Dartmouth College Medical School Pathology, and of Microbiology and Immunology Assistant ProfessorAppointed: 2004 | |
QualificationsM.D., Iuliu Hatieganu University of Medicine and Pharmacy, Medicine, 1993. Expertise and Research InterestsCellular and molecular biology of vascular system. Physiology of the transendothelial exchanges of water and solutes between blood plasma and the interstitial fluid. Structure and function of endothelial phenotypic differentiations involved in transendothelial exchanges: caveolae, fenestrae, transendothelial channels, vesiculo-vacuolar organelles. Transcytosis, endocytosis, exocytosis, intracellular trafficking of biological membranes. Cell biology, molecular biology, transgenic animals. Other ExpertiseCell biology, vesicular trafficking Light microscopy Electron microscopy Future ResearchMolecular mechanisms of vascular permeability in health and disease, endothelial differentiation, angiogenesis Industrial RelevanceVascular disease, stroke, cancer, inflammation KeywordsCOS Keywords:Angiogenesis, Blood Or Blood Products Or Transfusions, Cardiovascular Biology, Cardiovascular Diseases, Cardiovascular Physiology, Cardiovascular System, Cell Biology, Gene Cloning, Growth Factor Receptors, Heart, Membrane Structure Or Function, Membranes, Molecular Biology, Molecular Cloning, Monoclonal Antibodies, Pathophysiology, Proteins and Macromolecules, Receptors, Recombinant Dna, Respiratory System, Transgenic Animals, Vascular Diseases Or Injury.Additional Terms:Knock-out and Transgenic Animals.Languages(Reading, Writing, Speaking)English: (Fluent, Fluent, Fluent) Romanian: (Fluent, Fluent, Fluent) French: (Fluent, Functional, Functional) MembershipsAmerican Association for the Advancement of Science American Heart Association American Society for Cell Biology North American Vascular Biology Organization Previous Positions2000-2004, Assistant Research Cell Biologist,
University of California, San Diego,
School of Medicine,
Cellular and Molecular Medicine
1999-2000, Assistant Project Scientist,
University of California, San Diego,
School of Medicine,
Cellular and Molecular Medicine
1994-1999, Postgraduate Researcher,
University of California, San Diego,
School of Medicine,
Medicine,
Cellular and Molecular Medicine
Funding Received- National Heart, Lung and Blood Institute:
Molecular and functional aspects of vascular permeability,
Sep 1, 2001
to 2007.
- American Heart Association (AHA):
Structural and functional aspects of transendothelial permeability,
Jul 1, 2000
to Jun 30, 2002.
- American Lung Association (ALA):
Molecular and functional aspects of vascular permeability in the lung,
Jul 1, 2000
to Jun 30, 2001.
- NHLBI:
Cellular and Molecular Mechanisms of Vascular permeability,
2006
to 2010.
