Dr. Ananda S. Prasad

(Reading, Writing, Speaking)

National Institute of Allergy and Infectious Diseases: Zinc Deficiency and Th1 Functions: Molecular Mechanisms, $1,250,000, 2002 to 2006.
Karmanos Cancer Institute, Virtual Discovery Grant: Analytical Cytometry, 20,000, 1999 to 2001.
National Cancer Institute/National Institutes of Health: Zinc Supplementation in Head and Neck Cancer Patients, $292,563, 1998 to 2001.
Cancer Treatment Research Foundation: Zinc Supplementation Trial of Patients with Head/Neck Cancer, $207,724, 1997 to 2001.
George Eby Research: Zinc Acetate Lozenges for Treating the Common Cold, $150,000, 1997 to .
Labcatal Laboratories: Zinc Supplementation Study in the Elderly, $81,000, 1995 to 2001.
Food and Drug Administration: Clinical Trial of Zinc in Sickle Cell Anemia, $291,109, 1993 to 1997.
National Institutes of Health/NIDDK: Zinc Status and Immunological Effects, (Subproject of Program Project entitled Rehabilitation of Patients with Head and Neck Cancer, R. Mathog, Principal Investigator), $415,597, 1992 to 1996.
Veterans Administration Merit Review: Nutritional and Metabolic Study on Zinc and Other Micronutrients, $165,295, 1990 to 1992.
Food and Drug Administration: Clinical Trial of Zinc in Sickle Cell Anemia, $285,014, 1989 to 1992.
Labcatal Laboratories: Zinc Supplementation Study in the Elderly, $180,000, 1988 to 1995.
Veterans Administration Merit Review: Nutritional & Metabolic Study on Zinc and other Micronutrients, $222,565, 1987 to 1990.
W.K. Kellogg Foundation: A Model Health Promotion and Intervention Program for Urban Middle Aged and Elderly Americans, $1,066,666, 1987 to 1991.
National Institutes of Health/NIDDK: Absorption, Turnover & Biochemical Studies of Zinc in Man, $548,369, 1987 to 1991.
National Institutes of Health National Heart, Blood and Lung Institute: Metabolic & Renal Studies in Sickle Cell Anemia Subjects, $397,543, 1983 to 1986.
National Institutes of Health National Heart, Blood and Lung Institute: Adult Comprehensive Patient Care System, $197,978, 1983 to 1986.
Veterans Administration Merit Review: Nutritional & Metabolic Study on Zinc and other Micronutrients, $119,700, 1983 to 1986.
National Institutes of Health/NIDDK: Absorption, Turnover & Biochemical Studies of Zinc in Man, $415,700, 1982 to 1985.
U.S. Department of Agriculture: Human Requirements of Zinc, $150,000, 1979 to 1982.
National Institutes of Health National Heart, Blood and Lung Institute: Requirement of Zinc in Man, $82,467, 1977 to 1980.
Food and Drug Administration: Experimental Zinc Deficiency in Man, $377,000, 1974 to 1978.
Veterans Administration: Studies on Zinc Metabolism, $431,655, 1974 to 1982.
National Institutes of Health National Heart, Blood and Lung Institute: Studies in Sickle Cell Disease, $407,722, 1972 to 1975.
National Institutes of Health National Heart, Blood and Lung Institute: Interaction of Contraceptive Steroids with Essential Dietary Nutrients, $193,845, 1972 to 1976.
National Institutes of Health National Heart, Blood and Lung Institute: Nutritional and Metabolic Studies on Zinc, $124,316, 1968 to 1970.
Michigan Cancer Foundation: Study of Dysproteinemias Associated with Malignant Diseases, $15,000, 1967 to 1968.
American Cancer Society: Study of Pure Serum Protein Fractions, $15,703, 1966 to 1967.
Detroit General Hospital Research Corporation: SH Groups of Protein Fractions, $14,895, 1965 to 1967.
Nutrition Foundation: Studies on Zinc Metabolism, $14,000, 1965 to 1967.
National Institutes of Health; Arthritis, Metabolic Diseases: Studies on Zinc Metabolism, $420,000, 1963 to 1970.

