Maarten E. Reith |
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New York University Medicine Psychiatry Millhauser Labs ProfessorAppointed: 2003 Virginia Commonwealth University Medicine Pharmacology and Toxicology Affiliate graduate facultyAppointed: 2007 New York University Medicine Pharmacology ProfessorAppointed: 2006 New York University Medicine Sackler Institute for Biomedical Sciences FacultyAppointed: 2006 Illinois State University College of Arts & Sciences Department of Biological Sciences Adjunct ProfessorAppointed: 1996 |  |
Mailing AddressNew York University Dept. Psych. Room MHL-518A Millhauser Labs New York, New York 10016United States | Contact Information |
Qualifications
Ph.D..
Expertise and Research Interests
In order to better guide the development of medications for the treatment of dependence on cocaine or amphetamines, it is important to increase our understanding of the targets for these compounds, and one important target is the dopamine transporter (DAT). Thus, much of the research in the lab deals with the structure, function, and regulation of DAT. The link between drug reward and natural reward is intriguing and suggests that treatments for drug abuse could also be effective as treatments of eating disorders. The recently crystallized bacterial leucine transporter (LeuT) is a suitable template for modeling interactions of drugs with monoamine transporters. In addition, monoamine transporters play a role in depression and are of interest as targets for antidepressant medication development. Dopamine receptors are of interest as targets for antiparkinsonian drug leads.
My research interests are:
1) To further our understanding of the binding sites for cocaine, DA, and amphetamines on the DAT, by delineating the binding domains for cocaine and DA and groups involved in binding; and binding sites for antidepressants on the serotonin transporter.
2) To elucidate the molecular details governing the direction of binding and translocation of substrates for DAT, by addressing the role of intracellular Na+ on DAT function, delineating sidedness for substrate action, and assessing the functional role of DAT oligomerization.
3) To assess regulation of DAT by DA- and amphetamine-like substrates, and blockers such as cocaine, in relation to transporter trafficking and transporter oligomerization.
4) To study presynaptic DA mechanisms underlying enhanced sensitivity of food-restricted animals to drugs of abuse; in collaboration with Dr. Kenneth Carr (also in Millhauser Labs at NYU).
5) To use the bacterial monoamine transporter homolog LeuT as a model for drug interaction with human transporters; in collaboration with Dr. Da-Neng Wang (Skirball Institute of Biomolecular Medicine, NYU).
6) To develop DAT agents as medications against cocaine dependence in collaboration with Dr. Aloke Dutta (Wayne State University); newly synthesized GBR 12935 derivatives and structurally novel 3,6-disubstituted piperidine derivatives are tested for monoamine transporter activity and, in collaboration, behavioral activity. Triple monoamine uptake inhibitors are studied as potential leads for antidepressant activity.
7) To develop D3 DA receptor agents as medications against Parkinson's disease in collaboration with Dr. Aloke Dutta (Wayne State University), by testing newly synthesized 3,6-disubstituted piperidine derivatives and structurally constrained 1,4-diaza-bicyclo[3.3.1]nonane derivatives for D2 and D3 DA receptor activity and, in collaboration, for behavioral activity.
My research interests are:
1) To further our understanding of the binding sites for cocaine, DA, and amphetamines on the DAT, by delineating the binding domains for cocaine and DA and groups involved in binding; and binding sites for antidepressants on the serotonin transporter.
2) To elucidate the molecular details governing the direction of binding and translocation of substrates for DAT, by addressing the role of intracellular Na+ on DAT function, delineating sidedness for substrate action, and assessing the functional role of DAT oligomerization.
3) To assess regulation of DAT by DA- and amphetamine-like substrates, and blockers such as cocaine, in relation to transporter trafficking and transporter oligomerization.
4) To study presynaptic DA mechanisms underlying enhanced sensitivity of food-restricted animals to drugs of abuse; in collaboration with Dr. Kenneth Carr (also in Millhauser Labs at NYU).
5) To use the bacterial monoamine transporter homolog LeuT as a model for drug interaction with human transporters; in collaboration with Dr. Da-Neng Wang (Skirball Institute of Biomolecular Medicine, NYU).
6) To develop DAT agents as medications against cocaine dependence in collaboration with Dr. Aloke Dutta (Wayne State University); newly synthesized GBR 12935 derivatives and structurally novel 3,6-disubstituted piperidine derivatives are tested for monoamine transporter activity and, in collaboration, behavioral activity. Triple monoamine uptake inhibitors are studied as potential leads for antidepressant activity.
7) To develop D3 DA receptor agents as medications against Parkinson's disease in collaboration with Dr. Aloke Dutta (Wayne State University), by testing newly synthesized 3,6-disubstituted piperidine derivatives and structurally constrained 1,4-diaza-bicyclo[3.3.1]nonane derivatives for D2 and D3 DA receptor activity and, in collaboration, for behavioral activity.
Other Expertise
ACADEMIC EXPERIENCE:
2001-present :Member Editorial Board of Journal of Neuroscience Methods
2002-2008:Member Editorial Consultant Board of the European Journal of Pharmacology
2008-present :Member Editorial Board of the European Journal of Pharmacology
2004-present :Member Editorial Board of Neurochemical Research
INVITED PRESENTATIONS (LAST 15 YEARS):
May 20-21, 1993: Participant of NIDA Technical Review Conference 'Recent advances in the structure-activity chemistry and neurobiology of biogenic transporters'
April 1993: University of Colorado Medical Center, Denver, CO: 'Cocaine, transporters, autoreceptors'
Aug 1, 1994: Panelist, Symposium: 'The role of serotonin in the Actions of Psychostimulants' at IUPHAR Satellite on Serotonin
June 1995: Nanjing Medical University, Nanjing, China: 'Antagonism of the neuronal dopamine transporter: More than competition?'
Oct 1995: Illinois State University, Normal, IL: 'Cocaine action at the dopamine transporter: Can we develop an antagonist?'
Sept 1997: Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT:'Cocaine and the dopamine transporter'
April 1998: Emory University, Atlanta, GA: 'Cocaine and the dopamine transporter'
Nov 1998: University of Illinois at Chicago: 'Cocaine and its action on the dopamine transporter: Can we develop an antagonist?'
Nov 1999: Wayne State University, Detroit, MI: 'Cocaine interaction with the dopamine transporter: Unique binding domains or conformational changes?
Aug 2000: Brookhaven National Laboratories, Upton, NY: The Dopamine Transporter: Cocaine Binding and Substrate Permeation
Nov 2000: Washington State University, Pullman, WA: The Dopamine Transporter: Cocaine Binding and Substrate Permeation Jan 25, 2001: Member of Panel 'Regulation of Transporter Characteristics' at Winter Conference on Brain Research
March 2001: University of Illinois, College of Medicine, Dept. Neurology, Peoria, IL: Interaction between Cocaine and Dopamine Transporters
Jan 25, 2001: Member of panel 'Regulation of transporter characteristics' at Winter Conference on Brain Research.
April 2001: Virginia Commonwealth University, Richmond, VA: Cocaine and Neuronal Dopamine Transport: Clues from Mutagenesis Studies
July 2001: Bradley University, Peoria, IL: Cocaine and Neuronal Dopamine Transport: Clues from Mutagenesis Studies
Dec 2001: Loyola University, Chicago, IL: Cocaine and Neuronal Dopamine Transport: Clues from Mutagenesis Studies'
Nov 2002: St. Louis University, St. Louis, MO: 'Cocaine and the Dopamine Transporter: Structure-Function Studies'
Dec 2002: University of Illinois, Chicago, IL: 'Cocaine and the Dopamine Transporter: Structure-Function Studies'
Dec 2002: New York University, New York, NY: 'Cocaine and the Dopamine Transporter: Structure-Function Studies'
June 2003: College Problems Drug Dependence 65th Annual Meeting: 'Lead analogs for the dopamine transporter: Interactionwith mutant dopamine transporters lacking aspartate residues
Aug 21, 2003: Organizer of, and speaker in, Symposium 'Transporter-based therapeutic applications' at PharmaConference 2003, Pontresina, Switzerland
Jan 2004: South Carolina University: 'Dopamine Transporters: Structure, Function, and Regulation?'
March 3, 2004: New Jersey Institute of Technology: 'Dopamine Transporter as Target for Cocaine and Pharmacotherapy?'
March 10, 2004: New York University: 'Dopamine Transporter as Target for Dopamine, Cocaine and Pharmacotherapy?'
May 25, 2004: New York University: 'Dopamine Transporters: Structure and Function"
September 14, 2004: New York University: 'The Dopamine Transporter as a Target for Cocaine and Pharmacotherapy" Nov 10, 2005: New Perspectives in Neurotransmitter Transporter Biology, 15th Neuropharmacology Conference, Washington DC: "The dopamine transporter as target for DA, cocaine, and pharmacotherapy"
Oct 20, 2006: Keynote Speaker, NIDA Training Grant Symposium, University of Kentucky, Lexington, KY: "The ABC's of cocaine: DAT, hormones, and other regulatory affairs"
Sep 20, 2007: New York University, New York, NY: "Structure-Function and Regulation of the Dopamine Transporter"
Febr 15, 2008: Hunter College, New York, NY: "Interaction of Cocaine-like Compounds with the Dopamine Transporter: Structure-Activity Studies"
April 21, 2008: University of Texas Health Center, San Antonio, TX: "Interactions between Psychostimulants and the Dopamine Transporter"
May 5, 2008: Manhattan Psychiatric Center, New York, NY: Discussant on presentation of graduate student Kyle Schmitt "Rational Design of Dopaminergic Compounds for Treating Psychostimulant Dependence"
March 9, 2009: NIDA Intramural Research Program, Baltimore, MD: "Interaction between Psychostimulants and the Dopamine Transporter"
ORGANIZING PANELS/WORKSHOPS:
Jan 17, 1991: Organizer of Panel 'Cocaine: the dopamine system and beyond' at Winter Conference on Brain Research
Jan 23, 1995: Organizer of Workshop 'Cocaine antagonist research at a high' at Winter Conference on Brain Research.
