Peter S. Rabinovitch

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University of Washington
School of Medicine
Pathology
ProfessorAppointed: 1992
Fred Hutchinson Cancer Research Center
Public Health Sciences
Joint MemberAppointed: 1998
Professional Headshot of Peter S. Rabinovitch

Mailing Address

Department of Pathology
RM K081 HSB
Box 357705
Seattle, Washington 98195-7705
United States

Contact Information

Phone: (206) 685-3761
Fax: (206) 616-8571
petersr@u.washington.edu
http://www.pathology.washington.edu/research/labs/rabinovitch/

Qualifications

Ph.D., University of Washington, Genetics, 1980.
M.D., University of Washington, Medicine, 1979.

Expertise and Research Interests

The focus of the laboratory is upon studies of DNA damage and genomic instability in aging and in neoplastic progression. In aging, we are interested in the connection between DNA damage and free radical injury and lifespan and disease. Transgenic mice that overexpress antioxidant enzymes have enhanced longevity and are being examined to provide insights in this model system. Studies of neoplastic progression focus on human gastrointestinal cancers and precancerous diseases such as Barrett's esophagus and Ulcerative Colitis. A better understanding of neoplastic progression in these diseases may yield biomarkers of increased clinical risk for progression to cancer. Genomic instability has proven to be one such a marker. In both aging and neoplasia, we are interested in the role of telomere shortening in promoting genomic instability. Additional molecular genetic and cytometric indicators of genomic instability and DNA repair are being studied.

Keywords

COS Keywords:

Apoptosis, Cancer Biology, Cancer Or Carcinogenesis, Cell Biology, Cell Differentiation, Cell Proliferation, Cytology, DNA, DNA Repair, Flow Cytometry, Gene Expression, Genetics, Gerontology, Growth Factors, Mitosis, Mutagenesis, Mutation, Oncology, Pathology, Public Health, RNA.

Additional Terms:

Aging, Barrett's Esophagus, Cancer Biology, Cell Biology, Cell Differentiation, Cell Growth, Cell Kinetics, Chromosomal Instability, DNA, Genetics, Gerontology, Growth Factors, Mitosis, Mutagenesis, Mutation, Oncology, RNA, Telomeres, Tumor Biology, Ulcerative Colitis, Werner's Syndrome.

Memberships

International Society for Analytical Cytology

Patents

DNA Libraries (Methods for making and using single-chromosome amplification libraries, Patent Number: 5814444, , , United States of America.

