Dr. Ananda S. Prasad

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Wayne State University
School of Medicine
Hematology-Oncology
Distinguished ProfessorAppointed: 2000
Wayne State University
School of Medicine
Center for Molecular Medicine and Genetics
Adjunct FacultyAppointed: 1998
Professional Headshot of Ananda S. Prasad

Mailing Address

Wayne State University
1122 Elliman
421 East Canfield
Detroit, Michigan 48201-2194
United States

Contact Information

Phone: (313) 577-1597
Fax: (313) 577-1128
aa2704@wayne.edu

Qualifications

Ph.D., University of Minnesota, Internal Medicine, 1957.
Fellowship and Residency, University of Minnesota, 1956.
Internship, Patna Medical College Hospital, 1952.
Residency, St. Paul's Hospital, Dallas, Texas, Pathology, 1952.
M.B.B.S., Patna University, 1951.
B.S., Patna University, 1946.

Expertise and Research Interests

Trace elements: Zinc, Copper and Iron
Lymphocyte functions
Atomic absorption spectrophotometer
Varian, Ins.; Zinc enzymes
FPLC; Cell culture

Other Expertise

Editor, Trace Elements in Experimental Medicine, 1988-2005
Editor, American Journal of Hematology, 1976-2006
Invited Speaker:
Role of Zinc in Human Health, Department of Pharmaceutic Sciences, Wayne State University of Medicine, Detroit, MI January 28, 2004.
Zinc in Human Health: It's Role in Immunitty, Department of Internal Medicine, Gastroenterology, Wayne State University School of Medicine, Veterans Administration Bldg., Detroit, MI Mrach 10, 2004.
Discovery of Human Zinc Deficiency, 22nd Annual Convention- Aiimsonians of America, Troy, MI, August 15, 2004.
President D'Honneur Guest Speaker, Dietary antioxidants: Trace elements, vitamins and polyphenos- Functional and clinical aspects in Humans. 4th International Meeting. Monastir, Tunisia, April 16-20, 2005.
21st Conference of the European section of the International Commission on the Anthropology of Food. Oxford Brookes University, Headington, Oxford, United Kingdom. June 2-3 2005.
Turkish Academy of Sciences. Istanbul, Turkey, October 3, 2005.
Prasad, A.S. Inviated Guest Speaker, Society for International Nutrition Research Symposium at Experimental Biology-2006, San Francisco, CA, April 2, 2006.
Prasad, A.S. Invited Guest Speaker; Zinc Signals. Abbazia di MonteOliveto, Italy. September 16-21, 2006.
Prasad, A.S. Invited Guest Speaker. American Society of Hematology, Orlando, Florida. december 9-12, 2006
Prasad, A.S. Invited Guest Speaker, Zincage. Ancona, Italy, January 15-17, 2007.
Prasad, A.S. Invited Guest Speaker,UNESCO, Paris, France, January 26, 2007.
Prasad, A.S. Invited Guest Speaker, Zinc Signals, Houston, Texas, May 5-6 2007

Future Research

My major current research interest is in the field of Trace Elements, particularly Zinc. We are involved in studying the role of zinc in cell mediated immune functions in cell culture models and primary cells from humans.

Keywords

COS Keywords:

Cell Culture, Hematology, Internal Medicine, Iron, Metals Or Alloys, Nutrition Or Dietetics, Zinc.

Additional Terms:

Copper, Hematology, Internal Medicine, Iron, Nutrition, Trace Elements, Zinc, Zinc and Immunity.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Hindi: (Fluent, Fluent, Fluent)

Memberships

American Association for the Advancement of Science (Fellow)
American College of Nutrition (Master)
American College of Physicians (Master)
American Society for Clinical Investigation
American Society for Clinical Nutrition
American Society for Nutritional Sciences (Fellow)
Association of American Physicians
International Society for Trace Element Research in Humans
National Heart, Lung, and Blood Institute ( Member of Council, 2002-2004)

