Neogen Co.: Unspecified research on immunochemical mycotoxin assay, $32,000, 1991 to 1995.
National Kidney Foundation of Michigan: Vomitoxin-induced IgA Nephropathy, $38,000, 1991 to 1994.
Research Excellence Fund from center for Genetic Optimization of Domestic Animals and Toxicology: TLC-ELISAGRAM - A Multi-metabolite immunoassay: application to mycotoxins, 1990 to 1992.
USDA-ARS/Environmental Toxiccology Center: Immunoassay for Fusarium toxins, $98,000, 1989 to 1994.
NIEHS: Effect of trichothecene mycotoxins on IgA production, $406,538, 1988 to 1992.
AES Biomedical Research Funds: Induction of experimental IgA nephropathy by dietary exposure to the trichothecene vomitoxin, $3,800, 1988 to .
MSU Ag. Expt. Station Toxicology Grant: Vomitoxin-induced modulation of immunoglobulin A synthesis, $23,000, 1987 to 1988.
MSU Biotech. Research Center/MSU Research Excellence Economic Development Fund: Development of homologous transformation systems for A. parasiticus, $70,000, 1987 to 1989.
MSU Biotech Research Center/MSU Research Excellence/Economic Development Fund: Identification and cloning of genes associated with aflatoxin biosynthesis by transformation, $32,000, 1986 to 1987.
MSU Research Excellence/Economic Development Fund: Hybridoma-based diagnostic assays for swine mycotoxicoses, $86,000, 1986 to 1989.
MSU Research Excellence/Economic Development Fund: Hybridoma-based enzyme-linked immunosorbent assay for ergosterol in food products, $5,000, 1986 to 1987.
AES-Biomedical Research Funds: Identification of gene products associated with aflatoxin biosynthesis, $6,800, 1986 to 1987.
AES-Toxicology Funds: Identification of gene products associated with aflatoxin biosynthesis, $13,500, 1986 to 1987.
USDA-AES Animal Health Formula Funds: Hybridoma-based diagnostic assays for swine mycotoxicoses, $14,500, 1986 to 1987.
Institute for Internatinal Agriculture: Young Faculty International Travel Award, $1,500, 1986 to .
MSU Ag. Exp. Station Toxicology Grant: Identification of the gene products associated with aflatoxin biosynthesis, $13,000, 1986 to 1987.
MSU Research Excellence/Economic Development Fund: Funds for installation of biohazard containment equipment and molecular/cell biology equipment, $78,000, 1986 to .
Ex-Cello Co.: A new biotest for aseptic packages, $7,500, 1985 to .
USDA-ARS: Enzyme-linked immunosorbent assays for the detection of the 8-ketotrichothecenes, $58,000, 1985 to 1988.
MSU Environmental Toxicology Center: Studies on the mechanism, early diagnosis and treatment of primary hepatocellular carcinoma in the People's Republic of China, $15,000, 1985 to 1986.
USDA-AES Animal Health: Active and passive immunization against zearalenone mycotoxicoses, $12,500, 1984 to 1985.
MSU Ag. Exp. Station Toxicology Grant: 15-Monoacetyl deoxynivalenol: Role in deoxynivalenol biosynthesis and toxicity, $23,000, 1984 to 1986.
Neogen Co.: Hybridoma test kit for mycotoxins, $410,000, 1984 to 1986.
National Institute for Environmental Health: Immunotoxic effects of vomitoxin and zearalenone, $135,000, 1984 to 1987.
USDA Special Grant: Immunochemical methods for the detection and prevention of swine mycotoxicoses, $79,000, 1983 to 1985.
Kellogg Co.: Immunochemical detection methods for mycotoxins, $12,000, 1983 to .
MSU Agricultural Experiment Station Toxicology Grant: Development of monoclonal antibodies and enzyme linked immunosorbent assays for Fusarium toxins, $13,000, 1982 to .
All university Research Grant: Immunochemical analysis of zearalenone and its application to screening and inactivation studies, $3,000, 1982 to 1983.