Publications

  • Siahpush SH, Vaughan TL, Lampe JN, Freeman R, Lewis S, Odze RD, Blount PL, Ayub K, Rabinovitch PS, Reid BJ, Chen C (Nov 2007) Longitudinal Study of Insulin-like Growth Factor, Insulin-like Growth Factor Binding Protein-3, and their Polymorphisms: Risk of Neoplastic Progression in Barrett's Esophagus., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 16 (11), 2387-95 Abstract
  • Linford NJ, Beyer RP, Gollahon K, Krajcik RA, Malloy VL, Demas V, Burmer GC, Rabinovitch PS (Oct 2007) Transcriptional response to aging and caloric restriction in heart and adipose tissue., Aging cell, 6 (5), 673-88 Abstract
  • Huang S, Risques RA, Martin GM, Rabinovitch PS, Oshima J (Aug 2007) Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A. Abstract
  • Lai LA, Paulson TG, Li X, Sanchez CA, Maley C, Odze RD, Reid BJ, Rabinovitch PS (Jun 2007) Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-CGH., Genes, chromosomes & cancer, 46 (6), 532-42 Abstract
  • Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA (Apr 2007) Mitochondrial point mutations do not limit the natural lifespan of mice., Nature genetics, 39 (4), 540-3 Abstract
  • Harwood MM, Bleecker JV, Rabinovitch PS, Dovichi NJ (Mar 2007) Cell cycle-dependent characterization of single MCF-7 breast cancer cells by 2-D CE., Electrophoresis, 28 (6), 932-7 Abstract
  • Galipeau PC, Li X, Blount PL, Maley CC, Sanchez CA, Odze RD, Ayub K, Rabinovitch PS, Vaughan TL, Reid BJ (Feb 2007) NSAIDs modulate CDKN2A, TP53, and DNA content risk for progression to esophageal adenocarcinoma., PLoS medicine, 4 (2), e67 Abstract
  • Dhillon KK, Sidorova J, Saintigny Y, Poot M, Gollahon K, Rabinovitch PS, Monnat RJ (Feb 2007) Functional role of the Werner syndrome RecQ helicase in human fibroblasts., Aging cell, 6 (1), 53-61 Abstract
  • Kaeberlein M, Rabinovitch PS (Nov 2006) Medicine: grapes versus gluttony., Nature, 444 (7117), 280-1 Abstract
  • Chao DL, Maley CC, Wu X, Farrow DC, Galipeau PC, Sanchez CA, Paulson TG, Rabinovitch PS, Reid BJ, Spitz MR, Vaughan TL (Oct 2006) Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: a prospective analysis., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 15 (10), 1935-40 Abstract
  • Finley JC, Reid BJ, Odze RD, Sanchez CA, Galipeau P, Li X, Self SG, Gollahon KA, Blount PL, Rabinovitch PS (Aug 2006) Chromosomal instability in Barrett's esophagus is related to telomere shortening., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 15 (8), 1451-7 Abstract
  • Risques RA, Rabinovitch PS, Brentnall TA (Jul 2006) Cancer surveillance in inflammatory bowel disease: new molecular approaches., Current opinion in gastroenterology, 22 (4), 382-90 Abstract
  • Lomo LC, Blount PL, Sanchez CA, Li X, Galipeau PC, Cowan DS, Ayub K, Rabinovitch PS, Reid BJ, Odze RD (Apr 2006) Crypt dysplasia with surface maturation: a clinical, pathologic, and molecular study of a Barrett's esophagus cohort., The American journal of surgical pathology, 30 (4), 423-35 Abstract
  • Maley CC, Galipeau PC, Finley JC, Wongsurawat VJ, Li X, Sanchez CA, Paulson TG, Blount PL, Risques RA, Rabinovitch PS, Reid BJ (Apr 2006) Genetic clonal diversity predicts progression to esophageal adenocarcinoma., Nature genetics, 38 (4), 468-73 Abstract
  • O'Sullivan J, Risques RA, Mandelson MT, Chen L, Brentnall TA, Bronner MP, Macmillan MP, Feng Z, Siebert JR, Potter JD, Rabinovitch PS (Mar 2006) Telomere length in the colon declines with age: a relation to colorectal cancer?, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 15 (3), 573-7 Abstract
