Dr. Paul A. Romitti

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University of Iowa
College of Public Health
Epidemiology
Associate ProfessorAppointed: 2007
University of Iowa
College of Public Health
Iowa Registry for Congenital and Inherited Disorders
DirectorAppointed: 1999
Professional Headshot of Paul A. Romitti

Mailing Address

C21-E GH
200 Hawkins Drive
Iowa City, Iowa 52242
United States

Contact Information

Phone: (319) 384-5012
Fax: (319) 384-5004
paul-romitti@uiowa.edu
http://www.public-health.uiowa.edu/faculty-staff/faculty/directory/faculty-detail.asp?emailAddress=paul-romitti@uiowa.edu

Qualifications

Postdoctoral Fellow, University of Iowa, Molecular Epidemiology, 2000.
Ph.D., University of Iowa, Epidemiology, 1994.

Expertise and Research Interests

Behavioral (e.g., alcohol and tobacco) and environmental (e.g., pesticides) epidemiology of congenital and inherited disorders
Molecular epidemiology of congenital and inherited disorders
Surveillance for congenital and inherited disorers


Birth Defects/Developmental Disabilities
Molecular genetic epidemiology of cleft lip and palate
Center of excellence to investigate genetic and environmental component of birth defects
Trisomy 21: risk factors for chromosome nondisjunction

Cancer
Effect of cervical cancer on pregnancy outcome
Methods to identify affected relative pairs using SEER registries

Reproductive Health
Parental pesticide exposures and pregnancy outcomes
Examination of reproductive outcomes among female greenhouse workers: a feasibility study
Genetic and environmental risk factors for uterine leiomyomas

Other Expertise

Birth defect surveillance
Molecular epidemiology studies

Future Research

Prospective studies of pregnancy outcomes

Keywords

COS Keywords:

Birth or Congenital Defects, Cancer or Carcinogenesis, Craniofacial Disorders, Down Syndrome, Epidemiology, Lung Cancer, Molecular Epidemiology, Public Health, Reproductive Health Services.

Additional Terms:

Alcohol, Genetics, Pharmacoepidemiology, Tobacco.

Memberships

American Cleft Palate-Craniofacial Association
American Public Health Association
American Society of Human Genetics
International Epidemiological Association
International Genetic Epidemiology Society
International Society for Pharmacoepidemiology
International Society of Environmental Epidemiology
Iowa Public Health Association
Research Society on Alcoholism
Society for Epidemiologic Research
Society for Pediatric and Perinatal Epidemiology

Honors and Awards

2007, Service Award, College of Public Health, University of Iowa
2003-2007, Pediatric Research Loan Repayment Award, National Institute of Environmental Health Sciences
1997, Individual National Research Service, National Institute for Dental and Craniofacial Research
1994, Student Workshop, Society for Epidemiologic Research

Previous Positions

2000-2007, Assistant Professor, University of Iowa, College of Public Health, Epidemiology
1998-2000, Associate, University of Iowa, Carver College of Medicine, Preventive Medicine and Environmental Health