Jan 28, 1997: Organizer of Workshop 'The dopamine transporter: from clone to behavior' at Winter Conference on Brain Research.
WHO IS WHO
1998 - 2009: Listed in Marquis Who is Who in Science and Engineering, 4th, 5th, 9th and 10th Edition
1998 - 1999: Listed in American Men & Women of Science
2004 - 2009: Listed in Marquis Who is Who in America, 58th - 61st, 63rd Edition
2000 - 2007: Listed in Marquis Who is Who in the World, 17th,18th and 24th Edition
2006 - 2007: Listed in Marquis Who is Who in Medicine and Healthcare, 6th Edition
REVIEW MANUSCRIPTS for: Addiction Biology; Biochemical Pharmacology; Biochemistry, BioMed Central, Brain Research; Brain Research Bulletin; Circulation; Drug and Alcohol Dependence; European Journal of Pharmacology; International Journal of Neuropsychopharmacology; Journal of Biological Chemistry; Journal of Neurochemistry; Journalof Neuroscience; Journal of Pharmacology and Experimental Therapeutics; Life Sciences; Molecular Pharmacology; Neurobiology of Aging; Neurochemical Research; Neurochemistry International; Neuropsychopharmacology; NeuroReport; Neuroscience; Neuroscience Letters; Neuroscience Research Communications; Pharmacogenetics; Pharmacology Biochemistry and Behavior; Proceedings National Academy of Sciences USAPsychopharmacology; Trends in Pharmacological Sciences.
TRAINING POSTDOCTORAL FELLOWS
Dennis Sorce, Ph.D. (1987); Ildiko Zimanyi, Ph.D. (1986-1988); Edmund Debler, Ph.D. (1989); Harvey Wiener, Ph.D. (1989-1990); Limen Chi, Ph.D. (1991); Nian-Hang Chen, M.D. (1992-1994); Ming-Ya Li, M.D. (1994-1995; 1996); Shiouh-Yi Chen, Ph.D. (1995-1996); Lian Zhang, Ph.D. (1995 - 1996); Cen Xu, Ph.D. (1996 - 1998); Xiao-Dong Wang, M.D. (1996-1997); Mike Appell, Ph.D. (2001-2002); Juan Zhen, Ph.D. (2005 - 2007); Shu-Yuan Cheng, Ph.D. (2007 - 2008); Yingjian Liang, Ph.D. (2007-present); Yan Li, Ph.D. (2008 - present ). All individuals, except one with unknown status, are working in the research/medical arena.
TRAINING M.D. RESIDENTS
Seung S. Kim, M.D. (1-year research in 1985 counted as 1 year in his residency program); Paul Berger, M.D. (3-month research in 1985 was part of his residency program); both individuals are working in the research/medical area.
TRAINING GRADUATE STUDENTS
Donald L. Allen (M.S., research experience 1981-1982); Ken Kramer (M.S., research experience 1988-1989); Milo N. Lipovac (M.D., research in summers 1987, 1988, 1989, 1990 as part of his Ph.D. thesis); Cen Xu (B.S., 1992-1996, Ph.D. degree from Illinois State University with Dr. Reith as thesis advisor); Qun Wu (B.S., 1995-1997 as part of his Ph.D. thesis); Li-Bin Li (B.S., 1997- 2002: Ph.D. degree from Illinois State University with Dr. Reith as thesis advisor); Mike Appell (B.S., research in winter 2000/2001 as part of his Ph.D. thesis); Juan Zhen (B.S., 2001- 2005; Ph.D. degree from Illinois State University with Dr. Reith as thesis advisor); Kyle Schmitt (B.S., 2006- ; Ph.D. degree to be obtained from New York University). All individuals have remained in the research/medical area.
TRAINING MASTERS STUDENTS
Lucy Agyeman (B.S., 2007 as part of her Masters Pharmacy degree of School of Pharmacy, University of London); and Brinda Jugesssur (B.S., 2008 as part of her Masters Pharmacy degree of School of Pharmacy, University of London).
TRAINING TECHNICIANS
Isa Plucinska, B.S. (1981); Bernard E. Meisler, B.S. (1984-1985); Cathy O'Reilly, M.S. (1987-1988); Edward Wang, M.D. (1987-1988); Gabor Selmeci, M.D. (1989-1990); Lori L. Coffey, B.S. (1991-1997); Lijuan Wang, M.D. (1997 - 2003); Janet Berfield, B.S. (1997 - 2003); Xianon Cui, B.S. (2000-2002); Ingrid Parrington (2007-present); Tamara Antonio (2008 - present). Current status: one individual is now a physician, one is a high-school teacher, one is raising her children, one is a technician in her new location after moving away with husband, one is technician in different lab, and another is in multimedia computer programming; the status of two others is unknown.
COLLABORATION WITH FACULTY SUPPORTED BY TRANSPORT RESEARCH PROGRAM
Yangkyo Salch, Ph.D. (Instructor, 1996 - 1998); N. Chen, M.D. (Assistant Professor, 1999- ); Lingling Sun, M.D. (2000-2001); Limen Chi, Ph.D. (Visiting Scholar/Assistant Professor, 2001- 2003 ); Bo-Jin Cao, Ph.D. (Visiting Scholar/Assistant Professor, 2001- 2002); Oleg Tkalych, M.D. (Research Scientist, 2004); Juan Zhen, Ph.D. (Research Scientist, 2007 - present). All individuals, except one in computer programming, are working in the research/medical arena.
COMMITTEES (UNIVERSITY SERVICE)
1992: Member, Committeefor developing a joint graduate program between the University of Illinois and the Illinois State University
1992 - 1995: Chair, Research Committee of the College of Medicine at Peoria
1993 - 1997: Member, Department of Biomed. Therap. Sciences Executive Committee
1993 - 1994: Member, Microbiology/Virology Search Committee
1993 - 1998: Member, Pediatric Research Committee
1993 - 1996: Member, Faculty of the Year Award Committee of the College of Medicine of the University of Illinois
1995 - 1996: Chair, Faculty of the Year Award Committee of the College of Medicine of the University of Illinois
1993 - 1994: Chair, Committee to Develop a Strategic Plan for the Department of Basic Sciences
1996: Member, Committee to Review Public Relations of College of Medicine in Peoria
1996 - 1997: Member, Committee to Review 5-year performance of Chair DBTS at College of Medicine in Peoria
1996 - 1997: Member, Committee to Review 5-year performance of Dean at College of Medicine in Peoria
1997 - 1998: Member, Department of Biomedical and Therapeutic Sciences Promotion Committee
1997 - 1998: Member, Committee to Review Research and Scholarly Activity at College of Medicine in Peoria
1998 Member, Ad-Hoc Promotions Committee Department Neurosurgery at College of Medicine in Peoria
1998 - 2002: Chair, Research Committee of the College of Medicine in Peoria
1998 - 2003: Member, Medical Sciences Advisory Committee of the Central Illinois Biomedical Research (CIBR) Group
1999 - 2001: Member, Department of Biomed. Therap. Sciences Executive Committee
2000: Member, Department of Biomedical and Therapeutic Sciences Promotion Committee
2000 - 2001: Member, Committee to Review 5-year performance of Chair Neurosurgery at College of Medicine in Peoria
2001: Member, Thesis Committee for Ph.D. of Brian Bergstrom, Illinois State University, Normal, IL (Paul Garris, thesis advisor)
2001: Member, Thesis Committee for Ph.D. of Mike Appell, University of Illinois at Chicago School of Pharmacy, Chicago, IL (WilliamDunn, thesis advisor)
2001 - 2003: Member, Research Committee of the College of Medicine of the University of Illinois
2002: Member, Department of Biomedical and Therapeutic Sciences Promotion Committee
1998 -2002: Frequent Ad-Hoc, Executive Committee of the College of Medicine in Peoria
2002: Member, Executive Committee of the College of Medicine in Peoria
2002 - 2003: Member, Department of Biomed. Therap. Sciences Executive Committee
2006-: Member, Thesis committee for Z.S. Pearson, doctoral candidate (Dept. of Physiology and Neuroscience), Sackler Institute of Graduate Biomedical Sciences, New York University
2007- : Member thesis committee for S. Pecic, doctoral candidate (Dept. of Chemistry, CUNY, Hunter College, New York), The Graduate Center, CUNY, New York, NY.
2007- : Member thesis committee for A. Batman, doctoral candidate (Dept. of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA).
2004-present: Member, Research Committee of the Department of Psychiatry, New York University, School of Medicine.
2007-present: Member, Space Committee of the Department of Psychiatry, New York University, School of Medicine.
2008-present: Member, Appointments and Promotions Committee, Department of Psychiatry, New York University, School of Medicine
TEACHING:
1992 - 2003: Participant as lecturer in Pharmacology Course for 2nd year medical students
1981 - present: Training technicians, graduate students, and Postdoctoral Fellows (see above)
1985: Training M.D. residents (see above)
2007 - present : Participant as lecturer in Principles of Pharmacology course for graduate students in the Department of Pharmacology, New York University
CONSULTING
2003-2006, 2008:Consultant, IVAX, TEVA, Michael Best and Friedrich;
2005- present: Member Scientific Board of IES Brain Research Foundation
2006- :Consultant, NeuRxus, Inc.
