Prof. Robert A. Steiner

powered by
COS Expertise®
University of Washington
School of Medicine
Obstetrics & Gynecology
Reproductive Endocrinology & Infertility
ProfessorAppointed: 1977
University of Washington
School of Medicine
Physiology and Biophysics
ProfessorAppointed: 1977
University of Washington
College of Arts and Sciences
Biology
Professor (Adjunct)
Professional Headshot of Robert A. Steiner

Mailing Address

Department of Physiology and Biophysics
University of Washington
Box 357290
Seattle, Washington 98195-7290
United States

Contact Information

Phone: (206) 543-8712
Fax: (206) 685-0619
steiner@u.washington.edu
http://depts.washington.edu/pbiopage/people_fac_page.php?fac_ID=30

Qualifications

Ph.D., Oregon Health & Science University, Physiology, 1975.

Expertise and Research Interests

Research in the Steiner lab is directed toward understanding the neuroendocrine mechanisms that govern reproduction. We are curious about the cellular and molecular events that trigger the onset of puberty, the circadian signals that are coupled to the preovulatory GnRH/LH surge, and the mechanisms that orchestrate sexual differentiation of the brain. We are also trying to understand how the regulation of metabolism and body weight are physiologically coupled to reproduction. The daily work of the lab is focused on dissecting the cellular and molecular pathways through which sex steroids (e.g., estradiol and testosterone) and other hormones (such as leptin and insulin) regulate neuropeptide gene expression and defining the hypothalamic circuitry that controls the secretion of GnRH. We are currently investigating kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54) to learn how kisspeptin-GPR54 signaling regulates GnRH and gonadotropin secretion. To explore these questions, we use animal models, including the rat and mouse (wild-type as well as spontaneous and genetically engineered mutants), and we employ various techniques, such as in situ hybridization, neuroanatomical mapping, tract tracing, microarray analysis, radioimmunoassays, neurosurgical manipulations, cloning, and gene targeting to create knockouts. Our primary goal is to increase understanding of the biology of reproduction-- but we also hope that our work will have some practical value-- perhaps, to reveal the etiology (and treatment) of certain disorders of reproduction, such as hypogonadotropic hypogonadism and precocious puberty, or provide the scientific rationale for the development of newer and better strategies for hormonal contraception.

Other Expertise

Distinguished Teaching Award, University of Washington
Teaching Academy of the University of Washington
Service on NIH Study Sections (Reproductive Endocrinology, 1986-90; Small Business, 2002; Endocrinology, 2003; RPHB/BDA IRG, 2005; SCCPRR, 2006)

Editorial Boards:
Endocrinology, 1986-1990; 1994-1998; 2001-2004; 2007-
Neuroendocrinology, 2000-present
Molecular and Cellular Neurosciences, (Editor, 1991-1994)
Biology of Reproduction, 1986-1990
American Journal of Physiology, 1993-1998

Future Research

We are developing transgenic mice using the Cre/Lox system coupled with adeno-associated viral targeting to produce conditional deletion (or knock-down) of genes in subsets of hypothalamic neurons in vivo. We are also developing techniques to study the regulation of genes in isolated, phenotypically identified cells in the brain, using a combination of in situ hybridization, immunocytochemistry, laser capture microscopy and microarray analysis.

Industrial Relevance

The results of our research may be relevant to the development of drugs useful in the treatment of disorders of the neuroendocrine reproductive system (e.g., infertility, precocious puberty, aging-related problems), contraceptive development, as well as reproductive dysfunction that may be related to metabolic diseases, such as diabetes and obesity.

Keywords

COS Keywords:

Animal Models, Behavioral Biology, Biophysics, Brain, Cell Biology, Contraceptives, Developmental Biology, Endocrinology, Gene Expression, Gene Regulation, Hormones, Nervous System, Neurobiology, Neuroendocrinology, Neuropeptides, Neurotransmitters, Nutrition Or Dietetics, Obstetrics Or Gynecology, Physiology, Receptors, Reproductive Endocrinology.

