Dr. Robert J. Maier

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University of Georgia
Microbiology
Microbial Physiology
GRA Ramsey Eminent ScholarAppointed: 1998
Professional Headshot of Robert J. Maier

Mailing Address

University of Georgia
Department of Microbiology
815 Biological Sciences Building
Athens, Georgia 30602-2605
United States

Contact Information

Phone: (706) 542-2323
Fax: (706) 542-2674
rmaier@uga.edu

Qualifications

Ph.D., University of Wisconsin-Madison, Bacteriology, 1977.
M.S., University of Wisconsin-Madison, Bacteriology, 1975.
B.S., Michigan State University, Microbiology, 1973.

Expertise and Research Interests

Bacterial Physiology
Metabolism
Biochemistry

Current studies are focused on the physiology and biochemistry of the gastric and liver pathogens Helicobacter pylori and Helicobacter hepaticus, respectively. Those components that are important in virulence or for persistence in colonizing the host are studied. These include understanding metal sequestering proteins that store or mobilize metals into metal containing enzymes, enzymes responsible for combating oxidative stress, and the basis for use of molecular hydrogen as an energy source for growth of the pathogens. Approaches used include bacterial physiology and genetics, targeted mutagenesis of genes and specific residues, animal virulence models, and physical spectral approaches on pure proteins.

Other Expertise

Panel member/study section experience: Participated on three NIH study section panels in the past six years. Three USDA panels in the past 20 years.

Member of U.S. Environmental Protection Agency Biotechnology Science Advisory committee to review the safety of proposals for release of genetically engineered bacteria into the environment, Arlington, VA. March 1987, May, 1988, and November, 1994.

Program Manager for the USDA Competitive Grants Program (Nitrogen Fixation and Metabolism Program), 1989-1990.

American Society for Microbiology Travel Awards Committee, 1991-1996.

Congressional Liasion Committee Member of the ASBMB, to lobby congressional members for increased federal grant support, 1992-1998.

Volunteer workshop coordinator for the Johns Hopkins University Talented Youth Program (lab presentations and discussions to 8th and 9th graders interested in science), November; 1992, 1993, and 1994.

Presentations made at National and International Meetings: Invited presentations at International Conferences include the Metalloenzyme Meeting (Cancun, Mexico), at several Hydrogenases meetings in Europe, and as a keynote speaker at the University of Warwick (invited by the UK Society for General Microbiology), at two European Commission Biotechnology Workshops, and as a speaker at an NSF-sponsored Microbial Diversity workshop in Argentina. An invited presentation was made as a keynote speaker at the International Hydrogenases Conference in Reading, UK, August 29 2004. (title of talk: "Role of molecular hydrogen use in virulence by H2 oxidizing pathogenic bacteria").

In the past ten years seminars have been presented at the Medical College of Georgia, the NIH Rocky Mtn Labs (Hamilton, MT), Univ. of Florida (Gainesville), Univ. of Alabama-Birmingham, Michigan State Univ., Univ. of Buffalo, The University of Wisconsin-Madison, Univ. of Virginia (Charlottesville), Dalhousie Univ. (Halifax), and Uniformed Services Univ. (Bethesda MD).

Keywords

COS Keywords:

Bacteriology, Biochemistry, Biological Sciences, Gastroenterology, Metabolism, Microbiology, Mineral Metabolism, Oxidative Stress, Pathophysiology, Physiology.

Additional Terms:

Helicobacter, Hydrogen, Metalloprotein, Microaerobic Metabolism, Nickel Sequestering, Nickel-enzymes, Oxidative Stress.

Honors and Awards

2009, Invited Keynote speaker, Institute for Food Safety, Norwich, UK
2004, Creative Research Medal University of Georgia
2004, Invited Keynote Speaker, International Hydrogenases Conference, Univ. of Reading, Reading UK, Presentation on "Use of Molecular Hydrogen by Pathogenic Bacteria"
2003, Newcomb-Cleveland Award Nominee, AAAS

Previous Positions

1997-1998, Acting Chairman (Full Year), Johns Hopkins University, Krieger School of Arts and Sciences, Biology
1994-1995, Acting Chairman (Six Month Period), Johns Hopkins University, Krieger School of Arts and Sciences, Biology
1988-1998, Professor, Johns Hopkins University, Krieger School of Arts and Sciences, Biology
1984-1988, Associate Professor, Johns Hopkins University, McCollum-Pratt Institute, Biology
1979-1984, Assistant Professor, Johns Hopkins University, McCollum-Pratt Institute, Biology

Patents

A mutant strain of B. japonicum with altered molybdate transport and nitrogen fixing abilities, Patent Number: 5308616, 1994, Institution-owned, United States of America.