Funding Received

  • CDC/NCBDDD: Center of Excellence for Birth Defects Research and Prevention, $4,130,707, Sep 2002 to 2009.
  • NIH/NCI: Expanding surveillance of risk and prognostic factors - PI, $144,997, Sep 2000 to Sep 2002.
  • NIH/NIEHS: Comprehensive sequence evaluation of cleft lip and palate - co-investigator, $3,420,787, Sep 2000 to Sep 2005.
  • NIH/NCI: Methods to identify affected relative pairs using SEER registries - co-PI, $171,416, Oct 1997 to Sep 2000.
  • NIH/NCI: Effect of cervical cancer on pregnancy outcome - investigator, $58,718, Oct 1996 to Sep 1999.
  • CDC: Center of excellence to investigate genetic and environmental components of birth defects - co-investigator, $2,994,123, Oct 1996 to Sep 2001.
  • NIH/NICHD: Trisomy 21: Risk factors for chromosome nondisjunction - Iowa Center - PI, $347,988, Jun 2000 to May 2005.
  • NIH/NIDCR: The genetic epidemiology of orofacial clefts - PI, $95,300, Jun 1997 to Jun 2000.
  • University of Iowa/CHEEC: Evaluation of family hisotry information provided by maternal telephone interview - investigator, $15,000, Jan 1992 to Dec 1992.
  • University of Iowa/EHSRC: Examination of reproductive outcomes among female greenhouse workers: A feasibility study - PI, $6,680, Apr 2000 to Mar 2001.
  • University of Iowa/ EHSRC: Genetic determinants of lung cancer: a feasibiity study - co-investigator, $14,988, Apr 1998 to Mar 2000.
  • CDC/NCBDDD: Iowa Newborn Screening Surveillance Project, Iowa PI, $264,399, 2008 to 2009.
  • AAMC/CDC: Multi-State, Population-Based Evaluation of Birth Defects and Risk for Cancer, Co-I, $45,485, 2008 to 2009.
  • CDC: Health Outcomes and Improved Phenotypic Characterization of Cleft Lip and Palate, Co-I, $1,119,921, 2007 to 2008.
  • CDC/Mt Sinai School of Medicine: Population Study of Craniosynostois, PI, $258,504, 2007 to 2010.
  • NIH/Texas A&M: Nitrates, Nitrites and Nifrosatable Drugs and Risk of Selected Birth Defects, Co-I, $212,501, 2007 to 2011.
  • CDC/NCBDDD: Surveillance and Epidemiology of Duchenne and Becker Muscular Dystrophy, $3,012,952, 2006 to 2011.
  • NIH/NINR: Survival and Prevalence of Children Born with Down Syndrome and Spina Bifida in 10 Regions of the US - Junior Core Faculty, $1,086,071, 2006 to 2011.
  • CDC/NCBDDD: New York Surveillance and Epidemiology of Duchenne and Becker Muscular Dystrophy - PI, $174,867, 2006 to 2011.
  • NIH/NINR: Postdoctoral Training in Clinical Genetics Research - Junior Core Faculty, $1,086,071, 2006 to 2011.
  • NIH/NINDS: Muscular Dystrophy Cooperative Research Center - Co-Investigator, $4,888,975, 2005 to 2010.
  • HCCC: The Influence of Pregnancy during the Preclinical Stage of Breast Cancer on Tumor Characteristics and Mortality in Iowa Women - Co-Investigator, $10,000, 2005 to 2006.
  • CDC/NCBDDD: Iowa Stillbirth Surveillance Project - PI, $629,334, 2005 to 2010.
  • NIH/NIDCR: Molecular genetic epidemiology of cleft lip and palate - co-investigator, $2,475,750, 2004 to 2009.
  • NFFR: Follow-up Study for Children Affected by Craniofacial Malformation to Assess Access to Services, Impact on the Family and Long-term Outcomes - PI, $350,891, 2004 to 2007.
  • State of Iowa/Birth Certificate Revenue: Birth Defects Surveillance - Iowa Center for Congenital and Inherited Disorders - PI, $416,011, 2004 to 2009.
  • CDC: National Birth Defects Prevention Study: New York - PI, $789,766, 2004 to 2009.
  • University of Iowa/CHEEC: Parental pesticide exposure and pregnancy outcomes. Phase I: Evaluation of self-reports of pregnancy - Co-PI, $25,000, 2003 to 2005.