• Shi, Y., Pestka, J.J. (2006) Attenuation of mycotoxin-induced IgA nephropathy by eicosapentanoic acid in the mouse: Dose response and relation to IL-6 expression, J. Nutr. Bioch., In Press
• Mbandi, E., Pestka, J.J. (2006) Deoxynivalenol and satratoxin g potentiate proinflammatory cytokine and MIP-2 induction by Listeria and Salmonella in the macrophage, J. Food Prot., In Press
• Islam, Z., Gray, J.S., Pestka, J.J. (2006) P38 mediates IL-8 induction by the ribotoxin deoxynivalenol in human monocytes, Toxicol. Sci., In Press
• Jia, Q., Zhou, H.R., Shi, Y., Pestka, J.J. (2006) Docosahexaenoic acid consumption inhibits deoxynivalenol-induced CREB/ATF1 activation and IL-6 gene transcription in the macrophage of the mouse, J. Nutr., 136 (2), 366-372
• Islam, Z., Pestka, J.J. (2006) LPS priming potentiates and prolongs proinflammatory cytokine response to the trichothecene deoxynivalenol in the mouse, Toxicol. Appl. Pharmacol., 211 (1), 53-63
• Li M, Cuff CF, Pestka J (Sep 2005) Modulation of murine host response to enteric reovirus infection by the trichothecene deoxynivalenol., Toxicological Sciences : an Official Journal of the Society of Toxicology, 87 (1), 134-45
• Kinser S, Li M, Jia Q, Pestka JJ (Feb 2005) Truncated deoxynivalenol-induced splenic immediate early gene response in mice consuming (n-3) polyunsaturated fatty acids., The Journal of Nutritional Biochemistry, 16 (2), 88-95
• Moorman, M., Nettleton, W., Ryser, E., Linz, J., Pestka, J. (2005) Altered sensitivity to a quaternary ammonium sanitizer in stressed Listeria innocua, J. Food Prot., 68 (8), 1659-1663
• Pestka JJ, Uzarski RL, Islam Z (Jan 2005) Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes., Toxicology, 206 (2), 207-19
• Smolinski, A.T., Pestka, J.J. (2005) Comparative effects of the herbal constituent parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver, J. Inflamm. (Lond), 2, 6
• Zhou HR, Islam Z, Pestka JJ (Sep 2005) Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol., Toxicological Sciences : an Official Journal of the Society of Toxicology, 87 (1), 113-22
• Urraca, J.L., ito-Pena, E., Perez-Conde, C., Moreno-Bondi, M.C., Pestka, J.J. (2005) Analysis of zearalenone in cereal and swine feed samples using an automated flow through immunosensor, J. Agric. Food Chem, 53 (9), 3338-3344
• Zhou, H.R., Jia, Q., Pestka, J.J. (2005) Ribotoxic stress response to the trichothecene deoxynivalenol in the macrophage involves the SRC family kinase Hck, Toxicol. Sci., 85 (2), 916-926
• Jia, Q., Pestka, J.J. (2005) Role of cyclooxygenase-2 in deoxynivalenol-induced immuoglobulin a nephropathy, Food Chem. Toxicol., 43 (5), 721-728
• Pestka JJ, Smolinski AT (Jan-Feb 2005) Deoxynivalenol: toxicology and potential effects on humans., Journal of Toxicology and Environmental Health. Part B, Critical Reviews, 8 (1), 39-69
• Pestka JJ, Zhou HR, Moon Y, Chung YJ, Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unraveling a paradox, Toxicology Letters, 153(1), 61-73, Oct 2004
• Harkins JM, Moustaid-Moussa N, Chung YJ, Penner KM, Pestka JJ, North CM, Claycombe KJ (Oct 2004) Expression of interleukin-6 is greater in preadipocytes than in adipocytes of 3T3-L1 cells and C57BL/6J and ob/ob mice., The Journal of Nutrition, 134 (10), 2673-7
• Kinser S, Jia Q, Li M, Laughter A, Cornwell P, Corton JC, Pestka J, Gene expression profiling in spleens of deoxynivalenol-exposed mice: immediate early genes as primary targets, Journal of Toxicology and Environmental Health. Part a, 67(18), 1423-41, Sep 2004
• Jia Q, Shi Y, Bennink MB, Pestka JJ, Docosahexaenoic acid and eicosapentaenoic acid, but not alpha-linolenic acid, suppress deoxynivalenol-induced experimental IgA nephropathy in mice, The Journal of Nutrition, 134(6), 1353-61, 2004
• Gregory L, Pestka JJ, Dearborn DG, Rand TG, Localization of satratoxin-G in Stachybotrys chartarum spores and spore-impacted mouse lung using immunocytochemistry, Toxicologic Pathology, 32(1), 26-34, 2004
• Jia, Q., Zhou, H.R., Bennink, M., Pestka, J.J. (2004) Docosahexaenoic acid attenuates mycotoxin-induced immunoglobulin a nephropathy, interleukin-6 transcription, and mitogen-activated protein kinase phosphorylation in mice, J. Nutr., 134, 3343-3349
• Moon Y, Pestka JJ, Deoxynivalenol-induced mitogen-activated protein kinase phosphorylation and IL-6 expression in mice suppressed by fish oil, The Journal of Nutritional Biochemistry, 14(12), 717-26, 2003
• Chung YJ, Zhou HR, Pestka JJ, Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-alpha expression by deoxynivalenol (vomitoxin), Toxicology and Applied Pharmacology, 193(2), 188-201, 2003