Funding Received

  • United States Department of Energy (DOE): Bacterial Nickel Metabolism and Storage, $134,000, Jan 1, 2000 to Dec 31, 2001.
  • National Institutes of Health (NIH): Oxidative stress and Survival of Helicobacter pylori, $150,000 annu direct, Aug 1, 2001 to Jul 31, 2006.
  • National Institutes of Health (NIH): Nickel Metabolism in Helicobacter pylori, $175,000 annu direct, Apr 1, 2004 to 2008.
  • National Institutes of Health (NIH): Use of Molecular Hydrogen by Salmonella typhimurium, $150,000 annu direct, 2009 to 2011.
  • National Institutes of Health (NIH): Amino acid repair activity in H. pylori, $250,000 annu direct, 2008 to 2013.
  • National Institutes of Health (NIH): Virulence Factors in Helicobacter hepaticus, $50,000 annual, 2003 to 2005.
  • Georgia Research Foundation: Eminent Scholar Endowment Yield, $60,000-$80,000 annu, 1998 to 2015.

Publications

  • Zbell AL, Maier RJ (Mar 2009) Role of the Hya hydrogenase in recycling of anaerobically produced H2 in Salmonella enterica serovar Typhimurium., Applied and environmental microbiology, 75 (5), 1456-9 Abstract
  • Wang G, Olczak A, Forsberg LS, Maier RJ (Mar 2009) Oxidative stress-induced peptidoglycan deacetylase in Helicobacter pylori., The Journal of biological chemistry, 284 (11), 6790-800 Abstract
  • Wang G, Maier RJ (Jan 2009) A RecB-like helicase in Helicobacter pylori is important for DNA repair and host colonization., Infection and immunity, 77 (1), 286-91 Abstract
  • Zbell AL, Maier SE, Maier RJ (Oct 2008) Salmonella enterica serovar Typhimurium NiFe uptake-type hydrogenases are differentially expressed in vivo., Infection and immunity, 76 (10), 4445-54 Abstract
  • Benoit SL, Maier RJ (Mar 2008) Hydrogen and nickel metabolism in helicobacter species., Annals of the New York Academy of Sciences, 1125, 242-51 Abstract
  • Hong Y, Wang G, Maier RJ (Feb 2008) The NADPH quinone reductase MdaB confers oxidative stress resistance to Helicobacter hepaticus., Microbial pathogenesis, 44 (2), 169-74 Abstract
  • Brahmachary P, Wang G, Benoit SL, Weinberg MV, Maier RJ, Hoover TR (2008) The human gastric pathogen Helicobacter pylori has a potential acetone carboxylase that enhances its ability to colonize mice., BMC microbiology, 8, 14 Abstract
  • Wang G, Maier RJ (Jan 2008) Critical role of RecN in recombinational DNA repair and survival of Helicobacter pylori., Infection and immunity, 76 (1), 153-60 Abstract
  • Benoit SL, Zbell AL, Maier RJ (Nov 2007) Nickel enzyme maturation in Helicobacter hepaticus: roles of accessory proteins in hydrogenase and urease activities., Microbiology (Reading, England), 153 (Pt 11), 3748-56 Abstract
  • Zbell AL, Benoit SL, Maier RJ (Oct 2007) Differential expression of NiFe uptake-type hydrogenase genes in Salmonella enterica serovar Typhimurium., Microbiology (Reading, England), 153 (Pt 10), 3508-16 Abstract
  • Maier RJ, Benoit SL, Seshadri S (Jun 2007) Nickel-binding and accessory proteins facilitating Ni-enzyme maturation in Helicobacter pylori., Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 20 (3-4), 655-64 Abstract
  • Seshadri S, Benoit SL, Maier RJ (Jun 2007) Roles of His-rich hpn and hpn-like proteins in Helicobacter pylori nickel physiology., Journal of bacteriology, 189 (11), 4120-6 Abstract
  • Weinberg MV, Maier RJ (May 2007) Peptide transport in Helicobacter pylori: roles of dpp and opp systems and evidence for additional peptide transporters., Journal of bacteriology, 189 (9), 3392-402 Abstract
  • Benoit SL, Mehta N, Weinberg MV, Maier C, Maier RJ (May 2007) Interaction between the Helicobacter pylori accessory proteins HypA and UreE is needed for urease maturation., Microbiology (Reading, England), 153 (Pt 5), 1474-82 Abstract
  • Hong Y, Wang G, Maier RJ (Apr 2007) A Helicobacter hepaticus catalase mutant is hypersensitive to oxidative stress and suffers increased DNA damage., Journal of medical microbiology, 56 (Pt 4), 557-62 Abstract
