Peter Ronner

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Thomas Jefferson University
Jefferson Medical College
Biochemistry & Molecular Pharmacology
Associate ProfessorAppointed: 1994
Thomas Jefferson University
Thomas Jefferson University Hospital
Biochemistry & Molecular Pharmacology

Mailing Address

233 S. 10th St., 226 BLSB
Department of Biochemistry and Molecular Pharmacology
Thomas Jefferson University
Philadelphia, Pennsylvania 19107-5587
United States

Contact Information

Phone: (215) 503-5190
Fax: (215) 923-9162
Peter.Ronner@jefferson.edu
http://www.jefferson.edu/biochemistry/ronner.cfm

Qualifications

Dr. Sc. Nat., Swiss Federal Institute of Technology, Zurich, Biochemistry, 1978.

Expertise and Research Interests

I am interested in the mechanisms that control the release of insulin and glucagon from the pancreas.

Most of my current work is focused on glucagon release. We found that non-B islet cells (most likely glucagon-secreting A-cells) contain ATP-sensitive K-channels (KATP) that are pharmacologically and electrophysiologically indistinguishable from those in insulin-secreting B-cells. I am interested in defining the role of KATP in the regulation of both insulin and glucagon release.

In our studies of normal and tumoral pancreatic endocrine cells we use electrophysiology, flow-cytometric cell-sorting, immunohistochemistry, radioimmunoassays, and sensitive luminometric microhistochemical assays, which we developed recently.

Previously, I have studied the Ca,Mg-ATPase of human erythrocyte membranes, and hormone release from the in vitro micro-perfused endocrine pancreas (weight ~5 mg) of channel catfish (Ictalurus nebulosus).

Other Expertise

Experienced with teaching medical students and coordinating a biochemistry/molecular biology/cell biology/genetics course for first year medical students.

Experienced with the following lecture topics: thermodynamics and pH; carbohydrate uptake; glycolysis; pyruvate kinase deficiency; fructose intolerance and galactosemia; pentose phosphate shunt and glucose-6-phosphate dehydrogenase deficiency; citric acid cycle; pancreatic hormones; type 1 diabetes; exercise, insulin resistance and obesity; type 2 diabetes; phenylketonuria and maple syrupurine disease; one-carbon metabolism; purine nucleotide metabolism; hyperuricemia and gout; pyrimidines and chemotherapy.

Experienced with whole-class discussions of problem sets on hypophosphatemia, glucose-6-phosphate dehydrogenase deficiency, debranching enzyme deficiency, insulinoma, hypoalaninemia/insufficient cortisol release of childhood, diabetic ketoacidosis, abetalipoproteinemia, propionyl-CoA carboxylase deficiency, preeclampsia/HELLP syndrome, glucagonoma. Experienced with small group sessions(~12 students) on oncogenes, sickle cell anemia, diabetes, familial hypercholesterolemia, and gene therapy.

Future Research

Biochemistry review book for medical professionals

Industrial Relevance

Hypoglycemic agents
Diabetes

Keywords

COS Keywords:

Diabetes, Digestive Diseases and Disorders, Digestive System, Education or Instruction (Health or Safety or Medical), Electrophysiology, Endocrinologic Diseases, Flow Cytometry, Insulin, Kidney (Renal) Functions, Kidney Disease, Radioimmunoassay, Transfection, Transgenic Animals, Urology.

Additional Terms:

ATP-sensitive K+ Channel, Adenosine Diphosphate, Adenosine Triphosphate, BCECF, Biomedical Facility, Blood Glucose, Creatine Kinase, Drug Receptor, Electrophysiology, Flow Cytometry, Glucagon, Glucagonoma, Glyburide, Green Fluorescent Protein, Hormone Regulation Control Mechanism, Hyperglucagonemia, Hyperkalemia, Insulin, Insulinoma, KATP, Laboratory Mouse, Laboratory Rat, Luciferase, Membrane Potential, Membrane Protein, Noninsulin Dependent Diabetes Mellitus, PH, Pancreatic Islet, Perfusion, Potassium Channel, Radioimmunoassay, Somatostatin, Sulfonylurea, Tissue Cell Culture, Transfection, Transgenic Animal, Type 1 Diabetes.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
German: (Fluent, Fluent, Fluent)
Schwyzerdütsch: (Fluent, None, Fluent)
French: (Basic, Basic, Basic)