  • Wongsurawat VJ, Finley JC, Galipeau PC, Sanchez CA, Maley CC, Li X, Blount PL, Odze RD, Rabinovitch PS, Reid BJ (Mar 2006) Genetic mechanisms of TP53 loss of heterozygosity in Barrett's esophagus: implications for biomarker validation., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 15 (3), 509-16 Abstract
  • Linford NJ, Schriner SE, Rabinovitch PS (Mar 2006) Oxidative damage and aging: spotlight on mitochondria., Cancer research, 66 (5), 2497-9 Abstract
  • De Gottardi A, Dumonceau JM, Bruttin F, Vonlaufen A, Morard I, Spahr L, Rubbia-Brandt L, Frossard JL, Dinjens WN, Rabinovitch PS, Hadengue A (2006) Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro., Molecular cancer, 5, 48 Abstract
  • Vaughan TL, Dong LM, Blount PL, Ayub K, Odze RD, Sanchez CA, Rabinovitch PS, Reid BJ (Dec 2005) Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett's oesophagus: a prospective study., The lancet oncology, 6 (12), 945-52 Abstract
  • Chen R, Bronner MP, Crispin DA, Rabinovitch PS, Brentnall TA (Oct 2005) Characterization of genomic instability in ulcerative colitis neoplasia leads to discovery of putative tumor suppressor regions., Cancer genetics and cytogenetics, 162 (2), 99-106 Abstract
  • Kristal AR, Blount PL, Schenk JM, Sanchez CA, Rabinovitch PS, Odze RD, Standley J, Vaughan TL, Reid BJ (Oct 2005) Low-fat, high fruit and vegetable diets and weight loss do not affect biomarkers of cellular proliferation in Barrett esophagus., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 14 (10), 2377-83 Abstract
  • Chen R, Rabinovitch PS, Crispin DA, Emond MJ, Bronner MP, Brentnall TA, The Initiation of Colon Cancer in a Chronic Inflammatory Setting., Carcinogenesis, 26(9), 1513-9, Sep 2005 Abstract
  • Wolf N, Penn P, Pendergrass W, Van Remmen H, Bartke A, Rabinovitch P, Martin GM (Sep 2005) Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence., Experimental eye research, 81 (3), 276-85 Abstract
  • Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, Van Remmen H, Wallace DC, Rabinovitch PS, Extension of Murine Life Span By Overexpression of Catalase Targeted To Mitochondria., Science, 308(5730), 1909-11, Jun 2005 Abstract
  • Potter AJ, Rabinovitch PS, The Cell Cycle Phases of DNA Damage and Repair Initiated By Topoisomerase II-targeting Chemotherapeutic Drugs., Mutation Research, 572(1-2), 27-44, May 2005 Abstract
  • Mesiwala AH, Scampavia LD, Rabinovitch PS, Ruzicka J, Rostomily RC, On-line Flow Cytometry for Real-time Surgical Guidance., Neurosurgery, 55(3), 551-60; discussion 5, Sep 2004 Abstract
  • Blank A, Bobola MS, Gold B, Varadarajan S, D Kolstoe D, Meade EH, Rabinovitch PS, Loeb LA, Silber JR, The Werner Syndrome Protein Confers Resistance to the DNA Lesions N3-methyladenine and O6-methylguanine: Implications for WRN Function., Dna Repair, 3(6), 629-38, Jun 2004 Abstract
  • Poot M, Jin X, Hill JP, Gollahon KA, Rabinovitch PS, Distinct Functions for WRN and TP53 in a Shared Pathway of Cellular Response to 1-beta-D-arabinofuranosylcytosine and Bleomycin., Experimental Cell Research, 296(2), 327-36, Jun 2004 Abstract
  • O'Sullivan JN, Finley JC, Risques RA, Shen WT, Gollahon KA, Moskovitz AH, Gryaznov S, Harley CB, Rabinovitch PS, Telomere Length Assessment in Tissue Sections By Quantitative FISH: Image Analysis Algorithms., Cytometry. Part a : the Journal of the International Society for Analytical Cytology., 58A(2), 120-31, Apr 2004 Abstract
  • Palanca-Wessels MC, Klingelhutz A, Reid BJ, Norwood TH, Opheim KE, Paulson TG, Feng Z, Rabinovitch PS, Extended Lifespan of Barrett's Esophagus Epithelium Transduced With The Human Telomerase Catalytic Subunit: a Useful in Vitro Model., Carcinogenesis, 24(7), 1183-90, Jul 2003 Abstract
