Steven G. Self

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Fred Hutchinson Cancer Research Center
Vaccine and Infectious Disease Institute (VIDI)
Co-DirectorAppointed: 2007
Fred Hutchinson Cancer Research Center
Statistical Center for HIV/AIDS Research and Prevention (SCHARP)
Executive DirectorAppointed: 2004
HIV Vaccine Trials Network
Statistical and Data Management Center
DirectorAppointed: 2000
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Biostatistics and Biomathematics
Program Head and MemberAppointed: 1994
University of Washington
School of Public Health and Community Medicine
Biostatistics
ProfessorAppointed: 1991

Mailing Address

1100 Fairview Ave. N, LE-400
Fred Hutchinson Cancer Research Center
PO Box 19024
Seattle, Washington 98109-1024
United States

Contact Information

sself@fhcrc.org

Qualifications

Ph.D., University of Washington, Biostatistics, 1981.
M.S., California State University, Biology, 1977.

Expertise and Research Interests

The HIV epidemic continues to grow worldwide despite major advances in understanding the pathogenesis of HIV infection and in our ability to treat the disease. Control of the epidemic requires improved methods and strategies for preventing HIV infection. An HIV vaccine that is simple to administer, inexpensive and that induces long-lasting immunity to all known HIV strains would be the optimal preventive measure. The thorough and efficient clinical evaluation of HIV vaccine candidates presents many scientific and operational challenges. There are multiple mechanisms through which an HIV vaccine might be effective and clinical trials must be designed to assess each potential mechanism; there are significant global heterogeneities in human and viral populations for which an HIV vaccine is needed and a program of clinical trials must be designed to assess the impact of these heterogeneities on vaccine effectiveness; the most appropriate settings for clinical evaluation of HIV vaccines are ones which typically lack existing infrastructure to support rigorous clinical research so that such infrastructure must be developed as part of the clinical evaluation program.

The focus of my research is: 1) the design, coordination and analysis of a clinical trials program to evaluate promising candidate HIV vaccines and 2) the development of new statistical study designs and analytic techniques that will increase the efficiency of those evaluations. The coordination of field trials is performed largely throughactivities of the Statistical Center for HIV/AIDS Research and Prevention (SCHARP). SCHARP is composed of statistical coordinating centers for international NIH-funded clinical research networks including the HIV Vaccine Trials Network (HVTN) and the HIVPrevention Trials Network (HPTN. I serve as Co-Director of SCHARP. There are also methodological research groups working on biomathematical modeling of HIV infection dynamics and development of new statistical methods within SCHARP. Topics of current methodologic research include the use of interacting branching processes to model the early events of HIV infection and the potential for vaccines to impact the course of infection by changes in the dynamics of these processes, the development of efficient designs of Phase I/II vaccine trials for optimization of vaccination regimens over dose, schedule and route of administration, the development of statistical methods for the analysis and interpretation of new assays for cellular immune response, the development of new statistical methods for the analysis of effects of human and viral heterogeneity on vaccine efficacy and the use of post-infection biomarker data to assess potential vaccine effects on disease progression and secondary transmission.

Keywords

COS Keywords:

Biostatistics, Cancer Prevention, Data Analysis, HIV.

Additional Terms:

HIV Prevention Trials, HIV Vaccine Evaluation, Longitudinal Data Analysis, Survival Time Models.

Memberships

American Statistical Association Society for Clinical Trials
NCI Board of Scientific Counselors

Previous Positions

1986-1991, Associate Professor, University of Washington, Department of Biostatistics
1986-1989, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division
1984-1986, Assistant Professor, University of Washington, Department of Biostatistics
1984-1986, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division
1983, Visiting Scientist, Rothamsted Experimental Station, UK, Department of Statistics
1982, Assistant Professor of Oncology, Johns Hopkins University, School of Medicine, Oncology Center
1981-1984, Assistant Professor, Johns Hopkins University, Bloomberg School of Public Health, Department of Biostatistics
1980-1981, Statistical Research Associate, Fred Hutchinson Cancer Research Center
1979, Teaching Assistant, University of Washington
1977-1978, Research Assistant, Seattle Heart Watch
1975-1977, Teaching Assistant, California State University, Long Beach
1984-present, Adjunct Professor, Johns Hopkins University, Bloomberg School of Public Health, Department of Biostatistics