2001-present :Member Editorial Board of Journal of Neuroscience Methods
2002-2008:Member Editorial Consultant Board of the European Journal of Pharmacology
2008-present :Member Editorial Board of the European Journal of Pharmacology
2004-present :Member Editorial Board of Neurochemical Research
INVITED PRESENTATIONS (LAST 15 YEARS):
May 20-21, 1993: Participant of NIDA Technical Review Conference 'Recent advances in the structure-activity chemistry and neurobiology of biogenic transporters'
April 1993: University of Colorado Medical Center, Denver, CO: 'Cocaine, transporters, autoreceptors'
Aug 1, 1994: Panelist, Symposium: 'The role of serotonin in the Actions of Psychostimulants' at IUPHAR Satellite on Serotonin
June 1995: Nanjing Medical University, Nanjing, China: 'Antagonism of the neuronal dopamine transporter: More than competition?'
Oct 1995: Illinois State University, Normal, IL: 'Cocaine action at the dopamine transporter: Can we develop an antagonist?'
Sept 1997: Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT:'Cocaine and the dopamine transporter'
April 1998: Emory University, Atlanta, GA: 'Cocaine and the dopamine transporter'
Nov 1998: University of Illinois at Chicago: 'Cocaine and its action on the dopamine transporter: Can we develop an antagonist?'
Nov 1999: Wayne State University, Detroit, MI: 'Cocaine interaction with the dopamine transporter: Unique binding domains or conformational changes?
Aug 2000: Brookhaven National Laboratories, Upton, NY: The Dopamine Transporter: Cocaine Binding and Substrate Permeation
Nov 2000: Washington State University, Pullman, WA: The Dopamine Transporter: Cocaine Binding and Substrate Permeation Jan 25, 2001: Member of Panel 'Regulation of Transporter Characteristics' at Winter Conference on Brain Research
March 2001: University of Illinois, College of Medicine, Dept. Neurology, Peoria, IL: Interaction between Cocaine and Dopamine Transporters
Jan 25, 2001: Member of panel 'Regulation of transporter characteristics' at Winter Conference on Brain Research.
April 2001: Virginia Commonwealth University, Richmond, VA: Cocaine and Neuronal Dopamine Transport: Clues from Mutagenesis Studies
July 2001: Bradley University, Peoria, IL: Cocaine and Neuronal Dopamine Transport: Clues from Mutagenesis Studies
Dec 2001: Loyola University, Chicago, IL: Cocaine and Neuronal Dopamine Transport: Clues from Mutagenesis Studies'
Nov 2002: St. Louis University, St. Louis, MO: 'Cocaine and the Dopamine Transporter: Structure-Function Studies'
Dec 2002: University of Illinois, Chicago, IL: 'Cocaine and the Dopamine Transporter: Structure-Function Studies'
Dec 2002: New York University, New York, NY: 'Cocaine and the Dopamine Transporter: Structure-Function Studies'
June 2003: College Problems Drug Dependence 65th Annual Meeting: 'Lead analogs for the dopamine transporter: Interactionwith mutant dopamine transporters lacking aspartate residues
Aug 21, 2003: Organizer of, and speaker in, Symposium 'Transporter-based therapeutic applications' at PharmaConference 2003, Pontresina, Switzerland
Jan 2004: South Carolina University: 'Dopamine Transporters: Structure, Function, and Regulation?'
March 3, 2004: New Jersey Institute of Technology: 'Dopamine Transporter as Target for Cocaine and Pharmacotherapy?'
March 10, 2004: New York University: 'Dopamine Transporter as Target for Dopamine, Cocaine and Pharmacotherapy?'
May 25, 2004: New York University: 'Dopamine Transporters: Structure and Function"
September 14, 2004: New York University: 'The Dopamine Transporter as a Target for Cocaine and Pharmacotherapy" Nov 10, 2005: New Perspectives in Neurotransmitter Transporter Biology, 15th Neuropharmacology Conference, Washington DC: "The dopamine transporter as target for DA, cocaine, and pharmacotherapy"
Oct 20, 2006: Keynote Speaker, NIDA Training Grant Symposium, University of Kentucky, Lexington, KY: "The ABC's of cocaine: DAT, hormones, and other regulatory affairs"
Sep 20, 2007: New York University, New York, NY: "Structure-Function and Regulation of the Dopamine Transporter"
Febr 15, 2008: Hunter College, New York, NY: "Interaction of Cocaine-like Compounds with the Dopamine Transporter: Structure-Activity Studies"
April 21, 2008: University of Texas Health Center, San Antonio, TX: "Interactions between Psychostimulants and the Dopamine Transporter"
May 5, 2008: Manhattan Psychiatric Center, New York, NY: Discussant on presentation of graduate student Kyle Schmitt "Rational Design of Dopaminergic Compounds for Treating Psychostimulant Dependence"
March 9, 2009: NIDA Intramural Research Program, Baltimore, MD: "Interaction between Psychostimulants and the Dopamine Transporter"
ORGANIZING PANELS/WORKSHOPS:
Jan 17, 1991: Organizer of Panel 'Cocaine: the dopamine system and beyond' at Winter Conference on Brain Research
Jan 23, 1995: Organizer of Workshop 'Cocaine antagonist research at a high' at Winter Conference on Brain Research.
Jan 28, 1997: Organizer of Workshop 'The dopamine transporter: from clone to behavior' at Winter Conference on Brain Research.
WHO IS WHO
1998 - 2009: Listed in Marquis Who is Who in Science and Engineering, 4th, 5th, 9th and 10th Edition
1998 - 1999: Listed in American Men & Women of Science
2004 - 2009: Listed in Marquis Who is Who in America, 58th - 61st, 63rd Edition
2000 - 2007: Listed in Marquis Who is Who in the World, 17th,18th and 24th Edition
2006 - 2007: Listed in Marquis Who is Who in Medicine and Healthcare, 6th Edition
REVIEW MANUSCRIPTS for: Addiction Biology; Biochemical Pharmacology; Biochemistry, BioMed Central, Brain Research; Brain Research Bulletin; Circulation; Drug and Alcohol Dependence; European Journal of Pharmacology; International Journal of Neuropsychopharmacology; Journal of Biological Chemistry; Journal of Neurochemistry; Journalof Neuroscience; Journal of Pharmacology and Experimental Therapeutics; Life Sciences; Molecular Pharmacology; Neurobiology of Aging; Neurochemical Research; Neurochemistry International; Neuropsychopharmacology; NeuroReport; Neuroscience; Neuroscience Letters; Neuroscience Research Communications; Pharmacogenetics; Pharmacology Biochemistry and Behavior; Proceedings National Academy of Sciences USAPsychopharmacology; Trends in Pharmacological Sciences.
TRAINING POSTDOCTORAL FELLOWS
Dennis Sorce, Ph.D. (1987); Ildiko Zimanyi, Ph.D. (1986-1988); Edmund Debler, Ph.D. (1989); Harvey Wiener, Ph.D. (1989-1990); Limen Chi, Ph.D. (1991); Nian-Hang Chen, M.D. (1992-1994); Ming-Ya Li, M.D. (1994-1995; 1996); Shiouh-Yi Chen, Ph.D. (1995-1996); Lian Zhang, Ph.D. (1995 - 1996); Cen Xu, Ph.D. (1996 - 1998); Xiao-Dong Wang, M.D. (1996-1997); Mike Appell, Ph.D. (2001-2002); Juan Zhen, Ph.D. (2005 - 2007); Shu-Yuan Cheng, Ph.D. (2007 - 2008); Yingjian Liang, Ph.D. (2007-present); Yan Li, Ph.D. (2008 - present ). All individuals, except one with unknown status, are working in the research/medical arena.
TRAINING M.D. RESIDENTS
Seung S. Kim, M.D. (1-year research in 1985 counted as 1 year in his residency program); Paul Berger, M.D. (3-month research in 1985 was part of his residency program); both individuals are working in the research/medical area.
TRAINING GRADUATE STUDENTS
Donald L. Allen (M.S., research experience 1981-1982); Ken Kramer (M.S., research experience 1988-1989); Milo N. Lipovac (M.D., research in summers 1987, 1988, 1989, 1990 as part of his Ph.D. thesis); Cen Xu (B.S., 1992-1996, Ph.D. degree from Illinois State University with Dr. Reith as thesis advisor); Qun Wu (B.S., 1995-1997 as part of his Ph.D. thesis); Li-Bin Li (B.S., 1997- 2002: Ph.D. degree from Illinois State University with Dr. Reith as thesis advisor); Mike Appell (B.S., research in winter 2000/2001 as part of his Ph.D. thesis); Juan Zhen (B.S., 2001- 2005; Ph.D. degree from Illinois State University with Dr. Reith as thesis advisor); Kyle Schmitt (B.S., 2006- ; Ph.D. degree to be obtained from New York University). All individuals have remained in the research/medical area.
TRAINING MASTERS STUDENTS
Lucy Agyeman (B.S., 2007 as part of her Masters Pharmacy degree of School of Pharmacy, University of London); and Brinda Jugesssur (B.S., 2008 as part of her Masters Pharmacy degree of School of Pharmacy, University of London).
