Prof. Thomas E. Schlaepfer

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University of Bonn
Psychiatry and Psychotherapy
Vice ChairAppointed: 2003
University of Bonn
Faculty of Medicine
Dean of Medical EducationAppointed: 2006
Johns Hopkins University
Bloomberg School of Public Health
Mental Hygiene
Associate Professor (Part Time)Appointed: 1997
Johns Hopkins University
School of Medicine
Psychiatry and Behavioral Sciences
Psychiatric Neuroimaging
Associate Professor (Part Time)Appointed: 1997
Professional Headshot of Thomas E. Schlaepfer

Mailing Address

Brain Stimulation Group
Department of Psychiatry
University Hospital Bonn
Sigmund-Freud-Straße 25
Bonn, 53105
Germany

Contact Information

Phone: +49 228 287-15715
Fax: +49 228 287-15025
schlaepf@jhmi.edu
http://www.schlaepfer.org/

Qualifications

Certificate, Johns Hopkins University, Executive Medical-Business Graduate, 1995.
M.D., University of Berne, Medicine, 1987.
Matura Type C, Freies Gymnasium Bern, 1981.

Expertise and Research Interests

Brain stimulation methods (Electroconvulsive Therapy, Vagus Nerve Stimulation, Transcranial Magnetic Stimulation, Magnetic Seizure Therapy, Deep Brain Stimulation) in treatment resistant affective disorders

Cytokine induced depression

Functional Neuroimaging (fMRI, SPECT, PET) in affective and substance abuse disorders

Other Expertise

Editorial Boards:
Neuropsychopharmacology
CNS Spectrums
Journal of Convulsive Therapy
International Review of Psychiatry
Annals of Clinical Psychiatry

Reviewer for (Selection):
American Journal of Psychiatry
Archives of General Psychiatry
Biological Psychiatry
Brain
Journal of Neural Transmission
Neuropsychopharmacology
Psychiatry Research - Neuroimaging

Industrial Relevance

Institute for Medicine and Communication (IMC), Basel, Switzerland 1992-present
Member of the Board

Keywords

COS Keywords:

Affective Disorders, Alcohol Or Alcoholism, Blood Flow, Brain, Magnetic Resonance Imaging, Medical Or Diagnostic Imaging, Mental Disorders, Mental Health Services, Neuroimaging, Neuropsychopharmacology, Psychiatry, Psychopharmacology, Psychotherapy, Substance Abuse.

Additional Terms:

Affective Disorders, FMRI, MRI, PET, Psychopharmacology, SPECT, Substance Abuse, Transcranial Magnetic Stimulation.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
German: (Fluent, Fluent, Fluent)
French: (Fluent, Functional, Fluent)
Italian: (Functional, Basic, Functional)

Memberships

American Academy of Clinical Psychiatrists
American College of Neuropsychopharmacology
American Psychiatric Association
Association for Convulsive Therapy
Collegium Internationale Neuro-Psychopharmacologicum
European College of Neuropsychopharmacology
International Society for Neuroimaging in Psychiatry
International Society for Transcranial Stimulation
Society of Biological Psychiatry

Honors and Awards

2000, Jakob Kläsi Prize for Research in Depression and Schizophrenia, Swiss Academy of Medical Sciences
1997, BMS Travel Award, American College of Neuropsychopharmacology
1994, Young Investigators Award, Swiss Society for Biological Psychiatry
1986, Best Science Article, Swiss Association of Science Journalism

Previous Positions

2002-2006, Professor, University of Berne, Psychiatry
1996-2003, Associate Professor, University of Berne, Psychiatry, Psychiatric Neuroimaging Group
1994-1997, Assistant Professor, Johns Hopkins University, School of Medicine, Psychiatry, Psychiatric Neuroimaging
1994-1999, Guest Researcher, National Institute of Mental Health and Neuro Sciences, Neuropharmacology Branch, Laboratory of Clinical Science
1993-1994, Research Associate, Johns Hopkins University, Bloomberg School of Public Health, Mental Hygiene
1992-1994, Fellow, Johns Hopkins University, School of Medicine, Psychiatry and Behavioral Sciences, Psychiatric Neuroimaging
1988-1992, Resident, University of Berne, Psychiatry

