Yale University School of Medicine Internal Medicine Assistant ProfessorAppointed: 2004 | |
QualificationsC.C.S.T, Royal College of Physicians, Diabetes/ Endocrinology /Internal Medicine, 2000. M.D., Edinburgh University, Medical Sciences, 1999. M.R.C.P., Royal College of Physicians, Medicine, 1993. M.B.Ch.B., Edinburgh University, Medicine, 1989. Expertise and Research InterestsIndividuals with diabetes are prone to develop iatrogenic hypoglycemia secondary to insulin replacement therapy. The primary research interest in my laboratory is to explore the underlying mechanisms by which the brain, and in particular specific hypothalamic nuclei, sense a falling blood glucose and trigger a neuroendocrine stress response. We are also interested in studying those factors that modulate the neuroendocrine stress response in order to try and understand why this system is impaired in diabetes. On going projects use in vivo microinjection, microdialysis, and gene therapy approaches in animal models (rat and transgenic mice) as well as neuroimaging studies in humans subjects.
A second, and developing, research interest in my lab is in the central (primarily hypothalamic) regulation of peripheral metabolism and energy balance. Other ExpertiseType 1 Diabetes
Neuroendocrinology
Obesity KeywordsCOS Keywords:Animal Models, Diabetes, Endocrinology, Gene Therapy, Insulin, Internal Medicine, Metabolism, Neuroendocrinology, Neuroimaging.Additional Terms:Diabetes, Endocrinology.Languages(Reading, Writing, Speaking)English: (Fluent, Fluent, Fluent) MembershipsAmerican Diabetes Association European Society for the Study of Diabetes Funding Received- Juvenile Diabetes Research Foundation:
Restoring Hypoglycemic Counterregulation in Type 1 Diabetes,
$495,000,
2007
to 2010.
- National Institutes of Health (NIH):
Role for AMPK in hypoglycemia-sensing in the Ventromedial Hypothalamus,
2004
to 2009.
- Juvenile Diabetes Research Foundation:
Career Development Award,
2002
to 2007.
Publications- McCrimmon RJ (2008) The mechanisms that underlie glucose sensing in diabetes., Diabetic Medicine, In Press
- McCrimmon RJ (2008) Key role for AMP-activated protein kinase in regulating counterregulatory responses to acute hypoglycemia, Diabetes, 57, 444-450
- Cheng H (2007) Type 1 corticotrophin releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulation, American Journal of Physiology, 293, E705-E712
- Tong Q (2007) Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia, Cell Metabolism, 5 (5), 286-98
- Shaw MM (2007) 5'AMP-activated protein kinase alpha deficiency enhances stress induced apoptosis in BHK and PC12 cells, Journal of Cellular and Molecular Medicine, 11 (2), 286-98
- Zhou, L (2007) Serotonin2C receptor agonists improve type 2 diabetes via MC4 receptor signalling pathways, Cell Metabolism, 6, 397-405
- McCrimmon RJ (2006) Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation, Diabetes, 55, 1755-1760
- McCrimmon RJ (2006) Corticotrophin Releasing Factor Receptors within the Ventromedial Hypothalamus Regulate Hypoglycemia-Induced Hormonal Counterregulation, Journal of Clinical Investigation, 116, 1723-1730
- Goldberg P (2006) Antecedent hypercortisolemia is not primarily responsible for generating hypoglycemia-associated autonomic failure, Diabetes, 55, 1121-1126
- McNay EC (2006) Cognitive and neural hippocampal effects of long-term, moderate recurrent hypoglycemia, Diabetes, 55, 1088-1095
- Chan O (2006) Blockade of GABA-A receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal, but not hypothalamo-pituitary-adrenal response to hypoglyhcemia, Diabetes, 55, 1080-1087
- Ferguson SC, Blane A, Wardlaw J, Frier BM, Perros P, McCrimmon RJ, Deary IJ (Jun 2005) Influence of an early-onset age of type 1 diabetes on cerebral structure
and cognitive function, Diabetes Care, 28 (6), 1431-7
- Evans ML, McCrimmon RJ, Flanagan DE, Keshavarz T, Fan X, McNay EC, Jacob RJ, Sherwin RS (Oct 2004) Hypothalamic ATP-sensitive K + channels play a key role in sensing
hypoglycemia and triggering counterregulatory epinephrine and glucagon
responses, Diabetes, 53 (10), 2542-51
- McCrimmon RJ, Fan X, Ding Y, Zhu W, Jacob RJ, Sherwin RS (Aug 2004) Potential role for AMP-activated protein kinase in hypoglycemia sensing in
the ventromedial hypothalamus, Diabetes, 53 (8), 1953-8
- McCrimmon RJ, Jacob RJ, Fan X, McNay EC, Sherwin RS (Dec 2003) Effects of recurrent antecedent hypoglycaemia and chronic hyperglycaemia
on brainstem extra-cellular glucose concentrations during acute
hypoglycaemia in conscious diabetic BB rats, Diabetologia, 46 (12), 1658-61
- McCrimmon RJ, Deary IJ, Gold AE, Hepburn DA, MacLeod KM, Ewing FM, Frier BM (Jun 2003) Symptoms reported during experimental hypoglycaemia: effect of method of
induction of hypoglycaemia and of diabetes per se, Diabetic Medicine : a Journal of the British Diabetic Association, 20 (6), 507-9
- Strachan MW, Ewing FM, Frier BM, McCrimmon RJ, Deary IJ (Jan 2003) Effects of acute hypoglycaemia on auditory information processing in
adults with Type I diabetes, Diabetologia, 46 (1), 97-105
- Ferguson SC, Blane A, Perros P, McCrimmon RJ, Best JJ, Wardlaw J, Deary IJ, Frier BM (Jan 2003) Cognitive ability and brain structure in type 1 diabetes: relation to
microangiopathy and preceding severe hypoglycemia, Diabetes, 52 (1), 149-56
- McCrimmon RJ, Evans ML, Jacob RJ, Fan X, Zhu Y, Shulman GI, Sherwin RS (Nov 2002) AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon
secretion in the diabetic BB rat, American Journal of Physiology. Endocrinology and Metabolism, 283 (5), E1076-83
Profile DetailsCOS Expertise ID #1238183 Individual Expertise profile of Rory John McCrimmon, Copyright Rory John McCrimmon. © COS Expertise TM, 2009, ProQuest LLC All rights reserved. |