Publications

  • Brander C, Self SG, Korber B (2007) Capturing viral diversity for in-vitro test reagents and HIV vaccine immunogen design, Current Opinion in HIV and AIDS, 2 (3), 5
  • Russell ND, Graham BS, Keefer MC, McElrath MJ, Self SG, Weinhold KJ, Montefiori DC, Ferrari G, Horton H, Tomaras GD, Gurunathan S, Baglyos L, Frey SE, Mulligan MJ, Harro CD, Buchbinder SP, Baden LR, Blattner WA, Koblin BA, Corey L (Feb 2007) Phase 2 study of an HIV-1 canarypox vaccine (vCP1452) alone and in combination with rgp120: negative results fail to trigger a phase 3 correlates trial., Journal of acquired immune deficiency syndromes (1999), 44 (2), 203-12 Abstract
  • Li F, Horton H, Gilbert PB, McElrath JM, Corey L, Self SG (Jan 2007) HIV-1 CTL-based vaccine immunogen selection: antigen diversity and cellular response features., Current HIV research, 5 (1), 97-107 Abstract
  • Li F, Gilbert PB, Self SG (Jan 2007) Identification of cross-neutralization determinants by GAP analysis: a mutational behavior approach., Current HIV research, 5 (1), 87-96 Abstract
  • Li F, Malhotra U, Gilbert PB, Hawkins NR, Duerr AC, McElrath JM, Corey L, Self SG (Nov 2006) Peptide selection for human immunodeficiency virus type 1 CTL-based vaccine evaluation., Vaccine, 24 (47-48), 6893-904 Abstract
  • Finley JC, Reid BJ, Odze RD, Sanchez CA, Galipeau P, Li X, Self SG, Gollahon KA, Blount PL, Rabinovitch PS (Aug 2006) Chromosomal instability in Barrett's esophagus is related to telomere shortening., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 15 (8), 1451-7 Abstract
  • Moodie Z, Huang Y, Gu L, Hural J, Self SG (Aug 2006) Statistical positivity criteria for the analysis of ELISpot assay data in HIV-1 vaccine trials., Journal of immunological methods, 315 (1-2), 121-32 Abstract
  • Wick WD, Gilbert PB, Self SG, On Modeling HIV and T Cells in Vivo: Assessing Causal Estimators in Vaccine Trials, PLoS Computational Biology, 2(6):e64, 16 Jun 2006
  • Wick WD, Gilbert PB, Self SG (Jun 2006) On modeling HIV and T cells in vivo: assessing causal estimators in vaccine trials., PLoS computational biology, 2 (6), e64 Abstract
  • Qin LX, Self SG (Jun 2006) The clustering of regression models method with applications in gene expression data., Biometrics, 62 (2), 526-33 Abstract
  • Moodie Z, Rossini AJ, Hudgens MG, Gilbert PB, Self SG, Russell ND, Statistical evaluation of HIV vaccines in early clinical trials, Contemporary Clinical Trials, 27(2):147-60, Apr 2006
  • Cai T, Gilbert PB, Self SG (2006) Joint inferences on vaccine efficacy against infection and disease with application to the first HIV vaccine efficacy trial., Journal of biopharmaceutical statistics, 16 (4), 517-38 Abstract
  • Wick WD, Yang OO, Corey L, Self SG (Nov 2005) How many human immunodeficiency virus type 1-infected target cells can a cytotoxic T-lymphocyte kill?, Journal of Virology, 79 (21), 13579-86 Abstract
  • Gao DL, Thomas DB, Ray RM, Wang WW, Allison CJ, Chen FL, Porter P, Hu YW, Zhao GL, Pan LD, Li WJ, Wu CY, Coriaty Z, Evans I, Lin MG, Stalsberg H, Self SG (Jun 2005) [Randomized trial of breast self-examination in 266,064 women in Shanghai], Zhonghua zhong liu za zhi [Chinese journal of oncology], 27 (6), 350-4 Abstract
  • Hsu L, Self SG, Grove D, Randolph T, Wang K, Delrow JJ, Loo L, Porter P (Apr 2005) Denoising array-based comparative genomic hybridization data using wavelets., Biostatistics (oxford, England), 6 (2), 211-26 Abstract
  • Gilbert PB, Peterson ML, Follmann D, Hudgens MG, Francis DP, Gurwith M, Heyward WL, Jobes DV, Popovic V, Self SG, Sinangil F, Burke D, Berman PW (Mar 2005) Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial., The Journal of Infectious Diseases, 191 (5), 666-77 Abstract