Honors and Awards

2007, American College of Physcians Award for Outstanding Work in Science as Related to Medicine, American College of Physicians
2006, Zinc Consultant, Bill and Melinda Gates Foundation
2005, Appointed to the Advisory Councl for Asisan and Pacific Affairs, Council for Asian and Pacific Affairs
2003, Outstanding and Inspiring Leadership Award, Consul General of India, Dr. Prasad's Landmark discovery of the essentiality of zinc for human nutrition and that nutritional deficiency of zinc with serious health consequences was widely prevalent.
2003, Inducted in to the Heritage Hall of Fame, International Institute Foundation
2002, Honorable Member of Russian Society of Trace Elements in Medicine, Russian Federation, Moscow
2001, Klaus Schwarz Medal, International Association of Bioinorganic Scientists, Salt Lake City
2000, Turkish Academy of Sciences Award, Ankara, Turkey
2000, Elected as corresponding member of the European Academy of Sciences, Arts and Humanities
1999, Doctor Honoris Causat Claude Bernard University, Lyon, France
1997, Pioneer Award in Sickle Cell Research, National Heart, Lung and Blood Institute, NIH
1993, Michigan Laureate Award, American College of Physicians
1992, Elected to Academy of Scholars, Wayne State University
1989, Medal of Honor, Lyon, France
1989, Raulin Award, International Society for Trace Elements Research in Humans (ISTERH)
1988, Gopalan Oration Gold Medal, Nutrition Society of India
1986, Distinguished Faculty Fellowship Award, Wayne State University
1984, Robert H. Herman Award, American Society of Clinical Nutrition
1983-1994, Hoffman-La Roche Lecture, Canadian Society of Nutritional Sciences
1976, American College of Nutrition Award, Montreal
1975, Goldberger Award American Medical Association
1964, Research Recognition Award, Wayne State University
1960, Honorary Professor of Medicine, University of Shiraz, Iran
2007, Asian Academy Hall of Distinction Award, Asian Leaders Association

Previous Positions

2003, Director of Research, Division of Hematology-Oncology, Wayne State University School of Medicine, Detroit, Michigan
2000, Distinguished Professor Of Medicine, Division of Hematology-Oncology, Wayne State University School of Medicine, Detroit, Michigan
1968-1984, Professor, Wayne State University, Karmanos Cancer Institue, Medicine
1964-1968, Associate Professor, Wayne State University, Medicine, Hematology
1963-1984, Director Division of Hematology, Wayne State University, Medicine, Hematology
1963-1964, Assistant Professor, Wayne State University, Medicine, Hematology
1961-1963, Assistant Professor, Vanderbilt University, Medicine in Nutrition
1958-1960, Visiting Professor, University of Shiraz
1957-1958, Instructor, University of Minnesota, Medicine