  • Mehta NS, Benoit SL, Mysore J, Maier RJ (Feb 2007) In vitro and in vivo characterization of alkyl hydroperoxide reductase mutant strains of Helicobacter hepaticus., Biochimica et biophysica acta, 1770 (2), 257-65 Abstract
  • Eutsey R, Wang G, Maier RJ (Jan 2007) Role of a MutY DNA glycosylase in combating oxidative DNA damage in Helicobacter pylori., DNA repair, 6 (1), 19-26 Abstract
  • Wang G, Hong Y, Olczak A, Maier SE, Maier RJ (Dec 2006) Dual Roles of Helicobacter pylori NapA in inducing and combating oxidative stress., Infection and immunity, 74 (12), 6839-46 Abstract
  • Wang G, Hong Y, Johnson MK, Maier RJ (Nov 2006) Lipid peroxidation as a source of oxidative damage in Helicobacter pylori: protective roles of peroxiredoxins., Biochimica et biophysica acta, 1760 (11), 1596-603 Abstract
  • Wang G, Alamuri P, Maier RJ (Aug 2006) The diverse antioxidant systems of Helicobacter pylori., Molecular microbiology, 61 (4), 847-60 Abstract
  • Alamuri P, Maier RJ (Aug 2006) Methionine sulfoxide reductase in Helicobacter pylori: interaction with methionine-rich proteins and stress-induced expression., Journal of bacteriology, 188 (16), 5839-50 Abstract
  • Alamuri P, Mehta N, Burk A, Maier RJ (Jul 2006) Regulation of the Helicobacter pylori Fe-S cluster synthesis protein NifS by iron, oxidative stress conditions, and fur., Journal of bacteriology, 188 (14), 5325-30 Abstract
  • Hong Y, Wang G, Maier RJ (Jun 2006) Helicobacter hepaticus Dps protein plays an important role in protecting DNA from oxidative damage., Free radical research, 40 (6), 597-605 Abstract
  • Adriana Olczak, Ge Wang, R.J. Maier (2005) Up-expression of NapA and other oxidative stress proteins is a compensatory response to loss of major Helicobacter pylori stress resistance factors, Free Radical Research, 39 (11), 1173-1182
  • Mehta NS, Benoit S, Mysore JV, Sousa RS, Maier RJ (Sep 2005) Helicobacter hepaticus hydrogenase mutants are deficient in hydrogen-supported amino acid uptake and in causing liver lesions in A/J mice., Infection and Immunity, 73 (9), 5311-8 Abstract
  • Maier RJ (Feb 2005) Use of molecular hydrogen as an energy substrate by human pathogenic bacteria., Biochemical Society Transactions, 33 (Pt 1), 83-5 Abstract
  • Wang G, Olczak AA, Walton JP, Maier RJ, Contribution of the Helicobacter pylori Thiol Peroxidase Bacterioferritin Comigratory Protein to Oxidative Stress Resistance and Host Colonization., Infection and Immunity, 73(1), 378-84, Jan 2005
  • Wang G, Conover RC, Benoit S, Olczak AA, Olson JW, Johnson MK, Maier RJ, Role of a bacterial organic hydroperoxide detoxification system in preventing catalase inactivation, Journal of Biological Chemistry, 28 Nov 2004
  • Maier RJ, Olczak A, Maier S, Soni S, and J. Gunn, Respiratory Hydrogen Use by Salmonella enterica serovar Typhimurium is Essential for Virulence, Infection and Immun., 72(11), 6294-299, 15 Nov 2004
  • Alamuri P, Maier RJ, Methionine sulphoxide reductase is an important antioxidant enzyme in the gastric pathogen Helicobacter pylori, Molecular Microbiology, 53(5), 1397-406, Sep 2004 Abstract
  • Wang, G, RJ Maier, An NADPH quinone reductase of Helicobacter pylori plays an important role in oxidative stress resistance and host colonization, Infection and Immunity, 72(3), 1391-6, March 2004
  • Benoit S, Mehta N, Wang G, Gatlin M, RJ Maier, Requirement of hydD, hydE, hypC, and hypE genes for the hydrogenase activity in Helicobacter pylori, Microbial Pathogenesis, 36(3), 153-7, March 2004
  • Mehta N, Benoit S, Maier RJ, Roles of conserved nucleotide-binding domains in accessory proteins, HypB and UreG, in the maturation of nickel-enzymes required for efficient Helicobacter pylori colonization, Microbial Pathogenesis, 35(5), 229-34, November 2003 Abstract
  • Maier, RJ, Availability and use of molecular hydrogen as an energy substrate for Helicobacter species, Microbes and Infection, 5(12), 1159-63, Oct 2003