  • Moodie Z, Rossini AJ, Hudgens MG, Gilbert PB, Russell ND, Self SG, Statistical evaluation of HIV vaccines in early clinical trials, Controlled Clinical Trials, In Press, 2005
  • The rgp120 HIV Vaccine Study Group, Placebo-controlled trial of a recombinant glycoprotein 120 vaccine to prevent HIV infection, Journal of Infectious Diseases, 191: 654-665, 2005
  • Montefiori DC, Metch B, McElrath MJ, Self S, Weinhold KJ, Corey L, HIV Vaccine Trials Network (Dec 2004) Demographic factors that influence the neutralizing antibody response in recipients of recombinant HIV-1 gp120 vaccines., The Journal of Infectious Diseases, 190 (11), 1962-9 Abstract
  • Sacks SL, Griffiths PD, Corey L, Cohen C, Cunningham A, Dusheiko GM, Self S, Spruance S, Stanberry LR, Wald A, Whitley RJ (Aug 2004) HSV-2 transmission., Antiviral Research, 63 Suppl 1, S27-35 Abstract
  • Wick D, Self SG (Aug 2004) On simulating strongly interacting, stochastic population models. II. Multiple compartments., Mathematical Biosciences, 190 (2), 127-43 Abstract
  • Hsieh CS, Liang Y, Tyznik AJ, Self SG, Liggitt D, Rudensky AY (Aug 2004) Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors., Immunity, 21 (2), 267-77 Abstract
  • Hudgens MG, Self SG, Chiu YL, Russell ND, Horton H, McElrath MJ (May 2004) Statistical considerations for the design and analysis of the ELISpot assay in HIV-1 vaccine trials., Journal of Immunological Methods, 288 (1-2), 19-34 Abstract
  • Hudgens MG, Gilbert PB, Self SG (Apr 2004) Endpoints in vaccine trials., Statistical Methods in Medical Research, 13 (2), 89-114 Abstract
  • John R, Arango-Jaramillo S, Self S, Schwartz DH (Feb 2004) Modeling partially effective HIV vaccines in vitro., The Journal of Infectious Diseases, 189 (4), 616-23 Abstract
  • Wick D, Self SG (Jan 2004) On simulating strongly-interacting, stochastic population models., Mathematical Biosciences, 187 (1), 1-20 Abstract
  • Hudgens MG, Hoering A, Self SG (Jul 2003) On the analysis of viral load endpoints in HIV vaccine trials., Statistics in Medicine, 22 (14), 2281-98 Abstract
  • Gilbert PB, DeGruttola VG, Hudgens MG, Self SG, Hammer SM, Corey L (Jul 2003) What constitutes efficacy for a human immunodeficiency virus vaccine that ameliorates viremia: issues involving surrogate end points in phase 3 trials., The Journal of Infectious Diseases, 188 (2), 179-93 Abstract
  • Gilbert PG, DeGruttola V, Hudgens MG, Self SG, Hammer SM, Corey L, Viral load-based primary endpoints in HIV vaccine efficacy trials: Effect of treatment of seroconverters, Journal of Infectious Diseases, 188:179-183, 2003
  • Finley JC, Reid BJ, Blount PL, Odze RD, Sanchez CA, Galipeau P, Paulson T, Gollahon KA, Self SG, Vaughan T, Rabinovitch PS, Telomeres shorten early in Barrett's esophagus neoplastic progression, Gastroenterology, In Press, 2003
  • Wakefield J, Zhou C, Self SG, Modelling gene expression data over time: curve clustering with informative prior distributions, Bayesian Statistics 7, Proceedings of the Seventh Valencia International Meeting, p. 721-732, Oxford University Press, 2003
  • Wick D, Self SG (Nov 2002) What's the matter with HIV-directed killer T cells?, Journal of Theoretical Biology, 219 (1), 19-31 Abstract
  • Thomas DB, Gao DL, Ray RM, Wang WW, Allison CJ, Chen FL, Porter P, Hu YW, Zhao GL, Pan LD, Li W, Wu C, Coriaty Z, Evans I, Lin MG, Stalsberg H, Self SG (Oct 2002) Randomized trial of breast self-examination in Shanghai: final results., Journal of the National Cancer Institute, 94 (19), 1445-57 Abstract
