P. A. Ramachandran

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Washington University in St. Louis
School of Engineering & Applied Science
Chemical Engineering
Professor

Mailing Address

Washington University
Campus Box 1198
St. Louis, Missouri 63130
United States

Contact Information

Phone: (314) 935-6531
Fax: (314) 935-7211
rama@wuche3.wustl.edu

Qualifications

Ph.D., University of Bombay (India), Chemical Engineering, 1971.

Expertise and Research Interests

Three Phase Reactors:

Trickle bed and packed bed catalytic reactors are widely used in petroleum processing and in bulk chemical manufacturing processes. Commercial applications include hydrocracking, hydrodesulfurization and fine chemicals manufacturing. In such systems the interactions of hydrodynamics, mass transfer and kinetics are complex and the design of the reactor is initiated through numerical simulation. Such simulations are useful in optimization studies and may provide guidance in reactorselection which is then followed by experimental testing of the most promising cases only. The objective of this
research is to provide simulation tools for design and scale up of these reactors and to develop an integrated design enviormnent (TDE) forprocess synthesis and analysis of these class of reactors.

The earlier work of this investigator is published in a widely refered and cited book ``THREE PHASE CATALYTIC REACTORS' by P. A. Ramachandran and R. V. Chaudhari, Gordon and Breach Science. ISBN 0-677-05650-8.

Boundary Integral and Singularity Methods:

The goal of this reseacrh is to develop new numerical techniques based on the boundary integral and the dual reciprocity methods to solve transport phenomena problems. The use of these methods provide an accurate and more importantly a mesh free method for solving the common types of partial differential equations encountered in a
variety of engineering analysis problems. The mesh free aspects provide a platform for analysis of complex interconnected systems with a micro-macro structures. Examples of such systems include porous catalysts, fibre-matrix composites, catalytic surfaces with islands of activity, hollow fiber assembly, biological systems etc.

Some of the work of the author has been incorporated into the following book: 'BOUNDARY ELEMENT METHODS IN TRANSPORT PHENOMNEA' by P. A. Ramachandran, Computational Mechanics Publishers. ISBN 1-85961-026-5.

Additional monograph on this subject and a collection of related computer programs are being developed as a result of a NSF grant.

Packed Bed Bioreactor for Growth of Liver Cells (Hepatocytes):

This project, done jointly with the Washington Unverisity Medical School, aims to characterize the performance of cultered liver cells in a bioreactos. The information will be applied in the development of an extrcorporeal liver assist device and also as an experimental testing tool for drug metabolism and toxicology studies. The scope of the work in the chemcial engineering department will be to develop a kinetic model for the system and to develop models to analyze bolus injection type of experimental data. These models will be useful in two ways: (i) to obtain parameters which can be used in detailed pharmaco-kinetic models for drug transport and metabolism in the body and (ii) to evaluate a number of designs for extra corporeal liver assist device support. The experimental aspects of the work will be done in Washington University Medical School.

Some of the results on this project has been included in a recent doctoral thesis by my student, Timothy Whitehead.

Future Research

1. Computational Fluid Dynamics using vorticity-velocity formulation and boundary integral methods. Development of algorithms, applications to two phase flow, model development for generation of vorticity at gas-liquid interfaces.

2. Models development for catalytic and reactive distillation.

Industrial Relevance

The research is of importance to the design and performance analysis of three phase catalytic reactors which are widely used in chemical industry. Examples of such reactors include hydrodesulfurization, hydrocracking, oxidation, pollutant removal etc. The industrial applications of the research includes analysis of experimental reactor data, planning experiments for scale up and design of commercial scale reactors. A second industrail application of the research is to develop mathematical models and simulation software for chemical engineering systems. Prior applications have included modeling of crystal growth for semi-conductor silicon productions, simulation models for electrochemical reactors, models for production of MTBE, hydrocracker simulation models. Application to environmental reaction engineering, i.e., waste minimization through improved reactor design is also an another area of practical applications of the research.

Keywords

COS Keywords:

Chemical Engineering, Mechanical Engineering.

