Randall G. Worth

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University of Toledo
Medicine
Medical Microbiology & Immunology
Assistant ProfessorAppointed: 2005
Professional Headshot of Randall G. Worth

Mailing Address

Medical Microbiology and Immunology
University of Toledo College of Medicine
263 Health Education Building
3055 Arlington Ave.
Toledo, Ohio 43614-5806
United States

Contact Information

Phone: (419) 383-5192
Fax: (419) 383-3002
randall.worth@utoledo.edu

Qualifications

Postdoctoral Fellow, University of Pennsylvania, 2005.
Ph.D., Wayne State University, Biology/Biophysics, 1999.
B.S., University of Charleston, Biology, 1992.

Expertise and Research Interests

Membrane receptors
Receptor internalization/endocytosis
Particle phagocytosis/degradation/presentation

Fluorescence microscopy
Ultra high-speed video microscopy
Electron microscopy

Keywords

COS Keywords:

Biophysics, Cell Biology, Electron Microscopy, Hematology, Immunology, Medical Microbiology, Oncology, Receptors.

Additional Terms:

Biophysics, Cell Biology, Immunology.

Memberships

American Association for the Advancement of Science
American Society for Cell Biology
Joint Steering Committee on Public Policy

Previous Positions

2000-2005, Research Associate, University of Pennsylvania, School of Medicine, Medicine, Hematology & Oncology

Patents

Tripeptide of FcgammaRIIA, Patent Number: 6979678, 2005, Institution, United States of America.

Funding Received

  • Blue Cross/Blue Sheild of Michigan Foundation: Integrin interactions on neutrophil surfaces, $3,000, May 1998 to Aug 1998.
  • Arthritis Foundation: Mechanisms of FcgRIIA mediated phagolysosome fusion, $140,000, Jul 1, 2001 to Jun 30, 2005.
  • National Institutes of Health (NIH): Institutional Training Grant, $26,000, Jan 1, 2000 to Dec 31, 2000.
  • Arthritis Foundation: Role of FcgRIIA LTL motif in degradation of IgG complexes, $150,000, 2005 to 2007.

Publications

  • Huang ZY, Hunter S, Kim MK, Chien P, Worth RG, Indik ZK, Schreiber AD, The monocyte Fcgamma receptors FcgammaRI/gamma and FcgammaRIIA differ in their interaction with Syk and with Src-related tyrosine kinases, Journal of Leukocyte Biology, 76(2), 491-9, Aug 2004 Abstract
  • Kim MK, Huang ZY, Hwang PH, Jones BA, Sato N, Hunter S, Kim-Han TH, Worth RG, Indik ZK, Schreiber AD, Fcgamma receptor transmembrane domains: role in cell surface expression, gamma chain interaction, and phagocytosis, Blood, 101(11), 4479-4484, June 2003 Abstract
  • Worth RG, Kim MK, Kindzelskii AL, Petty HR, Schreiber AD, Signal sequence within Fc gamma RIIA controls calcium wave propagation patterns: apparent role in phagolysosome fusion, Proceedings of the National Academy of Sciences of the United States of America., 100(8), 4533-4538, April 2003 Abstract
  • Petty HR, Worth RG, Todd RF 3rd, Interactions of integrins with their partner proteins in leukocyte membranes, Immunologic Research, 25(1), 75-95, 2002 Abstract
  • Worth RG, Mayo-Bond L, Kim MK, van de Winkel JG, Todd RF 3rd, Petty HR, Schreiber AD, The cytoplasmic domain of FcgammaRIIA (CD32) participates in phagolysosome formation, Blood, 98(12), 3429-3434, December 2001 Abstract
  • Worth RG, Esper RM, Warra NS, Kindzelskii AL, Rosenspire AL, Todd RF 3rd, Petty HR, Mercury inhibition of neutrophil activity: evidence of aberrant cellular signalling and incoherent cellular metabolism, Scandinavian Journal of Immunology, 53(1), 49-55, Jan 2001 Abstract
  • Ben-Ozer EY, Rosenspire AJ, McCabe MJ Jr, Worth RG, Kindzelskii AL, Warra NS, Petty HR, Mercuric chloride damages cellular DNA by a non-apoptotic mechanism, Mutation Research, 470(1), 19-27, October 2000 Abstract
  • Petty HR, Worth RG, Kindzelskii AL, Imaging sustained dissipative patterns in the metabolism of individual living cells, Physical Review Letters, 84(12), 2754-2757, March 2000 Abstract
  • Worth RG, Mayo-Bond L, van de Winkel JG, Todd RF 3rd, Petty HR, CR3 (alphaM beta2; CD11b/CD18) restores IgG-dependent phagocytosis in transfectants expressing a phagocytosis-defective Fc gammaRIIA (CD32) tail-minus mutant, Journal of Immunology (baltimore, Md. : 1950), 157(12), 5660-5665, December 1996 Abstract

Profile Details

Last Updated: 10/11/2006

COS Expertise ID #1147388
Reference this profile directly: http://myprofile.cos.com/rande