  • Barrett MT, Pritchard D, Palanca-Wessels C, Anderson J, Reid BJ, Rabinovitch PS, Molecular Phenotype of Spontaneously Arising 4N (G2-tetraploid) Intermediates of Neoplastic Progression in Barrett's Esophagus., Cancer Research, 63(14), 4211-7, Jul 2003 Abstract
  • Moskovitz AH, Linford NJ, Brentnall TA, Bronner MP, Storer BE, Potter JD, Bell RH Jr, Rabinovitch PS, Chromosomal Instability in Pancreatic Ductal Cells From Patients With Chronic Pancreatitis and Pancreatic Adenocarcinoma., Genes, Chromosomes & Cancer, 37(2), 201-6, Jun 2003 Abstract
  • Reid BJ, Blount PL, Rabinovitch PS, Biomarkers in Barrett's Esophagus., Gastrointestinal Endoscopy Clinics of North America, 13(2), 369-97, Apr 2003 Abstract
  • Chen R, Rabinovitch PS, Crispin DA, Emond MJ, Koprowicz KM, Bronner MP, Brentnall TA, DNA Fingerprinting Abnormalities Can Distinguish Ulcerative Colitis Patients With Dysplasia and Cancer From Those Who Are Dysplasia/cancer-free., The American Journal of Pathology, 162(2), 665-72, Feb 2003 Abstract
  • O'Sullivan JN, Bronner MP, Brentnall TA, Finley JC, Shen WT, Emerson S, Emond MJ, Gollahon KA, Moskovitz AH, Crispin DA, Potter JD, Rabinovitch PS, Chromosomal Instability in Ulcerative Colitis Is Related to Telomere Shortening., Nature Genetics, 32(2), 280-4, Oct 2002 Abstract
  • Vaughan TL, Kristal AR, Blount PL, Levine DS, Galipeau PC, Prevo LJ, Sanchez CA, Rabinovitch PS, Reid BJ, Nonsteroidal Anti-inflammatory Drug Use, Body Mass Index, And Anthropometry in Relation to Genetic and Flow Cytometric Abnormalities In Barrett's Esophagus., Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology., 11(8), 745-52, Aug 2002 Abstract
  • Poot M, Gollahon KA, Emond MJ, Silber JR, Rabinovitch PS, Werner Syndrome Diploid Fibroblasts Are Sensitive To 4-nitroquinoline-N-oxide and 8-methoxypsoralen: Implications for The Disease Phenotype., The Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology., 16(7), 757-8, May 2002 Abstract
  • Poot M, Silber JR, Rabinovitch PS, A Novel Flow Cytometric Technique for Drug Cytotoxicity Gives Results Comparable to Colony-forming Assays., Cytometry, 48(1), 1-5, May 2002 Abstract
  • Barrett MT, Glogovac J, Prevo LJ, Reid BJ, Porter P, Rabinovitch PS, High-quality RNA and DNA From Flow Cytometrically Sorted Human Epithelial Cells and Tissues., Biotechniques, 32(4), 888-90, 892, 894, 89, Apr 2002 Abstract
  • Potter AJ, Gollahon KA, Palanca BJ, Harbert MJ, Choi YM, Moskovitz AH, Potter JD, Rabinovitch PS, Flow Cytometric Analysis of the Cell Cycle Phase Specificity of DNA Damage Induced By Radiation, Hydrogen Peroxide and Doxorubicin., Carcinogenesis, 23(3), 389-401, Mar 2002 Abstract
  • Barrett MT, Yeung KY, Ruzzo WL, Hsu L, Blount PL, Sullivan R, Zarbl H, Delrow J, Rabinovitch PS, Reid BJ, Transcriptional Analyses of Barrett's Metaplasia and Normal Upper GI Mucosae., Neoplasia (new York, N.y.), 4(2), 121-8, Mar-Apr 2002 Abstract
  • Rabinovitch PS, Longton G, Blount PL, Levine DS, Reid BJ., Predictors of progression in Barrett's esophagus III: baseline flow cytometric variables, American Journal of Gastroenterology, 96(11), 3071-83, November 2001
  • Rosato MT, Jabbour AJ, Ponce RA, Kavanagh TJ, Takaro TK, Hill JP, Poot M, Rabinovitch PS, Faustman EM, Simultaneous analysis of surface marker expression and cell cycle progression in human peripheral blood mononuclear cells, Journal of Immunological Methods, 256(1-2), 35-46, 2001 Abstract
  • Poot M, Yom JS, Whang SH, Kato JT, Gollahon KA, Rabinovitch PS, Werner syndrome cells are sensitive to DNA cross-linking drugs, Faseb Journal, 15(7), 1224-6, May 2001 Abstract