Funding Received

  • National Institute of Allergy and Infectious Diseases: Zinc Deficiency and Th1 Functions: Molecular Mechanisms, $1,250,000, 2002 to 2006.
  • Karmanos Cancer Institute, Virtual Discovery Grant: Analytical Cytometry, 20,000, 1999 to 2001.
  • National Cancer Institute/National Institutes of Health: Zinc Supplementation in Head and Neck Cancer Patients, $292,563, 1998 to 2001.
  • Cancer Treatment Research Foundation: Zinc Supplementation Trial of Patients with Head/Neck Cancer, $207,724, 1997 to 2001.
  • George Eby Research: Zinc Acetate Lozenges for Treating the Common Cold, $150,000, 1997 to .
  • Labcatal Laboratories: Zinc Supplementation Study in the Elderly, $81,000, 1995 to 2001.
  • Food and Drug Administration: Clinical Trial of Zinc in Sickle Cell Anemia, $291,109, 1993 to 1997.
  • National Institutes of Health/NIDDK: Zinc Status and Immunological Effects, (Subproject of Program Project entitled Rehabilitation of Patients with Head and Neck Cancer, R. Mathog, Principal Investigator), $415,597, 1992 to 1996.
  • Veterans Administration Merit Review: Nutritional and Metabolic Study on Zinc and Other Micronutrients, $165,295, 1990 to 1992.
  • Food and Drug Administration: Clinical Trial of Zinc in Sickle Cell Anemia, $285,014, 1989 to 1992.
  • Labcatal Laboratories: Zinc Supplementation Study in the Elderly, $180,000, 1988 to 1995.
  • Veterans Administration Merit Review: Nutritional & Metabolic Study on Zinc and other Micronutrients, $222,565, 1987 to 1990.
  • W.K. Kellogg Foundation: A Model Health Promotion and Intervention Program for Urban Middle Aged and Elderly Americans, $1,066,666, 1987 to 1991.
  • National Institutes of Health/NIDDK: Absorption, Turnover & Biochemical Studies of Zinc in Man, $548,369, 1987 to 1991.
  • National Institutes of Health National Heart, Blood and Lung Institute: Metabolic & Renal Studies in Sickle Cell Anemia Subjects, $397,543, 1983 to 1986.
  • National Institutes of Health National Heart, Blood and Lung Institute: Adult Comprehensive Patient Care System, $197,978, 1983 to 1986.
  • Veterans Administration Merit Review: Nutritional & Metabolic Study on Zinc and other Micronutrients, $119,700, 1983 to 1986.
  • National Institutes of Health/NIDDK: Absorption, Turnover & Biochemical Studies of Zinc in Man, $415,700, 1982 to 1985.
  • U.S. Department of Agriculture: Human Requirements of Zinc, $150,000, 1979 to 1982.
  • National Institutes of Health National Heart, Blood and Lung Institute: Requirement of Zinc in Man, $82,467, 1977 to 1980.
  • Food and Drug Administration: Experimental Zinc Deficiency in Man, $377,000, 1974 to 1978.
  • Veterans Administration: Studies on Zinc Metabolism, $431,655, 1974 to 1982.
  • National Institutes of Health National Heart, Blood and Lung Institute: Studies in Sickle Cell Disease, $407,722, 1972 to 1975.
  • National Institutes of Health National Heart, Blood and Lung Institute: Interaction of Contraceptive Steroids with Essential Dietary Nutrients, $193,845, 1972 to 1976.
  • National Institutes of Health National Heart, Blood and Lung Institute: Nutritional and Metabolic Studies on Zinc, $124,316, 1968 to 1970.
  • Michigan Cancer Foundation: Study of Dysproteinemias Associated with Malignant Diseases, $15,000, 1967 to 1968.
  • American Cancer Society: Study of Pure Serum Protein Fractions, $15,703, 1966 to 1967.
  • Detroit General Hospital Research Corporation: SH Groups of Protein Fractions, $14,895, 1965 to 1967.
  • Nutrition Foundation: Studies on Zinc Metabolism, $14,000, 1965 to 1967.
  • National Institutes of Health; Arthritis, Metabolic Diseases: Studies on Zinc Metabolism, $420,000, 1963 to 1970.