Publications- Stan RV., 'Caveolae' Review Series, J Cell Mol Med., 7(11), 1-4, Jan 2007
- Mayor S, Viola A, Stan RV, del Pozo MA., Flying kites on slippery slopes at Keystone. Symposium on Lipid Rafts and Cell Function., EMBO Rep., 7(11), 1089-93, Nov 2006
- Stan RV., Endocytosis pathways in endothelium: how many?, Am J Physiol Lung Cell Mol Physiol, 290(5), L806-8, May 2006
- Yu J, Bergaya S, Murata T, Alp IF, Bauer MP, Lin MI, Drab M, Kurzchalia TV, Stan RV, Sessa WC., Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels., J Clin Invest, 116(5), 1284-91, May 2006
- Stan RV., Structure of caveolae, Biochim Biophys Acta., 1746(3), 334-48, 16 Sep 2005
- Yao Q, Chen J, Cao H, Orth JD, McCaffery JM, Stan RV, McNiven MA., Caveolin-1 interacts directly with dynamin-2, J Mol Biol, 348(2), 491-501, 29 Apr 2005
- Bauer PM, Yu J, Chen Y, Hickey R, Bernatchez PN, Looft-Wilson R, Huang Y, Giordano F, Stan RV, Sessa WC., Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis., Proc Natl Acad Sci U S A., 102(15), 204-9, Jan 2005
- Madden SL, Cook BP, Nacht M, Weber WD, Callahan MR, Jiang Y, Dufault MR, Zhang X, Zhang W, Walter-Yohrling J, Rouleau C, Akmaev VR, Wang CJ, Cao X, St Martin TB, Roberts BL, Teicher BA, Klinger KW, Stan RV, Lucey B, Carson-Walter EB, Laterra J, Walter KA., Vascular gene expression in nonneoplastic and malignant brain., Am J Path, 165(2), 601-8, Aug 2004
- Tkachenko E, Lutgens E, Stan RV, Simons M., Fibroblast growth factor 2 endocytosis in endothelial cells proceed via syndecan-4-dependent activation of Rac1 and a Cdc42-dependent macropinocytic pathway., J Cell Sci, 117(15), 3189-99, Jul 2004
- Radu V. Stan, Eugene Tkachenko, and Ingrid R. Niesman, PV1 Is a Key Structural Component for the Formation of the Stomatal and Fenestral Diaphragms PV1 Is a Key Structural Component for the Formation of the Stomatal and Fenestral Diaphragms, Mol Biol Cell, 15(8), 3615-30, 21 May 2004
- Stan RV, Multiple PV1 dimers reside in the same stomatal or fenestral diaphragm, American Journal of Physiology. Heart and Circulatory Physiology, 286(4), H1347-53, 2004
 - Wadia JS, Stan RV, Dowdy SF, Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion
proteins after lipid raft macropinocytosis, Nature Medicine, 10(3), 310-5, 2004
 - Predescu SA, Predescu DN, Timblin BK, Stan RV, Malik AB, Intersectin regulates fission and internalization of caveolae in
endothelial cells, Molecular Biology of the Cell, 14(12), 4997-5010, 2003
 - Minshall RD, Sessa WC, Stan RV, Anderson RG, Malik AB, Caveolin regulation of endothelial function, American Journal of Physiology. Lung Cellular and Molecular Physiology, 285(6), L1179-83, 2003
 - Zhao YY, Liu Y, R.V. Stan, Fan L, Gu Y, Dalton N, Chu PH, Peterson K, Ross J Jr, Chien KR, Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice, Proc. Natl. Acad. Sci. USA, 99(17), 11375-80, 2002
- Radu V. Stan, Karen C. Arden and George E. Palade, cDNA and Protein Sequence, Genomic Organization and Analysis of cis-Regulatory Elements of Mouse and Human PLVAP Genes, Genomics, 72, 304-313, March 2001
- Radu V. Stan, Structure and function of endothelial caveolae, Microscopy Research and Technique, 57(5), 350-64, 2001
- Radu-Virgil Stan, Marion Kubitza and George E. Palade, PV-1 is a component of the stomatal and fenestral diapragms in the fenestrated endothelia, Proceedings of the National Academy of Sciences, 96(23), 13200-4, November 1999
- Radu-Virgil Stan, L. Ghitescu, B. S. Jacobson, and George E. Palade, Isolation, Cloning and Localization of Rat PV-1, a Novel Endothelial Caveolar Protein, Journal of Cell Biology, 145(6), 1189-1198, 14 Jun 1998
- Radu-Virgil Stan, W.G. Roberts, D. Predescu, K. Ihida, L. Saucan, L. Ghitescu, and G.E. Palade, Immunoisolation and partial characterization of endothelial plasmalemmal vesicles (caveolae), Molecular Biology of the Cell, 8, 595-605, April 1997
- G. E. Palade, D. Predescu, S. Predescu and R.-V. Stan, MalpighiÂ’s heritage Three Centuries Latter, 1997
Profile DetailsIndividual Expertise profile of Radu V. Stan, Copyright Radu V. Stan. © COS Expertise TM, 2010, ProQuest LLC All rights reserved. |