  • Wakefield J, Zhou C, Self SG, Modelling gene expression data over time: Curve clustering with informative prior distributions, Bayesian Statistics, In Press, 2002
  • Schubert EL, Hsu L, Cousens LA, Glogovac J, Self S, Reid BJ, Rabinovitch PS, Porter PL (Jan 2002) Single nucleotide polymorphism array analysis of flow-sorted epithelial cells from frozen versus fixed tissues for whole genome analysis of allelic loss in breast cancer., The American Journal of Pathology, 160 (1), 73-9 Abstract
  • Wick D, Self SG, Corey L (Jan 2002) Do scarce targets or T killers control primary HIV infection?, Journal of Theoretical Biology, 214 (2), 209-14 Abstract
  • Mayer-Hamblett N, Self S (Jun 2001) A regression modeling approach for describing patterns of HIV genetic variation., Biometrics, 57 (2), 449-60 Abstract
  • Belshe RB, Stevens C, Gorse GJ, Buchbinder S, Weinhold K, Sheppard H, Stablein D, Self S, McNamara J, Frey S, Flores J, Excler JL, Klein M, Habib RE, Duliege AM, Harro C, Corey L, Keefer M, Mulligan M, Wright P, Celum C, Judson F, Mayer K, McKirnan D, Marmor M, Woody G, National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group and HIV Network for Prevention Trials (HIVNET) (May 2001) Safety and immunogenicity of a canarypox-vectored human immunodeficiency virus Type 1 vaccine with or without gp120: a phase 2 study in higher- and lower-risk volunteers., The Journal of Infectious Diseases, 183 (9), 1343-52 Abstract
  • Berrey MM, Schacker T, Collier AC, Shea T, Brodie SJ, Mayers D, Coombs R, Krieger J, Chun TW, Fauci A, Self SG, Corey L (May 2001) Treatment of primary human immunodeficiency virus type 1 infection with potent antiretroviral therapy reduces frequency of rapid progression to AIDS., The Journal of Infectious Diseases, 183 (10), 1466-75 Abstract
  • Seage GR 3rd, Holte SE, Metzger D, Koblin BA, Gross M, Celum C, Marmor M, Woody G, Mayer KH, Stevens C, Judson FN, McKirnan D, Sheon A, Self S, Buchbinder SP (Apr 2001) Are US populations appropriate for trials of human immunodeficiency virus vaccine? The HIVNET Vaccine Preparedness Study., American Journal of Epidemiology, 153 (7), 619-27 Abstract
  • Schubert E, Cousens L, Hsu L, Glogovac J, Reid B, Self SG, Rabinovich P, Porter P, Allelic imbalance in routinely processed breast tumors determined by Affymetrix HuSNP array, Nature Genetics, 27, 85, 2001
  • Gilbert P, Self S, Rao M, Naficy A, Clemens J (Jan 2001) Sieve analysis: methods for assessing from vaccine trial data how vaccine efficacy varies with genotypic and phenotypic pathogen variation., Journal of Clinical Epidemiology, 54 (1), 68-85 Abstract
  • Hill DA, Weiss NS, Beresford SA, Voigt LF, Daling JR, Stanford JL, Self S (Dec 2000) Continuous combined hormone replacement therapy and risk of endometrial cancer., American Journal of Obstetrics and Gynecology, 183 (6), 1456-61 Abstract
  • Wick D, Self SG (Jun 2000) Early HIV infection in vivo: branching-process model for studying timing of immune responses and drug therapy., Mathematical Biosciences, 165 (2), 115-34 Abstract
  • Velentgas P, Daling JR, Malone KE, Weiss NS, Williams MA, Self SG, Mueller BA (Jun 1999) Pregnancy after breast carcinoma: outcomes and influence on mortality., Cancer, 85 (11), 2424-32 Abstract
  • Glidden DU, Self SG, Semi-parametric likelihood estimation in the Clayton-Cates failure time model, Scandinavian Journal of Statistics, 26:363-372, 1999
  • Sanderson M, Williams MA, Daling JR, Holt VL, Malone KE, Self SG, Moore DE (Oct 1998) Maternal factors and breast cancer risk among young women., Paediatric and Perinatal Epidemiology, 12 (4), 397-407 Abstract