Funding Received

  • Swiss National Science Foundation: Functional Neuroimaging in Opioid Craving, Abuse and Withdrawal, $100,000, 1997 to 2000.
  • Swiss Alcohol Foundation: Alcohol Induced Structural Brain Damage: How reversible is the condition? An MRI Study, $80,000, 07/1995 to 07/2000.
  • Swiss National Science Foundation: Effect of Rapid Transcranial Magnetic Stimulation (rTMS) on Refractory Major Depression, $370,000, 06/1996 to 06/2001.
  • Swiss National Science Foundation: SCORE-A (Swiss Clinicians Opting for Research, Advanced) Career Development Award, $750,000, 06/1996 to 06/2001.

Publications

  • Wade AG, Schlaepfer TE, Andersen HF, Kilts CD (Feb 2009) Clinical milestones predict symptom remission over 6-month and choice of treatment of patients with major depressive disorder (MDD)., Journal of psychiatric research, 43 (5), 568-75 Abstract
  • Onur OA, Walter H, Schlaepfer TE, Rehme AK, Schmidt C, Keysers C, Maier W, Hurlemann R (Feb 2009) Noradrenergic enhancement of amygdala responses to fear., Social cognitive and affective neuroscience Abstract
  • Hurlemann R, Schlaepfer TE, Matusch A, Reich H, Shah NJ, Zilles K, Maier W, Bauer A (Jan 2009) Reduced 5-HT2A receptor signaling following selective bilateral amygdala damage., Social cognitive and affective neuroscience Abstract
  • Synofzik M, Schlaepfer TE (Dec 2008) Stimulating personality: ethical criteria for deep brain stimulation in psychiatric patients and for enhancement purposes., Biotechnology journal, 3 (12), 1511-20 Abstract
  • Cohen MX, Axmacher N, Lenartz D, Elger CE, Sturm V, Schlaepfer TE (Dec 2008) Neuroelectric Signatures of Reward Learning and Decision-Making in the Human Nucleus Accumbens., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Abstract
  • Cohen MX, Axmacher N, Lenartz D, Elger CE, Sturm V, Schlaepfer TE (Aug 2008) Good Vibrations: Cross-frequency Coupling in the Human Nucleus Accumbens during Reward Processing., Journal of cognitive neuroscience Abstract
  • Schlaepfer TE, Frick C, Zobel A, Maier W, Heuser I, Bajbouj M, O'Keane V, Corcoran C, Adolfsson R, Trimble M, Rau H, Hoff HJ, Padberg F, Müller-Siecheneder F, Audenaert K, Van den Abbeele D, Matthews K, Christmas D, Stanga Z, Hasdemir M (May 2008) Vagus nerve stimulation for depression: efficacy and safety in a European study., Psychological medicine, 38 (5), 651-61 Abstract
  • Kosel M, Noss RS, Hämmig R, Wielepp P, Bundeli P, Heidbreder R, Kinser JA, Brenneisen R, Fisch HU, Kayser S, Schlaepfer TE (Apr 2008) Cerebral blood flow effects of acute intravenous heroin administration., European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 18 (4), 278-85 Abstract
  • Schlaepfer TE, Cohen MX, Frick C, Kosel M, Brodesser D, Axmacher N, Joe AY, Kreft M, Lenartz D, Sturm V (Jan 2008) Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 33 (2), 368-77 Abstract
  • Guyer S, Kosel M, Altrichter S, El-Koussy M, Haemmig R, Fisch HU, Lovblad KO, Schlaepfer TE (Dec 2007) Pattern of regional cerebral blood-flow changes induced by acute heroin administration--a perfusion MRI study., Journal of neuroradiology. Journal de neuroradiologie, 34 (5), 322-9 Abstract
  • Schlaepfer TE, Cohen MX, Frick C, Kosel M, Brodesser D, Axmacher N, Joe AY, Kreft M, Lenartz D, Sturm V (Apr 2007) Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression. Abstract