• Goodridge CF, Beaudry RM, Pestka JJ, Smith DM, ELISA for monitoring lipid oxidation in chicken myofibrils through quantification of hexanal-protein adducts, Journal of Agricultural and Food Chemistry, 51(26), 7533-9, 2003
• Uzarski RL, Pestka JJ, Comparative susceptibility of B cells with different lineages to cytotoxicity and apoptosis induction by translational inhibitors, Journal of Toxicology and Environmental Health. Part a, 66(22), 2105-18, 2003
• Smolinski AT, Pestka JJ, Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenol, Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association., 41(10), 1381-90, October 2003
• Uzarski RL, Islam Z, Pestka JJ, Potentiation of trichothecene-induced leukocyte cytotoxicity and apoptosis by TNF-alpha and Fas activation, Chemico-biological Interactions, 146(2), 105-19, October 2003
• Moon Y, Uzarski R, Pestka J, Relationship of trichothecene structure to cox-2 induction in the macrophage: selective action of type B (8-keto) trichothecenes, Journal of Toxicology and Environmental Health. Part a, 66(20), 1967-83, September 2003
• Zhou HR, Lau AS, Pestka JJ, Role of Double-Stranded RNA-Activated Protein Kinase R (PKR) in Deoxynivalenol-Induced Ribotoxic Stress Response, Toxicological Sciences : an Official Journal of the Society of Toxicology., 74(2), 335-44, August 2003
• Islam Z, Pestka JJ, Role of IL-1(beta) in endotoxin potentiation of deoxynivalenol-induced corticosterone response and leukocyte apoptosis in mice, Toxicological Sciences : an Official Journal of the Society of Toxicology., 74(1), 93-102, July 2003
• Goodridge CF, Beaudry RM, Pestka JJ, Smith DM, Solid phase microextraction-gas chromatography for quantifying headspace hexanal above freeze-dried chicken myofibrils, Journal of Agricultural and Food Chemistry, 51(15), 4185-90, July 2003
• Pestka JJ, Deoxynivalenol-induced IgA production and IgA nephropathy-aberrant mucosal immune response with systemic repercussions, Toxicology Letters, 140-141, 287-95, April 2003
• Chung YJ, Yang GH, Islam Z, Pestka JJ, Up-regulation of macrophage inflammatory protein-2 and complement 3A receptor by the trichothecenes deoxynivalenol and satratoxin G, Toxicology, 186(1-2), 51-65, April 2003
• Islam, Z., King, L.E., Fraker, P.J., and Pestka, J.J., Differential induction of glucocorticoid-dependent apoptosis in murine lymphoid subpopulations in vivo following coexposure to lipopolysaccharide and vomitoxin (deoxynivalenol), Toxicol. Appl. Pharmacol., 187(2), 69-79, 1 Mar 2003
• Moon Y, Pestka JJ, Cyclooxygenase-2 mediates interleukin-6 upregulation by vomitoxin (deoxynivalenol) in vitro and in vivo, Toxicology and Applied Pharmacology, 187(2), 80-8, March 2003
• Zhou HR, Islam Z, Pestka JJ, Kinetics of lipopolysaccharide-induced transcription factor activation/inactivation and relation to proinflammatory gene expression in the murine spleen, Toxicology and Applied Pharmacology, 187(3), 147-61, March 2003
• Zhou HR, Islam Z, Pestka JJ, Rapid, sequential activation of mitogen-activated protein kinases and transcription factors precedes proinflammatory cytokine mRNA expression in spleens of mice exposed to the trichothecen, Toxicological Sciences : an Official Journal of the Society of Toxicology., 72(1), 130-42, March 2003
• Islam Z, King LE, Fraker PJ, Pestka JJ, Differential induction of glucocorticoid-dependent apoptosis in murine lymphoid subpopulations in vivo following coexposure to lipopolysaccharide and vomitoxin (deoxynivalenol), Toxicology and Applied Pharmacology, 187(2), 69-79, March 2003
• Chung YJ, Jarvis B, Pestka J, Modulation of lipopolysaccharide-induced proinflammatory cytokine production by satratoxins and other macrocyclic trichothecenes in the murine macrophage, Journal of Toxicology and Environmental Health. Part a, 66(4), 379-91, February 2003
• Moon, Y., and Pestka, J.J., Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases, Toxicol. Sci., 69, 373-382, 2003
• Clifford LJ, Jia Q, Pestka JJ, An improved method for the purification of the trichothecene deoxynivalenol (vomitoxin) from Fusarium graminearum culture, Journal of Agricultural and Food Chemistry, 51(2), 521-3, January 2003
• Pestka JJ, Zhou HR, Effects of tumor necrosis factor type 1 and 2 receptor deficiencies on anorexia, growth and IgA dysregulation in mice exposed to the trichothecene vomitoxin, Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association., 40(11), 1623-31, November 2002
• Moon Y, Pestka JJ, Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases, Toxicological Sciences : an Official Journal of the Society of Toxicology., 69(2), 373-82, October 2002
• Wong SS, Zhou HR, Pestka JJ, Effects of vomitoxin (deoxynivalenol) on the binding of transcription factors AP-1, NF-kappaB, and NF-IL6 in raw 264.7 macrophage cells, Journal of Toxicology and Environmental Health. Part a, 65(16), 1161-80, Aug 2002
