Dr. Piotr J. Franaszczuk

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Johns Hopkins University
School of Medicine
Neurology
Epilepsy Center
Associate ProfessorAppointed: 2004
Johns Hopkins University
Epilepsy Research Laboratory
Co-director
Professional Headshot of Piotr J. Franaszczuk

Mailing Address

Johns Hopkins Medical Institutions
Meyer 2-147
600 North Wolfe Street
Baltimore, Maryland 21287-7247
United States

Contact Information

Phone: (410) 614-8770
Fax: (410) 955-0751
pfranasz@jhmi.edu

Qualifications

Postdoctoral, University of Maryland at Baltimore, Neurophysiology, 1991.
Ph.D., Warsaw University, Physics, 1988.
M.Sc., Warsaw University, Physics, 1978.

Expertise and Research Interests

I am mainly interested in advanced methods of analysis and modeling of brain activity. My research includes localization and detection of seizure onset in patients with epilepsy, analysis of dynamics of seizure spread in time and space, and modeling of seizure generation and propagation.
I am also interested in analysis of event related potentials recorded from intracranial electrodes especially auditory perception and language processing.

I am developing and implementing computational methods of signal analysis and neural modeling. Methods of EEG signal analysis include multichannel autoregressive modeling, Direct Transfer Function (DTF) method and time-frequency analysis using the Matching Pursuit algorithm. I am using a large (~1,000,000) realistic neuron network model to investigate patterns of propagation of epileptiform activity and its dependence on connectivity and physiological properties of neurons and synapses. Model can accomodate different types of neurons and synapses and is optimized for fast computations on cluster of PCs.

I am also developing a software for datana management and computation of large amounts of data using cluster opf computers.

Other Expertise

Advanced scientific computation using FORTRAN, C, C++, Matlab
Numerical methods of linear algebra (LAPACK, BLAS) and differential equations
Multichannel spectral and coherence time-series analysis alghoritms (AR, FFT)
Multivariate statistical methods:MANOVA,discriminant, cluster analysis using SPSS
Nonlinear dynamical systems: chaos, fractals
Distributed computing on clusters of PCs
Teaching mathematical modeling in biology and medicine, computer programming, basic physics
Distributed computing and data management on computer clusters

Future Research

Modeling of effects of brain stimulation on epileptic brain
Development of software tools for processing of multimodal brain measurements using cluster and blade servers

Industrial Relevance

The realistic modeling of effects of stimulation on brain tisue can speed up the process of testing applicability of brain stimulators in therapy.
The software system for efficient use of multiple computers in multichannel signal processing can lower costs of using advanced signal processing methods in analysis of large amounts of time-series data.

Keywords

COS Keywords:

Bioelectric Phenomena, Biomedical Engineering, Chaos, Computer Programming, Electroencephalography, Epilepsy, Experimental Physics, Mathematical Modeling (Medical), Neurology, Neurophysiology, Neuroscience, Nonlinear Dynamics, Physics.

Additional Terms:

Cluster Computations, Distributed Computing, EEG Analysis, Epileptic Seizure Detection, Epileptic Seizure Prediction, Epileptic Seizure Propagation, Matching Pursuit, Multichannel Autoregressive Modeling, Multichannel Spectral Analysis, Neural Network Modeling, Seizure Onset Localization, Time-Frequency Analysis.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Polish: (Fluent, Fluent, Fluent)
Russian: (Functional, Basic, Functional)

Memberships

American Epilepsy Society
IEEE - Engineering in Medicine and Biology Society (EMBS)
IEEE Signal Processing Society

Honors and Awards

1999-2000, Junior Investigator Award, Epilepsy Foundation, Epilepsy Modeling
1988, Outstanding Ph.D. Thesis, Ministry of Education of Poland, Physics
1984-1988, Award of the President of Warsaw University, Warsaw University, Medical Physics

Previous Positions

1999-2004, Assistant Professor, Johns Hopkins University, School of Medicine, Neurology, Epilepsy Center
1995-1999, Assistant Professor, University of Maryland at Baltimore, Medicine, Neurology
1991-1995, Visiting Assistant Professor, University of Maryland at Baltimore, Medicine, Neurology
1989-1991, Bennett Fellow, University of Maryland at Baltimore, Medicine, Neurology
1988-1996, Assistant Professor, Warsaw University, Faculty of Physics, Institute of Experimental Physics
1981-1988, Research/Teaching Associate, Warsaw University, Faculty of Physics, Institute of Experimental Physics
1981-1982, Research Associate, Military Institute of Aviation Medicine
1978-1980, Research/Teaching Assistant, Warsaw University, Faculty of Physics, Institute of Experimental Physics