Publications

  • Prasad A.S. (2007) The Role of Zinc in Human Health, Academy of Turkish Sciences
  • Prasad, A.S., Beck, F.W.J., Bao, B., Fitzgerald, J.T., Snell, D.C., Steinberg, J.D., Cardozo, L.J (2007) Zinc supplementation decreases incidence of infections in the elderly: Effect of zinc on generation of cytokines and oxidative stress, American Journal of Clinical Nutrition, 85 (3), 837-844
  • Prasad, A.S. (2007) Zinc: Mechanisms of Host Defense, Journal of Nutrition, 137, 1345-1349
  • Prasad A.S. (2007) The first thirty years of the American Journal of Hematology: My recollections., American Journal of Hematology, 82, 253-254
  • Beck,F.W.J., Li,Y.,Bao, B., Prasad, A.S., Sarker, F.H. (2006) Evidence for reprogramming global gene expression during zinc deficiency in the HUT-78 cell line, Nutrition, 22(10), 1045-1056
  • Meftah, S.P., Kuivaniemi, H. Tromp, G., Kerkeni, A., Sfar, M.T., Ayadi, A.,.,Prasad, A.S. (2006) A new mutation in exon 3 of the SCL39A4 Gene in a Tunisian family with severe acrodermatitis enteropathica, Nutrition, 22 (10), 1067-1070
  • Bao, B., Prasad, A.S., Beck, F.W.J., Suneja A., Sarkar, F.H. (2006) Toxic effect of zinc on NF-kappa beta IL-2, IL-2 receptor alpha, and TNF-alpha in HUT-78 (Th0) cells., Toxicology Letters, 166, 222-228
  • Prasad A.S., Bao, B., Beck, F.W.J., Sarkar, F.H. (2006) Correction of IL-2 gene expression by in vitro zinc addition to MNC from zinc deficient human subjects: A specific test for zinc deficiency in humans, Translation Research, 148 (6), 325-333
  • Ananda S. Prasad, Bin Bao, Frances W.J.Beck, Omer Kucuk and Fazlul H. Sarkar, Antioxidant Effect of Zinc in Humans, Free Radical Biology & Medicine, Elsevier Inc., 37(8), 1182-1190, 1 Jul 2004
  • Prasad, A.S., Bao, B., Beck, F.W.J., Kucuk, O., Sarkar, F.H. (2004) Antioxidant effect of zinc in humans, Free Rad. Bio. Med, 37 (8), 1182-1190
  • Beck, F.W.J., Prasad, A.S.;Butler, C.E., Sakr, W.A., Kucuk, O., Sarkar, F.H. (2004) Differential expression of hZnT-4 in human prostate tissues, The Prostate, 58 (374), 381
  • Prasad A.S. (2004) Zinc deficiency: Its characterization and treatment, Metal Ions in Bilogical Systems, A. Sigel, H. Sigel(Eds.) Marcel Dekker, Inc., 201-211 pages (bookchapter)
  • Bao,B., Prasad, A.S., Beck, F.W.J., Godmere,M., Zinc modulates mRNA levels of IL-2 and IFN-y positively in HUT-78 and D1.1 cells and negatively mRNA levels of TNF-alpha, IL-1 beta and IL-8 in HL-60 cells, American Journal of Physiology-Endocrinology and Metabolism, 285, E1095-1102, November 2003
  • Beck, F.W.J., Prasad, A.S., Butler, C.E., Sakr,W.A., Kucuk,O., Sarkar,F.H.., Differential expression of hZnT-4 in human prostate tissues, Prostate, 2003
  • Prasad,A.S., Discovery of zinc deficiency in humans: Forty years later, BMJ, 326, 409-410, 2003
  • Prasad,A.S., Zinc deficiency: Its characterization and treatment. In: Metal Ions in Bilogical Systems, A. Sigel, H. Sigel (Eds.) Marcel Dekker, Inc., New York, N.Y, 102-137, 2003
  • Kucuk O., Prasad A.S. (2003) Nutrients, phytochemicals, and squamous cell carcinoma of the head and neck, Head and Neck Cancer Emerging Perspectives, San Diego, California, Academic Press, 201-211 pages (bookchapter)
  • Prasad, A.S.,Bao, B., Beck, F.W.J., Sarkar, F.H., Zinc enhances the expression of IL-2 and IL-2 receptors in HUT-78 cells via NF-kB activation, Laboratory and Clinical Medicine, 140(4), 272-289, 2002
  • Prasad, A.S. Kucuk,O., Zinc in cancer prevention, Cancer and Metastasis Reviews, 21, 291-295, 2002
  • Prasad,A.S., Zinc deficiency in Sickle Cell Disease, The American Journal of Clinical Nutrition, 75(2), 181-182, 2002
  • Prasad,A.S., Zinc in Health and Disease, Kuwait Medical Journal, 34(2), 91-93, 2002