• Yang GH, Pestka JJ, Vomitoxin (deoxynivalenol)-mediated inhibition of nuclear protein binding to NRE-A, an IL-2 promoter negative regulatory element, in EL-4 cells, Toxicology, 172(3), 169-79, April 2002
• Islam Z, Moon YS, Zhou HR, King LE, Fraker PJ, Pestka JJ, Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids, Toxicology and Applied Pharmacology, 180(1), 43-55, April 2002
• Pestka JJ, Zhou HR, Jia Q, Timmer AM, Dietary fish oil suppresses experimental immunoglobulin a nephropathy in mice, Journal of Nutrition, 132(2), 261-9, February 2002
• Islam, Z., Moon, Y.S., Zhou, H-R., King, L.E., Fraker, P.J., and Pestka, J.J., Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids, Toxicol. Appl. Pharmacol., 180, 43-55, 2002
• Wong, S.S., Zhou, H-R., and Pestka, J.J., Effects of vomitoxin (deoxynivalenol) on the binding of transcription factors AP-1, NF-eB and NF-IL6 in raw 264.7 macrophage cells, Journal of Toxicology and Environmental Health, 65, 1161-1180, 2002
• Moon, Y., and Pestka, J.J., Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases, Toxicol. Sci., 69, 373-382, 2002
• Pestka, J.J., and Zhou, H.R., Effects of tumor necrosis factor type 1 and 2 receptor deficiencies on anorexia, growth and IgA dysregulation in mice exposed to the trichothecene vomitoxin, Food and Chemical Toxicology, 40, 1623-1631, 2002
• Christensen HR, Frokiaer H, Pestka JJ, Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells, Journal of Immunology (baltimore, Md. : 1950), 168(1), 171-8, January 2002
• Wong SS, Schwartz RC, Pestka JJ, Superinduction of TNF-alpha and IL-6 in macrophages by vomitoxin (deoxynivalenol) modulated by mRNA stabilization, Toxicology, 161(1-2), 139-149, 2001
• Pestka JJ, Ha CL, Warner RW, Lee JH, Ustunol Z, Effects of ingestion of yogurts containing Bifidobacterium and Lactobacillus acidophilus on spleen and Peyer's patch lymphocyte populations in the mouse, Journal of Food Protection, 64(3), 392-395, 2001
• Zhou HR, Harkema JR, Hotchkiss JA, Yan D, Roth RA, Pestka JJ, Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs, Toxicological Sciences, 53(2), 253-263, 2000
• Yuan Q, Hu W, Pestka JJ, He SY, Hart LP, Expression of a functional antizearalenone single-chain Fv antibody in transgenic arabidopsis plants, Applied and Environmental Microbiology, 66, 3499-3505, 2000
• Yang GH, Jarvis BB, Chung YJ, Pestka JJ, Apoptosis induction by the satratoxins and other trichothecene mycotoxins: relationship to ERK, p38 MAPK and SAPK/JNK activation, Toxicology and Applied Pharmacology, 164(2), 149-160, 2000
• Li SG, Ouyang YL, Yang GH, Pestka JJ, Modulation of transcription factor AP-1 in murine EL-4 thymoma cells by vomitoxin (Deoxynivalenol), Toxicology and Applied Pharmacology, 163(1), 17-25, 2000
• Yang GH, Li S, Pestka JJ, Down regulation of 78 ki Da glucose-regulated proteiby vomitoxin (deoxynivalenol) in murine EL-4 thymoma cells, Toxicology and Applied Pharmacology, 162(3), 207-217, 2000
• Pestka JJ, Zhou HR, Interleukin-6-deficient mice refractory to IgA dysregulation but not anorexia induced by vomitoxin (deoxynivalenol) ingestion, Food and Chemical Toxicology, 2000, 565-575, 2000
• Bondy GS, Pestka JJ, Immunomodulation by fungal toxins, Journal Toxicol Environ Health Crit Rev, 3(2), 109-143, 2000
• Banotai C, Greene-McDowelle DM, Azcona-Olivera JI, Pestka JJ, Effects of intermittent vomitoxin exposure on body weight, immunoglobulin levels and hematuria in the B6C3F1 mouse, Food and Chemical Toxicology, 37, 343-350, 2000
• Yuan Q, Pestka JJ, Hespenheide BM, Kuhn LA, Linz JE, Hart LP, Identification of mimotope peptides which bind to the mycotoxin deoxynivalenol-specific monoclonal antibody., Applied and Environmental Microbiology, 65(8), 3279-86, August 1999
• Sprando RL, Pestka JJ, Collins TF, Rorie J, O'Donnell M, Hinton D, Chirtel S, The effect of vomitoxin (deoxynivalenol) on testicular morphology, testicular spermatid counts and epididymal sperm counts in IL-6KO [B6129-IL6 TmlKopf (IL-6 gene deficient)] and WT [B6129F2 (wild typ, Food and Chemical Toxicology, 37(11), 1073-1079, 1999
• Tejada-Simon MV, Lee JH, Ustunol Z, Pestka JJ, Ingestion of yogurt containing lactobacillus acidophilus and bifidobacterium to potentiate immunoglobulin A responses to cholera toxin in mice, Journal of Dairy Science, 82, 649-660, 1999
• Banotai C, Azonca-Olivera JI, Greene-McDowelle DM, Pestka JJ, Effects of vomitoxin ingestion on murine models for systemic lupus erythematosus, Food and Chemical Toxicology, 37, 533-543, 1999
• Byrem TM, Pestka JJ, Chu FS, Analysis and pharmacokinetics of cyclopiazonic acid in market weight pigs, Journal of Animal Science, 77, 173-179, 1999