Additional Terms:

Brain, Endocrinology, Hormone Receptors, Hormone and Neurotransmitter Signaling Mechanisms, Hypothalamus, Nervous System, Neurobiology, Neuroendocrinology, Neuropeptides, Neurotransmitter Receptors.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
French: (Basic, Basic, Basic)

Memberships

American Association for the Advancement of Science
American Physiological Society
Endocrine Society
International Neuropeptide Society
International Society of Neuroendocrinology
Society for Behavioral Neuroendocrinology
Society for Neuroscience
Society for the Study of Reproduction

Honors and Awards

Distinguished Teaching Award University of Washington
Teaching Academy of the University of Washington
William A. Sadler Lectureship, National Institutes of Health (NIH)

Funding Received

  • NIH/NICHD: Kiss1-kisspeptin-GPR54 Signaling in the female brain, $875,000, 2006 to 2011.
  • NIH/NICHD: SCCPRR/U-54 Specialized Cooperative Centers Grant for Reproductive Research, $750,000, 2006 to 2011.
  • NIH/NIA: Neurochemical and neuroendocrine function during aging (PM Wise, PI), $1,025,000, 2005 to 2010.
  • NIH/NIDDK: Neuroendocrinology of galanin-like peptide (GALP), $528,000, 2003 to 2007.
  • National Institutes of Health (NIH): Training in Reproductive Biology, $270,331, 1999 to 2009.

