Ulrich Rodeck

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Thomas Jefferson University
Jefferson Medical College
Dermatology & Cutaneous Biology
ProfessorAppointed: 2003
Thomas Jefferson University
Thomas Jefferson University Hospital
Dermatology and Cutaneous Biology

Mailing Address

Philadelphia, Pennsylvania 19107-5587
United States

Contact Information

Phone: (215) 503-5622
Ulrich.Rodeck@jefferson.edu

Qualifications

Ph.D., University of Hamburg, Immunology, 1991.
M.D., University of Munster, 1980.

Expertise and Research Interests

My research interests revolve around signal transduction pathways regulating epithelial cell death and survival. Specifically, I am interested in coordinated signaling by receptor tyrosine kinases and integrins as it relates to the inappropriate survival of tumor cells. In these studies, we frequently use an EGFR antagonistic monoclonal antibody originally developed at the Wistar Institute (Rodeck et al. Cancer Res., 47:3692-6, 1987) and currently in phase II clinical trials in epithelial neoplasms (EMD59000; EMD72000). A second line of investigation focuses on molecular determinants of stress response pathways in vertebrate organisms. This work is done largely in zebrafish embryos to account or microenvironmental and tissue-specific effects. The goal of these studies is to identify targets for therapeutic intervention in cancer and inflammatory diseases.

Keywords

COS Keywords:

Apoptosis, Cancer or Carcinogenesis, Dermatology, Signal Transduction.

Additional Terms:

Apoptosis, Cancer Research, Receptor Tyrosine Kinases, Signal Transduction.

Languages

(Reading, Writing, Speaking)

German: (Fluent, Fluent, Fluent)

Memberships

American Association for Cancer Research
American Association for the Advancement of Science

Honors and Awards

1999-1999, Shannon Award, National Institutes of Health, Cancer Research

Patents

WT1 monoclonal antibodies and methods of use therefor, Patent Number: 5,633,142, 1997, Institution-owned, United States.
WT1 monoclonal antibodies, Patent Number: 5,622,835, 1997, Institution-owned, United States.
Method of treating human EGF receptor-expressing gliomas using radiolabeled EGF receptor-specific MAB 425, Patent Number: 5,470,571, 1995, Institution-owned, United States.