  • Benoit S, Maier RJ, Dependence of Helicobacter pylori urease activity on the nickel sequestering ability of the UreE accessory protein, Journal of Bacteriology, 185(16), 4787-95, August 2003
  • Maier RJ, Olson J, Olczak A, Hydrogen-Oxidizing Capabilities of Helicobacter hepaticus and in vivo availability of the substrate, Journal of Bacteriology, 185(8), 2680-2, April 2003
  • Mehta N, Olson JW, Maier RJ, Characterization of Helicobacter pylori nickel metabolism accessory proteins, Journal of Bacteriology, 185(3), 726-34, February 2003
  • Olczak AA, Seyler RW Jr, Olson JW, Maier RJ, Association of Helicobacter pylori antioxidant activities with host colonization proficiency, Infection and Immunity, 71(1), 580-3, January 2003
  • JW Olson and RJ Maier, Molecular Hydrogen as an Energy Source for Helicobacter pylori, Science, 298(5599), 1788-90, 29 Nov 2002
  • Olczak AA, Olson JW, Maier RJ, Oxidative-stress resistance mutants of Helicobacter pylori, Journal of Bacteriology, 184(12), 3186-93, June 2002 Abstract
  • Seyler RW Jr, Olson JW, Maier RJ, Superoxide dismutase-deficient mutants of Helicobacter pylori are hypersensitive to oxidative stress and defective in host colonization, Infection and Immunity, 69(6), 4034-40, June 2001 Abstract
  • Olson JW, Mehta NS, Maier RJ, Requirement of nickel metabolism proteins HypA and HypB for full activity of both hydrogenase and urease in Helicobacter pylori, Molecular Microbiology, 39(1), 176-82, Jan 2001 Abstract
  • Olson JW, Agar JN, Johnson MK, Maier RJ, Characterization of the NifU and NifS Fe-S cluster formation proteins essential for viability in Helicobacter pylori, Biochemistry, 39(51), 16213-9, 2000 Abstract
  • Maier RJ, Moshiri F, Role of the Azotobacter vinelandii nitrogenase-protective shethna protein in preventing oxygen-mediated cell death, Journal of Bacteriology, 182(13), 3854-7, July 2000 Abstract
  • Olson JW, Maier RJ, Dual roles of Bradyrhizobium japonicum nickelin protein in nickel storage and GTP-dependent Ni mobilization, Journal of Bacteriology, 182(6), 1702-5, March 2000 Abstract
  • Lou J, Moshiri F, Johnson MK, Lafferty ME, Sorkin DL, Miller A, Maier RJ, Mutagenesis studies of the FeSII protein of Azotobacter vinelandii: roles of histidine and lysine residues in the protection of nitrogenase from oxygen damage, Biochemistry, 38(17), 5563-71, 1999 Abstract
  • Surpin, MA, RJ Maier, Symbiotic Deficiencies associated with a coxWXYZ mutant of Bradyrhizobium japonicum, Appl Environ Microbiol, 65(1), 339-342, Jan 1999
  • Durmowicz MC, Maier RJ, The FixK2 protein is involved in regulation of symbiotic hydrogenase expression in Bradyrhizobium japonicum, Journal of Bacteriology, 180(12), 3253-6, June 1998 Abstract
  • Surpin, MA, Maier, RJ, Roles of the Bradyrhizobium japonicum terminal oxidase complexes in microaerobic H2-dependent growth, Biochim. et Biophys. Acta, 1364(1040 Blue Beech Pte), 37-45, 06 Apr 1998
  • Rey L, Maier RJ, Cytochrome c terminal oxidase pathways of Azotobacter vinelandii: analysis of cytochrome c4 and c5 mutants and up-regulation of cytochrome c-dependent pathways with N2 fixation, Journal of Bacteriology, 179(22), 7191-6, November 1997 Abstract
  • Olson JW, Maier RJ, The sequences of hypF, hypC and hypD complete the hyp gene cluster required for hydrogenase activity in Bradyrhizobium japonicum, Gene, 199(1-2), 93-9, 1997 Abstract
  • Durmowicz MC, Maier RJ, Roles of HoxX and HoxA in biosynthesis of hydrogenase in Bradyrhizobium japonicum, Journal of Bacteriology, 179(11), 3676-82, June 1997 Abstract
  • Kolonay JF, Maier RJ, Formation of pH and potential gradients by the reconstituted Azotobacter vinelandii cytochrome bd respiratory protection oxidase, Journal of Bacteriology, 179(11), 3813-7, June 1997 Abstract
  • Olson JW, Fu C, Maier RJ, The HypB protein from Bradyrhizobium japonicum can store nickel and is required for the nickel-dependent transcriptional regulation of hydrogenase, Molecular Microbiology, 24(1), 119-28, April 1997 Abstract