Publications

  • Popa SM, Clifton DK, Steiner RA (Mar 2008) The Role of Kisspeptins and GPR54 in the Neuroendocrine Regulation of Reproduction., Annual review of physiology, 70, 213-238 Abstract
  • Dungan Lemko HM, Clifton DK, Steiner RA, Fraley GS (2008) Altered response to metabolic challenges in mice with targeted deletions of galanin-like peptide (GALP), American Journal of Physiology: Endocrinology and Metabolism, In Press
  • Dungan HM, Gottsch ML, Zeng H, Gragerov A, Bergmann JE, Vassilatis DK, Clifton DK, Steiner RA (Oct 2007) The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone., The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 (44), 12088-95 Abstract
  • Kauffman AS, Clifton DK, Steiner RA (Oct 2007) Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction., Trends in neurosciences, 30 (10), 504-11 Abstract
  • Kauffman AS, Park JH, McPhie-Lalmansingh AA, Gottsch ML, Bodo C, Hohmann JG, Pavlova MN, Rohde AD, Clifton DK, Steiner RA, Rissman EF (Aug 2007) The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior., The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 (33), 8826-35 Abstract
  • Kauffman AS, Gottsch ML, Roa J, Byquist AC, Crown A, Clifton DK, Hoffman GE, Steiner RA, Tena-Sempere M (Apr 2007) Sexual differentiation of Kiss1 gene expression in the brain of the rat., Endocrinology, 148 (4), 1774-83 Abstract
  • Crown A, Clifton DK, Steiner RA (2007) Neuropeptide signaling in the integration of metabolism and reproduction., Neuroendocrinology, 86 (3), 175-82 Abstract
  • Kauffman AS, Clifton DK, Steiner RA (2007) Emerging ideas about kisspeptin-GPR54 signaling in the neuroendocrine regulation of reproduction, TRENDS in Neurosciences, 30, 504-511
  • Castellano JM, Navarro VM, Fernández-Fernández R, Roa J, Vigo E, Pineda R, Steiner RA, Aguilar E, Pinilla L, Tena-Sempere M (Dec 2006) Effects of galanin-like peptide on luteinizing hormone secretion in the rat: sexually dimorphic responses and enhanced sensitivity at male puberty., American journal of physiology. Endocrinology and metabolism, 291 (6), E1281-9 Abstract
  • Gottsch ML, Clifton DK, Steiner RA (Jul 2006) Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis., Molecular and cellular endocrinology, 254-255, 91-6 Abstract
  • Smith JT, Popa SM, Clifton DK, Hoffman GE, Steiner RA (Jun 2006) Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge., The Journal of neuroscience : the official journal of the Society for Neuroscience, 26 (25), 6687-94 Abstract
  • Smith JT, Clifton DK, Steiner RA (Apr 2006) Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling., Reproduction (Cambridge, England), 131 (4), 623-30 Abstract
  • Smith JT, Acohido BV, Clifton DK, Steiner RA (Apr 2006) KiSS-1 neurones are direct targets for leptin in the ob/ob mouse., Journal of neuroendocrinology, 18 (4), 298-303 Abstract
  • Dungan HM, Clifton DK, Steiner RA (Mar 2006) Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion., Endocrinology, 147 (3), 1154-8 Abstract
  • Krasnow SK and Steiner RA (2006) Physiological mechanisms integrating metabolism and reproduction, Knobil and Neill's Physiology of Reproduction, 3rd Edition, Philadelphia, PA, Elsevier Press, 2553-2625 pages (bookchapter)
  • Han SK, Gottsch ML, Lee KJ, Popa SM, Smith JT, Jakawich SK, Clifton DK, Steiner RA, Herbison AE (Dec 2005) Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty., The Journal of neuroscience : the official journal of the Society for Neuroscience, 25 (49), 11349-56 Abstract
  • Smith JT, Cunningham MJ, Rissman EF, Clifton DK, Steiner RA (Sep 2005) Regulation of Kiss1 gene expression in the brain of the female mouse., Endocrinology, 146 (9), 3686-92 Abstract
  • Stoyanovitch AG, Johnson MA, Clifton DK, Steiner RA, Fraley GS (Aug 2005) Galanin-like peptide rescues reproductive function in the diabetic rat., Diabetes, 54 (8), 2471-6 Abstract