• Prasad A.S. (2007) The Role of Zinc in Human Health, Academy of Turkish Sciences
• Prasad A.S. (2007) The first thirty years of the American Journal of Hematology: My recollections., American Journal of Hematology, 82, 253-254
• Prasad, A.S. (2007) Zinc: Mechanisms of Host Defense, Journal of Nutrition, 137, 1345-1349
• Prasad, A.S., Beck, F.W.J., Bao, B., Fitzgerald, J.T., Snell, D.C., Steinberg, J.D., Cardozo, L.J (2007) Zinc supplementation decreases incidence of infections in the elderly: Effect of zinc on generation of cytokines and oxidative stress, American Journal of Clinical Nutrition, 85 (3), 837-844
• Prasad A.S., Bao, B., Beck, F.W.J., Sarkar, F.H. (2006) Correction of IL-2 gene expression by in vitro zinc addition to MNC from zinc deficient human subjects: A specific test for zinc deficiency in humans, Translation Research, 148 (6), 325-333
• Bao, B., Prasad, A.S., Beck, F.W.J., Suneja A., Sarkar, F.H. (2006) Toxic effect of zinc on NF-kappa beta IL-2, IL-2 receptor alpha, and TNF-alpha in HUT-78 (Th0) cells., Toxicology Letters, 166, 222-228
• Meftah, S.P., Kuivaniemi, H. Tromp, G., Kerkeni, A., Sfar, M.T., Ayadi, A.,.,Prasad, A.S. (2006) A new mutation in exon 3 of the SCL39A4 Gene in a Tunisian family with severe acrodermatitis enteropathica, Nutrition, 22 (10), 1067-1070
• Beck,F.W.J., Li,Y.,Bao, B., Prasad, A.S., Sarker, F.H. (2006) Evidence for reprogramming global gene expression during zinc deficiency in the HUT-78 cell line, Nutrition, 22(10), 1045-1056
• Ananda S. Prasad, Bin Bao, Frances W.J.Beck, Omer Kucuk and Fazlul H. Sarkar, Antioxidant Effect of Zinc in Humans, Free Radical Biology & Medicine, Elsevier Inc., 37(8), 1182-1190, 1 Jul 2004
• Prasad, A.S., Bao, B., Beck, F.W.J., Kucuk, O., Sarkar, F.H. (2004) Antioxidant effect of zinc in humans, Free Rad. Bio. Med, 37 (8), 1182-1190
• Beck, F.W.J., Prasad, A.S.;Butler, C.E., Sakr, W.A., Kucuk, O., Sarkar, F.H. (2004) Differential expression of hZnT-4 in human prostate tissues, The Prostate, 58 (374), 381
• Prasad A.S. (2004) Zinc deficiency: Its characterization and treatment, Metal Ions in Bilogical Systems, A. Sigel, H. Sigel(Eds.) Marcel Dekker, Inc., 201-211 pages (bookchapter)
• Bao,B., Prasad, A.S., Beck, F.W.J., Godmere,M., Zinc modulates mRNA levels of IL-2 and IFN-y positively in HUT-78 and D1.1 cells and negatively mRNA levels of TNF-alpha, IL-1 beta and IL-8 in HL-60 cells, American Journal of Physiology-Endocrinology and Metabolism, 285, E1095-1102, November 2003
• Beck, F.W.J., Prasad, A.S., Butler, C.E., Sakr,W.A., Kucuk,O., Sarkar,F.H.., Differential expression of hZnT-4 in human prostate tissues, Prostate, 2003
• Prasad,A.S., Discovery of zinc deficiency in humans: Forty years later, BMJ, 326, 409-410, 2003
• Prasad,A.S., Zinc deficiency: Its characterization and treatment. In: Metal Ions in Bilogical Systems, A. Sigel, H. Sigel (Eds.) Marcel Dekker, Inc., New York, N.Y, 102-137, 2003
• Kucuk O., Prasad A.S. (2003) Nutrients, phytochemicals, and squamous cell carcinoma of the head and neck, Head and Neck Cancer Emerging Perspectives, San Diego, California, Academic Press, 201-211 pages (bookchapter)
• Prasad, A.S.,Bao, B., Beck, F.W.J., Sarkar, F.H., Zinc enhances the expression of IL-2 and IL-2 receptors in HUT-78 cells via NF-kB activation, Laboratory and Clinical Medicine, 140(4), 272-289, 2002
• Prasad, A.S. Kucuk,O., Zinc in cancer prevention, Cancer and Metastasis Reviews, 21, 291-295, 2002
• Prasad,A.S., Zinc deficiency in Sickle Cell Disease, The American Journal of Clinical Nutrition, 75(2), 181-182, 2002
