Dr. Robert Allen Scott

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University of Georgia
College of Arts and Sciences
Chemistry
Distinguished Research ProfessorAppointed: 2003
University of Georgia
Institute of Bioinformatics
Associate DirectorAppointed: 2006
Professional Headshot of Robert Allen Scott

Mailing Address

Department of Chemistry
University of Georgia
Athens, Georgia 30602-2556
United States

Contact Information

Phone: (706) 542-2240
Fax: (706) 542-2295
scott@chem.uga.edu
http://www.arches.uga.edu/~rscott

Qualifications

Ph.D., California Institute of Technology, Chemistry, 1980.
B.S., University of Illinois, Chemistry, 1975.

Expertise and Research Interests

Principal research interests involve biochemical studies and biophysical measurements of biologically important systems; specifically, the use of x-ray absorption spectroscopy (XAS) and extended x-ray absorption fine structure (EXAFS) in the elucidation of structural details of metalloprotein active sites; protein determinants of hyperthermostability, redox properties, and metal-binding specificity; archaeal transcription factors and their protein-protein and protein-DNA interactions; application of molecular and structural biology to metallobiomolecules; application of proteomics and genomics to transcriptional regulatory networks in prokaryotes.

Other Expertise

Academic Experience:
- National Science Foundation Predoctoral Fellowship, California Institute of Technology, 1975-1978
- National Institutes of Health Predoctoral Fellowship, California Institute of Technology, 1978-1979
- National Institutes of Health Postdoctoral Fellowship, Stanford University, 1979-1981
- Brookhaven National Laboratory National Synchrotron Light Source X-ray Proposal Study Panel, 1989-1991
- National Science Foundation, Member, Biophysics Advisory Panel, DMB, 1991-1997
- Board of Editors, Journal of Inorganic Biochemistry, 1991-1998; Editor, Journal of Biological Inorganic Chemistry, 1995-present
- Editorial Advisory Board, Biochemistry, 1998-present

Keywords

COS Keywords:

Biophysical Chemistry, Biophysics, High Temperature or Pressure Biology, Molecular Biology, Molecular Recognition, Resonance Spectroscopy, Spectroscopy, Structural Chemistry, Synchrotron Radiation.

Additional Terms:

Archaea, EXAFS, Metalloenzyme, Transcription Factor, Transcriptional Regulation, X-ray Absorption Spectroscopy.

Memberships

American Association for the Advancement of Science
American Chemical Society
American Society for Biochemistry and Molecular Biology
Protein Society
Society of Biological Inorganic Chemistry

Honors and Awards

2006-2008, President, Society of Biological Inorganic Chemistry
2003, Distinguished Research Professor, University of Georgia
1986-1988, Alfred P. Sloan Research Fellowship, Sloan Foundation, University of Illinois at Urbana-Champaign
1985-1990, Presidential Young Investigator Award, National Science Foundation
1985-1986, Beckman Fellow, Center for Advanced Study, University of Illinois at Urbana-Champaign
1981, Beckman Research Award, University of Illinois at Urbana-Champaign

Previous Positions

1996-2003, Head, University of Georgia, College of Arts and Sciences, Chemistry
1991-2003, Professor, University of Georgia, College of Arts and Sciences, Chemistry
1981-1987, Assistant Professor, University of Illinois at Chicago
1979-1981, NIH Postdoctoral Fellow, Stanford University
1978-1991, Associate Professor, University of Georgia

Funding Received

  • National Science Foundation (NSF): Topology of Archaeal Transcription Pre-Initiation Complex, $240,000, Sep 1, 1996 to Aug 31, 2000.
  • National Science Foundation (NSF): The Role of Transition Metals in Biology, $1,478,500, Jul 1, 1995 to Jun 30, 2000.
  • National Institutes of Health (NIH): X-Ray Absorption Spectroscopy of Metalloenzymes, $876,102, Dec 1, 2002 to Nov 30, 2006.
  • National Institutes of Health (NIH): X-Ray Absorption Spectroscopy of Metalloenzymes, $593,027, Dec 1, 1998 to Nov 30, 2002.