  • Popa SM, Clifton DK, Steiner RA (Aug 2005) A KiSS to remember., Trends in endocrinology and metabolism: TEM, 16 (6), 249-50 Abstract
  • Smith JT, Dungan HM, Stoll EA, Gottsch ML, Braun RE, Eacker SM, Clifton DK, Steiner RA (Jul 2005) Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse., Endocrinology, 146 (7), 2976-84 Abstract
  • Gottsch ML, Zeng H, Hohmann JG, Weinshenker D, Clifton DK, Steiner RA (Jun 2005) Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2)., Molecular and cellular biology, 25 (11), 4804-11 Abstract
  • Shahab M, Cunningham MJ, Steiner RA, Plant TM (2005) Galanin-Like peptide elicits a robust discharge of growth hormone in the rhesus monkey (Macaca mulatta)., Neuroendocrinology, 81 (4), 254-8 Abstract
  • He B, Counts SE, Perez SE, Hohmann JG, Koprich JB, Lipton JW, Steiner RA, Crawley JN, Mufson EJ (2005) Ectopic galanin expression and normal galanin receptor 2 and galanin receptor 3 mRNA levels in the forebrain of galanin transgenic mice., Neuroscience, 133 (2), 371-80 Abstract
  • Fraley GS, Thomas-Smith SE, Acohido BV, Steiner RA, Clifton DK, Stimulation of Sexual Behavior in the Male Rat By Galanin-like Peptide, Hormones and Behavior, 46(5), 551-7, Dec 2004 Abstract
  • Fraley GS, Thomas-Smith SE, Acohido BV, Steiner RA, Clifton DK (Dec 2004) Stimulation of sexual behavior in the male rat by galanin-like peptide., Hormones and behavior, 46 (5), 551-7 Abstract
  • Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, Steiner RA, A role for kisspeptins in the regulation of gonadotropin secretion in the mouse, Endocrinology, 145(9), 4073-7, September 2004 Abstract
  • Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, Steiner RA (Sep 2004) A role for kisspeptins in the regulation of gonadotropin secretion in the mouse., Endocrinology, 145 (9), 4073-7 Abstract
  • Gottsch ML, Clifton DK, Steiner RA, Galanin-like peptide as a link in the integration of metabolism and reproduction, Trends in Endocrinology and Metabolism: Tem, 15(5), 215-21, July 2004 Abstract
  • Gottsch ML, Clifton DK, Steiner RA (Jul 2004) Galanin-like peptide as a link in the integration of metabolism and reproduction., Trends in endocrinology and metabolism: TEM, 15 (5), 215-21 Abstract
  • Fraley GS, Scarlett JM, Shimada I, Teklemichael DN, Acohido BV, Clifton DK, Steiner RA, Effects of diabetes and insulin on the expression of galanin-like peptide in the hypothalamus of the rat, Diabetes, 53(5), 1237-42, May 2004 Abstract
  • Fraley GS, Scarlett JM, Shimada I, Teklemichael DN, Acohido BV, Clifton DK, Steiner RA (May 2004) Effects of diabetes and insulin on the expression of galanin-like peptide in the hypothalamus of the rat., Diabetes, 53 (5), 1237-42 Abstract
  • Cunningham MJ, Shahab M, Grove KL, Scarlett JM, Plant TM, Cameron JL, Smith MS, Clifton DK, Steiner RA, Galanin-like peptide as a possible link between metabolism and reproduction in the macaque, Journal of Clinical Endocrinology and Metabolism, 89(4), 1760-6, April 2004 Abstract
  • Hohmann JG, Teklemichael DN, Weinshenker D, Wynick D, Clifton DK, Steiner RA, Obesity and endocrine dysfunction in mice with deletions of both neuropeptide Y and galanin, Molecular and Cellular Biology, 24(7), 2978-85, April 2004 Abstract
  • Cunningham MJ, Shahab M, Grove KL, Scarlett JM, Plant TM, Cameron JL, Smith MS, Clifton DK, Steiner RA (Apr 2004) Galanin-like peptide as a possible link between metabolism and reproduction in the macaque., The Journal of clinical endocrinology and metabolism, 89 (4), 1760-6 Abstract
  • Yoshitake T, Wang FH, Kuteeva E, Holmberg K, Yamaguchi M, Crawley JN, Steiner R, Bartfai T, Ogren SO, Hokfelt T, Kehr J, Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test, Proceedings of the National Academy of Sciences of the United States of America., 101(1), 354-9, January 2004 Abstract