TRAINING TECHNICIANS
Isa Plucinska, B.S. (1981); Bernard E. Meisler, B.S. (1984-1985); Cathy O'Reilly, M.S. (1987-1988); Edward Wang, M.D. (1987-1988); Gabor Selmeci, M.D. (1989-1990); Lori L. Coffey, B.S. (1991-1997); Lijuan Wang, M.D. (1997 - 2003); Janet Berfield, B.S. (1997 - 2003); Xianon Cui, B.S. (2000-2002); Ingrid Parrington (2007-present); Tamara Antonio (2008 - present). Current status: one individual is now a physician, one is a high-school teacher, one is raising her children, one is a technician in her new location after moving away with husband, one is technician in different lab, and another is in multimedia computer programming; the status of two others is unknown.
COLLABORATION WITH FACULTY SUPPORTED BY TRANSPORT RESEARCH PROGRAM
Yangkyo Salch, Ph.D. (Instructor, 1996 - 1998); N. Chen, M.D. (Assistant Professor, 1999- ); Lingling Sun, M.D. (2000-2001); Limen Chi, Ph.D. (Visiting Scholar/Assistant Professor, 2001- 2003 ); Bo-Jin Cao, Ph.D. (Visiting Scholar/Assistant Professor, 2001- 2002); Oleg Tkalych, M.D. (Research Scientist, 2004); Juan Zhen, Ph.D. (Research Scientist, 2007 - present). All individuals, except one in computer programming, are working in the research/medical arena.
COMMITTEES (UNIVERSITY SERVICE)
1992: Member, Committeefor developing a joint graduate program between the University of Illinois and the Illinois State University
1992 - 1995: Chair, Research Committee of the College of Medicine at Peoria
1993 - 1997: Member, Department of Biomed. Therap. Sciences Executive Committee
1993 - 1994: Member, Microbiology/Virology Search Committee
1993 - 1998: Member, Pediatric Research Committee
1993 - 1996: Member, Faculty of the Year Award Committee of the College of Medicine of the University of Illinois
1995 - 1996: Chair, Faculty of the Year Award Committee of the College of Medicine of the University of Illinois
1993 - 1994: Chair, Committee to Develop a Strategic Plan for the Department of Basic Sciences
1996: Member, Committee to Review Public Relations of College of Medicine in Peoria
1996 - 1997: Member, Committee to Review 5-year performance of Chair DBTS at College of Medicine in Peoria
1996 - 1997: Member, Committee to Review 5-year performance of Dean at College of Medicine in Peoria
1997 - 1998: Member, Department of Biomedical and Therapeutic Sciences Promotion Committee
1997 - 1998: Member, Committee to Review Research and Scholarly Activity at College of Medicine in Peoria
1998 Member, Ad-Hoc Promotions Committee Department Neurosurgery at College of Medicine in Peoria
1998 - 2002: Chair, Research Committee of the College of Medicine in Peoria
1998 - 2003: Member, Medical Sciences Advisory Committee of the Central Illinois Biomedical Research (CIBR) Group
1999 - 2001: Member, Department of Biomed. Therap. Sciences Executive Committee
2000: Member, Department of Biomedical and Therapeutic Sciences Promotion Committee
2000 - 2001: Member, Committee to Review 5-year performance of Chair Neurosurgery at College of Medicine in Peoria
2001: Member, Thesis Committee for Ph.D. of Brian Bergstrom, Illinois State University, Normal, IL (Paul Garris, thesis advisor)
2001: Member, Thesis Committee for Ph.D. of Mike Appell, University of Illinois at Chicago School of Pharmacy, Chicago, IL (WilliamDunn, thesis advisor)
2001 - 2003: Member, Research Committee of the College of Medicine of the University of Illinois
2002: Member, Department of Biomedical and Therapeutic Sciences Promotion Committee
1998 -2002: Frequent Ad-Hoc, Executive Committee of the College of Medicine in Peoria
2002: Member, Executive Committee of the College of Medicine in Peoria
2002 - 2003: Member, Department of Biomed. Therap. Sciences Executive Committee
2006-: Member, Thesis committee for Z.S. Pearson, doctoral candidate (Dept. of Physiology and Neuroscience), Sackler Institute of Graduate Biomedical Sciences, New York University
2007- : Member thesis committee for S. Pecic, doctoral candidate (Dept. of Chemistry, CUNY, Hunter College, New York), The Graduate Center, CUNY, New York, NY.
2007- : Member thesis committee for A. Batman, doctoral candidate (Dept. of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA).
2004-present: Member, Research Committee of the Department of Psychiatry, New York University, School of Medicine.
2007-present: Member, Space Committee of the Department of Psychiatry, New York University, School of Medicine.
2008-present: Member, Appointments and Promotions Committee, Department of Psychiatry, New York University, School of Medicine
TEACHING:
1992 - 2003: Participant as lecturer in Pharmacology Course for 2nd year medical students
1981 - present: Training technicians, graduate students, and Postdoctoral Fellows (see above)
1985: Training M.D. residents (see above)
2007 - present : Participant as lecturer in Principles of Pharmacology course for graduate students in the Department of Pharmacology, New York University
CONSULTING
2003-2006, 2008:Consultant, IVAX, TEVA, Michael Best and Friedrich;
2005- present: Member Scientific Board of IES Brain Research Foundation
2006- :Consultant, NeuRxus, Inc.
Future Research
See above Expertise and Research Interests
Industrial Relevance
Medications targeting the dopamine and serotonin system
Keywords
COS Keywords:
Biochemistry, Cocaine, Dopamine, Drugs Or Drug Abuse, Molecular Biology, Mutagenesis, Neurochemistry, Neuropharmacology, Neuroscience, Neurotransmitters, Pharmacology, Psychiatry, Receptors.Additional Terms:
Amphetamine, Antidepressants, Cocaine, Cocaine Metabolites, Cocaine Receptors, Congeners, Dopamine, Dopamine Storage, Food Restriction, Insulin, Leucine Transporter LeuT, Local Anesthetic Drugs, Locomotor Stimulatory Effect, Microdialysis, Monoamine Transporters, Monoaminergic Neurotransmission, Mutagenesis, Pharmacokinetics of Cocaine, Plasma Membrane Vesicles, Psychostimulant Drugs, Receptor Sites, Sensitization Model, Serotonin, Serotonin Storage, Synaptic Vesicle, Tolerance Model, Transport Systems, Voltage-dependent Sodium Channels.Languages
(Reading, Writing, Speaking)
Dutch: (Fluent, Fluent, Fluent)
German: (Functional, Basic, Basic)
French: (Basic, Basic, Basic)
Memberships
American Society for Biochemistry and Molecular Biology
FASEB, Am. Soc. Pharmacol. Exp. Therap.
International Society for Neurochemistry
New York Academy of Sciences
Society for Neuroscience
Honors and Awards
2007, Study Section Member of NIH New England National Primate,
SEP ZRR1 CM-8 (01),
Research Center, SEP ZRR1 CM-8 (01), NIH
2007, Study Section Ad Hoc member,
National Institutes of Health (NIH),
Molecular Cellular Developmental Neuroscience Studysection BPNS,
reviewing grants
2007-2011,
Study Section Member,
National Institutes of Health (NIH),
Molecular Neuropharmacology and Signaling Study section MNPS,
reviewing grant applications
2006, Study Section Ad Hoc member,
National Institutes of Health (NIH),
Cell Biology Studysection ICI,
reviewing grant applications
2006, Study Section Write-in Reviewer,
National Institutes of Health (NIH),
Molecular Cellular Developmental Neuroscience Studysection BPNS,
reviewing grants
2005, Ad Hoc Member Board Scientific Counselors,
National Institutes of Health (NIH),
National Inst. on Drug Abuse,
evaluating intramural NIDA program
2004-2006,
Editor,
Kluwer Publishing Corp., New York, N.Y.
2003-2004,
Guest Editor,
J Neurosci Methods,
Editorial Board,
Special Issue Methods to study monoamine transporters
2002-2006,
Member of Centers Committee,
National Institute on Drug Abuse,
National Institutes of Health,
Reviewing grant applications for NIDA Centers
2002-2003,
Guest Editor,
European Journal of Pharmacology,
Editorial Board,
Special Issue Transporters as targets for drugs, toxins, ions
2002-2004,
Editor,
Humana Press,
Totowa NJ,
with editor W. Schmidt book Dopamine and glutamate in psychiatric diseases
2002-2003,
Outstanding Research Award,
Awards Committee,
University of Illinois,
performing research
2002-2005,
Site-visits,
National Institutes of Health (NIH),
NIDA Centers Committee,
site-visiting applicants for Center Grants
2001, Member Medications Developm Reseach Subcomm,
NIDA-L,
National Institutes of Health,
reviewing grant applications
2000-2001,
Editor,
Humana Press,
Totowa NJ,
book Neurotransmitter Transporters second edition
2000, Ad Hoc Member Board Scientific Counselors,
NIDA,
National Institutes of Health,
evaluating NIDA intramural program
2000, Site-visit,
National Institutes of Health (NIH)
1998-2000,
Editor,
Humana Press,
Totowa NJ,
book Cerebral Signal Transduction: From First to Fourth Messengers
1998-1999,
Outstanding Research Award,
Awards Committee,
University of Illinois,
performing research
1998-2000,
Study Section Member,
Cell Mol Dev Neurosci Comm MDCN-4,
National Institutes of Health,
reviewing grant applications
1996-1998,
Study Section Member,
NIDA/B Committee,
National Institutes of Health,
reviewing grant applications
1995-1997,
Editor,
Humana Press,
Totowa NJ,
book Neurotransmitter Transporters
1994-1995,
Outstanding Research Award,
Awards Committee,
University of Illinois,
performing research
1993, Ad Hoc Member,
Board Scientific Counselors,
National Institutes of Health,
evaluating intramural NIDA program
1991-1998,
Member of Consultant Panel,
NIDA,
National Institutes of Health,
consulting on screening contract for stimulants and biogenic amines
1990-2005,
Member of Site Visit Teams,
NIDA,
National Institutes of Health,
evaluating institutions for grant funds
1987-2005,
Study Section Member,
Ad Hoc Review Committees NIDA,
National Institutes of Health,
reviewing grants
1971, Research Fellowship,
European Brain and Behavior Society,
Medical Faculty, Strasbourg, France,
brain cellular fractionation techniques
Previous Positions
1996, Adjunct Professor,
Illinois State University,
Biology
1995-2003, Professor,
University of Illinois at Chicago,
College of Medicine,
Biomedical and Therapeutic Sciences,
Pharmacology
1990-1991, Research Scientist,
N.S. Kline Institute
1978-1990, Research Scientist,
N.S. Kline Institute for Psychiatric Research
1974-1978, Senior Research Scientist,
University of Utrecht
1971-1974, Research Scientist,
Rudolf Magnus Institute
Funding Received
- National Institutes of Health (NIH): Structural and mechanistic characterization of neurotransmitter reuptake inhibition, D.-N. Wang, PI, 2008 to 2013.