Publications

  • Surguladze D, Deevi D, Claros N, Corcoran E, Wang S, Plym MJ, Wu Y, Doody J, Mauro DJ, Witte L, Busam KJ, Pytowski B, Rodeck U, Tonra JR (Jul 2009) Tumor necrosis factor-alpha and interleukin-1 antagonists alleviate inflammatory skin changes associated with epidermal growth factor receptor antibody therapy in mice., Cancer research, 69 (14), 5643-7 Abstract
  • Rodeck U (Jan 2009) Skin toxicity caused by EGFR antagonists-an autoinflammatory condition triggered by deregulated IL-1 signaling?, Journal of cellular physiology, 218 (1), 32-4 Abstract
  • Lightcap CM, Kari G, Arias-Romero LE, Chernoff J, Rodeck U, Williams JC (2009) Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development., PloS one, 4 (6), e6025 Abstract
  • Rodeck U, Williams JC (Nov 2008) Nature's design: A blueprint for engineered therapeutic antibodies., Cancer biology & therapy, 7 (11) Abstract
  • Lightcap CM, Sun S, Lear JD, Rodeck U, Polenova T, Williams JC (Oct 2008) Biochemical and structural characterization of the Pak1-LC8 interaction., The Journal of biological chemistry, 283 (40), 27314-24 Abstract
  • Kamat V, Donaldson JM, Kari C, Quadros MR, Lelkes PI, Chaiken I, Cocklin S, Williams JC, Papazoglou E, Rodeck U (May 2008) Enhanced EGFR inhibition and distinct epitope recognition by EGFR antagonistic mAbs C225 and 425., Cancer biology & therapy, 7 (5), 726-33 Abstract
  • Kriete A, Mayo KL, Yalamanchili N, Beggs W, Bender P, Kari C, Rodeck U (2008) Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity., Immunity & ageing : I & A, 5, 5 Abstract
  • Rodeck U, Uitto J (Oct 2007) Recessive dystrophic epidermolysis bullosa-associated squamous-cell carcinoma: an enigmatic entity with complex pathogenesis., The Journal of investigative dermatology, 127 (10), 2295-6 Abstract
  • Kari G, Rodeck U, Dicker AP (Jul 2007) Zebrafish: an emerging model system for human disease and drug discovery., Clinical pharmacology and therapeutics, 82 (1), 70-80 Abstract
  • Rodeck U, Fertala A, Uitto J (Jun 2007) Anchorless keratinocyte survival: an emerging pathogenic mechanism for squamous cell carcinoma in recessive dystrophic epidermolysis bullosa., Experimental dermatology, 16 (6), 465-7 Abstract
  • Brennan D, Hu Y, Joubeh S, Choi YW, Whitaker-Menezes D, O'Brien T, Uitto J, Rodeck U, Mahoney MG (Mar 2007) Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes., Journal of cell science, 120 (Pt 5), 758-71 Abstract
  • Chung CH, Parker J, Levy S, Slebos RJ, Dicker AP, Rodeck U (2007) Gene expression profiles as markers of aggressive disease-EGFR as a factor., International journal of radiation oncology, biology, physics, 69 (2 Suppl), S102-5 Abstract
  • Daroczi B, Kari G, McAleer MF, Wolf JC, Rodeck U, Dicker AP (Dec 2006) In vivo radioprotection by the fullerene nanoparticle DF-1 as assessed in a zebrafish model., Clinical cancer research : an official journal of the American Association for Cancer Research, 12 (23), 7086-91 Abstract
  • McAleer MF, Duffy KT, Davidson WR, Kari G, Dicker AP, Rodeck U, Wickstrom E (Oct 2006) Antisense inhibition of cyclin D1 expression is equivalent to flavopiridol for radiosensitization of zebrafish embryos., International journal of radiation oncology, biology, physics, 66 (2), 546-51 Abstract
  • Bellone G, Carbone A, Smirne C, Scirelli T, Buffolino A, Novarino A, Stacchini A, Bertetto O, Palestro G, Sorio C, Scarpa A, Emanuelli G, Rodeck U (Sep 2006) Cooperative induction of a tolerogenic dendritic cell phenotype by cytokines secreted by pancreatic carcinoma cells., Journal of immunology (Baltimore, Md. : 1950), 177 (5), 3448-60 Abstract
  • Quadros MR, Connelly S, Kari C, Abrams MT, Wickstrom E, Rodeck U (May 2006) EGFR-dependent downregulation of Bim in epithelial cells requires MAPK and PKC-delta activities., Cancer biology & therapy, 5 (5), 498-504 Abstract
  • Ren Q, Kari C, Quadros MR, Burd R, McCue P, Dicker AP, Rodeck U (May 2006) Malignant transformation of immortalized HaCaT keratinocytes through deregulated nuclear factor kappaB signaling., Cancer research, 66 (10), 5209-15 Abstract
  • Zhang W, Alt-Holland A, Margulis A, Shamis Y, Fusenig NE, Rodeck U, Garlick JA (Jan 2006) E-cadherin loss promotes the initiation of squamous cell carcinoma invasion through modulation of integrin-mediated adhesion., Journal of cell science, 119 (Pt 2), 283-91 Abstract
  • McAleer MF, Davidson C, Davidson WR, Yentzer B, Farber SA, Rodeck U, Dicker AP, Novel Use of Zebrafish As a Vertebrate Model to Screen Radiation Protectors and Sensitizers., International Journal of Radiation Oncology, Biology, Physics, 61(1), 10-3, Jan 2005 Abstract
  • Jost M, Rodeck U, Keratinocyte Culture in the Absence of Substrate Attachment., Methods in Molecular Biology (clifton, N.j.), 289, 23-8, 2005 Abstract
  • Quadros MR, Peruzzi F, Kari C, Rodeck U, Complex Regulation of Signal Transducers and Activators of Transcription 3 Activation in Normal and Malignant Keratinocytes., Cancer Research, 64(11), 3934-9, Jun 2004 Abstract