Memberships

American Association for the Advancement of Science
American Diabetes Association
European Association for the Study of Diabetes

Honors and Awards

2004, Dean's Award for Distinguished Teaching in a Basic Science (chosen by the 4th year medical students), Thomas Jefferson University, Thomas Jefferson University, Medical Student Teaching
2004, 1st Year Medical Student's Award for Excellence in Teaching, Jefferson Medical College Class of 2007, Thomas Jefferson University, Medical Student Teaching
1999, The Christian R. and Mary F. Lindback Award for Distinguished Teaching in a Basic Science, Thomas Jefferson University, Medical Student Teaching
1998, Guest of Honor, 64th Annual Black and Blue Ball (Medical Students, Jefferson Medical College)
1980, Postdoctoral Fellowship, Swiss Academy of Sciences
1979, International Research Fellowship, John E. Fogarty International Center for Advanced Study in the Health Sciences, (declined for visa reasons)
1979, Postdoctoral Fellowship, Swiss Science Foundation

Previous Positions

1989-1994, Director, University of Pennsylvania, School of Medicine, Diabetes and Endocrinology Research Center, Radioimmunoassay Core Facility
1988-1994, Assistant Professor, University of Pennsylvania, School of Medicine, Biochemistry and Biophysics
1986-1988, Research Assistant Professor, University of Rochester, School of Medicine, Biochemistry
1984-1986, Investigator, Joslin Diabetes Center, Elliott P. Joslin Research Laboratories
1984-1986, Instructor, Harvard University, Medical School, Medicine, Physiology
1980-1984, Research Associate, University of Pennsylvania, School of Medicine, Biochemistry and Biophysics

Funding Received

  • : 5 P30 DK19525-20 SUB: 9001, DIABETES ENDOCRINOLOGY RESEARCH CENTER: CORE--RADIOIMMUNOASSAY, $134,687, 1996 to .
  • National Institutes of Health (NIH): 5 R01 DK51016-02, CONTROL OF GLUCAGON RELEASE FROM A-CELLS, $150,357, 1996 to 1997.