  • Gilbert PB, Self SG, Ashby MA (Sep 1998) Statistical methods for assessing differential vaccine protection against human immunodeficiency virus types., Biometrics, 54 (3), 799-814 Abstract
  • Habel LA, Daling JR, Newcomb PA, Self SG, Porter PL, Stanford JL, Seidel K, Weiss NS (Aug 1998) Risk of recurrence after ductal carcinoma in situ of the breast., Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology., 7 (8), 689-96 Abstract
  • Sanderson M, Williams MA, White E, Daling JR, Holt VL, Malone KE, Self SG, Moore DE (Jan 1998) Validity and reliability of subject and mother reporting of perinatal factors., American Journal of Epidemiology, 147 (2), 136-40 Abstract
  • Thomas DB, Gao DL, Self SG, Allison CJ, Tao Y, Mahloch J, Ray R, Qin Q, Presley R, Porter P (Mar 1997) Randomized trial of breast self-examination in Shanghai: methodology and preliminary results., Journal of the National Cancer Institute, 89 (5), 355-65 Abstract
  • Wick D, Self SG, Estimating disease attack rates in heterogeneous, interacting populations with applications to vaccine trials, Annals of Statistics, 25(2):642-661, 1997
  • Emond M, Self SG, An efficient estimator for the generalized semilinear model, Journal of the American Statistical Association, 92:1033-1040, 1997
  • Liang KY, Self SG, On the asymptotic behaviour of the pseudolikelihood ratio test statistic, Journal of the Royal Statistical Society (B), 58(4):785-796, 1996
  • Rossing MA, Daling JR, Weiss NS, Moore DE, Self SG (Jan 1996) Risk of breast cancer in a cohort in infertile women., Gynecologic Oncology, 60 (1), 3-7 Abstract
  • Rossing MA, Daling JR, Weiss NS, Moore DE, Self SG (Jan 1996) In situ and invasive cervical carcinoma in a cohort of infertile women., Fertility and Sterility, 65 (1), 19-22 Abstract
  • Rossing MA, Daling JR, Weiss NS, Moore DE, Self SG (Apr 1995) Risk of cutaneous melanoma in a cohort of infertile women., Melanoma Research, 5 (2), 123-7 Abstract
  • Self SG, Etzioni R (Mar 1995) A likelihood ratio test for cancer screening trials., Biometrics, 51 (1), 44-50 Abstract
  • Etzioni R, Self SG (Mar 1995) On the catch-up time method for analyzing cancer screening trials., Biometrics, 51 (1), 31-43 Abstract
  • Etzioni RD, Connor RJ, Porok PC, Self SG (Mar 1995) Design and analysis of cancer screening trials., Statistical Methods in Medical Research, 4 (1), 3-17 Abstract
  • Liang KY, Self SG, Bandeen-Roche KJ, Zeger SL (1995) Some recent developments for regression analysis of multivariate failure time data., Lifetime Data Analysis, 1 (4), 403-15 Abstract
  • Schaper C, Fleming TR, Self SG, Rida WN (1995) Statistical issues in the design of HIV vaccine trials., Annual Review of Public Health, 16, 1-22 Abstract
  • Rossing MA, Daling JR, Weiss NS, Moore DE, Self SG (Sep 1994) Ovarian tumors in a cohort of infertile women., The New England Journal of Medicine, 331 (12), 771-6 Abstract
  • Liang K-Y, Self SG, Chang Y-C, Modeling marginal hazards in multivariate failure-time data, Journal of the Royal Statistical Society (B), 54:441-454, 1993
  • Pawitan Y, Self SG, Modeling markers of progression to AIDS, Journal of the American Statistical Association, 88:719-726, 1993
  • Self SG, Mauritsen R, Ohara J, Power calculations for generalized linear models, Biometrics, 48:31-40, 1992
  • Zhao LP, Prentice RL, Self SG, Multivariate mean parameter estimation by using a partly exponential model, Journal of the Royal Statistical Society (B), 54:805-811, 1992