Funding Received

  • National Institutes of Health (NIH): A Neural Network Model of Propagation ofEpileptiform Activity, Jul 1, 1999 to Aug 31, 2006.
  • Epilepsy Foundation: A Neural A Neural Network Model of Epileptiform Activity, Apr 1, 1999 to Mar 31, 2000.
  • National Institutes of Health (NIH): Electrocorticographic studies of human cortical function(co-investigator Dr. Crone PI), , 2005 to 2009.
  • National Institutes of Health (NIH): Multichannel Parametric Analysis of Seizure Propagation (co-investigator, Dr. Bergey PI), , 1995 to 2009.

Publications

  • Korzeniewska A, Crainiceanu CM, KuÅ› R, Franaszczuk PJ, Crone NE (Aug 2007) Dynamics of event-related causality in brain electrical activity. Abstract
  • Anderson WS, Kudela P, Cho J, Bergey GK, Franaszczuk PJ (Aug 2007) Studies of stimulus parameters for seizure disruption using neural network simulations., Biological cybernetics, 97 (2), 173-94 Abstract
  • Jouny CC, Adamolekun B, Franaszczuk PJ, Bergey GK (Feb 2007) Intrinsic ictal dynamics at the seizure focus: effects of secondary generalization revealed by complexity measures., Epilepsia, 48 (2), 297-304 Abstract
  • Zygierewicz J, Mazurkiewicz J, Durka PJ, Franaszczuk PJ, Crone NE (Oct 2006) Estimation of short-time cross-correlation between frequency bands of event related EEG., Journal of neuroscience methods, 157 (2), 294-302 Abstract
  • Jouny CC, Franaszczuk PJ, Bergey GK, Signal Complexity and Synchrony of Epileptic Seizures: Is There An Identifiable Preictal Period?, Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology., 116(3), 552-8, Mar 2005 Abstract
  • Yang KH, Franaszczuk PJ, Bergey GK, Inhibition Modifies the Effects of Slow Calcium-activated Potassium Channels on Epileptiform Activity in a Neuronal Network Model., Biological Cybernetics, 92(2), 71-81, Feb 2005 Abstract
  • Zygierewicz J, Durka PJ, Klekowicz H, Franaszczuk PJ, Crone NE, Computationally Efficient Approaches to Calculating Significant ERD/ERS Changes in the Time-frequency Plane, Journal of Neuroscience Methods, 145(1-2), 267-276, 2005
  • Franaszczuk PJ, Jouny CC (2004) Software system for data management and distributed processing of multichannel biomedical signals., Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2, 983-5 Abstract
  • Jouny CC, Franaszczuk PJ, Adamolekun B, Bergey GK (2004) Gabor atom density as a measure of seizure complexity., Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 1, 310-2 Abstract
  • Ray S, Jouny CC, Crone NE, Boatman D, Thakor NV, Franaszczuk PJ, Human ECoG analysis during speech perception using matching pursuit: a comparison between stochastic and dyadic dictionaries, Ieee Transactions On Bio-medical Engineering, 50(12), 1371-3, Dec 2003 Abstract
  • Kudela P, Franaszczuk PJ, Bergey GK, Reduction of intracellular calcium removal rate can explain changes in seizure dynamics: studies in neuronal network models, Epilepsy Research, 57(2-3), 95-109, Dec 2003 Abstract
  • Yang KH, Franaszczuk PJ, Bergey GK, The influences of somatic and dendritic inhibition on bursting patterns in a neuronal circuit model, Biological Cybernetics, 89(4), 242-53, October 2003 Abstract
  • Kudela P, Franaszczuk PJ, Bergey GK, Changing excitation and inhibition in simulated neural networks: effects on induced bursting behavior, Biological Cybernetics, 88(4), 276-85, April 2003 Abstract
  • Jouny CC, Franaszczuk PJ, Bergey GK, Characterization of epileptic seizure dynamics using Gabor atom density, Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology., 114(3), 426-37, March 2003 Abstract
  • Franaszczuk PJ, Kudela P, Bergey GK, External excitatory stimuli can terminate bursting in neural network models, Epilepsy Research, 53(1-2), 65-80, February 2003 Abstract
  • P.Kudela, P.J. Franaszczuk, G.K. Bergey, External termination of recurrent bursting in a model of connected local neural sub-networks, Neurocomputing, 44-46, 897-905, 2002