Publications

  • Banci, L, Bertini, I, Ciofi-Baffoni, S, Su, XC, Miras, R, Bal, N, Mintz, E, Catty, P, Shokes, JE, Scott, RA (2006) Structural Basis for Metal Binding Specificity: the N-terminal Cadmium Binding Domain of the P1-type ATPase CadA, J. Mol. Biol., 356, 638-650
  • Dong, J, Shokes, JE, Scott, RA, Lynn, DG (2006) Modulating amyloid self-assembly and fibril morphology with Zn(II), J. Am. Chem. Soc., 128, 3540-3542
  • Shokes JE, Duin EC, Bauer C, Jaun B, Hedderich R, Koch J, Scott RA, Direct Interaction of Coenzyme M With the Active-site Fe-S Cluster Of Heterodisulfide Reductase., Febs Letters, 579(7), 1741-4, Mar 2005 Abstract
  • Iwasaki T, Kounosu A, Tao Y, Li Z, Shokes JE, Cosper NJ, Imai T, Urushiyama A, Scott RA, Rational Design of a Mononuclear Metal Site Into the Archaeal Rieske-type Protein Scaffold., The Journal of Biological Chemistry, 280(10), 9129-34, Mar 2005 Abstract
  • Scott RA, Shokes JE, Cosper NJ, Jenney FE, Adams MW, Bottlenecks and Roadblocks in High-throughput XAS for Structural Genomics., Journal of Synchrotron Radiation, 12(Pt 1), 19-22, Jan 2005 Abstract
  • Ghering AB, Shokes JE, Scott RA, Omichinski JG, Godwin HA, Spectroscopic determination of the thermodynamics of cobalt and zinc binding to GATA proteins, Biochemistry, 43(26), 8346-55, Jul 2004 Abstract
  • Benison GC, Di Lello P, Shokes JE, Cosper NJ, Scott RA, Legault P, Omichinski JG, A stable mercury-containing complex of the organomercurial lyase MerB: catalysis, product release, and direct transfer to MerA, Biochemistry, 43(26), 8333-45, Jul 2004 Abstract
  • Song L, Caguiat J, Li Z, Shokes J, Scott RA, Olliff L, Summers AO, Engineered single-chain, antiparallel, coiled coil mimics the MerR metal binding site, Journal of Bacteriology, 186(6), 1861-8, Mar 2004 Abstract
  • Kounosu A, Li Z, Cosper NJ, Shokes JE, Scott RA, Imai T, Urushiyama A, Iwasaki T, Engineering a three-cysteine, one-histidine ligand environment into a new hyperthermophilic archaeal Rieske-type [2Fe-2S] ferredoxin from Sulfolobus solfataricus, Journal of Bioligical Chemistry, 279(13), 12519-28, Mar 2004 Abstract
  • Renfrow MB, Naryshkin N, Lewis LM, Chen HT, Ebright RH, Scott RA, Transcription factor B contacts promoter DNA near the transcription start site of the archaeal transcription initiation complex, Journal of Bioligical Chemistry, 279(4), 2825-31, Jan 2004 Abstract
  • Li Z, Shokes JE, Kounosu A, Imai T, Iwasaki T, Scott RA, X-ray absorption spectroscopic analysis of reductive [2Fe-2S] cluster degradation in hyperthermophilic archaeal succinate:caldariellaquinone oxidoreductase subunits, Biochemistry, 42(50), 15003-8, Dec 2003 Abstract
  • Cosper NJ, Bienvenue DL, Shokes JE, Gilner DM, Tsukamoto T, Scott RA, Holz RC, The dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase from Haemophilus influenzae is a dinuclear metallohydrolase, Journal of the American Chemical Society, 125(48), 14654-5, Dec 2003 Abstract
  • Cosper MM, Cosper NJ, Hong W, Shokes JE, Broderick WE, Broderick JB, Johnson MK, Scott RA, Structural studies of the interaction of S-adenosylmethionine with the [4Fe-4S] clusters in biotin synthase and pyruvate formate-lyase activating enzyme, Protein Science : a Publication of the Protein Society, 12(7), 1573-7, July 2003 Abstract
  • Pennella MA, Shokes JE, Cosper NJ, Scott RA, Giedroc DP, Structural elements of metal selectivity in metal sensor proteins, Proceedings of the National Academy of Sciences (USA), 100(7), 3713-8, April 2003 Abstract
  • Duin EC, Cosper NJ, Mahlert F, Thauer RK, Scott RA, Coordination and geometry of the nickel atom in active methyl-coenzyme M reductase from Methanothermobacter marburgensis as detected by X-ray absorption spectroscopy, Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry., 8(1-2), 141-8, January 2003 Abstract
  • Cosper NJ, Eby DM, Kounosu A, Kurosawa N, Neidle EL, Kurtz DM Jr, Iwasaki T, Scott RA, Redox-dependent structural changes in archaeal and bacterial Rieske-type [2Fe-2S] clusters, Protein Science : a Publication of the Protein Society, 11(12), 2969-73, December 2002 Abstract
  • Iwasaki T, Kounosu A, Aoshima M, Ohmori D, Imai T, Urushiyama A, Cosper NJ, Scott RA, Novel [2Fe-2S]-type redox center C in SdhC of archaeal respiratory complex II from Sulfolobus tokodaii strain 7, Journal of Biological Chemistry, 277(42), 39642-8, October 2002 Abstract