  • Kosel M, Sturm V, Frick C, Lenartz D, Zeidler G, Brodesser D, Schlaepfer TE. (2006) Mood improvement after deep brain stimulation of the internal globus pallidus for tardive dyskinesia in a patient suffering from major depression, J Psychiatr Res. 2007, 41 (9), 801-3
  • Lieb K, Schlaepfer TE. (2006) Deep-brain stimulation for Parkinson's disease, N Engl J Med, 355 (21), 2256
  • Schlaepfer TE, Lieb K (Oct 2005) Deep brain stimulation for treatment of refractory depression., Lancet, 366 (9495), 1420-2 Abstract
  • Frick C, Kosel M, Schlaepfer TE, Stanga Z, Hasdemir MG, Incident Mania During Therapy With Vagus Nerve Stimulation., The Journal of ECT, 21(3), 197, Sep 2005 Abstract
  • Schulze-Rauschenbach SC, Harms U, Schlaepfer TE, Maier W, Falkai P, Wagner M, Distinctive Neurocognitive Effects of Repetitive Transcranial Magnetic Stimulation and Electroconvulsive Therapy in Major Depression., The British Journal of Psychiatry : the Journal of Mental Science, 186, 410-6, May 2005 Abstract
  • Wagner M, Quednow BB, Westheide J, Schlaepfer TE, Maier W, Kuhn KU, Cognitive Improvement in Schizophrenic Patients Does Not Require A Serotonergic Mechanism: Randomized Controlled Trial of Olanzapine Vs Amisulpride., Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology., 30(2), 381-90, Feb 2005 Abstract
  • Schlaepfer TE, Learning From the History of Neuroscience: Dogma and Patient Interests: Comment to Dr. Finks Commentary., The Journal of Ect, 20(3), 137-8; discussion 13, Sep 2004 Abstract
  • Holtzheimer PE, Avery D, Schlaepfer TE, Antidepressant effects of repetitive transcranial magnetic stimulation, The British Journal of Psychiatry; the Journal of Mental Science, 184, 541-2, June 2004 Abstract
  • Mosimann UP, Schmitt W, Greenberg BD, Kosel M, Muri RM, Berkhoff M, Hess CW, Fisch HU, Schlaepfer TE, Repetitive Transcranial Magnetic Stimulation: a Putative Add-on Treatment for Major Depression in Elderly Patients., Psychiatry Research, 126(2), 123-33, Apr 2004 Abstract
  • Kosel M, Rudolph U, Wielepp P, Luginbuhl M, Schmitt W, Fisch HU, Schlaepfer TE, Diminished GABA(A) Receptor-binding Capacity and a DNA Base Substitution in a Patient With Treatment-resistant Depression And Anxiety., Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology., 29(2), 347-50, Feb 2004 Abstract
  • Kosel M, Frick C, Lisanby SH, Fisch HU, Schlaepfer TE, Magnetic Seizure Therapy Improves Mood in Refractory Major Depression., Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology., 28(11), 2045-8, Nov 2003 Abstract
  • Lisanby SH, Luber B, Schlaepfer TE, Sackeim HA, Safety and Feasibility of Magnetic Seizure Therapy (MST) in Major Depression: Randomized Within-subject Comparison With Electroconvulsive Therapy., Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology., 28(10), 1852-65, Oct 2003 Abstract
  • Schlaepfer TE, Progress in therapeutic brain stimulation in neuropsychiatry, Cns Spectr, 8(7), 488, July 2003 Abstract
  • Belmaker B, Fitzgerald P, George MS, Lisanby SH, Pascual-Leone A, Schlaepfer TE, Wassermann E, Managing the risks of repetitive transcranial stimulation, Cns Spectr, 8(7), 489, July 2003 Abstract
  • Kosel M, Schlaepfer TE, Beyond the Treatment of Epilepsy: New Applications of Vagus Nerve Stimulation in Psychiatry., Cns Spectrums, 8(7), 515-21, Jul 2003 Abstract