  • Ng TC, Kwik JF, Maier RJ, Cloning and expression of the gene for a protein disulfide oxidoreductase from Azotobacter vinelandii: complementation of an Escherichia coli dsbA mutant strain, Gene, 188(1), 109-13, 1997 Abstract
  • Surpin MA, Lubben M, Maier RJ, The Bradyrhizobium japonicum coxWXYZ gene cluster encodes a bb3-type ubiquinol oxidase, Gene, 183(1-2), 201-6, 1996 Abstract
  • Maier RJ, Fu C, Gilbert J, Moshiri F, Olson J, Plaut AG, Hydrogen uptake hydrogenase in Helicobacter pylori, FEMS Microbiology Letters, 141(1), 71-6, 1996 Abstract
  • Ferber, DM, Moy, B. and RJ Maier, Bradyrhizobium japonicum hydrogen-ubiquinone reductase activity: quinone specificity, inhibition by quinone analogs, and evidence for separate sites of electron acceptor reactivity, Biochim et Biophys Acta, 1229, 334-346, May 1996
  • Maier RJ, Respiratory metabolism in hyperthermophilic organisms: hydrogenases, sulfur reductases, and electron transport factors that function at temperatures exceeding 100 degrees C, Advances in Protein Chemistry, 48, 35-99, 1996 Abstract
  • Moshiri F, Crouse BR, Johnson MK, Maier RJ, The 'nitrogenase-protective' FeSII protein of Azotobacter vinelandii: overexpression, characterization, and crystallization, Biochemistry, 34(40), 12973-82, 1995 Abstract
  • Ng TC, Laheri AN, Maier RJ, Cloning, sequencing, and mutagenesis of the cytochrome c4 gene from Azotobacter vinelandii: characterization of the mutant strain and a proposed new branch in the respiratory chain, Biochimica et Biophysica Acta, 1230(3), 119-29, 1995 Abstract
  • Black LK, Maier RJ, IHF- and RpoN-dependent regulation of hydrogenase expression in Bradyrhizobium japonicum, Molecular Microbiology, 16(3), 405-13, May 1995 Abstract
  • Fu C, Olson JW, Maier RJ, HypB protein of Bradyrhizobium japonicum is a metal-binding GTPase capable of binding 18 divalent nickel ions per dimer, Proceedings of the National Academy of Sciences (USA), 92(6), 2333-7, 1995 Abstract
  • Black LK, Fu C, Maier RJ, Sequences and characterization of hupU and hupV genes of Bradyrhizobium japonicum encoding a possible nickel-sensing complex involved in hydrogenase expression, Journal of Bacteriology, 176(22), 7102-6, November 1994 Abstract
  • Moshiri F, Kim JW, Fu C, Maier RJ, The FeSII protein of Azotobacter vinelandii is not essential for aerobic nitrogen fixation, but confers significant protection to oxygen-mediated inactivation of nitrogenase in vitro and in vivo, Molecular Microbiology, 14(1), 101-14, October 1994 Abstract
  • Maier, RJ, and C. Fu, Increased divalent metal ion uptake associated with hydrogenase constitutive phenotypes of Bradyrhizobium japonicum, BioMetals, 7(4), October 1994
  • Maier, RJ, and C. Fu, Increased divalent metal ion uptake associated with hydrogenase constitutive phenotypes of Bradyrhizobium japonicum, BioMetals, 7(4), October 1994
  • Fu C, Maier RJ, Organization of the hydrogenase gene cluster from Bradyrhizobium japonicum: sequences and analysis of five more hydrogenase-related genes, Gene, 145(1), 91-6, 1994 Abstract
  • Kolonay JF, Moshiri F, Gennis RB, Kaysser TM, Maier RJ, Purification and characterization of the cytochrome bd complex from Azotobacter vinelandii: comparison to the complex from Escherichia coli, Journal of Bacteriology, 176(13), 4177-81, July 1994 Abstract
  • Surpin MA, Moshiri F, Murphy AM, Maier RJ, Genetic evidence for a fourth terminal oxidase in Bradyrhizobium japonicum, Gene, 143(1), 73-7, 1994 Abstract
  • Fu C, Javedan S, Moshiri F, Maier RJ, Bacterial genes involved in incorporation of nickel into a hydrogenase enzyme, Proceedings of the National Academy of Sciences (USA), 91(11), 5099-103, 1994 Abstract
  • Fu C, Maier RJ, Sequence and characterization of three genes within the hydrogenase gene cluster of Bradyrhizobium japonicum, Gene, 141(1), 47-52, 1994 Abstract