Publications

  • Allen EG, Freeman SB, Druschel C, Hobbs CA, O'Leary LA, Romitti PA, Royle MH, Torfs CP, Sherman SL (Feb 2009) Maternal age and risk for trisomy 21 assessed by the origin of chromosome nondisjunction: a report from the Atlanta and National Down Syndrome Projects., Human genetics, 125 (1), 41-52 Abstract
  • Rocheleau CM, Romitti PA, Dennis LK (Feb 2009) Pesticides and hypospadias: a meta-analysis., Journal of pediatric urology, 5 (1), 17-24 Abstract
  • Browne ML, Rasmussen SA, Hoyt AT, Wallker DK, Druschel CM, Caton AR, Canfield MA, Lin AE, Carmichael SL, Romitti PA, and the National Birth Defects Prevention Study (2009) Carmichael SL, Romitti PA, and the National Birth Defects Prevention Study. Maternal thyroid disease, thyroid medication use and selected birth defects in the National Birth Defects Prevention Study, Birth Defects Res Part A Clin Mol Teratol, In Press
  • MacLehose RF, Olshan AF, Herring AH, Honein MA, Shaw GM, Romitti PA, and the National Birth Defect Prevention Study (2009) Shaw GM, Romitti PA, and the National Birth Defects Prevention Study. (2009) Bayesian methods for misclassification correction: an example from birth defects epidemiology, Epidemiology, 20, 27-35
  • Kancherla V, Romitti PA, Damiano PC, Tyler MC, Druschel CM, Robbins JM, Kizelnik-Freilich S (2009) Maternal reports of satisfaction with care and outcomes for children with microtia, Plast Recontr Surg, In Press
  • Wong-Gibbons DL, Kancherla V, Romitti PA, Tyler MC, Damiano PC, Druschel CM, Robbins JM, Kizelnik-Freilich S, Burnett W (Jan 2009) Maternal reports of satisfaction with care and outcomes for children with craniosynostosis., The Journal of craniofacial surgery, 20 (1), 138-42 Abstract
  • Cunniff C, Andrews J, Meaney FJ, Mathews KD, Matthews D, Ciafaloni E, Miller TM, Bodensteiner JB, Miller LA, James KA, Druschel CM, Romitti PA, Pandya S (Dec 2008) Mutation Analysis in a Population-Based Cohort of Boys With Duchenne or Becker Muscular Dystrophy., Journal of child neurology Abstract
  • Freeman SB, Druschel CM, Hobbs CA, Romitti PA, Royle MH, Torfs CP, Sherman SL (2008) Congenital gastrointestinal defects in Down Syndrome: a report from the National Down Syndrome Project, Clin Genet
  • Wong-Gibbons DL, Romitti PA, Sun L, Moore CA, Reefhuis J, Bell EM, Olshan AF (Nov 2008) Maternal periconceptional exposure to cigarette smoking and alcohol and esophageal atresia +/- tracheo-esophageal fistula., Birth defects research. Part A, Clinical and molecular teratology, 82 (11), 776-84 Abstract
  • Rocheleau CM, Romitti PA, Dennis LK (2008) Pesticides and hypospadias: A meta-analysis, Journal of Pediatric Urology
  • Waller DK, Correa A, Vo TM, Wang Y, Hobbs C, Langlois PH, Pearson K, Romitti PA, Shaw GM, Hecht JT (Sep 2008) The population-based prevalence of achondroplasia and thanatophoric dysplasia in selected regions of the US., American journal of medical genetics. Part A, 146A (18), 2385-9 Abstract
  • Lin S, Munsie JP, Herdt-Losavio ML, Bell E, Druschel C, Romitti PA, Olney R (Jul 2008) Maternal asthma medication use and the risk of gastroschisis., American journal of epidemiology, 168 (1), 73-9 Abstract
  • Malik S, Cleves MA, Honein MA, Romitti PA, Botto LD, Yang S, Hobbs CA (Apr 2008) Maternal smoking and congenital heart defects., Pediatrics, 121 (4), e810-6 Abstract
  • Freeman SB, Bean LH, Allen EG, Tinker SW, Locke AE, Druschel C, Hobbs CA, Romitti PA, Royle MH, Torfs CP, Dooley KJ, Sherman SL (Mar 2008) Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project., Genetics in medicine : official journal of the American College of Medical Genetics, 10 (3), 173-80 Abstract
  • Carter TC, Druschel CM, Romitti PA, Bell EM, Werler MM, Mitchell AA (Feb 2008) Antifungal drugs and the risk of selected birth defects., American journal of obstetrics and gynecology, 198 (2), 191.e1-7 Abstract
  • Damiano P, Tyler M, Romitti PA, Druschel C, Austin AA, Burnett W, Kizelnik-Freilich S, Robbins JM (2008) Demographic characteristics, care and outcomes for children with oral clefts in three states using participants from the National Birth Defects Prevention Study, Cleft Palate Craniofac J, In Press