  • Martin JL, Barbanoj MJ, Schlaepfer TE, Thompson E, Perez V, Kulisevsky J, Repetitive Transcranial Magnetic Stimulation for the Treatment Of Depression. Systematic Review and Meta-analysis., The British Journal of Psychiatry : the Journal of Mental Science, 182, 480-91, Jun 2003 Abstract
  • George MS, Nahas Z, Lisanby SH, Schlaepfer TE, Kozel A, Greenberg BD, Transcranial Magnetic Stimulation (TMS), Neurosurgery Clinics of North America, 2003(4), April 2003
  • Schlaepfer TE, Kosel M, Nemeroff CB, Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in The Treatment of Affective Disorders., Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology., 28(2), 201-5, Feb 2003 Abstract
  • Kosel M, Schlaepfer TE, Mechanisms and state of the art of vagus nerve stimulation, The Journal of Ect, 18(4), 189-92, December 2002 Abstract
  • Mosimann UP, Marre SC, Werlen S, Schmitt W, Hess CW, Fisch HU, Schlaepfer TE, Antidepressant effects of repetitive transcranial magnetic stimulation in the elderly: correlation between effect size and coil-cortex distance, Archives of General Psychiatry, 59(6), 560-1, June 2002 Abstract
  • Schlaepfer TE, Pearlson G, Heteromodal association cortex involvement in schizophrenia, European Psychiatry: The Journal of the Association of European Psychiatrists, 17 Suppl 1, 87, May 2002
  • Schlaepfer TE, Kosel M, Frick-Schroter C, Fisch HU, An overview of the antidepressant properties of transcranial magnetic stimulation, European Psychiatry: The Journal of the Association of European Psychiatrists, 17 Suppl 1, 4, May 2002
  • Schlaepfer TE, Lisanby HS, Fisch HU, Sackeim HA, Magnetic seizure induction for the treatment of major depression, European Psychiatry: The Journal of the Association of European Psychiatrists, 17 Suppl 1, 43, May 2002
  • Muri RM, Buhler R, Heinemann D, Mosimann UP, Felblinger J, Schlaepfer TE, Hess CW, Hemispheric Asymmetry in Visuospatial Attention Assessed With Transcranial Magnetic Stimulation., Experimental Brain Research. Experimentelle Hirnforschung. Experimentation Cerebrale., 143(4), 426-30, Apr 2002 Abstract
  • Martin JL, Barbanoj MJ, Schlaepfer TE, Clos S, Perez V, Kulisevsky J, Gironell A, Transcranial Magnetic Stimulation for Treating Depression., Cochrane Database of Systematic Reviews (online : Update Software), CD003493, 2002 Abstract
  • Hoehn-Saric R, Schlaepfer TE, Greenberg BD, McLeod DR, Pearlson GD, Wong SH, Cerebral Blood Flow in Obsessive-compulsive Patients With Major Depression: Effect of Treatment With Sertraline Or Desipramine On Treatment Responders and Non-responders., Psychiatry Research, 108(2), 89-100, Nov 2001 Abstract
  • Wipfli M, Felblinger J, Mosimann UP, Hess CW, Schlaepfer TE, Muri RM, Double-pulse transcranial magnetic stimulation over the frontal eye field facilitates triggering of memory-guided saccades, European Journal of Neuroscience, 14(3), 571-5, August 2001 Abstract
  • Graf T, Engeler J, Achermann P, Mosimann UP, Noss R, Fisch HU, Schlaepfer TE, High frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral cortex: EEG topography during waking and subsequent sleep, Psychiatry Research, 107(1), 1-9, 2001 Abstract
  • Mojon DS, Schlapfer TE, [Nonorganic Disorders in Ophthalmology: Overview of Diagnosis and Therapy], Klinische Monatsblatter Fur Augenheilkunde, 218(5), 298-304, May 2001 Abstract
  • Lisanby SH, Schlaepfer TE, Fisch HU, Sackeim HA, Magnetic seizure therapy of major depression, Archives of General Psychiatry, 58(3), 303-5, March 2001 Abstract