- National Institutes of Health (NIH): Dopamine Transporters and Ions, Substrates, Blockers, NIDA, $ 850,000, 2006 to 2011.
- National Institutes of Health (NIH): Dopamine Transporters: Mechanisms of Ligand Interaction, NIDA, $ 700,000, 2006 to 2010.
- National Institutes of Health (NIH): Novel neuroprotective treatment for Parkinson's disease (subcontract), INDS, A. Dutta, PI, $ 286,200, 2005 to 2010.
- National Institutes of Health (NIH): Dopamine Transporter Agents Against Cocaine Dependence (subcontract), A. Dutta, PI, NIDA, $ 150,000, 2005 to 2008.
- National Institutes of Health (NIH): Cocaine and regulation of the dopamine transporter, NIDA, $586,743, 2000 to 2005.
- National Institutes of Health (NIH): Dopamine transporters and ions, substrates, blockers, NIDA, $675,000, 2000 to 2005.
- National Institutes of Health (NIH): Cocaine and the dopamine transporter, NIDA, $654,220, 1999 to 2005.
- National Institutes of Health (NIH): Cocaine medications (subcontract), A. Makriyannis, PI, NIDA, $165,769, 1999 to 2005.
- National Institutes of Health (NIH): Dopamine transporter agents against cocaine dependence (subcontract), A. Dutta, PI, NIDA, $171,892, 1999 to 2004.
- National Institutes of Health (NIH): The dopamine transporter and cocaine, NIDA, $533,578, 1994 to 1998.
- National Institutes of Health (NIH): Potent and selective probes for the dopamine transporter, A. Dutta, PI, $25,865 subcontract, 1994 to 1999.
- National Institutes of Health (NIH): Cocaine, neurotransmitters, vesicles, and behavior, NIDA, $281,928, 1993 to 1997.
- National Institutes of Health (NIH): Cocaine, neurotransmission, and behavior, NIDA, $491,000, 1987 to 1993.
- New York State Health Research Council: Stimulant and antidepressant binding sites, $ 18,150, 1981 to 1982.
Publications
- Brown DA, Mishra M, Zhang S, Biswas S, Parrington I, Antonio T, Reith ME, Dutta AK (Jun 2009) Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor., Bioorganic & medicinal chemistry, 17 (11), 3923-33
- Kurian MA, Zhen J, Cheng SY, Li Y, Mordekar SR, Jardine P, Morgan NV, Meyer E, Tee L, Pasha S, Wassmer E, Heales SJ, Gissen P, Reith ME, Maher ER (Jun 2009) Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia., The Journal of clinical investigation, 119 (6), 1595-603
- Kharkar PS, Batman AM, Zhen J, Beardsley PM, Reith ME, Dutta AK (May 2009) Synthesis and Biological Characterization of (3R,4R)-4-(2-(benzhydryloxy)ethyl)-1-((R)-2-hydroxy-2-phenylethyl)-piperidin-3-ol and Its Stereoisomers for Activity toward Monoamine Transporters., ChemMedChem
- Zhou Z, Zhen J, Karpowich NK, Law CJ, Reith ME, Wang DN (May 2009) Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures., Nature structural & molecular biology
- Liang YJ, Zhen J, Chen N, Reith ME (May 2009) Interaction of catechol and non-catechol substrates with externally or internally facing dopamine transporters., Journal of neurochemistry, 109 (4), 981-94
- Brown DA, Kharkar PS, Parrington I, Reith ME, Dutta AK (Dec 2008) Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model., Journal of medicinal chemistry, 51 (24), 7806-19
- Zhu J, Reith ME (Nov 2008) Role of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuse., CNS & neurological disorders drug targets, 7 (5), 393-409
- Chen N, Reith ME (May 2008) Substrates dissociate dopamine transporter oligomers., Journal of neurochemistry, 105 (3), 910-20
- Biswas S, Hazeldine S, Ghosh B, Parrington I, Kuzhikandathil E, Reith ME, Dutta AK (May 2008) Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity., Journal of medicinal chemistry, 51 (10), 3005-19
- Dutta AK, Ghosh B, Biswas S, Reith ME (May 2008) D-161, a novel pyran-based triple monoamine transporter blocker: Behavioral pharmacological evidence for antidepressant-like action., European journal of pharmacology
- Mishra M, Kolhatkar R, Zhen J, Parrington I, Reith ME, Dutta AK (Mar 2008) Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters., Bioorganic & medicinal chemistry, 16 (6), 2769-78
- K.C. Schmitt, J. Zhen, P. Kharkar, M. Mishra, N. Chen, A.K. Dutta, and M.E.A. Reith (2008) Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wildtype and mutant human dopamine transporters: Molecular features that differentially determine antagonist binding properties, J Neurochem, In Press
- Kharkar PS, Reith ME, Dutta AK (Jan 2008) Three-dimensional quantitative structure-activity relationship (3D QSAR) and pharmacophore elucidation of tetrahydropyran derivatives as serotonin and norepinephrine transporter inhibitors., Journal of computer-aided molecular design, 22 (1), 1-17
- Biswas S, Zhang S, Fernandez F, Ghosh B, Zhen J, Kuzhikandathil E, Reith ME, Dutta AK (Jan 2008) Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-Affinity D3-preferring agonist with potent in vivo activity with long duration, Journal of medicinal chemistry, 51 (1), 101-17
- P.S. Kharkar, A.K. Dutta and M.E.A. Reith (2008) Structure-activity relationship study of piperidine derivatives for dopamine transporters, Dopamine Transporters, Chemistry, Biology, and Pharmacology, Hoboken, NJ, Wiley, 233-264 pages (bookchapter)
- Zhou Z, Zhen J, Karpowich NK, Goetz RM, Law CJ, Reith ME, Wang DN (Sep 2007) LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake., Science (New York, N.Y.), 317 (5843), 1390-3
- Chen N, Reith ME (Apr 2007) Substrates and inhibitors display different sensitivity to expression level of the dopamine transporter in heterologously expressing cells., Journal of neurochemistry, 101 (2), 377-88
- L.D. Jayanthi, D.J. Samuvel, E. Buck, M.E.A. Reith (2007) Regulation of Biogenic Amine Transporters, Chpt 18, Handbook of Neurochemistry and Molecular Neurobiology, Vol. 11, New York, Springer, 363-386 pages, ISBN=9780387303475 (bookchapter)
- Zhang S, Fernandez F, Hazeldine S, Deschamps J, Zhen J, Reith ME, Dutta AK (Jul 2006) Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity inte, Journal of medicinal chemistry, 49 (14), 4239-47
- Zhang S, Zhen J, Reith ME, Dutta AK (Jun 2006) Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine., Bioorganic & medicinal chemistry, 14 (11), 3953-66
- Zhen J, Reith ME, Carr KD (Apr 2006) Chronic food restriction and dopamine transporter function in rat striatum., Brain research, 1082 (1), 98-101
- Reith ME, Zhen J, Chen N (2006) The importance of company: Na+ and Cl- influence substrate interaction with SLC6 transporters and other proteins., Handbook of experimental pharmacology (175), 75-93
- Krunic A, Mariappan SV, Reith ME, Dunn WJ (Dec 2005) Synthesis and monoamine transporter affinity of 3-aryl substituted trop-2-enes., Bioorganic & medicinal chemistry letters, 15 (24), 5488-93
- Zhen J, Chen N, Reith ME (Nov 2005) Differences in interactions with the dopamine transporter as revealed by diminishment of Na(+) gradient and membrane potential: dopamine versus other substrates., Neuropharmacology, 49 (6), 769-79
- Zhang S, Zhen J, Reith ME, Dutta AK (Jul 2005) Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner., J. Med. Chem., 48 (15), 4962-71
- Reith ME (Apr 2005) Studying monoamine transporters: beyond hypermonoaminaemia., Journal of neuroscience methods, 143 (1), 1-2
- Reith ME, Wang LC, Dutta AK (Apr 2005) Pharmacological profile of radioligand binding to the norepinephrine transporter: instances of poor indication of functional activity., Journal of neuroscience methods, 143 (1), 87-94
- Zhen J, Maiti S, Chen N, Dutta AK, Reith ME (Dec 2004) Interaction between a hydroxypiperidine analogue of
4-(2-benzhydryloxy-ethyl)-1-(4-fluorobenzyl)piperidine and Aspartate 68 in
the human dopamine transporter., European Journal of Pharmacology, 506 (1), 17-26
- Chen N, Reith ME, Interaction between dopamine and its transporter: role of intracellular sodium ions and membrane potential, Journal of Neurochemistry, 89(3), 750-65, May 2004
- Chen N, Zhen J, Reith ME, Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine, Journal of Neurochemistry, 89(4), 853-64, May 2004
- Li LB, Chen N, Ramamoorthy S, Chi L, Cui XN, Wang LC, Reith ME, The role of N-glycosylation in function and surface trafficking of the human dopamine transporter, Journal of Bioligical Chemistry, 279(20), 21012-20, May 2004