  • Green RF, Olney RS, Reefhuis J, Botto LD, Romitti PA (Jan 2008) Maternal reports of family history from the National Birth Defects Prevention Study, 1997-2001., Genetics in medicine : official journal of the American College of Medical Genetics, 10 (1), 37-45 Abstract
  • Caton AR, Bell EM, Druschel CM, Werler MM, Mitchell AA, Browne ML, McNutt LA, Romitti PA, Olney RS, Correa A (Jan 2008) Maternal hypertension, antihypertensive medication use, and the risk of severe hypospadias., Birth defects research. Part A, Clinical and molecular teratology, 82 (1), 34-40 Abstract
  • Romitti PA, Sun L, Honein MA, Reefhuis, Correa A, Rasmussen SA, The National Birth Defects Prevention Study. (2007) Maternal periconceptional alcohol consumption and risk of orofacial clefts, Am J Epidemiol, 166 (7), 775-85
  • Romitti PA (2007) Utility of family history reports of major birth defects as a public health strategy, Pediatrics, 120 (Supple 2), S71-7
  • Damiano PC, Tyler MC, Romitti PA, Momany ET, Jones MP, Canady JW, Karnell MP, Murray JC (2007) Health-related quality of life among preadolescent children with oral clefts: the mother's perspective, Pediatrics, 120 (2), e283-90
  • Browne ML, Bell EM, Druschel CM, Gensburg LJ, Mitchell AA, Lin AE, Romitti PA, Correa A (Jul 2007) Maternal caffeine consumption and risk of cardiovascular malformations., Birth defects research. Part A, Clinical and molecular teratology, 79 (7), 533-43 Abstract
  • Honein MA, Rasmussen SA, Reefhuis J, Romitti PA, Lammer EJ, Sun L, Correa A (Mar 2007) Maternal smoking and environmental tobacco smoke exposure and the risk of orofacial clefts., Epidemiology (Cambridge, Mass.), 18 (2), 226-33 Abstract
  • Freeman SB, Allen EG, Oxford-Wright CL, Tinker S, Druschel C, Hobbs CA, O'Leary LA, Romitti PA, Royle MH, Torfs CT, Sherman SL (2007) The National Down Snydrome project: design and implementation, Public Health Rep, 122, 67-72
  • Bitsko R, Reefhuis J, Romitti PA, Moore C (2007) Periconceptional intake of vitamins containing folic acid and risk for multiple congential anomalies, Iowa, 1993-1995, Am JH Med Genetics A, 143, 2397-2405
  • Romitti PA, Herring AM, Dennis LK, Wong-Gibbons DL (2007) Meta-analysis: Pesticides and orofacial clefts, Cleft Palate-Craniofacial Journal, 44 (4), 358-65
  • Shi M, Christensen K, Weinberg CR, Romitti P, Bathum L, Lozada A, Morris RW, Lovett M, Murray JC (2007) Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants, Am J Hum Genet, 80 (1), 76-90
  • Miller LA, Romitti PA, Cunniff C, Druschel C, Mathews KD, Meaney FJ, Matthews D, Kantamneni J, Feng ZF, Zemblidge N, Miller TM, Andrews J, Fox D, Ciafaloni E, Pandya S, Montgomery A, Kenneson A (Nov 2006) The muscular Dystrophy Surveillance Tracking and Research Network (MD STARnet): surveillance methodology., Birth defects research. Part A, Clinical and molecular teratology, 76 (11), 793-7 Abstract
  • Damiano PC, Tyler MC, Romitti PA, Momany ET, Canady JW, Karnell MP, Murray JC (2006) Type of oral cleft and mothers' perceptions of care, health status, and outcomes for preadolescent children, Cleft Palate Craniofac J, 43 (6), 715-21
  • Warrington A, Vieira AR, Christensen K, Orioli IM, Castilla EE, Romitti PA (2006) Genetic evidence for the role of loci at 19q13 in cleft lip and palate, J Med Genet, 43 (6), 26
  • Olson CK, Keppler-Noreuil KM, Romitti PA, Budelier WT, Ryan G, Sparks AE, Van Voorhis BJ (Nov 2005) In vitro fertilization is associated with an increase in major birth defects., 84 (5), 1308-15
  • Hanke W, Romitti P, Fuortes L, Sobala W, Mikulski M, The use of pesticides in a Polish rural population and its effect on birth weight, International Archives of Occupational and Environmental Health, 76(8), 614-20, October 2003
  • Shi M, Caprau D, Romitti PA, Christensen K, Murray JC, Genotype frequencies and linkage disequilibrium in the CEPH human diversity panel for variants in folate pathway genes MTHFR, MTHFD, MTRR, RFC1, and GCP2, Birth Defects Research, 67(8), 545-9, August 2003