  • Krasnow SM, Hohmann JG, Gragerov A, Clifton DK, Steiner RA, Analysis of the contribution of galanin receptors 1 and 2 to the central actions of galanin-like peptide, Neuroendocrinology, 79(5), 268-77, 2004 Abstract
  • Cunnningham MJ, Krasnow SM, Gevers EF, Chen P, Thompson CK, Robinson IC, Smith MS, Clifton DK, Steiner RA, Regulation of galanin-like peptide gene expression by pituitary hormones and their downstream targets, Journal of Neuroendocrinology, 16(1), 10-8, January 2004 Abstract
  • Irwig MS, Fraley GS, Smith JT, Acohido BV, Popa SM, Cunningham MJ, Gottsch ML, Clifton DK, Steiner RA (2004) Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat., Neuroendocrinology, 80 (4), 264-72 Abstract
  • Krasnow SM, Hohmann JG, Gragerov A, Clifton DK, Steiner RA (2004) Analysis of the contribution of galanin receptors 1 and 2 to the central actions of galanin-like peptide., Neuroendocrinology, 79 (5), 268-77 Abstract
  • Hansen KR, Krasnow SM, Nolan MA, Fraley GS, Baumgartner JW, Clifton DK, Steiner RA, Activation of the Sympathetic Nervous System by Galanin-Like Peptide--A Possible Link between Leptin and Metabolism, Endocrinology, 144(11), 4709-17, November 2003 Abstract
  • Zachariou V, Brunzell DH, Hawes J, Stedman DR, Bartfai T, Steiner RA, Wynick D, Langel U, Picciotto MR, The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal, Proceedings of the National Academy of Sciences of the United States of America., 100(15), 9028-33, July 2003 Abstract
  • Hohmann JG, Krasnow SM, Teklemichael DN, Clifton DK, Wynick D, Steiner RA, Neuroendocrine profiles in galanin-overexpressing and knockout mice, Neuroendocrinology, 77(6), 354-66, June 2003 Abstract
  • Fraley GS, Shimada I, Baumgartner JW, Clifton DK, Steiner RA, Differential patterns of Fos induction in the hypothalamus of the rat following central injections of galanin-like peptide and galanin, Endocrinology, 144(4), 1143-6, April 2003 Abstract
  • Krasnow SM, Fraley GS, Schuh SM, Baumgartner JW, Clifton DK, Steiner RA, A role for galanin-like peptide in the integration of feeding, body weight regulation, and reproduction in the mouse, Endocrinology, 144(3), 813-22, March 2003 Abstract
  • Hohmann JG, Jureus A, Teklemichael DN, Matsumoto AM, Clifton DK, Steiner RA, Distribution and regulation of galanin receptor 1 messenger RNA in the forebrain of wild type and galanin-transgenic mice, Neuroscience, 117(1), 105-17, 2003 Abstract
  • Crawley JN, Mufson EJ, Hohmann JG, Teklemichael D, Steiner RA, Holmberg K, Xu ZQ, Blakeman KH, Xu XJ, Wiesenfeld-Hallin Z, Bartfai T, Hokfelt T, Galanin overexpressing transgenic mice, Neuropeptides, 36(2-3), 145-56, 2002 Abstract
  • Cunningham MJ, Scarlett JM, Steiner RA, Cloning and distribution of galanin-like peptide mRNA in the hypothalamus and pituitary of the macaque, Endocrinology, 143(3), 755-63, March 2002 Abstract
  • Jureus A, Cunningham MJ, Li D, Johnson LL, Krasnow SM, Teklemichael DN, Clifton DK, Steiner RA, Distribution and regulation of galanin-like peptide (GALP) in the hypothalamus of the mouse, Endocrinology, 142(12), 5140-4, December 2001 Abstract
  • Cheung CC, Thornton JE, Nurani SD, Clifton DK, Steiner RA, A reassessment of leptin's role in triggering the onset of puberty in the rat and mouse, Neuroendocrinology, 74(1), 12-21, July 2001 Abstract
  • Perez SE, Wynick D, Steiner RA, Mufson EJ, Distribution of galaninergic immunoreactivity in the brain of the mouse, Journal of Comparative Neurology, 434(2), 158-85, May 2001 Abstract
  • Steiner RA, Hohmann JG, Holmes A, Wrenn CC, Cadd G, Jureus A, Clifton DK, Luo M, Gutshall M, Ma SY, Mufson EJ, Crawley JN, Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease, Proceedings of the National Academy of Sciences (USA), 98(7), 4184-9, March 2001 Abstract