• Lee MG, Li S, Effects of satratoxins and other macrocyclic trichothecenes on IL-2 production and viability of EL-4 thymoma cells, Journal of Toxicology and Environmental Health, 57, 459-474, 1999
• Park SY, Ji GE, Ko YT, Jung HK, Ustunol Z, Pestka JJ, Potentiation of hydrogen peroxide, nitric oxide, and cytokine production in RAW 264.7 macrophage cells exposed to human and commercial isolates of Bifidobacterium, International Journal Food Microbiol, 46, 231-241, 1999
• Smith SA, Pestka JJ, Gray JI, Smith DM, Production and specificity of polyclonal antibodies to hexanal-lysine adducts, Journal of Agricultural and Food Chemistry, 47, 1389-1395, 1999
• Tejada-Simon MV, Ustunol Z, Pestka JJ, Ex vivo effects of Lactobacilli, Streptococci, and Bifidobacteria ingestion on cytokine and nitric oxide production in a murine model, Journal of Food Protection, 62, 162-169, 1999
• Tejada-Simon MV, Ustunol Z, Pestka JJ, Effects of lactic acid bacteria ingestion on basal cytokine mRNA and immunoglobulin levels in the mouse, Journal of Food Protection, 62, 287-291, 1999
• Zhou HR, Harkema JR, Yan D, Pestka JJ, Amplified proinflammatory cytokine expression and toxicity in mice coexposed to lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol), Journal of Toxicology and Environmental Health, 56, 115-136, 1999
• Ha CL, Lee JH, Zhou HR, Ustunol Z, Pestka JJ, Effects of yogurt ingestion on mucosal and systemic cytokine gene expression in the mouse, Journal of Food Protection, 62, 181-188, 1999
• Tejada-Simon MV, Pestka JJ, Production of polyclonal antibody against ergosterol hemisuccinate using Freund's and Titermax adjuvants, 61(8), 1060-3, August 1998
• Zhou HR, Yan D, Pestka JJ, Induction of cytokine gene expression in mice after repeated and subchronic oral exposure to vomitoxin (Deoxynivalenol): differential toxin-induced hyporesponsiveness and recovery, Toxicology and Applied Pharmacology, 151(2), 347-58, August 1998
• Marin ML, Tejada-Simon MV, Lee JH, Murtha J, Ustunol Z, Pestka JJ, Stimulation of cytokine production in clonal macrophage and T-cell models by Streptococcus thermophilus: comparison with Bifidobacterium sp. and Lactobacillus bulgaricus, 61(7), 859-64, July 1998
• Wong SS, Zhou HR, Marin-Martinez ML, Brooks K, Pestka JJ, Modulation of IL-1beta, IL-6 and TNF-alpha secretion and mRNA expression by the trichothecene vomitoxin in the RAW 264.7 murine macrophage cell line, Food and Chemical Toxicology, 36(5), 409-19, May 1998
• Yan D, Zhou HR, Brooks KH, Pestka JJ, Role of macrophages in elevated IgA and IL-6 production by Peyer's patch cultures following acute oral vomitoxin exposure, Toxicology and Applied Pharmacology, 148(2), 261-73, February 1998
• Ji GE, Park SY, Wong SS, Pestka JJ, Modulation of nitric oxide, hydrogen peroxide and cytokine production in a clonal macrophage model by the trichothecene vomitoxin (deoxynivalenol), Toxicology, 125(2-3), 203-14, February 1998
• Wong SS, Zhou HR, Marin-Martinez ML, Brooks RH, Pestka JJ, Modulation of IL-1 beta, IL-6, and TNF-alpha secretion and mRNA expression by the trichothecene vomitoxin in the RAW 264.7 murine macrophage cell line, Food and Chemical Toxicology, 36, 409-419, 1998
• Yan D, Rumbeiha WK, Pestka JJ, Experimental immune IgA nephropathy following passive administration of vomitoxin-induced IgA monoclonal antibodies, Food and Chemical Toxicology, 36, 1095-1106, 1998
• Tejada-Simon MV, Pestka JJ, Polyclonal antibody production against ergosterol-hemisuccinate using Freund's and Titermax adjuvants, Journal of Food Protection, 61, 1060-1063, 1998
• Marin ML, Tejada-Simon MV, Lee JH, Murtha J, Ustunol Z, Pestka JJ, Stimulation of cytokine production in clonal macrophage and cell models by Streptococcus thermophilus: Comparison with Bifidobacterium sp. and Lactobacillus bulgaricus, Journal of Food Protection, 61, 859-864, 1998
• Roth RA, Harkema JR, Pestka JJ, Ganey PE, Does exposure to bacterial endotoxin determine susceptibility to intoxication from xenobiotic agents?, Toxicology and Applied Pharmacology, 147, 300-311, 1998
• Li S, Ouyang YL, Dong W, Pestka JJ, Superinduction of IL-2 gene expression by vomitoxin (deoxynivalenol) involves increased mRNA stability, Toxicology and Applied Pharmacology, 147(2), 331-42, December 1997
• Marin ML, Lee JH, Murtha J, Ustunol Z, Pestka JJ, Differential cytokine production in clonal macrophage and T-cell lines cultured with bifidobacteria, Journal of Dairy Science, 80(11), 2713-20, November 1997
• Yan D, Zhou HR, Brooks KH, Pestka JJ, Potential role for IL-5 and IL-6 in enhanced IgA secretion by Peyer's patch cells isolated from mice acutely exposed to vomitoxin, Toxicology, 122(1-2), 145-58, September 1997