  • Self SG (Sep 1991) An adaptive weighted log-rank test with application to cancer prevention and screening trials., Biometrics, 47 (3), 975-86 Abstract
  • Self SG, Longton G, Kopecky KJ, Liang KY (Mar 1991) On estimating HLA/disease association with application to a study of aplastic anemia., Biometrics, 47 (1), 53-61 Abstract
  • Liang KY, Self SG, Liu XH (Sep 1990) The Cox proportional hazards model with change point: an epidemiologic application., Biometrics, 46 (3), 783-93 Abstract
  • Urban N, Self S, Kessler L, Prentice R, Henderson M, Iverson D, Thompson D, Byar D, Insull W, Gorbach SL, Et Al. (Apr 1990) Analysis of the costs of a large prevention trial., Controlled Clinical Trials, 11 (2), 129-46 Abstract
  • Yee GC, McGuire TR, St Pierre BA, Self SG, Zager RA, Sullivan KM, Deeg HJ (Nov 1989) Minimal risk of chronic renal dysfunction in marrow transplant recipients treated with cyclosporine for 6 months., Bone Marrow Transplantation, 4 (6), 691-4 Abstract
  • Pepe MS, Self SG, Prentice RL (Sep 1989) Further results on covariate measurement errors in cohort studies with time to response data., Statistics in Medicine, 8 (9), 1167-78; discussion Abstract
  • Prentice RL, Pepe M, Self SG (Jun 1989) Dietary fat and breast cancer: a quantitative assessment of the epidemiological literature and a discussion of methodological issues., Cancer Research, 49 (12), 3147-56 Abstract
  • Huster WJ, Brookmeyer R, Self SG (Mar 1989) Modelling paired survival data with covariates., Biometrics, 45 (1), 145-56 Abstract
  • Paul SR, Liang KY, Self SG (Mar 1989) On testing departure from the binomial and multinomial assumptions., Biometrics, 45 (1), 231-6 Abstract
  • Fait A, Grossman E, Self S, Jeffries J, Pellizzari ED, Emmett EA (Jan 1989) Polychlorinated biphenyl congeners in adipose tissue lipid and serum of past and present transformer repair workers and a comparison group., Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology., 12 (1), 42-55 Abstract
  • Yee GC, Self SG, McGuire TR, Carlin J, Sanders JE, Deeg HJ (Jul 1988) Serum cyclosporine concentration and risk of acute graft-versus-host disease after allogeneic marrow transplantation., The New England Journal of Medicine, 319 (2), 65-70 Abstract
  • Self S, Prentice R, Iverson D, Henderson M, Thompson D, Byar D, Insull W, Gorbach SL, Clifford C, Goldman S, Et Al. (Jun 1988) Statistical design of the Women's Health Trial., Controlled Clinical Trials, 9 (2), 119-36 Abstract
  • Self SG, Prentice RL, Asymptotic distribution theory and efficiency results for case-cohort studies, Annals of Statistics, 16(1):64-81, 1988
  • Self SG, Mauritsen RH, Power/sample size calculations for generalized linear models, Biometrics, 44:79-86, 1988
  • Prentice RL, Self SG (Jan-Feb 1988) Aspects of the use of relative risk models in the design and analysis of cohort studies and prevention trials., Statistics in Medicine, 7 (1-2), 275-87 Abstract
  • Klingemann HG, Self S, Banaji M, Deeg HJ, Doney K, Slichter SJ, Thomas ED, Storb R (May 1987) Refractoriness to random donor platelet transfusions in patients with aplastic anaemia: a multivariate analysis of data from 264 cases., British Journal of Haematology, 66 (1), 115-21 Abstract
  • Yee GC, Kennedy MS, Gmur DJ, Self SG, Deeg HJ (Feb 1987) Monitoring cyclosporin concentrations in marrow transplant recipients: comparison of two assay methods., Bone Marrow Transplantation, 1 (3), 289-95 Abstract
  • Self SG, Liang KY, Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under non-standard conditions, Journal of the American Statistical Association, 82:605-610, 1987