  • Mosimann UP, Rihs TA, Engeler J, Fisch H, Schlaepfer TE, Mood effects of repetitive transcranial magnetic stimulation of left prefrontal cortex in healthy volunteers, Psychiatry Research, 94(3), 251-6, July 2000 Abstract
  • Schlapfer TE, [Alcohol and the brain--morphological and functional brain changes], Therapeutische Umschau, 57(4), 191-5, April 2000 Abstract
  • Ji RR, Schlaepfer TE, Aizenman CD, Epstein CM, Qiu D, Huang JC, Rupp F, Repetitive transcranial magnetic stimulation activates specific regions in rat brain, Proceedings of the National Academy of Sciences (USA), 95(26), 15635-40, December 1998 Abstract
  • Eaton WW, Anthony JC, Romanoski A, Tien A, Gallo J, Cai G, Neufeld K, Schlaepfer T, Laugharne J, Chen LS, Onset and recovery from panic disorder in the Baltimore Epidemiologic Catchment Area follow-up, British Journal of Psychiatry, 173, 501-7, December 1998 Abstract
  • Tien AY, Schlaepfer TE, Orr W, Pearlson GD, SPECT Brain Blood Flow Changes With Continuous Ligand Infusion During Previously Learned WCST Performance., Psychiatry Research, 82(1), 47-52, Apr 1998 Abstract
  • Schlaepfer TE, Strain EC, Greenberg BD, Preston KL, Lancaster E, Bigelow GE, Barta PE, Pearlson GD, Site of Opioid Action in the Human Brain: Mu and Kappa Agonists' Subjective and Cerebral Blood Flow Effects., The American Journal of Psychiatry, 155(4), 470-3, Apr 1998 Abstract
  • Tien AY, Schlaepfer TE, Fisch HU, Self-reported Somatization Symptoms Associated With Risk for Extreme Alcohol Use., Archives of Family Medicine, 7(1), 33-7, Jan-Feb 1998 Abstract
  • Schlaepfer T E, Pearlson G D, Wong D F, Marenco S, Dannals R F, PET study of competition between intravenous cocaine and [11C]raclopride at dopamine receptors in human subjects, American Journal of Psychiatry, 154(9), 1209-13, September 1997 Abstract
  • Greenberg BD, George MS, Martin JD, Benjamin J, Schlaepfer TE, Altemus M, Wassermann EM, Post RM, Murphy DL, Effect of Prefrontal Repetitive Transcranial Magnetic Stimulation In Obsessive-compulsive Disorder: a Preliminary Study., The American Journal of Psychiatry, 154(6), 867-9, Jun 1997 Abstract
  • Pearlson G D, Schlaepfer T E, Sex differences in schizophrenia, Archives of General Psychiatry, 54(2), 189, February 1997 Abstract
  • Schlaepfer TE, Pearlson GD, Neuroimaging in affective disorders-Accomplishments and shortfalls, Child and Adolescent Psychiatric Clinics of North America, 6, 413-430, 1997
  • Tien A Y, Spevack T V, Jones D W, Pearlson G D, Schlaepfer T E, Strauss M E, Computerized Wisconsin Card Sorting Test: comparison with manual administration, Kao-hsiung I Hsueh Ko Hsueh Tsa Chih [kaohsiung Journal of Medical Sciences], 12(8), 479-85, August 1996 Abstract
  • Tien AY, Spevack TV, Jones DW, Pearlson GD, Schlaepfer TE, Strauss ME, Computerized Wisconsin Card Sorting Test: Comparison With Manual Administration., The Kaohsiung Journal of Medical Sciences, 12(8), 479-85, Aug 1996 Abstract
  • Tien AY, Eaton WW, Schlaepfer TE, McGilchrist IK, Menon R, Powers R, Aylward E, Barta P, Strauss ME, Pearlson GD, Exploratory Factor Analysis of MRI Brain Structure Measures In Schizophrenia., Schizophrenia Research, 19(2-3), 93-101, May 1996 Abstract
  • Schlaepfer TE, Strain EC, Bigelow GE, Lancaster E, Preston KL, Pearlson GD, Differential cerebral blood flow effects caused by mu versus kappa opioid agonists, NIDA Res Monogr, 162, 194-194, 1996