  • Agoff SN, Brentnall TA, Crispin DA, Taylor SL, Raaka S, Haggitt RC, Reed MW, Afonina IA, Rabinovitch PS, Stevens AC, Feng Z, Bronner MP, The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia, American Journal of Pathology, 157(3), 737-45, September 2000 Abstract
  • Reid BJ, Levine DS, Longton G, Blount PL, Rabinovitch PS, Predictors of progression to cancer in Barrett's esophagus: baseline histology and flow cytometry identify low- and high-risk patient subsets, American Journal of Gastroenterology, 95(7), 1669-76, July 2000 Abstract
  • Pierce RH, Campbell JS, Stephenson AB, Franklin CC, Chaisson M, Poot M, Kavanagh TJ, Rabinovitch PS, Fausto N, Disruption of redox homeostasis in tumor necrosis factor-induced apoptosis in a murine hepatocyte cell line, American Journal of Pathology, 157(1), 221-36, July 2000 Abstract
  • Rudolph RE, Vaughan TL, Storer BE, Haggitt RC, Rabinovitch PS, Levine DS, Reid BJ, Effect of segment length on risk for neoplastic progression in patients with Barrett esophagus, Annals of Internal Medicine, 132(8), 612-20, April 2000 Abstract
  • Rabinovitch PS, Dziadon S, Brentnall TA, Emond MJ, Crispin DA, Haggitt RC, Bronner MP, Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis, Cancer Research, 59(20), 5148-5153, 15 Oct 1999
  • Barrett MT, Sanchez CA, Prevo LJ, Wong DJ, Galipeau PC, Paulson TG, Rabinovitch PS, Reid BJ, Evolution of neoplastic cell lineages in Barrett oesophagus, Nature Genetics, 22(1), 106-9, May 1999 Abstract
  • Potter A, Kim C, Gollahon KA, Rabinovitch PS, Apoptotic human lymphocytes have diminished CD4 and CD8 receptor expression, Cellular Immunology, 193(1), 36-47, April 1999 Abstract
  • Poot M, Gollahon KA, Rabinovitch PS, Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase, Human Genetics, 104(1), 10-4, Jan 1999 Abstract
  • Palanca-Wessels MC, Barrett MT, Galipeau PC, Rohrer KL, Reid BJ, Rabinovitch PS, Genetic analysis of long-term Barrett's esophagus epithelial cultures exhibiting cytogenetic and ploidy abnormalities, Gastroenterology, 114(2), 295-304, February 1998 Abstract
  • Ogburn CE, Oshima J, Poot M, Chen R, Hunt KE, Gollahon KA, Rabinovitch PS, Martin GM, An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants, Human Genetics, 101(2), 121-5, December 1997 Abstract
  • Widrow RJ, Rabinovitch PS, Cho K, Laird CD, Separation of cells at different times within G2 and mitosis by cyclin B1 flow cytometry, Cytometry, 27(3), 250-4, March 1997 Abstract
  • Taylor CG, Potter AJ, Rabinovitch PS, Splenocyte glutathione and CD3-mediated cell proliferation are reduced in mice fed a protein-deficient diet, Journal of Nutrition, 127(1), 44-50, January 1997 Abstract
  • Glogovac JK, Porter PL, Banker DE, Rabinovitch PS, Cytokeratin labeling of breast cancer cells extracted from paraffin-embedded tissue for bivariate flow cytometric analysis, Cytometry, 24(3), 260-7, July 1996 Abstract
  • Galipeau PC, Cowan DS, Sanchez CA, Barrett MT, Emond MJ, Levine DS, Rabinovitch PS, Reid BJ, 17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus, Proceedings of the National Academy of Sciences (USA), 93(14), 7081-4, July 1996 Abstract
  • Brown RD, Linden MD, Mackowiak P, Kubus JJ, Zarbo RJ, Rabinovitch PS, The effect of number of histogram events on reproducibility and variation of flow cytometric proliferation measurement, American Journal of Clinical Pathology, 105(6), 696-704, June 1996 Abstract
  • Lohmiller JJ, Roellich KM, Toledano A, Rabinovitch PS, Wolf NS, Grossmann A, Aged murine T-lymphocytes are more resistant to oxidative damage due to the predominance of the cells possessing the memory phenotype, Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 51(2), B132-40, March 1996 Abstract