  • Cheung CC, Hohmann JG, Clifton DK, Steiner RA, Distribution of galanin messenger RNA-expressing cells in murine brain and their regulation by leptin in regions of the hypothalamus, Neuroscience, 103(2), 423-32, 2001 Abstract
  • Huizinga CT, Oudejans CB, Steiner RA, Clifton DK, Delemarre-van de Waal HA, Effects of intrauterine and early postnatal growth restriction on hypothalamic somatostatin gene expression in the rat, Pediatric Research, 48(6), 815-20, December 2000 Abstract
  • Mazarati AM, Hohmann JG, Bacon A, Liu H, Sankar R, Steiner RA, Wynick D, Wasterlain CG, Modulation of hippocampal excitability and seizures by galanin, The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 20(16), 6276-81, August 2000 Abstract
  • Jureus A, Cunningham MJ, McClain ME, Clifton DK, Steiner RA, Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat, Endocrinology, 141(7), 2703-6, July 2000 Abstract
  • Cheung CC, Clifton DK, Steiner RA, Perspectives on leptin's role as a metabolic signal for the onset of puberty, Frontiers of Hormone Research, 26, 87-105, 2000 Abstract
  • Hohmann JG, Teal TH, Clifton DK, Davis J, Hruby VJ, Han G, Steiner RA, Differential role of melanocortins in mediating leptin's central effects on feeding and reproduction, American Journal of Physiology. Regulatory, Integrative and Comparative Physiology., 278(1), R50-9, Jan 2000 Abstract
  • Finn PD, Pau KY, Spies HG, Cunningham MJ, Clifton DK, Steiner RA, Galanin's functional significance in the regulation of the neuroendocrine reproductive axis of the monkey, Neuroendocrinology, 71(1), 16-26, Jan 2000 Abstract
  • Cunningham MJ, Clifton DK, Steiner RA, Leptin's actions on the reproductive axis: perspectives and mechanisms, Biology of Reproduction, 60(2), 216-22, February 1999 Abstract
  • Hohmann JG, Clifton DK, Steiner RA, Galanin: analysis of its coexpression in gonadotropin-releasing hormone and growth hormone-releasing hormone neurons., Annals of the New York Academy of Sciences, 863, 221-35, 21 Dec 1998 Abstract
  • Hohmann JG, Clifton DK, Steiner RA (Dec 1998) Galanin: analysis of its coexpression in gonadotropin-releasing hormone and growth hormone-releasing hormone neurons, Annals of the New York Academy of Sciences, 863, 221-35
  • Finn PD, Clifton DK, Steiner RA (May 1998) The regulation of galanin gene expression in gonadotropin-releasing hormone neurons., Molecular and Cellular Endocrinology, 140 (1-2), 137-42
  • Finn PD, Steiner RA, Clifton DK, Temporal patterns of gonadotropin-releasing hormone \(GnRH\), c-fos, and galanin gene expression in GnRH neurons relative to the luteinizing hormone surge in the rat., Journal of Neuroscience, 18(2), 713-9, 15 1998 Abstract
  • Thornton J E, Cheung C C, Clifton D K, Steiner R A, Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice., Endocrinology, 138(11), 5063-6, November 1997 Abstract
  • Cheung C C, Clifton D K, Steiner R A, Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus., Endocrinology, 138(10), 4489-92, October 1997 Abstract
  • Weigle D S, Duell P B, Connor W E, Steiner R A, Soules M R, Kuijper J L, Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels., Journal of Clinical Endocrinology and Metabolism, 82(2), 561-5, February 1997 Abstract
  • Cheung C C, Thornton J E, Kuijper J L, Weigle D S, Clifton D K, Steiner R A, Leptin is a metabolic gate for the onset of puberty in the female rat., Endocrinology, 138(2), 855-8, February 1997 Abstract
  • Chan Y Y, Grafstein-Dunn E, Delemarre-van de Waal H A, Burton K A, Clifton D K, Steiner R A, The role of galanin and its receptor in the feedback regulation of growth hormone secretion., Endocrinology, 137(12), 5303-10, December 1996 Abstract
  • Finn P D, McFall T B, Clifton D K, Steiner R A, Sexual differentiation of galanin gene expression in gonadotropin-releasing hormone neurons., Endocrinology, 137(11), 4767-72, November 1996 Abstract