• Prasad,A.S., Zinc in Health and Disease, Kuwait Medical Journal, 34(2), 91-93, 2002
• Prasad, A.S. (2002) Infection and Immune Functions, Nutrition and Immune Function, New York, CABI Publishing, 193-207 pages (bookchapter)
• Prasad AS, Bao B, Beck FWJ, Sarkar FH, Zinc activates NF-kB in HUT-78 cells, Journal of Laboratory and Clinical Medicine, 138, :250-255, 2001
• Bao B, Lee DY, Prasad AS, Isolation and characterization of mammary cDNA differentially expressed in lethal mild mutation mice, Journal of Trace Elements in Experimental Medicine, 14, 371-382, 2001
• Prasad,A.S., Recognition of zinc-deficiency syndrome, Nutrition, 17, 67-69, 2001
• Prasad A.S, Fitzgerald JT, Bao B, Beck WJ, Chadrasekar PH, Duration of symptoms and levels of plasam cytokines, Annals of Internal Medicine, 133, 245-252, 2000
• Prasad, A.S. (2000) Trace Element in Human Health and Disease: An Update, Vol. 13, New York, Wiley-Liss
• Kucuk O., Prasad, A.S. Nutrients, phytochemicals, and squamous cell carcinoma of the head and neck (2000) Head and Neck Cancer Emerging Perspectives, Nutrients, phytochemicals, and squamous cell carcinoma of the head and neck, San Diego, California, J.F. ensley, J.S. Gutkind, J.R. Jacobs, S.M. Lippman, Kucuk O.., Prasad, A.S., 201-211 pages, ISBN=Academic Pres (bookchapter)
• Prasad AS, Beck FW, Kaplan J, Chandrasekar PH, Ortega J, Fitzgerald JT, Swerdlow P, Effect of zinc supplementation on incidence of infections and hospital admissions in sickle cell disease (SCD), American Journal of Hematology, 61(3), 194-202, July 1999
• Mantzoros C S, Prasad A S, Beck F W, Grabowski S, Kaplan J, Adair C, Brewer G J, Zinc may regulate serum leptin concentrations in humans., Journal of The American College of Nutrition, 17(3), 270-5, June 1998
• Doerr T D, Marks S C, Shamsa F H, Mathog R H, Prasad A S, Effects of zinc and nutritional status on clinical outcomes in head and neck cancer., Nutrition, 14(6), 489-95, June 1998
• Doerr T D, Prasad A S, Marks S C, Beck F W, Shamsa F H, Penny H S, Mathog R H, Zinc deficiency in head and neck cancer patients, Journal of The American College of Nutrition, 16(5), 418-22, October 1997
• Doerr TD, Prasad AS, Marks SC, Beck FW, Shamsa FH, Penny HS, Mathog RH, Zinc deficiency in head and neck cancer patients, Journal of the American College of Nutrition, 16(5), 418-22, October 1997
• Beck F W, Kaplan J, Fine N, Handschu W, Prasad A S, Decreased expression of CD73 (ecto-5'-nucleotidase) in the CD8+ subset is associated with zinc deficiency in human patients [see comments], Journal of Laboratory and Clinical Medicine, 130(2), 147-56, August 1997
• Beck F W, Prasad A S, Kaplan J, Fitzgerald J T, Brewer G J, Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans., American Journal of Physiology, 272(6 Pt 1), E1002-7, June 1997
• Prasad A S, Kaplan J, Beck F W, Penny H S, Shamsa F H, Salwen W A, Marks S C, Mathog R H, Trace elements in head and neck cancer patients: zinc status and immunologic functions., Otolaryngology - Head and Neck Surgery, 116(6 Pt 1), 624-9, June 1997
• Prasad A S, Beck F W, Grabowski S M, Kaplan J, Mathog R H, Zinc deficiency: changes in cytokine production and T-cell subpopulations in patients with head and neck cancer and in noncancer subjects., Proceedings of The Association of American Physicians, 109(1), 68-77, January 1997
• Prasad A S, Beck F W, Endre L, Handschu W, Kukuruga M, Kumar G, Zinc deficiency affects cell cycle and deoxythymidine kinase gene expression in HUT-78 cells, Journal of Laboratory and Clinical Medicine, 128(1), 51-60, July 1996