  • D'souza VM, Swierczek SI, Cosper NJ, Meng L, Ruebush S, Copik AJ, Scott RA, Holz RC, Kinetic and structural characterization of manganese(II)-loaded methionyl aminopeptidases, Biochemistry, 41(43), 13096-105, October 2002 Abstract
  • Bonomi F, Burden AE, Eidsness MK, Fessas D, Iametti S, Kurtz DM Jr, Mazzini S, Scott RA, Zeng Q, Thermal stability of the [Fe(SCys)(4)] site in Clostridium pasteurianum rubredoxin: contributions of the local environment and Cys ligand protonation, Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry., 7(4-5), 427-36, April 2002 Abstract
  • Cosper NJ, D'souza VM, Scott RA, Holz RC, Structural evidence that the methionyl aminopeptidase from Escherichia coli is a mononuclear metalloprotease, Biochemistry, 40(44), 13302-9, November 2001 Abstract
  • Cosper NJ, Scott RA, Hori H, Nishino T, Iwasaki T, X-ray absorption spectroscopic analysis of the high-spin ferriheme site in substrate-bound neuronal nitric-oxide synthase, Journal of Biochemistry, 130(2), 191-8, August 2001 Abstract
  • Busenlehner LS, Cosper NJ, Scott RA, Rosen BP, Wong MD, Giedroc DP, Spectroscopic properties of the metalloregulatory Cd(II) and Pb(II) sites of S. aureus pI258 CadC, Biochemistry, 40(14), 4426-36, April 2001 Abstract
  • Cosper NJ, Booker SJ, Ruzicka F, Frey PA, Scott RA, Direct FeS cluster involvement in generation of a radical in lysine 2,3-aminomutase, Biochemistry, 39(51), 15668-73, 2000 Abstract
  • Cosper NJ, Collier LS, Clark TJ, Scott RA, Neidle EL, Mutations in catB, the gene encoding muconate cycloisomerase, activate transcription of the distal ben genes and contribute to a complex regulatory circuit in Acinetobacter sp. strain ADP1, Journal of Bacteriology, 182(24), 7044-52, December 2000 Abstract
  • Smith KS, Cosper NJ, Stalhandske C, Scott RA, Ferry JG, Structural and kinetic characterization of an archaeal beta-class carbonic anhydrase, Journal of Bacteriology, 182(23), 6605-13, December 2000 Abstract
  • VanZile ML, Cosper NJ, Scott RA, Giedroc DP, The zinc metalloregulatory protein Synechococcus PCC7942 SmtB binds a single zinc ion per monomer with high affinity in a tetrahedral coordination geometry, Biochemistry, 39(38), 11818-29, 2000 Abstract
  • Chen HT, Legault P, Glushka J, Omichinski JG, Scott RA, Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription, Protein Science, 9(9), 1743-52, September 2000 Abstract
  • Iwasaki T, Watanabe E, Ohmori D, Imai T, Urushiyama A, Akiyama M, Hayashi-Iwasaki Y, Cosper NJ, Scott RA, Spectroscopic investigation of selective cluster conversion of archaeal zinc-containing ferredoxin from Sulfolobus sp. strain 7, Journal of Biological Chemistry, 275(33), 25391-401, 2000 Abstract
  • Colangelo CM, Lewis LM, Cosper NJ, Scott RA, Structural evidence for a common zinc binding domain in archaeal and eukaryal transcription factor IIB proteins, Journal of Biological Inorganic Chemistry, 5(2), 276-83, April 2000
  • McGuirl, M. A., Bollinger, J. A., Cosper, N. J., Scott, R. A., Dooley, D. M., Expression, Purification and Characterization of NosL, a Novel Cu(I) Protein of the Nitrous Oxide Reductase (nos) Gene Cluster, Journal of Biological Inorganic Chemistry, 6, 189-195, 2000
  • Eidsness MK, Burden AE, Richie KA, Kurtz DM Jr, Scott RA, Smith ET, Ichiye T, Beard B, Min T, Kang C, Modulation of the redox potential of the [Fe(SCys)(4)] site in rubredoxin by the orientation of a peptide dipole, Biochemistry, 38(45), 14803-9, November 1999 Abstract
  • Alber BE, Colangelo CM, Dong J, St alhandske CM, Baird TT, Tu C, Fierke CA, Silverman DN, Scott RA, Ferry JG, Kinetic and spectroscopic characterization of the gamma-carbonic anhydrase from the methanoarchaeon Methanosarcina thermophila, Biochemistry, 38(40), 13119-28, October 1999 Abstract
  • Cosper NJ, St alhandske CM, Iwasaki H, Oshima T, Scott RA, Iwasaki T, Structural conservation of the isolated zinc site in archaeal zinc-containing ferredoxins as revealed by x-ray absorption spectroscopic analysis and its evolutionary implications, Journal of Biological Chemistry, 274(33), 23160-8, August 1999 Abstract
  • Yamaguchi K, Cosper NJ, Stalhandske C, Scott RA, Pearson MA, Karplus PA, Hausinger RP, Characterization of metal-substituted Klebsiella aerogenes urease, Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry, 4(4), 468-77, August 1999 Abstract