  • Brentnall TA, Crispin DA, Bronner MP, Cherian SP, Hueffed M, Rabinovitch PS, Rubin CE, Haggitt RC, Boland CR, Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis, Cancer Research, 56(6), 1237-40, March 1996 Abstract
  • Grossmann A, Rabinovitch PS, Kavanagh TJ, Jinneman JC, Gilliland LK, Ledbetter JA, Kanner SB, Activation of murine T-cells via phospholipase-C gamma 1-associated protein tyrosine phosphorylation is reduced with aging, Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 50(4), B205-12, July 1995 Abstract
  • Poot M, Teubert H, Rabinovitch PS, Kavanagh TJ, De novo synthesis of glutathione is required for both entry into and progression through the cell cycle, Journal of Cellular Physiology, 163(3), 555-60, June 1995 Abstract
  • Grossmann A, Rabinovitch PS, Lane MA, Jinneman JC, Ingram DK, Wolf NS, Cutler RG, Roth GS, Influence of age, sex, and dietary restriction on intracellular free calcium responses of CD4 lymphocytes in rhesus monkeys (Macaca mulatta), Journal of Cellular Physiology, 162(2), 298-303, February 1995 Abstract
  • Novak EJ, Rabinovitch PS, Improved sensitivity in flow cytometric intracellular ionized calcium measurement using fluo-3/Fura Red fluorescence ratios, Cytometry, 17(2), 135-41, October 1994 Abstract
  • Brentnall TA, Crispin DA, Rabinovitch PS, Haggitt RC, Rubin CE, Stevens AC, Burmer GC, Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis, Gastroenterology, 107(2), 369-78, August 1994 Abstract
  • Kallioniemi OP, Visakorpi T, Holli K, Isola JJ, Rabinovitch PS, Automated peak detection and cell cycle analysis of flow cytometric DNA histograms, Cytometry, 16(3), 250-5, July 1994 Abstract
  • Riley DE, Krieger JN, Miner D, Rabinovitch PS, Trichomonas vaginalis: dominant G2 period and G2 phase arrest in a representative of an early branching eukaryotic lineage., Journal of Eukaryotic Microbiology, 41(4), 408-14, 1994 Abstract
  • VanDevanter DR, Choongkittaworn NM, Dyer KA, Aten J, Otto P, Behler C, Bryant EM, Rabinovitch PS, Pure chromosome-specific PCR libraries from single sorted chromosomes, Proceedings of the National Academy of Sciences (USA), 91(13), 5858-62, June 1994 Abstract
  • Kavanagh TJ, Raghu G, White CC, Martin GM, Rabinovitch PS, Eaton DL, Enhancement of glutathione content in glutathione synthetase-deficient fibroblasts from a patient with 5-oxoprolinuria via metabolic cooperation with normal fibroblasts, Experimental Cell Research, 212(1), 69-76, May 1994 Abstract
  • Rabinovitch PS, DNA content histogram and cell-cycle analysis, Methods in Cell Biology, 41, 263-96, 1994 Abstract
  • Poot M, Hoehn H, Kubbies M, Grossmann A, Chen Y, Rabinovitch PS, Cell-cycle analysis using continuous bromodeoxyuridine labeling and Hoechst 33358-ethidium bromide bivariate flow cytometry, Methods in Cell Biology, 41, 327-40, 1994 Abstract
  • June CH, Rabinovitch PS, Intracellular ionized calcium, Methods in Cell Biology, 41, 149-74, 1994 Abstract
  • Chang M, Tsuchiya K, Batchelor RH, Rabinovitch PS, Kulander BG, Haggitt RC, Burmer GC, Deletion mapping of chromosome 8p in colorectal carcinoma and dysplasia arising in ulcerative colitis, prostatic carcinoma, and malignant fibrous histiocytomas, American Journal of Pathology, 144(1), 1-6, January 1994 Abstract
  • Grossmann A, Kukull WA, Jinneman JC, Bird TD, Villacres EC, Larson EB, Rabinovitch PS, Intracellular calcium response is reduced in CD4 lymphocytes in Alzheimer's disease and in older persons with Down's syndrome, Neurobiology of Aging, 14(2), 177-85, 1993 Abstract