  • Appelbaum FR, Storb R, Ramberg RE, Shulman HM, Buckner CD, Clift RA, Deeg HJ, Fefer A, Sanders J, Self S, Et Al. (Jan 1987) Treatment of preleukemic syndromes with marrow transplantation., Blood, 69 (1), 92-6 Abstract
  • Deeg HJ, Self S, Storb R, Doney K, Appelbaum FR, Witherspoon RP, Sullivan KM, Sheehan K, Sanders J, Mickelson E, Et Al. (Dec 1986) Decreased incidence of marrow graft rejection in patients with severe aplastic anemia: changing impact of risk factors., Blood, 68 (6), 1363-8 Abstract
  • Self SG, Grossman EA (Sep 1986) Linear rank tests for interval-censored data with application to PCB levels in adipose tissue of transformer repair workers., Biometrics, 42 (3), 521-30 Abstract
  • Klingemann HG, Deeg HJ, Self S, Thomas ED, Storb R (May 1986) Is race a risk factor for allogeneic marrow transplantation?, Bone Marrow Transplantation, 1 (1), 87-94 Abstract
  • Yee GC, Kennedy MS, Self SG, Storb R, Deeg HJ, Pharmacodynamics of cyclosporine in patients undergoing bone marrow transplantation, Transplantation Proceedings, 18(4):774-776, 1986
  • Beaty TH, Self SG, Liang KY, Connolly MA, Chase GA, Kwiterovich PO (Oct 1985) Use of robust variance components models to analyse triglyceride data in families., Annals of Human Genetics, 49 ( Pt 4), 315-28 Abstract
  • Appelbaum FR, Deeg HJ, Storb R, Self S, Graham TC, Sale GE, Weiden PL (May 1985) Marrow transplant studies in dogs with malignant lymphoma., Transplantation, 39 (5), 499-504 Abstract
  • Brookmeyer R, Self SG (Mar 1985) The effect of additional follow-up and accrual on survival time data., Biometrics, 41 (1), 129-36 Abstract
  • Liang KY, Self SG, Tests for homogeneity of odds ratios when data are sparse, Biometrika, 72(2):353-358, 1985
  • Zeger S, Liang KY, Self SG, The analysis of binary longitudinal data with time independent covariates, Biometrika, 72:31, 1985
  • Khoury MJ, Beaty TH, Tockman MS, Self SG, Cohen BH (1985) Familial aggregation in chronic obstructive pulmonary disease: use of the loglinear model to analyze intermediate environmental and genetic risk factors., Genetic Epidemiology, 2 (2), 155-66 Abstract
  • Pestronk A, Drachman DB, Self SG (Mar-Apr 1985) Measurement of junctional acetylcholine receptors in myasthenia gravis: clinical correlates., Muscle & Nerve, 8 (3), 245-51 Abstract
  • Beaty TH, Self SG, Chase GA, Kwiterovich PO (Sep 1983) Assessment of variance components models on pedigrees using cholesterol, low-density, and high-density lipoprotein measurements., American Journal of Medical Genetics, 16 (1), 117-29 Abstract
  • Chase GA, Folstein MF, Breitner JC, Beaty TH, Self SG (May 1983) The use of life tables and survival analysis in testing genetic hypotheses, with an application to Alzheimer's disease., American Journal of Epidemiology, 117 (5), 590-7 Abstract
  • Prentice RL, Self SG, Asymptotic distribution theory for Cox-type regression models with general relative risk form, Annals of Statistics, 11:804-813, 1983
  • Drachman DB, Adams RN, Josifek LF, Self SG (Sep 1982) Functional activities of autoantibodies to acetylcholine receptors and the clinical severity of myasthenia gravis., The New England Journal of Medicine, 307 (13), 769-75 Abstract
  • Self SG, Prentice RL, Commentary on Andersen and Gill's 'Cox regression model for counting processes: A large sample study, Annals of Statistics, 10:1121, 1982
  • Grados OB (Apr 1975) [The laboratory in programs for enteric infection control], Boletín de la Oficina Sanitaria Panamericana. Pan American Sanitary Bureau, 78 (4), 318-22 Abstract

Profile Details

Last Updated: 4/22/2008

COS Expertise ID #373798
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