  • Steiner R A, Lords and ladies leapin' on leptin [editorial; comment], Endocrinology, 137(11), 4533-5, November 1996 Abstract
  • Barash I A, Cheung C C, Weigle D S, Ren H, Kabigting E B, Kuijper J L, Clifton D K, Steiner R A, Leptin is a metabolic signal to the reproductive system., Endocrinology, 137(7), 3144-7, July 1996 Abstract
  • Rossmanith W G, Clifton D K, Steiner R A, Galanin gene expression in hypothalamic GnRH-containing neurons of the rat: a model for autocrine regulation., Hormone and Metabolic Research, 28(6), 257-66, June 1996 Abstract
  • Chan Y Y, Steiner R A, Clifton D K, Regulation of hypothalamic neuropeptide-Y neurons by growth hormone in the rat., Endocrinology, 137(4), 1319-25, April 1996 Abstract
  • Rossmanith W G, Marks D L, Clifton D K, Steiner R A, Induction of galanin mRNA in GnRH neurons by estradiol and its facilitation by progesterone., Journal of Neuroendocrinology, 8(3), 185-91, March 1996 Abstract
  • Rossmanith W G, Marks D L, Steiner R A, Clifton D K, Inhibition of steroid-induced galanin mRNA expression in GnRH neurons by specific NMDA-receptor blockade., Journal of Neuroendocrinology, 8(3), 179-84, March 1996 Abstract
  • Chan Y Y, Clifton D K, Steiner R A, Role of NPY neurones in GH-dependent feedback signalling to the brain., Hormone Research, 45 Suppl 1, 12-4, 1996 Abstract
  • Burton K A, Kabigting E B, Steiner R A, Clifton D K, Identification of target cells for growth hormone's action in the arcuate nucleus., American Journal of Physiology, 269(4 Pt 1), E716-22, October 1995 Abstract
  • Steiner R A, Kabigting E, Lent K, Clifton D K, Diurnal rhythm in proopiomelanocortin mRNA in the arcuate nucleus of the male rat., Journal of Neuroendocrinology, 6(6), 603-8, December 1994 Abstract
  • Grafstein-Dunn E, Clifton D K, Steiner R A, Regulation of galanin and gonadotropin-releasing hormone gene expression in the hypothalamus and basal forebrain of the rat., Hormones and Behavior, 28(4), 417-23, December 1994 Abstract
  • Rossmanith W G, Marks D L, Clifton D K, Steiner R A, Induction of galanin gene expression in gonadotropin-releasing hormone neurons with puberty in the rat., Endocrinology, 135(4), 1401-8, October 1994 Abstract
  • Soules M R, Merriggiola M C, Steiner R A, Clifton D K, Toivola B, Bremner W J, Short-term fasting in normal women: absence of effects on gonadotrophin secretion and the menstrual cycle., Clinical Endocrinology, 40(6), 725-31, June 1994 Abstract
  • Marks D L, Lent K L, Rossmanith W G, Clifton D K, Steiner R A, Activation-dependent regulation of galanin gene expression in gonadotropin-releasing hormone neurons in the female rat [see comments], Endocrinology, 134(5), 1991-8, May 1994 Abstract
  • Christensen R B, Forage R G, Steiner R A, Bremner W J, Effects of castration and recombinant human inhibin administration on circulating levels of inhibin and gonadotropins in adult male monkeys., Journal of Andrology, 15(2), 125-31, Spring 1994 Abstract
  • Delemarre-van de Waal H A, Burton K A, Kabigting E B, Steiner R A, Clifton D K, Expression and sexual dimorphism of galanin messenger ribonucleic acid in growth hormone-releasing hormone neurons of the rat during development., Endocrinology, 134(2), 665-71, February 1994 Abstract
  • Grossman A B, Rossmanith W G, Kabigting E B, Cadd G, Clifton D, Steiner R A, The distribution of hypothalamic nitric oxide synthase mRNA in relation to gonadotrophin-releasing hormone neurons., Journal of Endocrinology, 140(2), R5-8, February 1994 Abstract
  • Marks D L, Smith M S, Clifton D K, Steiner R A, Regulation of gonadotropin-releasing hormone (GnRH) and galanin gene expression in GnRH neurons during lactation in the rat [published erratum appears in Endocrinology 1994 Jan;134(1):498], Endocrinology, 133(3), 1450-8, September 1993 Abstract