- Chen N, Rickey J, Berfield JL, Reith ME, Aspartate 345 of the dopamine transporter is critical for conformational changes in substrate translocation and cocaine binding, Journal of Bioligical Chemistry, 279(7), 5508-19, February 2004
- N. Chen, M.E.A. Reith, M.W. Quick, Synaptic uptake and beyond: The sodium- and chloride-dependent neurotransmitter family SLC6, Pflügers Archiv. Eur. J. Physiol., 447, 519-531, 2004
- R.B. Kolhatkar, C.D. Cook, S.K. Ghorai, J. Deschamps, P.M. Beardsley, M. E. A. Reith, A.K. Dutta, Further Structurally Constrained Analogues of Cis-(6-benzhydryl-piperidin-3-yl)-benzylamine With Elucidation of Bioactive Conformation: Development of 1,4-diaza-bicyclo-[3.3.1]nonane Derivatives and T, J. Med. Chem., 47, 5101-5113, 2004
- A.K. Dutta, S.K. Venkataraman, X.-S. Fei, R. Kolhatkar, S. Zhang, M. E. A. Reith, Synthesis and Biological Characterization of Novel Hybrid 7-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphtalen-2-ol and Their Heterocyclic Bioisosteric Analogues for Dopam, Bioorg. Med. Chem., 12, 4361-4373, 2004
- S. Zhang, J. Zhen, M. E. A. Reith, A.K. Dutta, Structural Requirements for 2,4- and 3,6-disubstituted Pyran Biomimetics of Cis-3,6-disubstituted Piperidine Compounds to Interact With Monoamine Transporters, Bioorg. Med. Chem., 12, 6301-6315, 2004
- Appell M, Berfield JL, Wang LC, Dunn WJ 3rd, Chen N, Reith ME, Structure-activity relationships for substrate recognition by the human dopamine transporter, Biochemical Pharmacology, 67(2), 293-302, January 2004
- Wang LC, Cui XN, Chen N, Reith ME, Binding of cocaine-like radioligands to the dopamine transporter at 37 degrees C: effect of Na+ and substrates, Journal of Neuroscience Methods, 131(1-2), 27-33, December 2003
- Chi L, Reith ME, Substrate-induced trafficking of the dopamine transporter in heterologously expressing cells and in rat striatal synaptosomal preparations, Journal of Pharmacology and Experimental Therapeutics, 307(2), 729-36, November 2003
- Chen N, Appell M, Berfield JL, Reith ME, Inhibition by arachidonic acid and other fatty acids of dopamine uptake at the human dopamine transporter, European Journal of Pharmacology, 478(2-3), 89-95, October 2003
- Reith ME, Preface, European Journal of Pharmacology, 479(1-3), 1, October 2003
- Chen N, Reith ME, Na(+) and the substrate permeation pathway in dopamine transporters, European Journal of Pharmacology, 479(1-3), 213-21, October 2003
- Dutta AK, Zhang S, Kolhatkar R, Reith ME, Dopamine transporter as target for drug development of cocaine dependence medications, European Journal of Pharmacology, 479(1-3), 93-106, October 2003
- Chen N, Rickey J, Reith ME, Na+ stimulates binding of dopamine to the dopamine transporter in cells but not in cell-free preparations, Journal of Neurochemistry, 86(3), 678-86, August 2003
- Zhang S, Reith ME, Dutta AK, Design, synthesis, and activity of novel cis- and trans-3,6-disubstituted pyran biomimetics of 3,6-disubstituted piperidine as potential ligands for the dopamine transporter, Bioorganic and Medicinal Chemistry Letters, 13(9), 1591-5, May 2003
- Kolhatkar RB, Ghorai SK, George C, Reith ME, Dutta AK, Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidi, Journal of Medicinal Chemistry, 46(11), 2205-15, May 2003
- Ghorai SK, Cook C, Davis M, Venkataraman SK, George C, Beardsley PM, Reith ME, Dutta AK, High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo, Journal of Medicinal Chemistry, 46(7), 1220-8, March 2003
- Cao BJ, Reith ME, Nitric oxide inhibits uptake of dopamine and N-methyl-4-phenylpyridinium (MPP+) but not release of MPP+ in rat C6 glioma cells expressing human dopamine transporter, British Journal of Pharmacology, 137(8), 1155-62, December 2002
- Cao BJ, Reith ME, Nitric oxide scavenger carboxy-PTIO potentiates the inhibition of dopamine uptake by nitric oxide donors, European Journal of Pharmacology, 448(1), 27-30, July 2002
- Wu Q, Reith ME, Walker QD, Kuhn CM, Carroll FI, Garris PA, Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study, The Journal of Neuroscience : the Official Journal of the Society for Neuroscience., 22(14), 6272-81, July 2002
- Chen N, Sun L, Reith ME, Cationic interactions at the human dopamine transporter reveal binding conformations for dopamine distinguishable from those for the cocaine analog 2 alpha-carbomethoxy-3 alpha-(4-fluoroph, Journal of Neurochemistry, 81(6), 1383-93, June 2002
- Appell M, Dunn WJ 3rd, Reith ME, Miller L, Flippen-Anderson JL, An analysis of the binding of cocaine analogues to the monoamine transporters using tensor decomposition 3-d QSAR, Bioorganic and Medicinal Chemistry, 10(5), 1197-206, May 2002
- Dutta AK, Fei XS, Reith ME, A novel series of hybrid compounds derived by combining 2-aminotetralin and piperazine fragments: binding activity at D2 and D3 receptors, Bioorganic and Medicinal Chemistry Letters, 12(4), 619-22, February 2002
- N. Chen, M.E.A. Reith (2002) Structure-function relationships for biogenic amine neurotransmitter transporters, Transporters: Structure, Function, and Regulation, 2nd edition,M.E.A. R, Totowa, New Jersey, Humana Press, 355-380 pages (bookchapter)
- A. Patel, M.E.A. Reith (2002) Neurotransmitter transporter proteins: Post-translational modifications, Neurotransmitter Transporters: Structure, Function, and Regulation, 2nd edition, M.E.A., Totowa, NJ, Humana Press, 355-380 pages (bookchapter)
- Wu Q, Reith ME, Wightman RM, Kawagoe KT, Garris PA, Determination of release and uptake parameters from electrically evoked dopamine dynamics measured by real-time voltammetry, Journal of Neuroscience Methods, 112(2), 119-33, December 2001
- Dutta AK, Davis MC, Reith ME, Rational design and synthesis of novel 2,5-disubstituted cis- and trans-piperidine derivatives exhibiting differential activity for the dopamine transporter, Bioorganic and Medicinal Chemistry Letters, 11(17), 2337-40, September 2001
- Wu Q, Reith ME, Kuhar MJ, Carroll FI, Garris PA, Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission, The Journal of Neuroscience : the Official Journal of the Society for Neuroscience., 21(16), 6338-47, August 2001
- Reith ME, Berfield JL, Wang LC, Ferrer JV, Javitch JA, The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter, Journal of Biological Chemistry, 276(31), 29012-8, August 2001
- Chen N, Vaughan RA, Reith ME, The role of conserved tryptophan and acidic residues in the human dopamine transporter as characterized by site-directed mutagenesis, Journal of Neurochemistry, 77(4), 1116-27, May 2001
- Vaughan RA, Gaffaney JD, Lever JR, Reith ME, Dutta AK, Dual incorporation of photoaffinity ligands on dopamine transporters implicates proximity of labeled domains, Molecular Pharmacology, 59(5), 1157-64, May 2001
- Dutta AK, Fei XS, Beardsley PM, Newman JL, Reith ME, Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine, Journal of Medicinal Chemistry, 44(6), 937-48, March 2001
- Dutta AK, Fei XS, Vaughan RA, Gaffaney JD, Wang N, Lever JR, Reith ME, Design, synthesis, and characterization of a novel, 4-[2-(diphenylmethoxy)ethyl]-1-benzyl piperidine-based, dopamine transporter photoaffinity label, Life Sciences, 68(16), 1839-49, March 2001
- Dutta AK, Reith ME, Madras BK, Synthesis and preliminary characterization of a high-affinity novel radioligand for the dopamine transporter, Synapse (new York, N.y.), 39(2), 175-81, February 2001
- Chen N, Reith ME, Structure and function of the dopamine transporter, European Journal of Pharmacology, 405(1-3), 329-39, September 2000
- Wang LC, Berfield JL, Kuhar MJ, Carroll FI, Reith ME, RTI-76, an isothiocyanate derivative of a phenyltropane cocaine analog, as a tool for irreversibly inactivating dopamine transporter function in vitro, Naunyn-Schmiedebergs Archives of Pharmacology, 362(3), 238-47, September 2000
- Seo DO, Shin CY, Ryu JR, Cheong JH, Choi CR, Dailey JW, Reith ME, Jobe PC, Ko KH, Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats, European Journal of Pharmacology, 396(2-3), 53-8, May 2000