  • Osborne JP, Cosper NJ, Stalhandske CM, Scott RA, Alben JO, Gennis RB, Cu XAS shows a change in the ligation of CuB upon reduction of cytochrome bo3 from Escherichia coli, Biochemistry, 38(14), 4526-32, April 1999 Abstract
  • Cosper NJ, St alhandske CM, Saari RE, Hausinger RP, Scott RA, X-ray absorption spectroscopic analysis of Fe(II) and Cu(II) forms of a herbicide-degrading alpha-ketoglutarate dioxygenase, Journal of Biological Inorganic Chemistry, 4(1), 122-9, February 1999 Abstract
  • Stein J, Lewis LN, Gao Y, Scott RA, In Situ Determination of the Active Catalyst in Hydrosilylation Reactions Using Highly Reactive Pt(0) Catalyst Precursors, Journal of the American Chemical Society, 121, 3693-703, 1999
  • Zeng Q, St alhandske C, Anderson MC, Scott RA, Summers AO, The core metal-recognition domain of MerR, Biochemistry, 37(45), 15885-95, November 1998 Abstract
  • Easterling M L, Colangelo C M, Scott R A, Amster I J, Monitoring protein expression in whole bacterial cells with MALDI time-of-flight mass spectrometry., Analytical Chemistry, 70(13), 2704-9, 1 Jul 1998 Abstract
  • Dooley, D. M., Scott, R. A., Knowles, P. F., Colangelo, C. M., McGuirl, M. A., Brown, D. E., Structures of the Cu(I) and Cu(II) Forms of Amine Oxidases from X-ray Absorption Spectroscopy, Journal of the American Chemical Society, 120, 2599-2605, 1998
  • George, G. N., Colangelo, C. M., Dong, J., Scott, R. A., Khangulov, S. V., Gladyshev, V. N., Stadtman, T. C., X-ray Absorption Spectroscopy of the Molybdenum Site of Escherichia coli Formate Dehydrogenase, Journal of the American Chemical Society, 120, 1267-1273, 1998
  • Bertini, I., Kurtz, D. M., Jr., Eidsness, M. K., Liu, G., Luchinat, C., Rosato, A., Scott, R. A., Solution Structure of Reduced Clostridium pasteurianum Rubredoxin, JBIC, 3, 401-410, 1998
  • Colpas GJ, Brayman TG, McCracken J, Pressler MA, Babcock GT, Ming L-J, Colangelo CM, Scott RA, Hausinger RP, Spectroscopic Characterization of Metal Binding by Klebsiella aerogenes UreE Urease Accessory Protein, Journal of Biological Inorganic Chemistry, 34, 1650-60, 1998
  • Russell WK, Stålhandske CMV, Xia J, Scott RA, Lindahl PA, Spectroscopic, Redox, and Structural Characterization of the Ni-Labile and Nonlabile Forms of the Acetyl-CoA Synthase Active Site of Carbon Monoxide Dehydrogenase, Journal of the American Chemical Society, 120, 7502-10, 1998
  • Bau R, Rees DC, Kurtz DM, Scott RA, Huang H, Adams MWW, Eidsness MK, Crystal structure of rubredoxin from Pyrococcus furiosus at 0.95 Å resolution, and the structures of N-terminal methionine and formylmethionine variants of Pf Rd. Contributions of N-terminal interacti, Journal of Biological Inorganic Chemistry, 3, 484-93, 1998
  • Rose K, Shadle SE, Eidsness MK, Kurtz DM, Scott RA, Hedman B, Hodgson KO, Solomon EI, Investigation of Iron-Sulfur Covalency in Rubredoxins and a Model System Using Sulfur K-edge X-ray Absorption Spectroscopy, Journal of the American Chemical Society, 120, 10743-5, 1998
  • Gilles de Pelichy LD, Eidsness MK, Kurtz DM, Scott RA, Smith ET, Pressure-Controlled Voltammetry of a Redox Protein: An Experimental Approach to Probing the Internal Protein Dielectric Constant?, Current Separations, 17, 79-82, 1998
  • Meyer J, Gagnon J, Gaillard J, Lutz M, Achim C, Munck E, Petillot Y, Colangelo C M, Scott R A, Assembly of a [2Fe-2S]2+ cluster in a molecular variant of Clostridium pasteurianum rubredoxin., Biochemistry, 36(43), 13374-80, 28 Oct 1997 Abstract
  • Burdette D S, Secundo F, Phillips R S, Dong J, Scott R A, Zeikus J G, Biophysical and mutagenic analysis of Thermoanaerobacter ethanolicus secondary-alcohol dehydrogenase activity and specificity., Biochemical Journal, 326 ( Pt 3), 717-24, 15 Sep 1997 Abstract
  • Eidsness M K, Richie K A, Burden A E, Kurtz D M Jr, Scott R A, Dissecting contributions to the thermostability of Pyrococcus furiosus rubredoxin: beta-sheet chimeras., Biochemistry, 36(34), 10406-13, 26 Aug 1997 Abstract
  • Telser J, Fann Y-C, Renner MW, Fajer J, Wang S, Zhang H, Scott RA, Hoffman BM, Investigation by EPR and ENDOR Spectroscopy of the Ni(I) Form of Cofactor F430 of Methanobacterium thermoautotrophicum and of Ni(I) Octaethylisobacteriochlorin, Journal of the American Chemical Society, 119, 733-43, 1997