• Pestka JJ, Mechanisms of trichothecene-induced murine IgA nephropathy, Mucosal Immunology Update, 49-52, September 1997
• Yuan Q, Clarke JR, Zhou HR, Linz JE, Pestka JJ, Hart LP, Molecular cloning, expression, and characterization of a functional single-chain Fv antibody to the mycotoxin zearalenone, Applied and Environmental Microbiology, 63(1), 263-9, January 1997
• Marin ML, Tejada-Simon MV, Murtha J, Ustunol Z, Pestka JJ, Effects of Lactobacillus sp. on cytokine production by RAW 264.7 macrophage and EL-4 thymoma cell lines, Journal of Food Protection, 60, 1364-1370, 1997
• Zhou HR, Yan D, Pestka JJ, Differential cytokine mRNA expression in mice of oral exposure to vomitoxin dose response and time course, Toxicology and Applied Pharmacology, 144, 294-305, 1997
• Smith DM, Desrocher LD, Booren AM, Wang CH, Abouzied MM, Pestka JJ, Veeramuthu GJ, Cooking temperature of turkey ham affects lactate dehydrogenase, serum albumin and immunoglobulin G as determined by ELISA, Journal of Food Science, 61, 209-212 & 234, 1997
• Marin ML, Wong SS, Pestka JJ, Increased IL-1, IL-6 and TNF alpha secretion and mRNA levels in WEHI-3 cells exposed to cyclopiazonic acid, Toxicology, 114(1), 67-79, November 1996
• Ouyang YL, Li S, Pestka JJ, Effects of vomitoxin (deoxynivalenol) on transcription factor NF-kappa B/Rel binding activity in murine EL-4 thymoma and primary CD4 T cells, Toxicology and Applied Pharmacology, 140(2), 328-36, October 1996
• Marin ML, Murtha J, Dong W, Pestka JJ, Effects of mycotoxins on cytokine production and proliferation in EL-4 thymoma cells, Journal of Toxicology and Environmental Health, 48(4), 379-96, July 1996
• Ouyang YL, Azcona-Olivera JI, Murtha J, Pestka JJ, Vomitoxin-mediated IL-2, IL-4, and IL-5 superinduction in murine CD4 T cells stimulated with phorbol ester calcium ionophore: relation to kinetics of proliferation, Toxicology and Applied Pharmacology, 138(2), 324-34, June 1996
• Rotter BA, Prelusky DB, Pestka JJ, Toxicology of deoxynivalenol (vomitoxin), Journal of Toxicology and Environmental Health, 48(1), 1-34, May 1996
• Orta-Ramirez A, Wang CH, Abouzied MM, Veeramutha GJ, Price JF, Pestka JJ, Smith DM, Lactate dehydrogenate monoclonal cooking temperature of ground beef, Journal of Agricultural and Food Chemistry, 44, 4048-4051, 1996
• Zhou HR, Pestka JJ, Hart LP, Development of recombinant phage antibody against fumonisin B1, Journal of Food Protection, 59, 1208-1212, 1996
• Sutikno, Abouzied MM, Azcona-Olivera JI, Hart LP, Pestka JJ, Detection of fumonisiins in Fusarium cultures, corn and corn products by polyclonal antibody-based ELISA; Relation to fumonisin B1 detection by liquid chromatography, Journal of Food Protection, 59, 645-651, 1996
• Wang CH, Abouzied MM, Pestka JJ, Smith DM, Lactate dehydrogenase polyclonal antibody sandwich ELISA for determination of endpoiint heating temperatures of ground beef, Journal of Food Protection, 59, 51-55, 1996
• Ouyang YL, Azcona-Olivera JI, Pestka JJ, Effects of trichothecene structure on cytokine secretion and gene expression in murine CD4 T-cells, Toxicology, 104(1-3), 187-202, December 1995
• Azcona-Olivera JI, Ouyang Y, Murtha J, Chu FS, Pestka JJ, Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition, Toxicology and Applied Pharmacology, 133(1), 109-20, July 1995
• Greene DM, Azcona-Olivera JI, Murtha JM, Pestka JJ, Effects of dihydrotestosterone and estradiol on experimental IgA nephropathy induced by vomitoxin, Fundamental and Applied Toxicology, 26(1), 107-16, June 1995
• Azcona-Olivera JI, Ouyang YL, Warner RL, Linz JE, Pestka JJ, Effects of vomitoxin (deoxynivalenol) and cycloheximide on IL-2, 4, 5 and 6 secretion and mRNA levels in murine CD4 cells, Food and Chemical Toxicology, 33(6), 433-41, June 1995
• Pestka JJ, Yan D, King LE, Flow cytometric analysis of the effects of in vitro exposure to vomitoxin (deoxynivalenol) on apoptosis in murine T, B and IgA+ cells, Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association., 32(12), 1125-36, December 1994
• Greene DM, Azcona-Olivera JI, Pestka JJ, Vomitoxin (deoxynivalenol)-induced IgA nephropathy in the B6C3F1 mouse: dose response and male predilection, Toxicology, 92(1-3), 245-60, September 1994
• Dong W, Azcona-Olivera JI, Brooks KH, Linz JE, Pestka JJ, Elevated gene expression and production of interleukins 2, 4, 5, and 6 during exposure to vomitoxin \(deoxynivalenol\) and cycloheximide in the EL-4 thymoma., Toxicology and Applied Pharmacology, 127(2), 282-90, 1994
• Warner RL, Brooks K, Pestka JJ, In vitro effects of vomitoxin (deoxynivalenol) on T-cell interleukin production and IgA secretion, Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association., 32(7), 617-25, July 1994