  • Bergey GK, Franaszczuk PJ, Epileptic seizures are characterized by changing signal complexity, Clinical Neurophysiology, 112(2), 241-9, February 2001 Abstract
  • Franaszczuk PJ, Bergey GK, An autoregressive method for the measurement of synchronization of interictal and ictal EEG signals, Biological Cybernetics, 81(1), 3-9, July 1999 Abstract
  • Kudela P, Franaszczuk PJ, Bergey GK, Model of the propagation of synchronous firing in a reduced neuron network, Neurocomputing, 26-27, 411-418, 1999
  • Franaszczuk PJ, Bergey GK, Application of the directed transfer function method to mesial and lateral onset temporal lobe seizures, Brain Topography, 11(1), 13-21, 1998 Abstract
  • Franaszczuk PJ, Bergey GK, Durka PJ, Eisenberg HM, Time-frequency analysis using the matching pursuit algorithm applied to seizures originating from the mesial temporal lobe, Electroencephalography and Clinical Neurophysiology, 106(6), 513-21, June 1998 Abstract
  • Kudela P, Franaszczuk PJ, Bergey GK, A simple computer model of excitable synaptically connected neurons, Biological Cybernetics, 77(1), 71-7, July 1997 Abstract
  • Kelly EF, Lenz JE, Franaszczuk PJ, Truong YK, A general statistical framework for frequency-domain analysis of EEG topographic structure, Computers and Biomedical Research, 30(2), 129-64, April 1997 Abstract
  • Franaszczuk PJ, Bergey GK, Kudela P, Detection of spontaneous postsynaptic potentials, Computers and Biomedical Research, 28(5), 354-70, October 1995 Abstract
  • Franaszczuk PJ, Bergey GK, Kaminski MJ, Analysis of mesial temporal seizure onset and propagation using the directed transfer function method, Electroencephalography and Clinical Neurophysiology, 91(6), 413-27, December 1994 Abstract
  • Blinowska KJ, Franaszczuk PJ, Kaminski MJ, Parametric methods of EEG Analysis, In: Mathematical approaches to brain functioning diagnostics. Proceedings in Nonlinear Science. Eds. I.Dvorak, A.V.Holden, pp:139-157, 1991
  • Franaszczuk PJ, Mitraszewski P, Blinowska K, FAD-parametric description of EEG time series, Acta Physiologica Polonica, 40(4), 418-22, 1989 Abstract
  • Szelenberger W, Skalski M, Franaszczuk P, Mitraszewski P, Blinowska K, Pharmaco-EEG analysis by means of FFT and FAD, Acta Physiologica Polonica, 40(4), 423-30, 1989 Abstract
  • Blinowska KJ, Kowalczyk M, Franaszczuk PJ, Mitraszewski P, The EEG time series parametrization method in the study of nociception, Acta Neurobiologiae Experimentalis, 49(4), 193-206, 1989 Abstract
  • Blinowska KJ, Franaszczuk PJ, A Model of the Generation of Electrocortical Rhythms, In: Brain Dynamics:Progress and Perspectives. Springer Series in Brain Dynamics 2. Eds. E.Basar, T.H. Bullock. Springer-Verlag Berlin Heidelberg, pp:192-201, 1989
  • Leszczynski KW, Franaszczuk PJ, Penczek PA, Alternative reconstruction algorithm for NMR imaging, Medical and Biological Engineering and Computing, 26(2), 186-92, March 1988 Abstract
  • Blinowska KJ, Franaszczuk PJ, Mitraszewski P, A new method of presentation of the average spectral properties of the EEG time series, International Journal of Bio-medical Computing, 22(2), 97-106, March 1988 Abstract
  • Mitraszewski P, Blinowska KJ, Franaszczuk PJ, Kowalczyk M, A study of stability of electrocortical rhythm generators, Biological Cybernetics, 56(4), 255-60, 1987 Abstract
  • Franaszczuk PJ, Blinowska KJ, Linear model of brain electrical activity--EEG as a superposition of damped oscillatory modes, Biological Cybernetics, 53(1), 19-25, 1985 Abstract
  • Franaszczuk PJ, Blinowska KJ, Kowalczyk M, The application of parametric multichannel spectral estimates in the study of electrical brain activity, Biological Cybernetics, 51(4), 239-47, 1985 Abstract
  • Blinowska KJ, Czerwosz LT, Drabik W, Franaszczuk PJ, Ekiert H, EEG data reduction by means of autoregressive representation and discriminant analysis procedures, Electroencephalography and Clinical Neurophysiology, 51(6), 650-8, June 1981 Abstract

Profile Details

Last Updated: 3/12/2008

COS Expertise ID #693028
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