  • Bellone G, Ferrero D, Carbone A, De Quadros MR, Gramigni C, Prati A, Davidson W, Mioli P, Dughera L, Emanuelli G, Rodeck U, Inhibition of Cell Survival and Invasive Potential of Colorectal Carcinoma Cells By the Tyrosine Kinase Inhibitor STI571., Cancer Biology & Therapy, 3(4), 385-92, Apr 2004 Abstract
  • Kari C, Chan TO, Rocha de Quadros M, Rodeck U, Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage, Cancer Research, 63(1), 1-5, January 2003 Abstract
  • Emrich JG, Brady LW, Quang TS, Class R, Miyamoto C, Black P, Rodeck U, Radioiodinated (I-125) monoclonal antibody 425 in the treatment of high grade glioma patients: ten-year synopsis of a novel treatment, American Journal of Clinical Oncology : the Official Publication of the American Radium Society., 25(6), 541-6, December 2002 Abstract
  • Pistritto G, Jost M, Srinivasula SM, Baffa R, Poyet JL, Kari C, Lazebnik Y, Rodeck U, Alnemri ES, Expression and transcriptional regulation of caspase-14 in simple and complex epithelia, Cell Death and Differentiation, 9(9), 995-1006, September 2002 Abstract
  • Wahl ML, Owen JA, Burd R, Herlands RA, Nogami SS, Rodeck U, Berd D, Leeper DB, Owen CS, Regulation of intracellular pH in human melanoma: potential therapeutic implications, Molecular Cancer Therapeutics, 1(8), 617-28, June 2002 Abstract
  • Aho S, Levansuo L, Montonen O, Kari C, Rodeck U, Uitto J, Specific sequences in p120ctn determine subcellular distribution of its multiple isoforms involved in cellular adhesion of normal and malignant epithelial cells, Journal of Cell Science, 115(Pt 7), 1391-402, April 2002 Abstract
  • Chan TO, Rodeck U, Chan AM, Kimmelman AC, Rittenhouse SE, Panayotou G, Tsichlis PN, Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit, Cancer Cell, 1(2), 181-91, March 2002 Abstract
  • Mahoney MG, Simpson A, Jost M, Noe M, Kari C, Pepe D, Choi YW, Uitto J, Rodeck U, Metastasis-associated protein (MTA)1 enhances migration, invasion, and anchorage-independent survival of immortalized human keratinocytes, Oncogene, 21(14), 2161-70, March 2002 Abstract
  • Giambernardi TA, Sakaguchi AY, Gluhak J, Pavlin D, Troyer DA, Das G, Rodeck U, Klebe RJ, Neutrophil collagenase (MMP-8) is expressed during early development in neural crest cells as well as in adult melanoma cells, Matrix Biology : Journal of the International Society for Matrix Biology, 20(8), 577-87, December 2001 Abstract
  • Shin I, Bakin AV, Rodeck U, Brunet A, Arteaga CL, Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1, Molecular Biology of the Cell, 12(11), 3328-39, November 2001 Abstract
  • Graeven U, Rodeck U, Karpinski S, Jost M, Philippou S, Schmiegel W, Modulation of angiogenesis and tumorigenicity of human melanocytic cells by vascular endothelial growth factor and basic fibroblast growth factor, Cancer Research, 61(19), 7282-90, October 2001 Abstract
  • Simpson A, Uitto J, Rodeck U, Mahoney MG, Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3, Gene, 273(1), 29-39, July 2001 Abstract
  • Jost M, Gasparro FP, Jensen PJ, Rodeck U, Keratinocyte apoptosis induced by ultraviolet B radiation and CD95 ligation -- differential protection through epidermal growth factor receptor activation and Bcl-x(L) expression, The Journal of Investigative Dermatology, 116(6), 860-6, June 2001 Abstract
  • Jost M, Huggett TM, Kari C, Rodeck U, Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway, Molecular Biology of the Cell, 12(5), 1519-27, May 2001 Abstract
  • Jost M, Huggett TM, Kari C, Boise LH, Rodeck U, Epidermal growth factor receptor-dependent control of keratinocyte survival and Bcl-xL expression through a MEK-dependent pathway, Journal of Bioligical Chemistry, 276(9), 6320-6, March 2001 Abstract
  • Bellone G, Carbone A, Sibona N, Bosco O, Tibaudi D, Smirne C, Martone T, Gramigni C, Camandona M, Emanuelli G, Rodeck U, Aberrant activation of c-kit protects colon carcinoma cells against apoptosis and enhances their invasive potential, Cancer Research, 61(5), 2200-6, March 2001 Abstract
  • Bellone G, Carbone A, Tibaudi D, Mauri F, Ferrero I, Smirne C, Suman F, Rivetti C, Migliaretti G, Camandona M, Palestro G, Emanuelli G, Rodeck U, Differential expression of transforming growth factors-beta1, -beta2 and -beta3 in human colon carcinoma, European Journal of Cancer (oxford, England : 1990), 37(2), 224-33, Jan 2001 Abstract
  • Jost M, Kari C, Rodeck U, The EGF receptor - an essential regulator of multiple epidermal functions, European Journal of Dermatology : Ejd, 10(7), 505-10, 2000 Abstract
  • Graeven U, Rodeck U, Karpinski S, Jost M, Andre N, Schmiegel W, Expression patterns of placenta growth factor in human melanocytic cell lines, The Journal of Investigative Dermatology, 115(1), 118-23, July 2000 Abstract