  • Flanagan S, Dong J, Haller K, Wang S, Scheidt WR, Scott RA, Webb TR, Stanbury DM, Wilson LJ, Macrocyclic [CuI/II(bite)]+/2+ (bite = biphenyldiimino dithioether): An Example of Fully-Gated Electron Transfer and its Biological Relevance, Journal of the American Chemical Society, 119, 8857-68, 1997
  • Park I S, Michel L O, Pearson M A, Jabri E, Karplus P A, Wang S, Dong J, Scott R A, Koehler B P, Johnson M K, Hausinger R P, Characterization of the mononickel metallocenter in H134A mutant urease., Journal of Biological Chemistry, 271(31), 18632-7, 2 Aug 1996 Abstract
  • Shi W, Dong J, Scott R A, Ksenzenko M Y, Rosen B P, The role of arsenic-thiol interactions in metalloregulation of the ars operon., Journal of Biological Chemistry, 271(16), 9291-7, 19 Apr 1996 Abstract
  • Zhu W, Zeng Q, Colangelo C M, Lewis M, Summers M F, Scott R A, The N-terminal domain of TFIIB from Pyrococcus furiosus forms a zinc ribbon [letter], Nature Structural Biology, 3(2), 122-4, February 1996 Abstract
  • Zeng Q, Smith ET, Kurtz DM, Scott RA, Protein Determinants of Metal Site Redox Potentials. Site-Directed Mutagenesis Studies of Clostridium pasteurianum Rubredoxin, Inorg. Chim. Acta, 242, 245-51, 1996
  • Zeng Q, Lewis LM, Colangelo CM, Dong J, Scott RA, A Transcription Factor IIB Homolog from the Hyperthermophilic Archaeon Pyrococcus furiosus Binds Zn or Fe in an N-terminal Cys4 Motif, Journal of Biological Inorganic Chemistry, 1, 162-8, 1996
  • Zeng Q, Kurtz DM, Scott RA, Popovich LL, Smith ET, Probing Protein Electrostatic Interactions by Direct Electrochemistry, Current Separations, 14, 90-2, 1996
  • Gu Z, Dong J, Allan CB, Choudhury SB, Franco R, Moura JJG, Moura I, LeGall J, Przybyla AE, Roseboom WR, Albracht SPJ, Axley MJ, Scott RA, Maroney MJ, Structure of the Ni Sites in Hydrogenases by X-ray Absorption Spectroscopy. Species Variation and the Effects of Redox Poise, Journal of the American Chemical Society, 118, 11155-65, 1996
  • Scott R A, Functional significance of cytochrome c oxidase structure., Structure, 3(10), 981-6, 15 Oct 1995 Abstract
  • Wang Y, Zhang H, Scott R A, A new computational model for protein folding based on atomic solvation., Protein Science, 4(7), 1402-11, July 1995 Abstract
  • Wang S, Scott R A, Lebioda L, Zhou Z H, Brewer J M, An X-ray absorption spectroscopy study of the interactions of Ni2+ with yeast enolase., Journal of Inorganic Biochemistry, 58(3), 209-21, 15 May 1995 Abstract
  • Wang Y, Zhang H, Li W, Scott R A, Discriminating compact nonnative structures from the native structure of globular proteins., Proceedings of the National Academy of Sciences (USA), 92(3), 709-13, 31 Jan 1995 Abstract
  • Knowles PF, Brown RD, Koenig SH, Wang S, Scott RA, McGuirl MA, Brown DE, Dooley DM, Spectroscopic Studies of the Active Site of Galactose Oxidase, Inorg. Chem., 34, 3895-902, 1995
  • Qiu H, Wang S, Guo J, Scott RA, Giedroc DP, X-ray and Visible Absorption Spectroscopy of Wild-type and Mutant T4 Gene 32 Proteins: His64, not His81, is the Non-thiolate Zinc Ligand, Journal of the American Chemical Society, 117, 9437-40, 1995
  • Scott RA, Biological Applications of Synchrotron Radiation, SLAC Beam Line, 24, 19-28, 1995
  • Lewis LN, Colborn RE, Grade H, Bryant GL, Sumpter CA, Scott RA, Mechanism of Formation of Platinum(0) Complexes Containing Silicon-Vinyl Ligands, Organometallics, 14, 2202-13, 1995
  • Xia J, Dong J, Wang S, Scott RA, Lindahl PA, EXAFS, EPR, and Electronic Absorption Spectroscopic Study of the ? Metallosubunit of CO Dehydrogenase from Clostridium thermoaceticum, Journal of the American Chemical Society, 117, 7065-70, 1995
  • Wang S, Lee MH, Hausinger RP, Clark PA, Wilcox DE, Scott RA, Structure of the Dinuclear Active Site of Urease. X-Ray Absorption Spectroscopic Study of Native and 2-Mercaptoethanol-Inhibited Bacterial and Plant Enzymes, Inorg. Chem., 33, 1589-93, 1994
  • Lynch WE, Kurtz DM, Wang S, Scott RA, Structural and Functional Models for the Dicopper Site in Hemocyanin. Dioxygen Binding by Copper Complexes of Tris(1-R-4-R'-Imidazolyl-?N)Phosphines, Journal of the American Chemical Society, 116, 11030-8, 1994
  • O'Dell SE, Kurtz DM, Scott RA, Smith ET, Mutations of Cysteine Ligands in Rubredoxin. Altered Properties of the Iron Site, J. Inorg. Biochem., 56, 18, 1994
  • Brenner M C, Zhang H, Scott R A, Nature of the low activity of S-methyl-coenzyme M reductase as determined by active site titrations., Journal of Biological Chemistry, 268(25), 18491-5, 5 Sep 1993 Abstract