• Prasad A S, Mantzoros C S, Beck F W, Hess J W, Brewer G J, Zinc status and serum testosterone levels of healthy adults., Nutrition, 12(5), 344-8, May 1996
• Prasad A S, Zinc deficiency in women, infants and children., Journal of The American College of Nutrition, 15(2), 113-20, April 1996
• Prasad A S, Zinc: an overview., Nutrition, 11(1 Suppl), 93-9, January 1995
• Lee D Y, Prasad A S, Hydrick-Adair C, Brewer G, Johnson P E, Homeostasis of zinc in marginal human zinc deficiency: role of absorption and endogenous excretion of zinc., Journal of Laboratory and Clinical Medicine, 122(5), 549-56, November 1993
• Prasad A S, Zinc in human health and disease., Journal of The Association of Physicians of India, 41(8), 519-21, August 1993
• Prasad A S, Fitzgerald J T, Hess J W, Kaplan J, Pelen F, Dardenne M, Zinc deficiency in elderly patients., Nutrition, 9(3), 218-24, May 1993
• Prasad A S, Essentiality and toxicity of zinc., Scandinavian Journal of Work, Environment and Health, 19 Suppl 1, 134-6, 1993
• Prasad A S, Marginal deficiency of zinc and immunological effects., Progress In Clinical and Biological Research, 380, 1-22, 1993
• Dardenne M, Pleau J M, Savino W, Prasad A S, Bach J F, Biochemical and biological aspects of the interaction between thymulin and zinc., Progress In Clinical and Biological Research, 380, 23-32, 1993
• Prasad A S, Role of zinc in human health., Boletin - Asociacion Medica De Puerto Rico, 83(12), 558-60, December 1991
• Meftah S, Prasad A S, Lee D Y, Brewer G J, Ecto 5' nucleotidase (5'NT) as a sensitive indicator of human zinc deficiency., Journal of Laboratory and Clinical Medicine, 118(4), 309-16, October 1991
• Prasad A, Day G P, Tobey R G, New methods of evaluation of compatible metal-ceramic alloys, Dental Labor, 39(10), 1403-6, 1409-11, October 1991
• Prasad A S, Discovery of human zinc deficiency and studies in an experimental human model., American Journal of Clinical Nutrition, 53(2), 403-12, February 1991
• Cossack Z T, Prasad A S, Activities of purine catabolism related enzymes in zinc deficiency: relationship to T-lymphocyte dysfunction and hyperammonemia., International Journal for Vitamin and Nutrition Research, 61(1), 51-6, 1991
• Prasad,A.S., Coppor, iron and zinc in human metabolism, Encyclopedia of Human Biology, 2, 649-660, 1991
• Prasad A.S., Miale A, Jr., Farid Z, Sandstead HH, Schulert AR., Landmark Article, 'Clinical and experimental zinc metabolism in patients with syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism and hypogonadism', Journal of Laboratory and Clinical Medicine, Nov 1990
• Lee H H, Hill G M, Sikha V K, Brewer G J, Prasad A S, Owyang C, Pancreaticobiliary secretion of zinc and copper in normal persons and patients with Wilson's disease., Journal of Laboratory and Clinical Medicine, 116(3), 283-8, September 1990
• Prasad, AS, Miale A, Farid Z, Sandstead HH, Schulert AR, Citation Classic, 'Zinc Metabolism in Patients with the Syndrome of Iron Deficiency Anemia, hepato-plenomegaly, Dwarfism, and Hypogonadism', Current Contents, 18 Sep 1989
• Sandstead HH, Prasad AS, Schulert AR, Farid Z, Miale A, Bassilly S, Darby WJ, Citation Classic, 'Human Zinc Deficiency, Endocrine Manifestations and Response to Treatment', Current Contents, 17 Apr 1989
• Prasad A S, Clinical and biochemical manifestations of zinc deficiency in human subjects., Journal of The American College of Nutrition, 4(1), 65-72, 1985
• Prasad AS, Halsted JA, Nadimi M, Nutrition Classic, 'Syndrome of Iron Deficiency Anemia, Hepatosplenomegaly, Hypogonadism, Dwarfism and Geophagia', Nutrition Reviews, July 1983