  • Fu C, Maier RJ, Nucleotide sequences of two hydrogenase-related genes (hypA and hypB) from Bradyrhizobium japonicum, one of which (hypB) encodes an extremely histidine-rich region and guanine nucleotide-binding domai, Biochimica Et Biophysica Acta, 1184(1), 135-8, 1994 Abstract
  • Gabel C, Bittinger MA, Maier RJ, Cytochrome aa3 gene regulation in members of the family Rhizobiaceae: comparison of copper and oxygen effects in Bradyrhizobium japonicum and Rhizobium tropici, Applied and Environmental Microbiology, 60(1), 141-8, January 1994 Abstract
  • Keefe RG, Maier RJ, Purification and characterization of an O2-utilizing cytochrome-c oxidase complex from Bradyrhizobium japonicum bacteroid membranes, Biochimica Et Biophysica Acta, 1183(1), 91-104, 1993 Abstract
  • Fu C, Maier RJ, Rapid and efficient selection of recombinant site-directed mutants of Bradyrhizobium japonicum by colony hybridization, Fems Microbiology Letters, 109(1), 33-8, 1993 Abstract
  • Fu C, Maier RJ, A genetic region downstream of the hydrogenase structural genes of Bradyrhizobium japonicum that is required for hydrogenase processing, Journal of Bacteriology, 175(1), 295-8, January 1993 Abstract
  • Gabel C, Maier RJ, Oxygen-dependent transcriptional regulation of cytochrome aa3 in Bradyrhizobium japonicum, Journal of Bacteriology, 175(1), 128-32, January 1993 Abstract
  • Kim H, Gabel C, Maier RJ, Expression of hydrogenase in Hupc strains of Bradyrhizobium japonicum, Archives of Microbiology, 160(1), 43-50, 1993 Abstract
  • Ferber DM, Maier RJ, Hydrogen-ubiquinone oxidoreductase activity by the Bradyrhizobium japonicum membrane-bound hydrogenase, FEMS Microbiology Letters, 110(3), 257-64, 1993
  • Ferber DM, Maier RJ, Incorporation of a bacterial membrane-bound hydrogenase into proteoliposomes, Analytical Biochemistry, 203(2), 235-44, June 1992 Abstract
  • Fu C, Maier RJ, Nickel-dependent reconstitution of hydrogenase apoprotein in Bradyrhizobium japonicum Hupc mutants and direct evidence for a nickel metabolism locus involved in nickel incorporation into the enzyme, Archives of Microbiology, 157(6), 493-8, 1992 Abstract
  • Pihl TD, Black LK, Schulman BA, Maier RJ, Hydrogen-oxidizing electron transport components in the hyperthermophilic archaebacterium Pyrodictium brockii, Journal of Bacteriology, 174(1), 137-43, January 1992 Abstract
  • Moshiri F, Smith EG, Taormino JP, Maier RJ, Transcriptional regulation of cytochrome d in nitrogen-fixing Azotobacter vinelandii. Evidence that up-regulation during N2 fixation is independent of nifA but dependent on ntrA, Journal of Biological Chemistry, 266(34), 23169-74, 1991 Abstract
  • Fu CL, Maier RJ, Competitive inhibition of an energy-dependent nickel transport system by divalent cations in Bradyrhizobium japonicum JH, Applied and Environmental Microbiology, 57(12), 3511-6, December 1991 Abstract
  • Fu CL, Maier RJ, Identification of a locus within the hydrogenase gene cluster involved in intracellular nickel metabolism in Bradyrhizobium japonicum, Applied and Environmental Microbiology, 57(12), 3502-10, December 1991 Abstract
  • Moshiri F, Chawla A, Maier RJ, Cloning, characterization, and expression in Escherichia coli of the genes encoding the cytochrome d oxidase complex from Azotobacter vinelandii, Journal of Bacteriology, 173(19), 6230-41, October 1991 Abstract
  • Kim H, Yu C, Maier RJ, Common cis-acting region responsible for transcriptional regulation of Bradyrhizobium japonicum hydrogenase by nickel, oxygen, and hydrogen, Journal of Bacteriology, 173(13), 3993-9, July 1991 Abstract
  • Pihl TD, Maier RJ, Purification and characterization of the hydrogen uptake hydrogenase from the hyperthermophilic archaebacterium Pyrodictium brockii, Journal of Bacteriology, 173(6), 1839-44, March 1991 Abstract
  • Kim H, Maier RJ, Transcriptional regulation of hydrogenase synthesis by nickel in Rhizobium japonicum, Journal of Biological Chemistry, 265(31), 18729-32, 01 Nov 1990