Publications

  • Ronner P, Naumann CM, and Friel E, Effects of glucose and amino acids on free ADP in beta HC9 insulin-secreting cells, Diabetes, 50(2), 291-300, February 2001
  • Ronner P, Friel E, Czerniawski K, Frankle S, Luminometric assays of ATP, phosphocreatine, and creatine for estimation of free ADP and free AMP, Analytical Biochemistry, 275(2), 208-16, November 1999 Abstract
  • Ronner P, Perfusion of pancreatic endocrine tissue of teleost fish, Biochemistry and Molecular Biology of Fishes, vol. 3, Analytical Techniques; Hochachka PW and Mommsen TP, eds.; Elsevier Science, Amsterdam, pp. 179-189, 1994
  • Li G, Kesavan P, Najafi H, Wang L, Ronner P, Liang Y, and Matschinsky FM, Fundamentals of fuel sensing and intermediary metabolism in pancreatic A and B cells, Contemporary Biomedicine, vol. on 'Molecular Biology of Diabetes', Draznin B and Leroith D, eds.; Humana Press, Totowa, NJ, pp. 175-192, 1994
  • Ronner P, Matschinsky FM, Hang TL, Epstein AJ, Buettger C, Sulfonylurea-binding sites and ATP-sensitive K channels in alpha-TC glucagonoma and beta-TC insulinoma cells, Diabetes, 42(12), 1760-72, December 1993 Abstract
  • Ronner P, Hang TL, Kraebber MJ, Higgins TJ, Effect of the hypoglycaemic drug (-)-AZ-DF-265 on ATP-sensitive potassium channels in rat pancreatic beta-cells, British Journal of Pharmacology, 106(2), 250-5, June 1992 Abstract
  • Ghosh A, Ronner P, Cheong E, Khalid P, Matschinsky FM, The role of ATP and free ADP in metabolic coupling during fuel-stimulated insulin release from islet beta-cells in the isolated perfused rat pancreas, Journal of Biological Chemistry, 266(34), 22887-92, December 1991 Abstract
  • Ronner P, Higgins TJ, Kimmich GA, Inhibition of ATP-sensitive K channels in pancreatic beta-cells by nonsulfonylurea drug linogliride, Diabetes, 40(7), 885-92, July 1991 Abstract
  • Ronner P, Cheong E, Khalid P, Tuman RW, Matschinsky FM, Effect of linogliride on hormone release from perfused rat pancreas. Fuel dependence and desensitization by tolbutamide, Diabetes, 40(7), 878-84, July 1991 Abstract
  • Ronner P, 2-Deoxyglucose stimulates the release of insulin and somatostatin from the perfused catfish pancreas, General and Comparative Endocrinology, 81(2), 276-83, February 1991 Abstract
  • Ronner P, Scarpa A, Secretagogues for pancreatic hormone release in the channel catfish (Ictalurus punctatus), General and Comparative Endocrinology, 65(3), 354-62, March 1987 Abstract
  • Ronner P, Transmembrane ion distribution and insulin secretion, Annals of the New York Academy of Sciences, 488, 341-55, 1986 Abstract
  • Dettori-Gera C, Ronner P, Scarpa A, Difference in dose-response curves for glucose-induced insulin and somatostatin release in rat pancreas, Biochimica Et Biophysica Acta, 839(3), 281-6, May 1985 Abstract
  • Andrews PC, Ronner P, Isolation and structures of glucagon and glucagon-like peptide from catfish pancreas, Journal of Biological Chemistry, 260(7), 3910-4, April 1985 Abstract
  • Ronner P, Scarpa A, Difference in glucose dependency of insulin and somatostatin release, American Journal of Physiology, 246(6 Pt 1), E506-9, June 1984 Abstract
  • Ronner P, Scarpa A, Isolated perfused Brockmann body as a model for studying pancreatic endocrine secretion, American Journal of Physiology, 243(5), E352-9, November 1982 Abstract
  • Niggli V, Ronner P, Carafoli E, Penniston JT, Effects of calmodulin on the (Ca2 Mg2 )ATPase partially purified from erythrocyte membranes, Archives of Biochemistry and Biophysics, 198(1), 124-30, November 1979 Abstract
  • Ronner P, Calcium transport in resealed erythrocytes and the use of a calcium electrode, Membrane Biochemistry; a Laboratory Manual on Transport and Bioenergetics, Carafoli E and Semenza G, eds.; Springer Verlag, Berlin, pp. 41-50, 1979
  • Schatzmann H-J, Ronner P, Niggli V, Net Na+ and K+ movements in human red blood cells after cold storage, Membrane Biochemistry; a Laboratory Manual on Transport and Bioenergetics, Carafoli E and Semenza G, eds.; Springer Verlag, Berlin, pp. 35-40, 1979
  • Peterson SW, Ronner P, Carafoli E, Partial purification and reconstitution of the (Ca2 Mg2 )-ATPase of erythrocyte membranes, Archives of Biochemistry and Biophysics, 186(1), 202-10, February 1978 Abstract
  • Ronner P, Further characterization and partial purification of the calcium, magnesium-stimulated adenosine triphosphatase of human erythrocyte membranes, Thesis no. 6191, Swiss Federal Institute of Technology, Zurich, Switzerland, 1978
  • Ronner P, Gazzotti P, Carafoli E, A lipid requirement for the (Ca2 Mg2 )-activated ATPase of erythrocyte membranes, Archives of Biochemistry and Biophysics, 179(2), 578-83, March 1977 Abstract
  • Sigrist H, Ronner P, Semenza G, A hydrophobic form of the small-intestinal sucrase-isomaltase complex, Biochimica Et Biophysica Acta, 406(3), 433-46, October 1975 Abstract

Profile Details

Last Updated: 3/14/2006

COS Expertise ID #542779
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