  • Lee M H, Pankratz H S, Wang S, Scott R A, Finnegan M G, Johnson M K, Ippolito J A, Christianson D W, Hausinger R P, Purification and characterization of Klebsiella aerogenes UreE protein: a nickel-binding protein that functions in urease metallocenter assembly., Protein Science, 2(6), 1042-52, June 1993 Abstract
  • Frauenhoff M M, Scott R A, The role of tyrosine 67 in the cytochrome c heme crevice structure studied by semisynthesis., Proteins, 14(2), 202-12, October 1992 Abstract
  • Gorren A C, Chan M L, Crouse B R, Scott R A, Synthesis and characterization of singly modified (carboxyferrocenyl)cytochrome c derivatives., Bioconjugate Chemistry, 3(4), 291-4, July 1992 Abstract
  • Eidsness M K, O'Dell S E, Kurtz D M Jr, Robson R L, Scott R A, Expression of a synthetic gene coding for the amino acid sequence of Clostridium pasteurianum rubredoxin., Protein Engineering, 5(4), 367-71, June 1992 Abstract
  • Scott R A, Wang S, Eidsness M K, Kriauciunas A, Frolik C A, Chen V J, X-ray absorption spectroscopic studies of the high-spin iron(II) active site of isopenicillin N synthase: evidence for Fe-S interaction in the enzyme-substrate complex., Biochemistry, 31(19), 4596-601, 19 May 1992 Abstract
  • Brenner M C, Ma L, Johnson M K, Scott R A, Spectroscopic characterization of the alternate form of S-methylcoenzyme M reductase from Methanobacterium thermoautotrophicum (strain delta H)., Biochimica Et Biophysica Acta, 1120(2), 160-6, 8 Apr 1992 Abstract
  • Conrad DW, Zhang H, Stewart DE, Scott RA, Distance Dependence of Long-Range Electron Transfer in Cytochrome c Derivatives Containing Covalently Attached Cobalt Cage Complexes, Journal of the American Chemical Society, 114, 9909-15, 1992
  • Hamilton C L, Ma L, Renner M W, Scott R A, Ni(II) and Ni(I) forms of pentaalkylamide derivatives of cofactor F430 of Methanobacterium thermoautotrophicum., Biochimica Et Biophysica Acta, 1074(2), 312-9, 8 Jul 1991 Abstract
  • Dooley DM, McGuirl MA, Rosenzweig AC, Landin JA, Scott RA, Zumft WG, Devlin F, Stephens PJ, Spectroscopic Studies of the Copper Sites in Wild-Type Pseudomonas stutzeri N2O Reductase and in an Inactive Protein Isolated from a Mutant Deficient in Copper-Site Biosynthesis, Inorg. Chem., 30, 3006-11, 1991
  • Kaplan WA, Suslick KS, Scott RA, Core Size and Flexibility of Metallohydroporphyrin Macrocycles. Implications for F430 Coordination Chemistry, Journal of the American Chemical Society, 113, 9824-7, 1991
  • Clark PA, Wilcox DE, Scott RA, X-ray Absorption Spectroscopic Evidence for Binding of the Competitive Inhibitor 2-Mercaptoethanol to the Nickel Sites of Jackbean Urease. A New Ni-Ni Interaction in the Inhibited Enzyme, Inorg. Chem., 29, 579-81, 1990
  • Shapley JR, Uchiyama WS, Scott RA, Bimetallic Catalysts from Alumina-Supported Molybdenum-Iridium Clusters, J. Phys. Chem., 94, 1190-6, 1990
  • Kaplan WA, Scott RA, Suslick KS, Probing Macrocycle Flexibility: Ligand Binding to Zinc and Nickel Tetraphenylhydroporphyrins, Journal of the American Chemical Society, 112, 1283-5, 1990
  • Shiemke AK, Shelnutt JA, Scott RA, Coordination chemistry of F430. Axial ligation equilibrium between square-planar and bis-aquo species in aqueous solution, Journal of Bioligical Chemistry, 264(19), 11236-45, Jul 1989 Abstract
  • Hamilton CL, Scott RA, Johnson MK, The magnetic and electronic properties of Methanobacterium thermoautotrophicum (strain delta H) methyl coenzyme M reductase and its nickel tetrapyrrole cofactor F430. A low temperature mag, Journal of Bioligical Chemistry, 264(20), 11605-13, Jul 1989 Abstract
  • Scott R A, Zumft W G, Coyle C L, Dooley D M, Pseudomonas stutzeri N2O reductase contains CuA-type sites [published erratum appears in Proc Natl Acad Sci U S A 1989 Dec;86(23):9278], Proceedings of the National Academy of Sciences (USA), 86(11), 4082-6, June 1989 Abstract
  • Shiemke AK, Kaplan WA, Hamilton CL, Shelnutt JA, Scott RA, Structural and spectroscopic characterization of exogenous ligand binding to isolated factor F430 and its configurational isomers, Journal of Bioligical Chemistry, 264(13), 7276-84, May 1989 Abstract
  • Scott R A, X-ray absorption spectroscopic investigations of cytochrome c oxidase structure and function., Annual Review of Biophysics and Biophysical Chemistry, 18, 137-58, 1989 Abstract