• Rasooly L, Pestka JJ, Polyclonal autoreactive IgA increase and mesangial deposition during vomitoxin-induced IgA nephropathy in the BALB/c mouse, Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association., 32(4), 329-36, April 1994
• Rasooly L, Abouzied MM, Brooks KH, Pestka JJ, Polyspecific and autoreactive IgA secreted by hybridomas derived from Peyer's patches of vomitoxin-fed mice: characterization and possible pathogenic role in IgA nephropathy, Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association., 32(4), 337-48, April 1994
• Pestka JJ, Dong W, Progressive serum IgE elevation in the B6C3F1 mouse following withdrawal of dietary vomitoxin (deoxynivalenol), Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology., 22(2), 314-6, February 1994
• Abouzied MM, Azcona-Olivera JI, Yoshizawa T, Pestka JJ, Production of polyclonal antibodies to the trichothecene mycotoxin 4,15-diacetylnivalenol with the carrier-adjuvant cholera toxin, Applied and Environmental Microbiology, 59(5), 1264-8, May 1993
• Pestka JJ, Food, diet, and gastrointestinal immune function, Advances in Food and Nutrition Research, 37, 1-66, 1993
• Minervini F, Dong W, Pestka J, In vitro vomitoxin exposure alters IgA and IgM secretion by CH12LX B cells. Relationship to proliferation and macromolecular synthesis, Mycopathologia, 121(1), 33-40, January 1993
• Dong W, Pestka JJ, Persistent dysregulation of IgA production and IgA nephropathy in the B6C3F1 mouse following withdrawal of dietary vomitoxin (deoxynivalenol), Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology., 20(1), 38-47, January 1993
• Rasooly L, Pestka JJ, Vomitoxin-induced dysregulation of serum IgA, IgM and IgG reactive with gut bacterial and self antigens, Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association., 30(6), 499-504, June 1992
• Brooks KH, Yol YS, Pestka JJ, CD5 expression is modulated as the B cell moves through the cell cycle, Annals of the New York Academy of Sciences, 651, 259-60, May 1992
• Bondy GS, Pestka JJ, Dietary exposure to the trichothecene vomitoxin (deoxynivalenol) stimulates terminal differentiation of Peyer's patch B cells to IgA secreting plasma cells, Toxicology and Applied Pharmacology, 108(3), 520-30, May 1991
• Abouzied MM, Azcona JI, Braselton WE, Pestka JJ, Immunochemical assessment of mycotoxins in 1989 grain foods: evidence for deoxynivalenol (vomitoxin) contamination, Applied and Environmental Microbiology, 57(3), 672-7, March 1991
• Pestka JJ, High performance thin layer chromatography ELISAGRAM. Application of a multi-hapten immunoassay to analysis of the zearalenone and aflatoxin mycotoxin families, Journal of Immunological Methods, 136(2), 177-83, February 1991
• Horng JS, Chang PK, Pestka JJ, Linz JE, Development of a homologous transformation system for Aspergillus parasiticus with the gene encoding nitrate reductase, Molecular & General Genetics : Mgg, 224(2), 294-6, November 1990
• MacDougald OA, Thulin AJ, Weldon WC, Pestka JJ, Fogwell RL, Effects of immunizing gilts against zearalenone on height of vaginal epithelium and urinary excretion of zearalenone, Journal of Animal Science, 68(11), 3713-8, November 1990
• Pestka JJ, Dong W, Warner RL, Rasooly L, Bondy GS, Effect of dietary administration of the trichothecene vomitoxin (deoxynivalenol) on IgA and IgG secretion by Peyer's patch and splenic lymphocytes, Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association., 28(10), 693-9, October 1990
• Pestka JJ, Dong W, Warner RL, Rasooly L, Bondy GS, Brooks KH, Elevated membrane IgA+ and CD4+ (T helper) populations in murine Peyer's patch and splenic lymphocytes during dietary administration of the trichothecene vomitoxin (deoxynivalenol), Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association., 28(6), 409-20, June 1990
• Tai JH, Pestka JJ, T-2 toxin impairment of murine response to Salmonella typhimurium: a histopathologic assessment, Mycopathologia, 109(3), 149-55, March 1990
• MacDougald OA, Thulin AJ, Pestka JJ, Determination of zearalenone and related metabolites in porcine urine by modified enzyme-linked immunosorbent assay, Journal of the Association of Official Analytical Chemists, 73(1), 65-8, 1990
• Chung DH, Abouzied MM, Pestka JJ, Immunochemical assay applied to mycotoxin biosynthesis: ELISA comparison of sterigmatocystin production by Aspergillus versicolor and Aspergillus nidulans, Mycopathologia, 107(2-3), 93-100, September 1989
• Park DL, Miller BM, Hart LP, Yang G, McVey J, Page SW, Pestka J, Brown LH, Enzyme-linked immunosorbent assay for screening aflatoxin B1 in cottonseed products and mixed feed: collaborative study, Journal of the Association of Official Analytical Chemists, 72(2), 326-32, 1989