  • Schlaepfer T E, Pearlson G D, Pitfalls of SPECT studies of acute ethanol-induced changes in cerebral blood flow, American Journal of Psychiatry, 152(11), 1695-6, November 1995 Abstract
  • Schlaepfer TE, Harris GJ, Tien AY, Peng L, Lee S, Pearlson GD, Structural Differences in the Cerebral Cortex of Healthy Female and Male Subjects: a Magnetic Resonance Imaging Study., Psychiatry Research, 61(3), 129-35, Sep 1995 Abstract
  • Aylward EH, Brettschneider PD, McArthur JC, Harris GJ, Schlaepfer TE, Henderer JD, Barta PE, Tien AY, Pearlson GD, Magnetic Resonance Imaging Measurement of Gray Matter Volume Reductions In HIV Dementia., The American Journal of Psychiatry, 152(7), 987-94, Jul 1995 Abstract
  • Michel K, Frey C, Schlaepfer TE, Valach L, Suicide reporting in the swiss print media: Frequency, form and content of articles, European Journal of Public Health, 5, 199-203, 1995
  • Pearlson GD, Schlaepfer TE, Brain imaging in affective disorders, Psychopharmacology: The Fourth Generation of Progress, 1995
  • Harris GJ, Schlaepfer TE, Peng LW, Lee S, Federman EB, Pearlson GD, Magnetic Resonance Imaging Evaluation of the Effects of Ageing On Grey-white Ratio in the Human Brain., Neuropathology and Applied Neurobiology, 20(3), 290-3, Jun 1994 Abstract
  • Schlaepfer TE, Harris GJ, Tien AY, Peng LW, Lee S, Federman EB, Chase GA, Barta PE, Pearlson GD, Decreased Regional Cortical Gray Matter Volume in Schizophrenia., The American Journal of Psychiatry, 151(6), 842-8, Jun 1994 Abstract
  • Harris GJ, Barta PE, Peng LW, Lee S, Brettschneider PD, Shah A, Henderer JD, Schlaepfer TE, Pearlson GD, MR Volume Segmentation of Gray Matter and White Matter Using Manual Thresholding: Dependence on Image Brightness., Ajnr. American Journal of Neuroradiology, 15(2), 225-30, Feb 1994 Abstract
  • Widler P, Fisch HU, Schlaepfer T, Reichen J, Schoch P, The involvement of benzodiazepine receptor ligands in hepatic encephalopathy, Hepatology, 20, 541-543, 1994
  • Widler P, Fisch HU, Zimmermann A, Schlaepfer TE, Reichen J, Schoch P, Detection of benzodiazepine-like activity in hepatic encephalopathy requires an initial lipophilic extraction procedure, Hepatology, 20, 544-546, 1994
  • Widler P, Fisch HU, Schoch P, Zimmermann A, Schlapfer TE, Reichen J, Increased benzodiazepine-like activity is neither necessary nor sufficient to explain acute hepatic encephalopathy in the thioacetamide-treated rat, Hepatology, 18(6), 1459-64, December 1993 Abstract
  • Schlaepfer TE, Bartsch P, Fisch HU, Paradoxical effects of mild hypoxia and moderate altitude on human visual perception, Clinical Science, 83(5), 633-6, November 1992 Abstract
  • Schlapfer TE, Groner M, Lavoyer E, Fisch HU, Visual Masking: a Reliable Measure for the Assessment of Cognitive Dysfunction in the Elderly?, Journal of Gerontology, 46(4), P157-61, Jul 1991 Abstract
  • Pearlson GD, Kreger L, Rabins PV, Chase GA, Cohen B, Wirth JB, Schlaepfer TB, Tune LE, A chart review study of late-onset and early-onset schizophrenia, American Journal of Psychiatry, 146(12), 1568-74, December 1989 Abstract
  • Schlapfer TE, Fisch HU, [HIV infection of the central nervous system: psychiatric consequences], Schweizerische Medizinische Wochenschrift. Journal Suisse De Medecine, 118(16), 571-6, April 1988 Abstract

Profile Details

Last Verified: 3/4/2009

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