  • Prasad, A.S. (2002) Infection and Immune Functions, Nutrition and Immune Function, New York, CABI Publishing, 193-207 pages (bookchapter)
  • Prasad AS, Bao B, Beck FWJ, Sarkar FH, Zinc activates NF-kB in HUT-78 cells, Journal of Laboratory and Clinical Medicine, 138, :250-255, 2001
  • Bao B, Lee DY, Prasad AS, Isolation and characterization of mammary cDNA differentially expressed in lethal mild mutation mice, Journal of Trace Elements in Experimental Medicine, 14, 371-382, 2001
  • Prasad,A.S., Recognition of zinc-deficiency syndrome, Nutrition, 17, 67-69, 2001
  • Prasad A.S, Fitzgerald JT, Bao B, Beck WJ, Chadrasekar PH, Duration of symptoms and levels of plasam cytokines, Annals of Internal Medicine, 133, 245-252, 2000
  • Prasad, A.S. (2000) Trace Element in Human Health and Disease: An Update, Vol. 13, New York, Wiley-Liss
  • Kucuk O., Prasad, A.S. Nutrients, phytochemicals, and squamous cell carcinoma of the head and neck (2000) Head and Neck Cancer Emerging Perspectives, Nutrients, phytochemicals, and squamous cell carcinoma of the head and neck, San Diego, California, J.F. ensley, J.S. Gutkind, J.R. Jacobs, S.M. Lippman, Kucuk O.., Prasad, A.S., 201-211 pages, ISBN=Academic Pres (bookchapter)
  • Prasad AS, Beck FW, Kaplan J, Chandrasekar PH, Ortega J, Fitzgerald JT, Swerdlow P, Effect of zinc supplementation on incidence of infections and hospital admissions in sickle cell disease (SCD), American Journal of Hematology, 61(3), 194-202, July 1999
  • Mantzoros C S, Prasad A S, Beck F W, Grabowski S, Kaplan J, Adair C, Brewer G J, Zinc may regulate serum leptin concentrations in humans., Journal of The American College of Nutrition, 17(3), 270-5, June 1998 Abstract
  • Doerr T D, Marks S C, Shamsa F H, Mathog R H, Prasad A S, Effects of zinc and nutritional status on clinical outcomes in head and neck cancer., Nutrition, 14(6), 489-95, June 1998 Abstract
  • Doerr T D, Prasad A S, Marks S C, Beck F W, Shamsa F H, Penny H S, Mathog R H, Zinc deficiency in head and neck cancer patients, Journal of The American College of Nutrition, 16(5), 418-22, October 1997 Abstract
  • Doerr TD, Prasad AS, Marks SC, Beck FW, Shamsa FH, Penny HS, Mathog RH, Zinc deficiency in head and neck cancer patients, Journal of the American College of Nutrition, 16(5), 418-22, October 1997 Abstract
  • Beck F W, Kaplan J, Fine N, Handschu W, Prasad A S, Decreased expression of CD73 (ecto-5'-nucleotidase) in the CD8+ subset is associated with zinc deficiency in human patients [see comments], Journal of Laboratory and Clinical Medicine, 130(2), 147-56, August 1997 Abstract
  • Beck F W, Prasad A S, Kaplan J, Fitzgerald J T, Brewer G J, Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans., American Journal of Physiology, 272(6 Pt 1), E1002-7, June 1997 Abstract
  • Prasad A S, Kaplan J, Beck F W, Penny H S, Shamsa F H, Salwen W A, Marks S C, Mathog R H, Trace elements in head and neck cancer patients: zinc status and immunologic functions., Otolaryngology - Head and Neck Surgery, 116(6 Pt 1), 624-9, June 1997 Abstract
  • Prasad A S, Beck F W, Grabowski S M, Kaplan J, Mathog R H, Zinc deficiency: changes in cytokine production and T-cell subpopulations in patients with head and neck cancer and in noncancer subjects., Proceedings of The Association of American Physicians, 109(1), 68-77, January 1997 Abstract
  • Prasad A S, Beck F W, Endre L, Handschu W, Kukuruga M, Kumar G, Zinc deficiency affects cell cycle and deoxythymidine kinase gene expression in HUT-78 cells, Journal of Laboratory and Clinical Medicine, 128(1), 51-60, July 1996 Abstract
  • Prasad A S, Mantzoros C S, Beck F W, Hess J W, Brewer G J, Zinc status and serum testosterone levels of healthy adults., Nutrition, 12(5), 344-8, May 1996 Abstract