Additional Terms:

Boundary Element Analysis, Engineering-chemical, Process & Reaction Engineering, Three Phase Catalytic Reactors.

Languages

(Reading, Writing, Speaking)

Hindi: (Fluent, Functional, Functional)

Memberships

American Institute of Chemical Engineers
International Society of Boundary Elements
Sigma Xi, The Scientific Research Society

Previous Positions

1982-1998, Professor, Associate, Washington University in St. Louis, School of Engineering and Applied Science, Chemical Engineering

Funding Received

  • National Science Foundation (NSF), 9527671, New Numerical Tools for Diffusion-Reaction Problems, $122,350 (Estimated), June 15, 1996-May 31, 1999 (Estimated)

Publications

  • K. Balakrishnan and P. A. Ramachandran, Particular solution Trefftz method for non-linear Problems in heat and mass transfer, Journal of Computational Physics, 150, 239-267, 1999
  • Karur Sriganesh R, Ramachandran P A, Solving linear diffusion-reaction networks in porous catalyst particles using BEM, AIChE Journal, 42(2), 383-390, 1996
  • Karur Sriganesh R, Ramachandran P A, Augmented thin plate spline approximation in DRM, Boundary Elements Communications, 6(2), 55-58, 1995
  • Kasab John J, Karur Sriganesh R, Ramachandran P A, Quasilinear boundary element method for nonlinear Poisson type problems, Engineering Analysis with Boundary Elements, 15(3), 277-282, 1995
  • Holub R A, Dudukovic M P, Ramachandran P A, Pressure drop, liquid holdup, and flow regime transition in trickle flow, AIChE Journal, 39(2), 302-321, 1993
  • Ramachandran P A, Boundary integral solution method for the Graetz problem, Numerical Heat Transfer, Part B: Fundamentals, 23(2), 257-268, 1993
  • Holub R A, Dudukovic M P, Ramachandran P A, Phenomenological model for pressure drop, liquid holdup, and flow regime transition in gas-liquid trickle flow, Chemical Engineering Science, 47(9-11), 2343-2348, 28 Jun 1992
  • Ramachandran P A, Boundary integral element method for linear diffusion-reaction problems with discontinuous boundary conditions, Chemical Engineering Journal and the Biochemical Engineering Journal, 47(3), 169-185, 1991
  • Ramachandran P A, Boundary integral solution method for axial-dispersion-with-reaction problems, Chemical Engineering Journal and the Biochemical Engineering Journal, 45(1), 49-54, 1990
  • Ramachandran P A, Application of the boundary element method to non-linear diffusion with reaction problems, International Journal for Numerical Methods in Engineering, 29(5), 1021-1031, 1990
  • Ramachandran P A, Boundary element method based solution procedure for non-linear boundary value problems, Computers & Mathematics with Applications, 19(10), 63-76, 1990
  • Ramachandran P A, Dudukovic M P, Dorsey D, Modeling the effect of operating parameters on oxygen content in Czochralski growth of silicon, Journal of the Electrochemical Society, 137(10), 3229-3237, 1990
  • Ramachandran P A, Diffusion-reaction problem revisited via a new boundary element discretization, Chemical Engineering Science, 45(12), 3525-3532, 1990
  • Munjal Sarat, Dudukovic Milorad P, Ramachandran Palghat, Mass-transfer in rotating packed beds. I. Development of gas-liquid and liquid-solid mass-transfer correlations, Chemical Engineering Science, 44(10), 2245-2256, 1989
  • Thomas F B, Ramachandran P A, Dudukovic M P, Jansson R E, Laminar radial flow electrochemical reactors. II. Convective diffusion of inert tracer, Journal of Applied Electrochemistry, 19(6), 845-855, 1989
  • Munjal Sarat, Dudukovic Milorad P, Ramachandran Palghat, Mass-transfer in rotating packed beds. II. Experimental results and comparison with theory and gravity flow, Chemical Engineering Science, 44(10), 2257-2268, 1989

Profile Details

Last Updated: 6/20/2000

COS Expertise ID #511908
Reference this profile directly: http://myprofile.cos.com/ramachap08