Dr. Robert C. Bateman

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University of Southern Mississippi
College of Science and Technology
Chemistry and Biochemistry
ProfessorAppointed: 1988
Professional Headshot of Robert C. Bateman

Mailing Address

Department of Chemistry and Biochemistry
University of Southern Mississippi
118 College Drive #5043
Hattiesburg, Mississippi 39406-0001
United States

Contact Information

Phone: (601) 266-4701
Fax: (601) 266-6075
robert.bateman@usm.edu
http://ocean.otr.usm.edu/~w304739

Qualifications

Postdoctoral Fellowship, University of Texas Southwestern Medical Center at Dallas, Biochemistry, 1988.
Ph.D., University of North Carolina at Chapel Hill, Biochemistry, 1985.
B.S., Louisiana State University, Biochemistry, 1980.

Expertise and Research Interests

Our laboratory has been studying enzymes involved in the maturation of bioactive peptides, with a particular focus on glutaminyl cyclase (QC). This enzyme is responsible for formation of the pyroglutamyl group at the amino terminus of many bioactive peptides. We have cloned the human and papaya variants and expressed both in insect cells. With the expressed enzyme we are able to study the reaction mechanism and protein structure as well as generate tools such as inhibitors and antibodies to probe the biological role of QC.

Other work in our laboratory is directed towards the development of rapid biosensors for detecting spoilage in seafood. These "dipsticks" change color in the presence of amines produced upon microbial decomposition of fish, particularly those in the tuna family. We are exploring the use of these dipsticks in detecting spoilage in fermented foods and in detecting amines in other biological systems.

Other Expertise

I am also interested in the teaching of structural biochemistry using molecular graphics. The specific areas of interest are (1) the development of student-friendly software and accompanying materials, and (2) the development of graphics-based assessment tools for molecular 3D literacy.

Keywords

COS Keywords:

Biochemistry, Biosensors, Chemical Sciences, Life Sciences, Scientific Instrumentation, Spoilage.

Additional Terms:

Life Science Biological, Undergraduate Instrumentation, Undergraduate Laboratory Improvement.

Memberships

American Chemical Society
American Society for Biochemistry and Molecular Biology
Mississippi Academy of Sciences

Honors and Awards

2001, Award for Outstanding Contributions to Science, Mississippi Academy of Sciences
2001, Faculty Excellence Award - Applied Research University of Southern Mississippi
1991, Faculty Excellence Award- Basic Research, University of Southern Mississippi

Patents

Surfactant properties of menhaden fish protein, Patent Number: 5985840, 1999, Institution-owned, United States.
Inhibitors of neutral endopeptidase/CALLA as chemotherapeutic agents, Patent Number: 5200426, 1993, , United States.

Funding Received

  • National Science Foundation (NSF): 9250686, Enhancement of Undergraduate Biochemistry Instruction, $18,274 (Estimated), June 15, 1992 to November 30, 1994 (E.
  • National Science Foundation (NSF): Student Authoring of Three-Dimensional Illustrations in Undergraduate Biochemistry, $445,240, Feb 15, 2000 to Jan 31, 2004.

Publications

  • Booth D, Sirochman R, Richardson J, Richardson D, Bateman RC Jr (2005) Assessment of Molecular Construction in Undergraduate Biochemistry., Journal of Chemical Education, 82, 1854-1858
  • Stieff M, Bateman RC Jr, Uttall D (2005) Teaching and learning with three-dimensional representations, Visualization in science education, Oxford University Press, 93-120 pages (bookchapter)
  • Booth RE, Lovell SC, Misquitta SA, Bateman RC Jr, Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site, BMC Biology, 2(1), 2, 10 Feb 2004
  • Booth RE, Misquitta SA, Bateman RC Jr, Human pituitary glutaminyl cyclase: expression in insect cells and dye affinity purification, Protein Expression and Purification, 32(1), 141-6, November 2003 Abstract
  • Bateman RC Jr, Structure visualization in biochemistry education, Journal of the Mississippi Academy of Sciences, 7, 149-152, 2002
  • Bateman RC Jr, Booth D, Sirochman R, Richardson J, Richardson, D, Teaching and assessing three-dimensional molecular literacy in undergraduate biochemistry, Journal of Chemical Education, 79, 551-552, 2002
  • Bateman RC Jr, Temple JS, Misquitta SA, Booth RE, Evidence for essential histidines in human pituitary glutaminyl cyclase, Biochemistry, 40(37), 11246-50, September 2001 Abstract
  • Word JM, Bateman RC Jr, Presley BK, Lovell SC, Richardson DC, Exploring steric constraints on protein mutations using MAGE/PROBE, Protein Science, 9(11), 2251-9, November 2000
  • Dahl SW, Slaughter C, Lauritzen C, Bateman RC, Connerton I, Pedersen J, Carica papaya glutamine cyclotransferase belongs to a novel plant enzyme subfamily: cloning and characterization of the recombinant enzyme, Protein Expression and Purification, 20(1), 27-36, October 2000 Abstract
  • Hall M, Sykes PA, Fairclough DL, Lucchese LJ 2nd, Rogers P, Staruszkiewicz W, Bateman RC Jr, A test strip for diamines in tuna, Journal of AOAC, International, 82(5), 1102-8, September 1999 Abstract
  • Sykes PA, Watson SJ, Temple JS, Bateman RC Jr, Evidence for tissue-specific forms of glutaminyl cyclase, FEBS Letters, 445(1-2), 159-161, 16 Jul 1999 Abstract
  • Sykes PA, Shiue HC, Walker J, Bateman RC Jr, Determination of myoglobin stability by visible spectroscopy, Journal of Chemical Education, 76, 1283-4, 1999
  • Houseknecht JB, Temple JS, Bateman RC Jr, In situ detection method for glutaminyl cyclase activity in polyacrylamide gels, Biotechniques, 346-348, 1998 Abstract

Profile Details

Last Updated: 4/17/2007

COS Expertise ID #1106163
Reference this profile directly: http://myprofile.cos.com/rbateman