Karen C. Schneider

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Yale University
School of Medicine
Pediatrics
Research Scientist

Mailing Address

3088-B LMP
Yale University School of Medicine
333 Cedar Street
New Haven, Connecticut 06520
United States

Contact Information

Phone: (203) 785-7394
karen.schneider@yale.edu

Qualifications

M.P.H., Yale University, 1978.
B.S., Wagner College, 1961.

Expertise and Research Interests

Intraventricular hemorrhage (IVH), hemorrhage into the germinal matrix tissues of the developing brain, remains a major problem of preterm neonates. My work involves follow-up evaluations of a cohort of infants of 600-1250 grams birth weight who were enrolled between 1989 and 1992 in a prospective, randomized, placebo-controlled multicenter clinical trial to test the hypothesis that low dose indomethacin would lower the incidence and decrease the serverity of IVH. The in-patient phase of the study has been completed and follow-up evaluations are being conducted at 3 sites on the 440 survivors. The follow-up developmental testing has included mental and motor Bayley scoring at 7 and 18 months corrected age, Stanford-Binet testing at 36 months corrected age, WPPSI-R testing at 54 months and 72 months corrected age, WISC-III testing at 96 months corrected age, WISC-III and language processing testing at 12 years chronologic age, and currently WISC-III and other testing at 16 years of age. Demographic and neurologic data are also collected. At 96 months corrected age we conducted fMRI and structural MRI testing of the study children and of 65 control children. In the spring of 2002 we began MRI testing of the 12-year old subjects and a group of matched controls. These tests have been completed and we began MRI testing of 16-year old study subjects and matched controls in August 2005.

Keywords

COS Keywords:

Clinical Trial, Neonatal Disorders, Neurology, Pediatrics.

Additional Terms:

FMRI, Indomethacin, Intraventricular Hemorrhage, Low Birth Weight Infants, MRI, Preterm Neonate.

Languages

(Reading, Writing, Speaking)

French: (Functional, None, Basic)