  • Reid BJ, Blount PL, Rubin CE, Levine DS, Haggitt RC, Rabinovitch PS, Flow-cytometric and histological progression to malignancy in Barrett's esophagus: prospective endoscopic surveillance of a cohort [see comments], Gastroenterology, 102(4 Pt 1), 1212-9, April 1992 Abstract
  • Blount PL, Ramel S, Raskind WH, Haggitt RC, Sanchez CA, Dean PJ, Rabinovitch PS, Reid BJ, 17p allelic deletions and p53 protein overexpression in Barrett's adenocarcinoma, Cancer Research, 51(20), 5482-6, October 1991 Abstract
  • Parker JD, Rabinovitch PS, Burmer GC, Targeted gene walking polymerase chain reaction, Nucleic Acids Research, 19(11), 3055-60, June 1991 Abstract
  • Grossmann A, Maggio-Price L, Jinneman JC, Rabinovitch PS, Influence of aging on intracellular free calcium and proliferation of mouse T-cell subsets from various lymphoid organs, Cellular Immunology, 135(1), 118-31, June 1991 Abstract
  • Kavanagh TJ, Grossmann A, Jaecks EP, Jinneman JC, Eaton DL, Martin GM, Rabinovitch PS, Proliferative capacity of human peripheral blood lymphocytes sorted on the basis of glutathione content, Journal of Cellular Physiology, 145(3), 472-80, December 1990 Abstract
  • Chen YY, Rabinovitch PS, Mitogen response and cell cycle kinetics of Swiss 3T3 cells in defined medium: differences from human fibroblasts and effects of cell density, Experimental Cell Research, 190(2), 145-50, October 1990 Abstract
  • Chen YY, Rabinovitch PS, Altered cell cycle responses to insulin-like growth factor I, but not platelet-derived growth factor and epidermal growth factor, in senescing human fibroblasts, Journal of Cellular Physiology, 144(1), 18-25, July 1990 Abstract
  • Grossmann A, Ledbetter JA, Rabinovitch PS, Aging-related deficiency in intracellular calcium response to anti-CD3 or concanavalin A in murine T-cell subsets, Journal of Gerontology, 45(3), B81-6, May 1990 Abstract
  • June CH, Rabinovitch PS, Flow cytometric measurement of intracellular ionized calcium in single cells with indo-1 and fluo-3, Methods in Cell Biology, 33, 37-58, 1990 Abstract
  • Chen Y, Rabinovitch PS, Platelet-derived growth factor, epidermal growth factor, and insulin-like growth factor I regulate specific cell-cycle parameters of human diploid fibroblasts in serum-free culture, Journal of Cellular Physiology, 140(1), 59-67, July 1989 Abstract
  • Grossmann A, Ledbetter JA, Rabinovitch PS, Reduced proliferation in T lymphocytes in aged humans is predominantly in the CD8 subset, and is unrelated to defects in transmembrane signaling which are predominantly in the CD4 subset, Experimental Cell Research, 180(2), 367-82, February 1989 Abstract
  • Reid BJ, Haggitt RC, Rubin CE, Rabinovitch PS, Barrett's esophagus. Correlation between flow cytometry and histology in detection of patients at risk for adenocarcinoma, Gastroenterology, 93(1), 1-11, July 1987 Abstract
  • Rabinovitch PS, June CH, Grossmann A, Ledbetter JA, Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry, Journal of Immunology, 137(3), 952-61, August 1986 Abstract
  • Rabinovitch PS, Torres RM, Engel D, Simultaneous cell cycle analysis and two-color surface immunofluorescence using 7-amino-actinomycin D and single laser excitation: applications to study of cell activation and the cell cycle of murine, Journal of Immunology, 136(8), 2769-75, April 1986 Abstract
  • Rabinovitch PS, Regulation of human fibroblast growth rate by both noncycling cell fraction transition probability is shown by growth in 5-bromodeoxyuridine followed by Hoechst 33258 flow cytometry, Proceedings of the National Academy of Sciences (USA), 80(10), 2951-5, May 1983 Abstract

Profile Details

Last Updated: 11/21/2007

COS Expertise ID #307830
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