- Li LB, Reith ME, Interaction of Na+, K+, and Cl- with the binding of amphetamine, octopamine, and tyramine to the human dopamine transporter, Journal of Neurochemistry, 74(4), 1538-52, April 2000
- Yan Q, Reith ME, Yan S, Enhanced accumbal dopamine release following 5-HT(2A) receptor stimulation in rats pretreated with intermittent cocaine, Brain Research, 863(1-2), 254-8, April 2000
- Li LB, Reith ME, Modeling of the interaction of Na+ and K+ with the binding of dopamine and [3H]WIN 35,428 to the human dopamine transporter, Journal of Neurochemistry, 72(3), 1095-109, March 1999
- Berfield JL, Wang LC, Reith ME, Which form of dopamine is the substrate for the human dopamine transporter: the cationic or the uncharged species?, Journal of Biological Chemistry, 274(8), 4876-82, February 1999
- Seo DO, Shin CY, Lee CJ, Dailey JW, Reith ME, Jobe PC, Ko KH, Effect of alterations in extracellular norepinephrine on adrenoceptors: a microdialysis study in freely moving rats, European Journal of Pharmacology, 365(1), 39-46, Jan 1999
- Yan QS, Reith ME, Yan SG, Jobe PC, Effect of systemic ethanol on basal and stimulated glutamate releases in the nucleus accumbens of freely moving Sprague-Dawley rats: a microdialysis study., Neuroscience Letters, 258(1), 29-32, 11 Dec 1998
- Dutta AK, Xu C, Reith ME, Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-an, Journal of Medicinal Chemistry, 41(17), 3293-7, August 1998
- Dutta AK, Coffey LL, Reith ME, Potent and selective ligands for the dopamine transporter (DAT): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues, Journal of Medicinal Chemistry, 41(5), 699-705, February 1998
- Reith ME, Xu C, Carroll FI, Chen NH, Inhibition of [3H]dopamine translocation and [3H]cocaine analog binding: a potential screening device for cocaine antagonists, Methods in Enzymology, 296, 248-59, 1998
- Dailey JW, Reith ME, Yan QS, Li MY, Jobe PC, Anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: dose response relationships., Neuroscience Letters, 227(1), 13-6, 9 1997
- Zhang L, Coffey LL, Reith ME, Regulation of the functional activity of the human dopamine transporter by protein kinase C., Biochemical Pharmacology, 53(5), 677-88, 7 1997
- Zhang L, Reith ME, Regulation of the functional activity of the human dopamine transporter by the arachidonic acid pathway, European Journal of Pharmacology, 315(3), 345-54, November 1996
- Li MY, Yan QS, Coffey LL, Reith ME, Extracellular dopamine, norepinephrine, and serotonin in the nucleus accumbens of freely moving rats during intracerebral dialysis with cocaine and other monoamine uptake blockers., Journal of Neurochemistry, 66(2), 559-68, 1996
- Xu C, Coffey LL, Reith ME, Translocation of dopamine and binding of 2 beta-carbomethoxy-3 beta-\(4-fluorophenyl\) tropane \(WIN 35,428\) measured under identical conditions in rat striatal synaptosomal preparations. Inhibition, Biochemical Pharmacology, 49(3), 339-50, 31 1995
- Chen NH, Reith ME, Autoregulation and monoamine interactions in the ventral tegmental area in the absence and presence of cocaine: a microdialysis study in freely moving rats, The Journal of Pharmacology and Experimental Therapeutics, 271(3), 1597-610, December 1994
- Reith ME, Coffey LL, Xu C, Chen NH, GBR 12909 and 12935 block dopamine uptake into brain synaptic vesicles as well as nerve endings., European Journal of Pharmacology, 253(1-2), 175-8, 21 1994
- Coffey LL, Reith ME, 3H]WIN 35,428 binding to the dopamine uptake carrier. I. Effect of tonicity and buffer composition., Journal of Neuroscience Methods, 51(1), 23-30, 1994
- Reith ME, Coffey LL, 3H]WIN 35,428 binding to the dopamine uptake carrier. II. Effect of membrane fractionation procedure and freezing., Journal of Neuroscience Methods, 51(1), 31-8, 1994
- Chen NH, Reith ME (Dec 1993) Dopamine and serotonin release-regulating autoreceptor sensitivity in
A9/A10 cell body and terminal areas after withdrawal of rats from
continuous infusion of cocaine., The Journal of Pharmacology and Experimental Therapeutics, 267 (3), 1445-53
- Chen NH, Reith ME (Oct 1993) [3H]dopamine and [3H]serotonin release in vitro induced by electrical
stimulation in A9 and A10 dopamine regions of rat brain: characterization
and responsiveness to cocaine., The Journal of Pharmacology and Experimental Therapeutics, 267 (1), 379-89
- Wiener HL, Reith ME, Unknown radioligand specific activity., Trends in Pharmacological Sciences, 14(8), 294-6, Aug 1993
- Reith ME, Coffey LL (Jul 1993) Cationic and anionic requirements for the binding of 2 beta-carbomethoxy-3
beta-(4-fluorophenyl)[3H]tropane to the dopamine uptake
carrier., Journal of Neurochemistry, 61 (1), 167-77
- Lipovac MN, Debler EA, Zlokovic BV, Jacobson AE, Rice KC, de Costa B, Selmeci G, Chi L, Reith ME (Mar-Apr 1993) Metaphit-induced audiogenic seizures in mice: II. Studies on
N-methyl-D-aspartic acid, GABA, and sodium channel receptors and on the
disposition of metaphit in the brain., Epilepsia, 34 (2), 211-9
- Debler EA, Lipovac MN, Lajtha A, Zlokovic BV, Dunlop DS, Jacobson AE, Rice KC, de Costa B, Reith ME (Mar-Apr 1993) Metaphit-induced audiogenic seizures in mice: I. Pharmacologic
characterization., Epilepsia, 34 (2), 201-10
- Reith ME, de Costa B, Rice KC, Jacobson AE (Dec 1992) Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and
dopamine to the dopamine transporter., European Journal of Pharmacology, 227 (4), 417-25
- Wiener HL, Reith ME (Nov 1992) Determination of radioligand specific activity using competition binding
assays., Analytical Biochemistry, 207 (1), 58-62
- Benuck M, Reith ME (Jun 1992) Dopamine releasing effect of phenylbiguanide in rat striatal slices., Naunyn-schmiedeberg's Archives of Pharmacology, 345 (6), 666-72
- Reith ME, Selmeci G (Mar 1992) Radiolabeling of dopamine uptake sites in mouse striatum: comparison of
binding sites for cocaine, mazindol, and GBR 12935., Naunyn-schmiedeberg's Archives of Pharmacology, 345 (3), 309-18
- Reith ME, Selmeci G (Jan 1992) Cocaine binding sites in mouse striatum, dopamine autoreceptors, and
cocaine-induced locomotion., Pharmacology, Biochemistry, and Behavior, 41 (1), 227-30
- Reith ME, Jacobson AE, Rice KC, Benuck M, Zimanyi I (Dec 1991) Effect of metaphit on dopaminergic neurotransmission in rat striatal
slices: involvement of the dopamine transporter and voltage-dependent
sodium channel., The Journal of Pharmacology and Experimental Therapeutics, 259 (3), 1188-96
- Debler EA, Sershen H, Hashim A, Lajtha A, Reith ME (Feb 1991) Carrier-mediated efflux of [3H]dopamine and [3H]1-methyl-4-phenylpyridine:
effect of ascorbic acid., Synapse (new York, N.y.), 7 (2), 99-105
- Reith ME, Wiener HL, Fischette CT (1991) Sertraline and cocaine-induced locomotion in mice. I. Acute studies., Psychopharmacology, 103 (3), 297-305
- Reith ME, Fischette CT (1991) Sertraline and cocaine-induced locomotion in mice. II. Chronic studies., Psychopharmacology, 103 (3), 306-13
- Susic V, Reith ME, Zlokovic BV, Lajtha A, Jacobson AE, Rice KC, Lipovac MN (Nov-Dec 1991) Electroencephalographic characteristics of audiogenic seizures induced in
metaphit-treated small rodents., Epilepsia, 32 (6), 783-90
- Wiener HL, Reith ME (Oct 1990) Differential effects of daily administration of cocaine on hepatic and
cerebral glutathione in mice., Biochemical Pharmacology, 40 (8), 1763-8
- Reith ME (Sep 1990) 5-HT3 receptor antagonists attenuate cocaine-induced locomotion in mice., European Journal of Pharmacology, 186 (2-3), 327-30
- Wiener HL, Reith ME (Jul 1990) Correlation between cocaine-induced locomotion and cocaine disposition in
the brain among four inbred strains of mice., Pharmacology, Biochemistry, and Behavior, 36 (3), 699-701
- Reith ME, O'Reilly CA (Jun 1990) Inhibition of serotonin uptake into mouse brain synaptosomes by ionophores
and ion-channel agents., Brain Research, 521 (1-2), 347-51
- Wiener HL, Kramer HK, Reith ME (May 1990) Separation and determination of sertraline and its metabolite,
desmethylsertraline, in mouse cerebral cortex by reversed-phase
high-performance liquid chromatography., Journal of Chromatography, 527 (2), 467-72
- Berger P, Elsworth JD, Reith ME, Tanen D, Roth RH (Feb 1990) Complex interaction of cocaine with the dopamine uptake carrier., European Journal of Pharmacology, 176 (2), 251-2