Publications

  • Ment LR, Peterson BS, Vohr B, Allan W, Schneider KC, Lacadie C, Katz KH, Maller-Kesselman J, Pugh K, Duncan CC, Makuch RW, Constable RT (2006) Cortical recruitment patterns in children born prematurely compared with control subjects during a passive listening functional magnetic resonance imaging task, J Pediatr, 149, 490-8
  • Kesler Shelli R, Vohr Betty, Schneider Karen C, Katz Karol H, Makuch Robert W, Reiss Allan L, Ment Laura R (2006) Increased temporal lobe gyrification in preterm children, Neuropsychologia, 44, 445-453
  • Ment LR, Vohr BR, Makuch RW, Westerveld M, Katz KH, Schneider KC, Duncan CC, Ehrenkranz R, Oh W, Philip AG, Scott DT, Allan WC (Dec 2004) Prevention of intraventricular hemorrhage by indomethacin in male preterm infants., J Pediatr, 145 (6), 832-4 Abstract
  • Kesler SR, Ment LR, Vohr B, Pajot SK, Schneider KC, Katz KH, Ebbitt TB, Duncan CC, Makuch RW, Reiss AL (Nov 2004) Volumetric analysis of regional cerebral development in preterm children., Pediatric Neurology, 31 (5), 318-25 Abstract
  • Reiss AL, Kesler SR, Vohr B, Duncan CC, Katz KH, Scheider KC, Makuch RW, Ment LR, Sex differences in cerebral volumes of 8-year olds born preterm, J Pediatr, 145, 242-249, 2004
  • Vohr BR, Allan WC, Westerveld M, Schneider KC, Katz KH, Makuch RW, Ment LR, School-age outcomes of very low birth weight infants in the indomethacin intraventricular hemorrhage prevention trial, Pediatrics, 111(4 Pt 1), e340-6, April 2003 Abstract
  • Ment LR, Vohr B, Allan W, Katz KH, Schneider KC, Westerveld M, Duncan CC, Makuch RW, Change in cognitive function over time in very low-birth-weight infants, Jama : the Journal of the American Medical Association, 289(6), 705-11, February 2003 Abstract
  • Peterson BS, Vohr B, Kane MJ, Whalen DH, Schneider KC, Katz KH, Zhang H, Duncan CC, Makuch R, Gore JC, Ment LR, A functional magnetic resonance imaging study of language processing and its cognitive correlates in prematurely born children, Pediatrics, 110(6), 1153-62, December 2002 Abstract
  • Anderson AW, Marois R, Colson ER, Peterson BS, Duncan CC, Ehrenkranz RA, Schneider KC, Gore JC, Ment LR, Neonatal auditory activation detected by functional magnetic resonance imaging, Magnetic Resonance Imaging, 19, 1-5, 2001
  • Ment LR, Schneider KC, Ainley MA, Allan WC, Adaptive mechanisms of developing brain, Clinics in Perinatology, 27, 303-323, 2000
  • Ment LR, Vohr B, Allan W, Westerveld M, Sparrow SS, Schneider KC, Katz KH, Duncan CC, Makuch RW, Outcome of children in the indomethacin IVH prevention trial, Pediatrics, 105, 485-491, 2000
  • Peterson BS, Vohr B, Staib LH, Cannistraci CJ, Dolberg A, Schneider KC, Katz KH, Westerveld M, Sparrow S, Anderson AW, Duncan CC, Makuch RW, Gore JC, Ment LR, Regional brain volume abnormalities and long-term cognitive outcome in preterm infants, JAMA, 284, 1939-1947, 2000
  • Ment LR, Vohr B, Allan W, Westerveld M, Katz KH, Schneider KC, Makuch RW, The etiology and outcome of cerebral ventriculomegaly at term in very low birth weight preterm infants, Pediatrics, 104(2 Pt 1), 243-8, August 1999
  • Vohr B, Allan WC, Scott DT, Katz KH, Schneider KC, Makuch RW, Ment LR, Early onset intraventricular hemorrhage in preterm neonates: Incidence of neurodevelopmental handicap, Seminars in Perinatology, 23, 212-217, 1999
  • Ment L R, Vohr B, Oh W, Scott D T, Allan W C, Westerveld M, Duncan C C, Ehrenkranz R A, Katz K H, Schneider K C, Makuch R W, Neurodevelopmental outcome at 36 months' corrected age of preterm infants in the Multicenter Indomethacin Intraventricular Hemorrhage Prevention Trial [see comments], Pediatrics, 98(4 Pt 1), 714-8, October 1996
  • Ment LR, Vohr B, Oh W, Scott DT, Allan WC, Westerveld M, Duncan CC, Ehrenkranz RA, Katz KH, Schneider KC, Makuch RW, Neurodevelopmental outcome at 36 months' corrected age of preterm infants in the Multicenter Indomethacin Intraventricular Hemorrhage Prevention Trial, Pediatrics, 98(4 Pt 1), 714-8, October 1996 Abstract
  • Freeman JL, Fetter RB, Park H, Schneider KC, Lichtenstein JL, Hughes JS, Bauman WA, Duncan CC, Freeman DH Jr, Palmer GR, Diagnosis-related group refinement with diagnosis- and procedure-specific comorbidities and complications, Medical Care, 33(8), 806-27, August 1995 Abstract
  • Ment L R, Oh W, Ehrenkranz R A, Phillip A G, Vohr B, Allan W, Makuch R W, Taylor K J, Schneider K C, Katz K H, et al, Low-dose indomethacin therapy and extension of intraventricular hemorrhage: a multicenter randomized trial, Journal of Pediatrics, 124(6), 951-5, June 1994
  • Ment, L.R., Oh, W., Ehrenkranz, R.A., Philip, A.G.S., Vohr, B., Allan, W., Duncan, C.C., Scott, D.T., Taylor, K.J.W., Katz, K.H., Schneider, K.C., Makuch, R.W., Low dose indomethacin and prevention of intraventricular hemorrhage: A multicenter randomized trial, Pediatrics, 93, 543-550, 1994
  • Ment LR, Oh W, Ehrenkranz RA, Philip AGS, Schneider KC, Katz KH, Taylor KJW, Duncan CC, Makuch RW, Risk period for intraventricular hemorrhage of the preterm neonate is independent of gestational age, Sem Perinatol, 17, 338-341, 1993
  • Ment, L.R. and Schneider, K.C., Intraventricular hemorrage of the preterm infant, Seminars in Neurology, 13, 40-47, 1993
  • Ment, L.R., Oh. W., Philip, A.G.S., Ehrenkranz, R.A., Duncan, C.C., Allan, W., Taylor, K.J.W., Schneider, K., Katz, K.H., Makuch, R.W., Risk factors for early intraventricular hemorrhage in low birth weight infants, Journal of Pediatrics, 121, 776-783, 1992
  • Schneider KC, Lichtenstein JL, Freeman JL, Newbold RC, Fetter RB, Gottlieb L, Leaf PJ, Portlock CS, Ambulatory visit groups: an outpatient classification system, Journal of Ambulatory Care Management, 11(3), 1-12, August 1988 Abstract
  • Dove HG, Schneider KC, Gitelson DA, Identifying patients who need social work services: an interdisciplinary analysis, Social Work, 30(3), 214-8, 1985 Abstract
  • Dove HG, Schneider KC, Wallace JD, Evaluating and predicting outcome of acute cerebral vascular accident, Stroke; a Journal of Cerebral Circulation, 15(5), 858-64, 1984 Abstract
  • Schneider KC, Dove HG, High users of VA emergency room facilities: are outpatients abusing the system or is the system abusing them?, Inquiry : a Journal of Medical Care Organization, Provision and Financing., 20(1), 57-64, Spring 1983 Abstract
  • Dove HG, Schneider KC, Richardson F, Rehabilitation of patients following lower extremity amputation: an analysis of baseline, process and outcome, American Corrective Therapy Journal, 36(4), 94-102, 1982 Abstract
  • Dove HG, Schneider KC, Fries BE, The analysis of clinic no-show rates to establish optimal outpatient scheduling quotas, Journal of Ambulatory Care Management, 5(2), 24-31, May 1982 Abstract
  • Dove HG, Schneider KC, The usefulness of patients' individual characteristics in predicting no-shows in outpatient clinics, Medical Care, 19(7), 734-40, July 1981 Abstract
  • Dove HG, Gifford R, Schneider KC, The trips of slips. Time delays in laboratory and X-ray data for outpatients in a teaching hospital, Jama : the Journal of the American Medical Association, 243(6), 537-9, February 1980 Abstract
  • Dove HG, Schneider KC, The application of prognostic criteria in outpatient quality assessment: Control of hypertension, Journal of Medical Systems, 4(1), 45-58, 1980 Abstract

Profile Details

Last Updated: 6/21/2007

COS Expertise ID #397312
Reference this profile directly: http://myprofile.cos.com/schneidk12