  • Eidsness M K, Scott R A, Prickril B C, DerVartanian D V, Legall J, Moura I, Moura J J, Peck H D Jr, Evidence for selenocysteine coordination to the active site nickel in the [NiFeSe]hydrogenases from Desulfovibrio baculatus., Proceedings of the National Academy of Sciences (USA), 86(1), 147-51, January 1989 Abstract
  • Goodwin JA, Wilson LJ, Stanbury DM, Scott RA, Ligand-Substitution and Electron-Transfer Reactions of Pentacoordinate Copper(I) Complexes, Inorg. Chem., 28, 42-50, 1989
  • Conrad DW, Scott RA, Long-Range Electron Transfer in a Cytochrome c Derivative Containing a Covalently Attached Cobalt-Cage Complex, Journal of the American Chemical Society, 111, 3461-3, 1989
  • Scott RA, Comparative X-ray Absorption Spectroscopic Structural Characterization of Nickel Metalloenzyme Active Sites, Physica B, 158, 84-6, 1989
  • Hartzell CR, Beinert H, Babcock GT, Chan SI, Palmer G, Scott RA, Heterogeneity in an isolated membrane protein. Has the 'authentic cytochrome oxidase' been identified?, Febs Letters, 236(1), 1-4, Aug 1988 Abstract
  • Scott RA, Sullivan RJ, DeWolf WE Jr, Dolle RE, Kruse LI, The copper sites of dopamine beta-hydroxylase: an X-ray absorption spectroscopic study, Biochemistry, 27(15), 5411-7, 1988 Abstract
  • Shiemke AK, Hamilton CL, Scott RA, Structural heterogeneity and purification of protein-free F430 from the cytoplasm of Methanobacterium thermoautotrophicum, Journal of Bioligical Chemistry, 263(12), 5611-6, Apr 1988 Abstract
  • Scott RA, Li PM, Chan SI, The binuclear site of cytochrome c oxidase. Structural evidence from iron X-ray absorption spectroscopy, Annals of the New York Academy of Sciences, 550, 53-8, 1988 Abstract
  • Shiemke AK, Scott RA, Shelnutt JA, Resonance Raman Spectroscopic Investigation of Axial Coordination in M. thermoautotrophicum Methyl Reductase and its Nickel Tetrapyrrole Cofactor F430, Journal of the American Chemical Society, 110, 1645-6, 1988
  • Scott RA, Eidsness MK, The Use of X-Ray Absorption Spectroscopy for Detection of Metal-Metal Interactions. Application to Copper-Containing Enzymes, Comments Inorg. Chem., 7, 235-67, 1988
  • Scott RA, Cote CE, Dooley DM, Copper X-ray Absorption Spectroscopic Studies of the Bovine Plasma Amine Oxidase-Sulfide Complex, Inorg. Chem., 27, 3859-61, 1988
  • Li PM, Gelles J, Chan SI, Sullivan RJ, Scott RA, Extended X-ray absorption fine structure of copper in CuA-depleted, p-(hydroxymercuri)benzoate-modified, and native cytochrome c oxidase, Biochemistry, 26(8), 2091-5, Apr 1987 Abstract
  • Cramer SP, Eidsness MK, Pan W-H, Morton TA, Ragsdale SW, DerVartanian DV, Ljungdahl LG, Scott RA, X-ray Absorption Spectroscopic Evidence for a Unique Nickel Site in Clostridium thermoaceticum Carbon Monoxide Dehydrogenase, Inorg. Chem., 26, 2477-9, 1987
  • Scott RA, Schwartz JR, Cramer SP, Structural aspects of the copper sites in cytochrome c oxidase. An X-ray absorption spectroscopic investigation of the resting-state enzyme, Biochemistry, 25(19), 5546-55, Sep 1986 Abstract
  • Scott RA, Jacobson AJ, Chianelli RR, Pan W-H, Stiefel EI, Hodgson KO, Cramer SP, Reactions of MoS3, WS3, WSe3, and NbSe3 with Lithium. Metal Cluster Rearrangement Revealed by EXAFS, Inorg. Chem., 25, 1461-6, 1986
  • Weatherill TD, Rauchfuss TB, Scott RA, Structural Evidence Concerning the Frontier Orbitals in [Fe2(E2)(CO)6]2- (E=S, Se): Redox Active Dichalcogen Ligands, Inorg. Chem., 25, 1466-72, 1986
  • Eidsness MK, Sullivan RJ, Schwartz JR, Hartzell PL, Wolfe RS, Flank A-M, Cramer SP, Scott RA, Structural Diversity of F430 from Methanobacterium thermoautotrophicum. A Nickel X-ray Absorption Spectroscopic Study, Journal of the American Chemical Society, 108, 3120-1, 1986
  • Stephens PJ, Morgan TV, Devlin F, Penner-Hahn JE, Hodgson KO, Scott RA, Stout CD, Burgess BK, [4Fe-4S]-cluster-depleted Azotobacter vinelandii ferredoxin I: a new 3Fe iron-sulfur protein, Proceedings of the National Academy of Sciences of the United States of America., 82(17), 5661-5, Sep 1985 Abstract
  • Arif Kazmi S, Mills MA, Pitluk ZW, Scott RA, Kinetics of dithionite reduction of the heme nonapeptide of cytochrome c, Journal of Inorganic Biochemistry, 24(1), 9-12, May 1985 Abstract
  • Scott RA, Schwartz JR, Cramer SP, Effect of cyanide binding on the copper sites of cytochrome c oxidase: an X-ray absorption spectroscopic study, Journal of Inorganic Biochemistry, 23(3-4), 199-205, Mar-A 1985 Abstract