  • Prasad A S, Zinc deficiency in women, infants and children., Journal of The American College of Nutrition, 15(2), 113-20, April 1996 Abstract
  • Prasad A S, Zinc: an overview., Nutrition, 11(1 Suppl), 93-9, January 1995 Abstract
  • Lee D Y, Prasad A S, Hydrick-Adair C, Brewer G, Johnson P E, Homeostasis of zinc in marginal human zinc deficiency: role of absorption and endogenous excretion of zinc., Journal of Laboratory and Clinical Medicine, 122(5), 549-56, November 1993 Abstract
  • Prasad A S, Zinc in human health and disease., Journal of The Association of Physicians of India, 41(8), 519-21, August 1993 Abstract
  • Prasad A S, Fitzgerald J T, Hess J W, Kaplan J, Pelen F, Dardenne M, Zinc deficiency in elderly patients., Nutrition, 9(3), 218-24, May 1993 Abstract
  • Prasad A S, Essentiality and toxicity of zinc., Scandinavian Journal of Work, Environment and Health, 19 Suppl 1, 134-6, 1993 Abstract
  • Prasad A S, Marginal deficiency of zinc and immunological effects., Progress In Clinical and Biological Research, 380, 1-22, 1993 Abstract
  • Dardenne M, Pleau J M, Savino W, Prasad A S, Bach J F, Biochemical and biological aspects of the interaction between thymulin and zinc., Progress In Clinical and Biological Research, 380, 23-32, 1993 Abstract
  • Prasad A S, Role of zinc in human health., Boletin - Asociacion Medica De Puerto Rico, 83(12), 558-60, December 1991 Abstract
  • Meftah S, Prasad A S, Lee D Y, Brewer G J, Ecto 5' nucleotidase (5'NT) as a sensitive indicator of human zinc deficiency., Journal of Laboratory and Clinical Medicine, 118(4), 309-16, October 1991 Abstract
  • Prasad A, Day G P, Tobey R G, New methods of evaluation of compatible metal-ceramic alloys, Dental Labor, 39(10), 1403-6, 1409-11, October 1991 Abstract
  • Prasad A S, Discovery of human zinc deficiency and studies in an experimental human model., American Journal of Clinical Nutrition, 53(2), 403-12, February 1991 Abstract
  • Cossack Z T, Prasad A S, Activities of purine catabolism related enzymes in zinc deficiency: relationship to T-lymphocyte dysfunction and hyperammonemia., International Journal for Vitamin and Nutrition Research, 61(1), 51-6, 1991 Abstract
  • Prasad,A.S., Coppor, iron and zinc in human metabolism, Encyclopedia of Human Biology, 2, 649-660, 1991
  • Prasad A.S., Miale A, Jr., Farid Z, Sandstead HH, Schulert AR., Landmark Article, 'Clinical and experimental zinc metabolism in patients with syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism and hypogonadism', Journal of Laboratory and Clinical Medicine, Nov 1990
  • Lee H H, Hill G M, Sikha V K, Brewer G J, Prasad A S, Owyang C, Pancreaticobiliary secretion of zinc and copper in normal persons and patients with Wilson's disease., Journal of Laboratory and Clinical Medicine, 116(3), 283-8, September 1990 Abstract
  • Prasad, AS, Miale A, Farid Z, Sandstead HH, Schulert AR, Citation Classic, 'Zinc Metabolism in Patients with the Syndrome of Iron Deficiency Anemia, hepato-plenomegaly, Dwarfism, and Hypogonadism', Current Contents, 18 Sep 1989
  • Sandstead HH, Prasad AS, Schulert AR, Farid Z, Miale A, Bassilly S, Darby WJ, Citation Classic, 'Human Zinc Deficiency, Endocrine Manifestations and Response to Treatment', Current Contents, 17 Apr 1989
  • Prasad A S, Clinical and biochemical manifestations of zinc deficiency in human subjects., Journal of The American College of Nutrition, 4(1), 65-72, 1985 Abstract
  • Prasad AS, Halsted JA, Nadimi M, Nutrition Classic, 'Syndrome of Iron Deficiency Anemia, Hepatosplenomegaly, Hypogonadism, Dwarfism and Geophagia', Nutrition Reviews, July 1983

Profile Details

Last Updated: 3/11/2008

COS Expertise ID #398745
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