- Reith ME, Kramer HK, Sershen H, Lajtha A (Feb 1990) D-tartrate alters uptake of [3H]dopamine into brain synaptic vesicles., Journal of Neuroscience Methods, 31 (2), 133-6
- Reith ME (Jan 1990) [14C]guanidinium ion influx into Na+ channel preparations from mouse
cerebral cortex., European Journal of Pharmacology, 188 (1), 33-41
- Kramer HK, Sershen H, Lajtha A, Reith ME (Dec 1989) The effect of nicotine on catecholaminergic storage vesicles., Brain Research, 503 (2), 296-8
- Zimanyi I, Lajtha A, Reith ME (Dec 1989) Comparison of characteristics of dopamine uptake and mazindol binding in
mouse striatum., Naunyn-schmiedeberg's Archives of Pharmacology, 340 (6), 626-32
- Zimanyi I, Weiss SR, Lajtha A, Post RM, Reith ME (Aug 1989) Evidence for a common site of action of lidocaine and carbamazepine in
voltage-dependent sodium channels., European Journal of Pharmacology, 167 (3), 419-22
- Benuck M, Reith ME, Lajtha A (Aug 1989) Phosphoinositide hydrolysis induced by depolarization and sodium channel
activation in mouse cerebrocortical slices., Neuropharmacology, 28 (8), 847-54
- Reith ME, Zimanyi I, O'Reilly CA (Jul 1989) Role of ions and membrane potential in uptake of serotonin into plasma
membrane vesicles from mouse brain., Biochemical Pharmacology, 38 (13), 2091-7
- Debler EA, Lipovac MN, Lajtha A, Zlokovic BV, Jacobson AE, Rice KC, Reith ME (Jun 1989) Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in
mice., European Journal of Pharmacology, 165 (1), 155-9
- Zimanyi I, Wang E, Lajtha A, Reith ME (Feb 1989) Effect of cocaine and cocaine congeners on veratridine-induced
depolarization in mouse cerebrocortical synaptoneurosomes., Journal of Neuroscience Research, 22 (2), 201-8
- Benuck M, Reith ME, Sershen H, Wiener HL, Lajtha A (Jan 1989) Oxidative metabolism of cocaine: comparison of brain and liver., Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (new York, N. Y.), 190 (1), 7-13
- Benuck M, Reith ME, Lajtha A (Jan 1989) Evidence for the involvement of Na+/Ca2+ exchange in the stimulation of
inositol phospholipid hydrolysis by sodium channel activation and
depolarization., European Journal of Pharmacology, 159 (2), 187-90
- O'Reilly CA, Reith ME, Uptake of [3H]serotonin into plasma membrane vesicles from mouse cerebral cortex, Journal of Bioligical Chemistry, 263(13), 6115-21, May 1988
- Benuck M, Reith ME, Lajtha A (Mar 1988) Presence of the toxic metabolite N-hydroxy-norcocaine in brain and liver
of the mouse., Biochemical Pharmacology, 37 (6), 1169-72
- Zimanyi I, Lajtha A, Vizi ES, Reith ME (Feb 1988) Interaction of yohimbine with batrachotoxinin binding to mouse brain
sodium channels., Biochemical Pharmacology, 37 (4), 641-5
- Kim SS, Reith ME (Feb 1988) Inhibition by cocaine of inositol phospholipid hydrolysis induced by the
sodium channel activator batrachotoxin in mouse cerebral
cortex., Biochemical Pharmacology, 37 (4), 773-5
- Zimanyi I, Lajtha A, Reith ME (Jan 1988) The mode of action of ethanol on batrachotoxinin-A benzoate binding to
sodium channels in mouse brain cortex., European Journal of Pharmacology, 146 (1), 7-16
- Korpi ER, Reith ME, Lajtha A (Jan-Feb 1988) Synaptosomal sodium channels in rat lines selected for alcohol-related
behaviors., Alcohol (fayetteville, N.y.), 5 (1), 81-4
- Reith ME, Kim SS, Lajtha A (Nov 1987) Binding sites for [3H]tetracaine in synaptosomal sodium channel
preparations from mouse brain., European Journal of Pharmacology, 143 (2), 171-8
- Reith ME, Benuck M, Lajtha A (Oct 1987) Cocaine disposition in the brain after continuous or intermittent
treatment and locomotor stimulation in mice., The Journal of Pharmacology and Experimental Therapeutics, 243 (1), 281-7
- Benuck M, Lajtha A, Reith ME (Oct 1987) Pharmacokinetics of systemically administered cocaine and locomotor
stimulation in mice., The Journal of Pharmacology and Experimental Therapeutics, 243 (1), 144-9
- Reith ME (Oct 1986) Effect of repeated administration of various doses of cocaine and WIN
35,065-2 on locomotor behavior of mice., European Journal of Pharmacology, 130 (1-2), 65-72
- Berger P, Jacobsen AE, Rice KC, Lessor RA, Reith MA (Aug 1986) Metaphit, a receptor acylator, inactivates cocaine binding sites in
striatum and antagonizes cocaine-induced locomotor stimulation in
rodents., Neuropharmacology, 25 (8), 931-3
- Reith ME, Kim SS, Lajtha A, Structural requirements for cocaine congeners to interact with [3H]batrachotoxinin A 20-alpha-benzoate binding sites on sodium channels in mouse brain synaptosomes, Journal of Bioligical Chemistry, 261(16), 7300-5, June 1986
- Kim SS, Reith ME (Jun 1986) Effect of serotonin on the dissociation of high-affinity binding of
[3H]imipramine in mouse cerebral cortex., Neuroscience Letters, 67 (2), 123-8
- Reith ME, Meisler BE, Sershen H, Lajtha A (Apr 1986) Structural requirements for cocaine congeners to interact with dopamine
and serotonin uptake sites in mouse brain and to induce stereotyped
behavior., Biochemical Pharmacology, 35 (7), 1123-9
- Reith ME, Lajtha A (Feb 1986) Locomotor depression in mice by norcocaine does not involve central alpha
2-adrenergic or presynaptic dopamine receptors., Pharmacology, Biochemistry, and Behavior, 24 (2), 305-7
- Reith ME, Sershen H, Lajtha A (Jan 1986) Binding sites for [3H]cocaine in mouse striatum and cerebral cortex have
different dissociation kinetics., Journal of Neurochemistry, 46 (1), 309-12
- Reith ME, Meisler BE, Lajtha A (Nov 1985) Locomotor effects of cocaine, cocaine congeners, and local anesthetics in
mice., Pharmacology, Biochemistry, and Behavior, 23 (5), 831-6
- Reith ME, Possible artefacts in imipramine binding assays., Journal of Neurochemistry, 45(2), 661-3, Aug 1985
- Reith ME, Meisler BE, Sershen H, Lajtha A (Dec 1984) [3H]cocaine binding in brain is inhibited by Tris (hydroxymethyl)
aminomethane., Journal of Neuroscience Methods, 12 (2), 151-4
- Reith ME, Sershen H, Lajtha A (Dec 1984) Thermodynamics of the interactions of tricyclic drugs with binding sites
for [3H]imipramine in mouse cerebral cortex., Biochemical Pharmacology, 33 (24), 4101-4
- Reith ME, Sershen H, Lajtha A (Jul 1984) Binding of imipramine and cocaine to a model lipid membrane: comparison
with binding to brain membranes., Neurochemical Research, 9 (7), 965-77
- Sershen H, Reith ME, Hashim A, Lajtha A (Jun 1984) Reduction of dopamine uptake and cocaine binding in mouse striatum by
N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine., European Journal of Pharmacology, 102 (1), 175-8
- Allen DL, Reith ME, Sershen H, Lajtha A (May 1983) Imipramine does not act as a false transmitter in the rat hypothalamus., Brain Research, 267 (1), 161-4
- Reith ME, Sershen H, Allen DL, Lajtha A (May 1983) A portion of [3H]cocaine binding in brain is associated with serotonergic
neurons., Molecular Pharmacology, 23 (3), 600-6
- Reith ME, Sershen H, Allen D, Lajtha A (Feb 1983) High- and low-affinity binding of [3H]imipramine in mouse cerebral cortex., Journal of Neurochemistry, 40 (2), 389-95
- Sershen H, Reith ME, Lajtha A (May 1982) Comparison of the properties of central and peripheral binding sites for
cocaine., Neuropharmacology, 21 (5), 469-74
- Reith ME, Sershen H, Vadasz C, Lajtha A (Sep 1981) Strain differences in opiate receptors in mouse brain., European Journal of Pharmacology, 74 (4), 377-80
- Reith ME, Neidle A (1981) Breakdown and fate of ACTH and MSH., Pharmacology & Therapeutics, 12 (3), 449-61
- Reith ME, Sershen H, Lajtha A (Dec 1980) Endogenous peptide(s) inhibiting [3H]cocaine binding in mouse brain., Neurochemical Research, 5 (12), 1291-9
- Sershen H, Reith ME, Lajtha A (Nov 1980) The pharmacological relevance of the cocaine binding site in mouse brain., Neuropharmacology, 19 (11), 1145-8
- Reith ME, Sershen H, Lajtha A (Sep 1980) Saturable (3H)cocaine binding in central nervous system of mouse., Life Sciences, 27 (12), 1055-62
- Neidle A, Reith ME (Aug 1980) The degradation of adrenocorticotrophic hormone-(1-4) by mouse brain
cytosol., Archives of Biochemistry and Biophysics, 203 (1), 288-95
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