  • Gabel C, Maier RJ, Nucleotide sequence of the coxA gene encoding subunit I of cytochrome aa3 of Bradyrhizobium japonicum, Nucleic Acids Research, 18(20), 6143, 1990 Abstract
  • Maier RJ, Pihl TD, Stults L, Sray W, Nickel accumulation and storage in Bradyrhizobium japonicum, Applied and Environmental Microbiology, 56(6), 1905-11, June 1990 Abstract
  • Pihl TD, Schicho RN, Black LK, Schulman BA, Maier RJ, Kelly RM, Hydrogen-sulfur autotrophy in the hyperthermophilic archaebacterium, Pyrodictium brockii, Biotechnology and Genetic Engineering Reviews, 8, 345-77, 1990 Abstract
  • O'Brian MR, Maier RJ, Molecular aspects of the energetics of nitrogen fixation in Rhizobium-legume symbioses, Biochimica Et Biophysica Acta, 974(3), 229-46, 1989 Abstract
  • Novak PD, Maier RJ, Hydrogenase synthesis in Bradyrhizobium japonicum Hupc mutants is altered in sensitivity to DNA gyrase inhibitors, Applied and Environmental Microbiology, 55(5), 1157-64, May 1989 Abstract
  • Pihl TD, Schicho RN, Kelly RM, Maier RJ, Characterization of hydrogen-uptake activity in the hyperthermophile Pyrodictium brockii, Proceedings of the National Academy of Sciences (USA), 86(1), 138-41, January 1989 Abstract
  • Maier RJ, Graham L, Molybdate transport by Bradyrhizobium japonicum bacteroids, Journal of Bacteriology, 170(12), 5613-9, December 1988 Abstract
  • Moshiri F, Maier RJ, Conformational changes in the membrane-bound hydrogenase of Bradyrhizobium japonicum. Evidence that the redox state of the enzyme affects its accessibility to protease and membrane-impermeant reagents, Journal of Biological Chemistry, 263(33), 17809-16, 1988 Abstract
  • Maier RJ, Prosser J, Hydrogen-mediated mannose uptake in Azotobacter vinelandii, Journal of Bacteriology, 170(4), 1986-9, April 1988 Abstract
  • van Berkum P, Maier RJ, Lack of carbon substrate repression of uptake hydrogenase activity in Bradyrhizobium japonicum SR, Journal of Bacteriology, 170(4), 1962-4, April 1988 Abstract
  • Prosser J, Graham L, Maier RJ, Hydrogen-mediated enhancement of hydrogenase expression in Azotobacter vinelandii, Journal of Bacteriology, 170(4), 1990-3, April 1988 Abstract
  • O'Brian MR, Maier RJ, Hydrogen metabolism in Rhizobium: energetics, regulation, enzymology and genetics, Advances in Microbial Physiology, 29, 1-52, 1988 Abstract
  • O'Brian MR, Kirshbom PM, Maier RJ, Bacterial heme synthesis is required for expression of the leghemoglobin holoprotein but not the apoprotein in soybean root nodules, Proceedings of the National Academy of Sciences (USA), 84(23), 8390-3, December 1987 Abstract
  • Graham L, Maier RJ, Variability in molybdenum uptake activity in Bradyrhizobium japonicum strains, Journal of Bacteriology, 169(6), 2555-60, June 1987 Abstract
  • Novak PD, Maier RJ, Inhibition of hydrogenase synthesis by DNA gyrase inhibitors in Bradyrhizobium japonicum, Journal of Bacteriology, 169(6), 2708-12, June 1987 Abstract
  • Maier RJ, Graham L, Keefe RG, Pihl T, Smith E, Bradyrhizobium japonicum mutants defective in nitrogen fixation and molybdenum metabolism, Journal of Bacteriology, 169(6), 2548-54, June 1987 Abstract
  • Stults LW, Mallick S, Maier RJ, Nickel uptake in Bradyrhizobium japonicum, Journal of Bacteriology, 169(4), 1398-402, April 1987 Abstract
  • O'Brian MR, Kirshbom PM, Maier RJ, Tn5-induced cytochrome mutants of Bradyrhizobium japonicum: effects of the mutations on cells grown symbiotically and in culture, Journal of Bacteriology, 169(3), 1089-94, March 1987 Abstract
  • Stults LW, Moshiri F, Maier RJ, Aerobic purification of hydrogenase from Rhizobium japonicum by affinity chromatography, Journal of Bacteriology, 166(3), 795-800, June 1986 Abstract
  • Wong TY, Maier RJ, H2-dependent mixotrophic growth of N2-fixing Azotobacter vinelandii, Journal of Bacteriology, 163(2), 528-33, August 1985 Abstract
  • Wong TY, Maier RJ, Chlorpromazine inhibition of electron transport in Azotobacter vinelandii membranes, Biochimica Et Biophysica Acta, 807(3), 320-3, 1985 Abstract