  • Marks D L, Smith M S, Vrontakis M, Clifton D K, Steiner R A, Regulation of galanin gene expression in gonadotropin-releasing hormone neurons during the estrous cycle of the rat., Endocrinology, 132(4), 1836-44, April 1993 Abstract
  • Bergendahl M, Wiemann J N, Clifton D K, Huhtaniemi I, Steiner R A, Short-term starvation decreases POMC mRNA but does not alter GnRH mRNA in the brain of adult male rats., Neuroendocrinology, 56(6), 913-20, December 1992 Abstract
  • Burton K A, Kabigting E B, Clifton D K, Steiner R A, Growth hormone receptor messenger ribonucleic acid distribution in the adult male rat brain and its colocalization in hypothalamic somatostatin neurons., Endocrinology, 131(2), 958-63, August 1992 Abstract
  • Zeitler P, Tannenbaum G S, Clifton D K, Steiner R A, Ultradian oscillations in somatostatin and growth hormone-releasing hormone mRNAs in the brains of adult male rats [published erratum appears in Proc Natl Acad Sci U S A 1992 Mar 1;89(5):1997], Proceedings of the National Academy of Sciences (USA), 88(20), 8920-4, 15 Oct 1991 Abstract
  • Bremner W J, Bagatell C J, Steiner R A, Gonadotropin-releasing hormone antagonist plus testosterone: a potential male contraceptive., Journal of Clinical Endocrinology and Metabolism, 73(3), 465-9, September 1991 Abstract
  • Argente J, Chowen J A, Zeitler P, Clifton D K, Steiner R A, Sexual dimorphism of growth hormone-releasing hormone and somatostatin gene expression in the hypothalamus of the rat during development., Endocrinology, 128(5), 2369-75, May 1991 Abstract
  • Soules M R, Bremner W J, Steiner R A, Clifton D K, Prolactin secretion and corpus luteum function in women with luteal phase deficiency., Journal of Clinical Endocrinology and Metabolism, 72(5), 986-92, May 1991 Abstract
  • Adams L A, Vician L, Clifton D K, Steiner R A, Testosterone regulates pro-opiomelanocortin gene expression in the primate brain., Endocrinology, 128(4), 1881-6, April 1991 Abstract
  • Chowen J A, Argente J, Vician L, Clifton D K, Steiner R A, Pro-opiomelanocortin messenger RNA in hypothalamic neurons is increased by testosterone through aromatization to estradiol., Neuroendocrinology, 52(6), 581-8, December 1990 Abstract
  • Argente J, Chowen-Breed J A, Steiner R A, Clifton D K, Somatostatin messenger RNA in hypothalamic neurons is increased by testosterone through activation of androgen receptors and not by aromatization to estradiol., Neuroendocrinology, 52(4), 342-9, October 1990 Abstract
  • Zeitler P, Argente J, Chowen-Breed J A, Clifton D K, Steiner R A, Growth hormone-releasing hormone messenger ribonucleic acid in the hypothalamus of the adult male rat is increased by testosterone., Endocrinology, 127(3), 1362-8, September 1990 Abstract
  • Zeitler P, Vician L, Chowen-Breed J A, Argente J, Tannenbaum G S, Clifton D K, Steiner R A, Regulation of somatostatin and growth hormone-releasing hormone gene expression in the rat brain., Metabolism: Clinical and Experimental, 39(9 Suppl 2), 46-9, September 1990 Abstract
  • Wiemann J N, Clifton D K, Steiner R A, Gonadotropin-releasing hormone messenger ribonucleic acid levels are unaltered with changes in the gonadal hormone milieu of the adult male rat., Endocrinology, 127(2), 523-32, August 1990 Abstract
  • Chowen-Breed J A, Steiner R A, Clifton D K, Sexual dimorphism and testosterone-dependent regulation of somatostatin gene expression in the periventricular nucleus of the rat brain., Endocrinology, 125(1), 357-62, July 1989 Abstract
  • Wiemann J N, Clifton D K, Steiner R A, Pubertal changes in gonadotropin-releasing hormone and proopiomelanocortin gene expression in the brain of the male rat., Endocrinology, 124(4), 1760-7, April 1989 Abstract

Profile Details

Last Updated: 6/12/2008

COS Expertise ID #307951
Reference this profile directly: http://myprofile.cos.com/robertsteiner