  • Scott RA, Measurement of Metal-Ligand Distances by EXAFS, Methods in Enzymology, 117, 414-59, 1985
  • Scott RA, Dooley DM, X-ray Absorption Spectroscopic Studies of the Cu(II) Sites in Bovine Plasma Amine Oxidase, Journal of the American Chemical Society, 107, 4348-50, 1985
  • Scott RA, Czechowski M, DerVartanian DV, LeGall J, Peck HD, Moura I, Nickel X-ray Absorption Spectroscopy of Desulfovibrio gigas Hydrogenase, Rev. Portug. Chim., 27, 67-70, 1985
  • Scott RA, Mauk AG, Gray HB, Experimental Approaches to Studying Biological Electron Transfer, Journal of Chemical Education, 62, 932-8, 1985
  • Scott RA, Wallin SA, Czechowski M, DerVartanian DV, LeGall J, Peck HD, Moura I, X-ray Absorption Spectroscopy of Nickel in the Hydrogenase from Desulfovibrio gigas, Journal of the American Chemical Society, 106, 6864-5, 1984
  • Beinert H, Emptage MH, Dreyer JL, Scott RA, Hahn JE, Hodgson KO, Thomson AJ, Iron-sulfur stoichiometry and structure of iron-sulfur clusters in three-iron proteins: evidence for [3Fe-4S] clusters, Proceedings of the National Academy of Sciences of the United States of America., 80(2), 393-6, Jan 1983 Abstract
  • Hahn JE, Scott RA, Hodgson KO, Doniach S, Desjardins SR, Solomon EI, Observation of an Electric Quadrupole Transition in the X-ray Absorption Spectrum of a Cu(II) Complex, Chem. Phys. Lett., 88, 595-8, 1982
  • Mauk AG, Scott RA, Gray HB, A Calculator Program for Determination of Phosphate Buffer Composition, Computers and Chemistry, 5, 67-9, 1981
  • Scott RA, Cramer SP, Gray HB, Shaw RW, Beinert H, Extended X-ray Absorption Fine Structure of Copper in Cytochrome c Oxidase. Direct Evidence for Copper-Sulfur Ligation, Proc. Natl. Acad. Sci. USA, 78, 664-7, 1981
  • Cramer SP, Scott RA, New Fluorescence Detection System for X-ray Absorption Spectroscopy, Rev. Sci. Inst., 52, 395-9, 1981
  • Co MS, Scott RA, Hodgson KO, Metalloprotein EXAFS. A Group Fitting Procedure for Imidazole Ligands, Journal of the American Chemical Society, 103, 986-8, 1981
  • Kutzler FW, Scott RA, Berg JM, Hodgson KO, Doniach S, Cramer SP, Chang CH, Single-Crystal Polarized X-ray Absorption Spectroscopy. Observation and Theory for (MoO2S2)2-, Journal of the American Chemical Society, 103, 6083-8, 1981
  • LuBien CD, Winkler ME, Thamann TJ, Scott RA, Co MS, Hodgson KO, Solomon EI, Chemical and Spectroscopic Properties of the Binuclear Copper Active Site in Rhus Laccase: Direct Confirmation of a Reduced Binuclear Type 3 Copper Site in Type 2 Depleted Laccase and Intramolecular C, Journal of the American Chemical Society, 103, 7014-6, 1981
  • Scott RA, Gray HB, Cytochrome aa3 Electron-Transfer Reactions. Kinetics of Hexaammineruthenium(II) Reduction of the Beef Heart Enzyme, Journal of the American Chemical Society, 102, 3219-24, 1980
  • Mauk AG, Scott RA, Gray HB, Distances of Electron Transfer to and from Metalloprotein Redox Sites in Reactions with Inorganic Complexes, Journal of the American Chemical Society, 102, 4360-63, 1980
  • Dooley DM, Scott RA, Ellinghaus J, Solomon EI, Gray HB, Magnetic susceptibility studies of laccase and oxyhemocyanin, Proceedings of the National Academy of Sciences of the United States of America., 75(7), 3019-22, Jul 1978 Abstract
  • Holwerda RA, Read RA, Scott RA, Wherland S, Gray HB, Millett F, Electron Transfer Reactions of Trifluoroacetylated Horse Heart Cytochrome c, Journal of the American Chemical Society, 100, 5028-33, 1978
  • Scott RA, Haight GP, Separation and Detection of Ortho-, Pyro-, and Tripolyphosphate by Anion Exchange Thin Layer Chromatography, Anal. Chem., 47, 2439-41, 1975
  • Woltermann GM, Scott RA, Haight GP Jr, Letter: On the coupling of adenosine triphosphate hydrolysis to a simple inorganic redox system: VO2+ plus H2O2, Journal of the American Chemical Society, 96(24), 7569-70, Nov 1974 Abstract
  • Haight GP, Scott RA, Woltermann GM, Mechanisms for electron transfer assisted phosphorylation, and ATP hydrolysis, Physiological Chemistry and Physics, 6(4), 375-8, 1974 Abstract
  • Scott RA, Haight GP, Cooper JN, Proton Assisted Two-Electron Transfer from Hydroxylammonium Ion to Chromium(VI) through Oxygen Bridges, Journal of the American Chemical Society, 96, 4136-42, 1974

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