  • Jezewski PA, Vieira AR, Nishimura C, Ludwig B, Johnson M, O'Brien SE, Daack-Hirsch S, Schultz RE, Weber A, Nepomucena B, Romitti PA, Christensen K, Orioli IM, Castilla EE, Machida J, Natsume N, Murray JC, Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate, Journal of Medical Genetics, 40(6), 399-407, June 2003 Abstract
  • Vieira AR, Romitti PA, Orioli IM, Castilla EE, Inheritance of cleft palate in South America: Evidence for a major locus recessive, Orthod Craniofacial Res, 6, 83-7, 2003
  • Rasmussen SA, Lammer EJ, Shaw GM, Finnell RH, McGehee RE Jr, Gallagher M, Romitti PA, Murray JC, National Birth Defects Prevention Study, Integration of DNA sample collection into a multi-site birth defects case-control study, Teratology, 66(4), 177-84, October 2002 Abstract
  • Barrow LL, Wines ME, Romitti PA, Holdener BC, Murray JC, Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate evaluation for human orofacial clefts, Teratology, 66(2), 85-90, Aug 2002 Abstract
  • Van Voorhis BJ, Romitti PA, Jones MP, Family history as a risk factor for development of uterine leiomyomas. Results of a pilot study, The Journal of Reproductive Medicine, 47(8), 663-9, Aug 2002 Abstract
  • Yoon PW, Rasmussen SA, Lynberg MC, Moore CA, Anderka M, Carmichael SL, Costa P, Druschel C, Hobbs CA, Romitti PA, Langlois P, Edmonds LD and the National Birth Defects Prevention Study, The National Birth Defects Prevention Study, Public Health Reports, 116(Supp), 32-40, 2001
  • Rohrer JE, Saleh SS, Rohland BM, Romitti PA, Telepsychiatry: Acceptability to a rural population, Psychiatr Serv, 51, 672-4, 2000
  • Bauer EP, Romitti PA, Reynolds SJ, Evaluation of reports of periconceptual occupational exposure: maternal-assessed versus industrial hygienist-assessed exposure, American Journal of Industrial Medicine, 36(5), 573-8, November 1999 Abstract
  • Romitti PA, Lidral AC, Munger RG, Daack-Hirsch S, Burns TL, Murray JC, Candidate genes for nonsyndromic cleft lip and palate and maternal cigarette smoking and alcohol consumption: evaluation of genotype-environment interactions from a population-based case-control study, Teratology, 59(1), 39-50, Jan 1999 Abstract
  • Lidral AC, Romitti PA, Basart AM, Doetschman T, Leysens NJ, Daack-Hirsch S, Semina EV, Johnson LR, Machida J, Burds A, Parnell TJ, Rubenstein JL, Murray JC, Association of MSX1 and TGFB3 with nonsyndromic clefting in humans, American Journal of Human Genetics, 63(2), 557-68, August 1998 Abstract
  • Romitti PA, Munger RG, Murray JC, Daack-Hirsch S, Hanson JW, Burns TL, The effect of follow-up on limiting non-participation bias in genetic epidemiologic investigations, European Journal of Epidemiology, 14(2), 129-38, February 1998 Abstract
  • Romitti PA, Burns TL, Murray JC, Maternal interview reports of family history of birth defects: evaluation from a population-based case-control study of orofacial clefts, American Journal of Medical Genetics, 72(4), 422-9, 1997 Abstract
  • Dungy CI, Losch ME, Russell D, Romitti PA, Dusdieker LB, Hospital infant formula discharge packages: Do they affect duration of breast feeding?, Archives of Pediatrics and Adolescent Medicine, 151, 724-9, 1997
  • Romitti PA, Burns TL, The feasibility of collecting disease reports from relatives for genetic epidemiologic investigations, Human Heredity, 47, 351-7, 1997
  • Munger RG, Romitti PA, Daack-Hirsch S, Burns TL, Murray JC, Hanson J, Maternal alcohol use and risk of orofacial cleft birth defects, Teratology, 54(1), 27-33, July 1996 Abstract
  • Shiang R, Lidral AC, Ardinger HH, Buetow KH, Romitti PA, Munger RG, Murray JC, Association of transforming growth-factor alpha gene polymorphisms with nonsyndromic cleft palate only (CPO), American Journal of Human Genetics, 53(4), 836-43, October 1993 Abstract

Profile Details

Last Updated: 9/10/2009

COS Expertise ID #978988
Reference this profile directly: http://myprofile.cos.com/promitti