• Pestka JJ, Enhanced surveillance of foodborne mycotoxins by immunochemical assay, Journal of the Association of Official Analytical Chemists, 71(6), 1075-81, 1988
• Tai JH, Pestka JJ, Synergistic interaction between the trichothecene T-2 toxin and Salmonella typhimurium lipopolysaccharide in C3H/HeN and C3H/HeJ mice, Toxicology Letters, 44(1-2), 191-200, November 1988
• Pestka JJ, Tai JH, Witt MF, Dixon DE, Forsell JH, Suppression of immune response in the B6C3F1 mouse after dietary exposure to the Fusarium mycotoxins deoxynivalenol (vomitoxin) and zearalenone, Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association., 25(4), 297-304, April 1987
• Forsell JH, Jensen R, Tai JH, Witt M, Lin WS, Pestka JJ, Comparison of acute toxicities of deoxynivalenol (vomitoxin) and 15-acetyldeoxynivalenol in the B6C3F1 mouse, Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association., 25(2), 155-62, February 1987
• Ram BP, Hart LP, Shotwell OL, Pestka JJ, Enzyme-linked immunosorbent assay of aflatoxin B1 in naturally contaminated corn and cottonseed, Journal of the Association of Official Analytical Chemists, 69(5), 904-7, 1986
• Gendloff EH, Casale WL, Ram BP, Tai JH, Pestka JJ, Hart LP, Hapten-protein conjugates prepared by the mixed anhydride method. Cross-reactive antibodies in heterologous antisera, Journal of Immunological Methods, 92(1), 15-20, August 1986
• Forsell JH, Witt MF, Tai JH, Jensen R, Pestka JJ, Effects of 8-week exposure of the B6C3F1 mouse to dietary deoxynivalenol (vomitoxin) and zearalenone, Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association., 24(3), 213-9, March 1986
• Wolzak A, Pearson AM, Coleman TH, Pestka JJ, Gray JI, Aflatoxin deposition and clearance in the eggs of laying hens, Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association., 23(12), 1057-61, December 1985
• Forsell JH, Pestka JJ, Relation of 8-ketotrichothecene and zearalenone analog structure to inhibition of mitogen-induced human lymphocyte blastogenesis, Applied and Environmental Microbiology, 50(5), 1304-7, November 1985
• Thompson SS, Naidu YM, Pestka JJ, Ultrastructural localization of an extracellular protease in Pseudomonas fragi by using the peroxidase-antiperoxidase reaction, Applied and Environmental Microbiology, 50(4), 1038-42, October 1985
• Liu MT, Ram BP, Hart LP, Pestka JJ, Indirect enzyme-linked immunosorbent assay for the mycotoxin zearalenone, Applied and Environmental Microbiology, 50(2), 332-6, August 1985
• Forsell JH, Kateley JR, Yoshizawa T, Pestka JJ, Inhibition of mitogen-induced blastogenesis in human lymphocytes by T-2 toxin and its metabolites, Applied and Environmental Microbiology, 49(6), 1523-6, June 1985
• Sawyer CA, Pestka JJ, Foodservice systems: presence of injured bacteria in foods during food product flow, Annual Review of Microbiology, 39, 51-67, 1985
• Delwiche EA, Pestka JJ, Tortorello ML, The veillonellae: gram-negative cocci with a unique physiology, Annual Review of Microbiology, 39, 175-93, 1985
• Chen C, Pearson AM, Coleman TH, Gray JI, Pestka JJ, Aust SD, Tissue deposition and clearance of aflatoxins from broiler chickens fed a contaminated diet, Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association., 22(6), 447-51, June 1984
• Gendloff EH, Pestka JJ, Swanson SP, Hart LP, Detection of T-2 toxin in Fusarium sporotrichioides-infected corn by enzyme-linked immunosorbent assay, Applied and Environmental Microbiology, 47(5), 1161-3, May 1984
• Pestka JJ, Chu FS, Aflatoxin B1 dihydrodiol antibody: production and specificity, Applied and Environmental Microbiology, 47(3), 472-7, March 1984
• Pestka JJ, Beery JT, Chu FS, Indirect immunoperoxidase localization of aflatoxin B1 in rat liver, Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association., 21(1), 41-8, February 1983
• Pestka JJ, Delwiche EA, 2-phosphoglycerate phosphatase and serine biosynthesis in Veillonella alcalescens, Canadian Journal of Microbiology, 27(8), 808-14, August 1981
• Pestka JJ, Li Y, Harder WO, Chu FS, Comparison of radioimmunoassay and enzyme-linked immunosorbent assay for determining aflatoxin M1 in milk, Journal of the Association of Official Analytical Chemists, 64(2), 294-301, March 1981
• Gaur PK, Lau HP, Pestka JJ, Chu FS, Production and characterization of aflatoxin B2a antiserum, Applied and Environmental Microbiology, 41(2), 478-82, February 1981
• Pestka JJ, Gaur PK, Chu FS, Quantitation of aflatoxin B1 and aflatoxin B1 antibody by an enzyme-linked immunosorbent microassay, Applied and Environmental Microbiology, 40(6), 1027-31, December 1980