  • Hom SS, Graham LA, Maier RJ, Isolation of genes (nif/hup cosmids) involved in hydrogenase and nitrogenase activities in Rhizobium japonicum, Journal of Bacteriology, 161(3), 882-7, March 1985 Abstract
  • O'Brian MR, Maier RJ, Expression of cytochrome o in hydrogen uptake constitutive mutants of Rhizobium japonicum, Journal of Bacteriology, 161(2), 507-14, February 1985 Abstract
  • O'Brian MR, Maier RJ, Role of ubiquinone in hydrogen-dependent electron transport in Rhizobium japonicum, Journal of Bacteriology, 161(2), 775-7, February 1985 Abstract
  • Merberg D, Maier RJ, Coordinate expression of hydrogenase and ribulose bisphosphate carboxylase in Rhizobium japonicum Hup-constitutive mutants, Journal of Bacteriology, 160(1), 448-50, October 1984 Abstract
  • Wong TY, Maier RJ, Hydrogen-oxidizing electron transport components in nitrogen-fixing Azotobacter vinelandii, Journal of Bacteriology, 159(1), 348-52, July 1984 Abstract
  • Stults LW, O'Hara EB, Maier RJ, Nickel is a component of hydrogenase in Rhizobium japonicum, Journal of Bacteriology, 159(1), 153-8, July 1984 Abstract
  • Merberg D, O'Hara EB, Maier RJ, Regulation of hydrogenase in Rhizobium japonicum: analysis of mutants altered in regulation by carbon substrates and oxygen, Journal of Bacteriology, 156(3), 1236-42, December 1983 Abstract
  • O'Brian MR, Maier RJ, Involvement of cytochromes and a flavoprotein in hydrogen oxidation in Rhizobium japonicum bacteroids, Journal of Bacteriology, 155(2), 481-7, August 1983 Abstract
  • Moshiri F, Stults L, Novak P, Maier RJ, Nif- Hup- mutants of Rhizobium japonicum, Journal of Bacteriology, 155(2), 926-9, August 1983 Abstract
  • D. Merberg and R.J. Maier, Mutant strains of Rhizobium japonicum with increased hydrogenase activity, Science, 220, 1064-1065, 1983
  • O'Brian MR, Maier RJ, Electron transport components involved in hydrogen oxidation in free-living Rhizobium japonicum, Journal of Bacteriology, 152(1), 422-30, October 1982 Abstract
  • Maier RJ, Merberg DM, Rhizobium japonicum mutants that are hypersensitive to repression of H2 uptake by oxygen, Journal of Bacteriology, 150(1), 161-7, April 1982 Abstract
  • Maier RJ, Mutaftschiev S, Reconstitution of H2 oxidation activity from H2 uptake-negative mutants of Rhizobium japonicum bacteroids, Journal of Biological Chemistry, 257(4), 2092-6, 1982 Abstract
  • Maier RJ, Rhizobium japonicum mutant strains unable to grow chemoautotrophically with H2, Journal of Bacteriology, 145(1), 533-40, January 1981 Abstract
  • Hanus FJ, Maier RJ, Evans HJ, Autotrophic growth of H2-uptake-positive strains of Rhizobium japonicum in an atmosphere supplied with hydrogen gas, Proceedings of the National Academy of Sciences (USA), 76(4), 1788-92, April 1979 Abstract
  • Maier RJ, Hanus FJ, Evans HJ, Regulation of hydrogenase in Rhizobium japonicum, Journal of Bacteriology, 137(2), 825-9, February 1979 Abstract
  • Maier, RJ, Campbell, NE, Hanus, FJ, Simpson, FB, Evans, HJ (1978) Expression of hydrogenase activity in free-living Rhizobium japonicum, Proceed National Acad Sci, 75 (7), 3258-3262
  • Maier RJ, Bishop PE, Brill WJ, Transfer from Rhizobium japonicum to Azotobacter vinelandii of genes required for nodulation, Journal of Bacteriology, 134(3), 1199-201, June 1978 Abstract
  • Maier RJ, Brill WJ, Involvement of Rhizobium japonicum O antigen in soybean nodulation, Journal of Bacteriology, 133(3), 1295-9, March 1978 Abstract
  • Bishop PE, Dazzo FB, Appelbaum ER, Maier RJ, Brill WJ, Intergeneric transfer of genes involved in the Rhizobium-legume symbiosis, Science, 198(4320), 938-40, 1977 Abstract
  • Maier RJ, Brill WJ, Ineffective and non-nodulating mutant strains of Rhizobium japonicum, Journal of Bacteriology, 127(2), 763-9, August 1976 Abstract

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Last Updated: 8/31/2009

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