  • Bellone G, Smirne C, Carbone A, Mareschi K, Dughera L, Farina EC, Alabiso O, Valente G, Emanuelli G, Rodeck U, Production and pro-apoptotic activity of soluble CD95 ligand in pancreatic carcinoma, Clinical Cancer Research : an Official Journal of the American Association for Cancer Research., 6(6), 2448-55, June 2000 Abstract
  • Graeven U, Fiedler W, Karpinski S, Ergun S, Kilic N, Rodeck U, Schmiegel W, Hossfeld DK, Melanoma-associated expression of vascular endothelial growth factor and its receptors FLT-1 and KDR, Journal of Cancer Research and Clinical Oncology, 125(11), 621-9, November 1999 Abstract
  • Basu A, Rodeck U, Prendergast GC, Howe CC, Loss of insulin-like growth factor I receptor-dependent expression of p107 and cyclin A in cells that lack the extracellular matrix protein secreted protein acidic and rich in cysteine, Cell Growth and Differentiation, 10(11), 721-8, November 1999 Abstract
  • Ge K, DuHadaway J, Du W, Herlyn M, Rodeck U, Prendergast GC, Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma, Proceedings of the National Academy of Sciences (USA), 96(17), 9689-94, August 1999 Abstract
  • Rodeck U, Nishiyama T, Mauviel A, Independent regulation of growth and SMAD-mediated transcription by transforming growth factor beta in human melanoma cells, Cancer Research, 59(3), 547-50, February 1999 Abstract
  • Jost M, Kari C, Rodeck U, An episomal vector for stable tetracycline-regulated gene expression, Nucleic Acids Research, 25(15), 3131-4, August 1997 Abstract
  • Rodeck U, Jost M, DuHadaway J, Kari C, Jensen PJ, Risse B, Ewert DL, Regulation of Bcl-xL expression in human keratinocytes by cell-substratum adhesion and the epidermal growth factor receptor, Proceedings of the National Academy of Sciences (USA), 94(10), 5067-72, May 1997 Abstract
  • Rodeck U, Jost M, Kari C, Shih DT, Lavker RM, Ewert DL, Jensen PJ, EGF-R dependent regulation of keratinocyte survival, Journal of Cell Science, 110 ( Pt 2), 113-21, January 1997 Abstract
  • Simon HG, Risse B, Jost M, Oppenheimer S, Kari C, Rodeck U, Identification of differentially expressed messenger RNAs in human melanocytes and melanoma cells, Cancer Research, 56(13), 3112-7, July 1996 Abstract
  • Van Belle P, Rodeck U, Nuamah I, Halpern AC, Elder DE, Melanoma-associated expression of transforming growth factor-beta isoforms, American Journal of Pathology, 148(6), 1887-94, June 1996 Abstract
  • Bellone G, Aste-Amezaga M, Trinchieri G, Rodeck U, Regulation of NK cell functions by TGF-beta 1, Journal of Immunology, 155(3), 1066-73, August 1995 Abstract
  • Vardy DA, Kari C, Lazarus GS, Jensen PJ, Zilberstein A, Plowman GD, Rodeck U, Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1, Journal of Cellular Physiology, 163(2), 257-65, May 1995 Abstract
  • Rodeck U, Bossler A, Graeven U, Fox FE, Nowell PC, Knabbe C, Kari C, Transforming growth factor beta production and responsiveness in normal human melanocytes and melanoma cells, Cancer Research, 54(2), 575-81, January 1994 Abstract
  • Rodeck U, Growth factor independence and growth regulatory pathways in human melanoma development, Cancer and Metastasis Reviews, 12(3-4), 219-26, September 1993 Abstract
  • Jensen PJ, Rodeck U, Autocrine/paracrine regulation of keratinocyte urokinase plasminogen activator through the TGF-alpha/EGF receptor, Journal of Cellular Physiology, 155(2), 333-9, May 1993 Abstract
  • Schmiegel W, Roeder C, Schmielau J, Rodeck U, Kalthoff H, Tumor necrosis factor alpha induces the expression of transforming growth factor alpha and the epidermal growth factor receptor in human pancreatic cancer cells, Proceedings of the National Academy of Sciences (USA), 90(3), 863-7, February 1993 Abstract
  • Rodeck U, Melber K, Kath R, Menssen HD, Varello M, Atkinson B, Herlyn M, Constitutive expression of multiple growth factor genes by melanoma cells but not normal melanocytes, Journal of Investigative Dermatology, 97(1), 20-6, July 1991 Abstract
  • Rodeck U, Williams N, Murthy U, Herlyn M, Monoclonal antibody 425 inhibits growth stimulation of carcinoma cells by exogenous EGF and tumor-derived EGF/TGF-alpha, Journal of Cellular Biochemistry, 44(2), 69-79, October 1990 Abstract
  • Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ, Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens, Proceedings of the National Academy of Sciences (USA), 87(17), 6833-7, September 1990 Abstract
  • Rodeck U, Herlyn M, Herlyn D, Molthoff C, Atkinson B, Varello M, Steplewski Z, Koprowski H, Tumor growth modulation by a monoclonal antibody to the epidermal growth factor receptor: immunologically mediated and effector cell-independent effects, Cancer Research, 47(14), 3692-6, July 1987 Abstract
  • Westermark B, Johnsson A, Paulsson Y, Betsholtz C, Heldin CH, Herlyn M, Rodeck U, Koprowski H, Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor, Proceedings of the National Academy of Sciences (USA), 83(19), 7197-200, October 1986 Abstract

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