Dr. Michael N. Shadlen

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University of Washington
School of Medicine
Physiology and Biophysics
ProfessorAppointed: 2005
University of Washington
Graduate Program in Neurobiology & Behavior
Co-directorAppointed: 2001
University of Washington
School of Medicine
Neurology
Adjunct ProfessorAppointed: 2001
University of Washington
School of Medicine
Physiology and Biophysics
Howard Hughes Medical Institute
InvestigatorAppointed: 2000
Regional Primate Research Center
Core Staff ScientistAppointed: 1995
Professional Headshot of Michael N. Shadlen

Mailing Address

Department of Physiology and Biophysics
University of Washington Medical School
Box 357290
Seattle, Washington 98195-7290
United States

Contact Information

Phone: (206) 616-4630
Fax: (206) 543-1196
shadlen@u.washington.edu
http://depts.washington.edu/pbiopage/people_fac_page.php?fac_ID=28

Qualifications

M.D., Brown University, Bio/Med Sciences, 1988.
Ph.D., University of California, Berkeley, 1985.
B.A., Brown University, 1981.

Expertise and Research Interests

Neural basis of visual perception, cortical electrophysiology
Neural basis of decision making and higher brain function
Neural basis of time perception
Computational aspects of visual perception and cerebral cortical function
Visual psychophysics of motion and depth perception

Keywords

COS Keywords:

Biomedical Research (Multidisciplinary), Biophysics, Brain, Central Nervous System, Electrophysiology, Human Ethology, Nervous System, Neurobiology, Neuroethology, Neurology, Neurons, Ophthalmology, Physiology, Psychophysics, Sensory Physiology, Sensory System, Vision.

Additional Terms:

Brain, Central Nervous System, Eye Movement, Nervous System, Neurobiology, Neuroglia, Neurons, Peripheral Nervous System, Sensory, Vision Research.

Memberships

American Academy of Neurology
American Association for the Advancement of Science
American Physiological Society
Association for Research in Vision and Ophthalmology
Committee for Animals in Research
Computational and Systems Neuroscience (CoSyNe), organizing committee
Computational and Systems Neuroscience, Organizing Committee
McKnight Foundation, Technology Board
National Association for Biomedical Research
Neural Control of Movement Society
Neuroethics Society
Neurosciences Research Program
Northwest Association for Biomedical Research
Society for Neuroscience
The Neuroscience Research Program
Vision Sciences Society
Washington Association for Biomedical Research
Washington University IGERT advisory board

Honors and Awards

2009, Alden Spencer Prize, Columbia University, Columbia University
2007, Swartz Foundation MInd/Brain lecturer, Swartz Foundation, SUNY Stony Brook
2007-2008, Visiting Fellow Commoner, Trinity College, Cambridge, UK
2006, Elected Associate, Neuroscience Research Program, The Neurosciences Institute
2001, New Investigator Science in Medicine Lecture,
2000, Investigator, Howard Hughes Medical Research Institute, University of Washington, Neuroscience
1999, William Rushton lecture in Neuroscience, Florida State University, Title: "Between seeing and doing: neural computation of a decision in parietal and prefrontal cortex"
1995-1998, McKnight Scholars Award, McKnight Foundation, University of Washington, Neuroscience
1992, Sandoz Award, Stanford University, Neurology and Neuroscience
1992-1995, Dana Fellowship, Dana Society, Stanford, Basic Research in Neurological Sciences
1992-1995, Physician/Scientist Award, Howard Hughes Medical Research Institute, Stanford, Neuroscience

Previous Positions

1996-2001, Adjunct Assistant Professor, University of Washington, School of Medicine, Neurology
1995-2001, Assistant Professor, University of Washington, School of Medicine, Physiology and Biophysics
1993-1995, Clinical Instructor, Stanford University, School of Medicine, Neurology

Funding Received

  • NIH RO1EY 11378: Neural Mechanisms of Visual Perception, May 1, 1996 to Apr 30, 2006.
  • National Institutes of Health (NIH): Neural Basis of Bayesian Inference and Decision Making, 2007 to 2012.
  • Howard Hughes Medical Institute: HHMI, 2000 to 2010.
  • McKnight Endowment Fund for Neuroscience: Temporal Integration and Working Memory, 1996 to 1999.

Publications

  • Resulaj, A., Kiani, R., Wolpert, D.M., Shadlen, M.N. (2009) Changes of mind in decision-making, Nature, In Press
  • Kiani, R., Shadlen, M.N. (2009) Representation of confidence associated with a decision by neurons in the parietal cortex, Science, 324, 759-764
  • Beck, J.M., Ma, W.J., Kiani, R., Hanks, T., Churchland, A.K., Roitman, J., Shadlen, M.N., Latham, P.E., Pouget, A. (2008) Probabilistic population codes for Bayesian decision making, Neuron, 60, 1142-1152
  • Churchland, A.K., Kiani, R., Shadlen, M.N. (2008) Decision-making with multiple alternatives, Nature Neuroscience, 11, 693-702
  • Ganguli, S., Bisley, J.W., Roitman, J.D., Shadlen, M.N., Goldberg, M.E., Miller, K.D. (2008) One-dimensional dynamics of attention and decision making in LIP, Neuron, 58, 15-25
  • Kiani, R., Hanks, T.D., Shadlen, M.N. (2008) Bounded integration in parietal cortex underlies decisions even when viewing duration is dictated by the environment, J Neuroscience, In Press
  • Wong, K.F., Huk, A.C., Shadlen, M.N., Wang, X.J. (2008) Neural circuit dynamics underlying accumulation of time-varying evidence during decision-making, Frontiers in Neuroscience, In Press
  • Shadlen, M.N., Kiani, R., Hanks, T.D., Churchalnd, A.K. (2008) Neurobiology of decision making. An intentional framework In Engel, C., Singer, W. (eds), Strungmann Forum Report: Better than Conscious? Implications for Performance and Institutional Analysis (bookchapter)
  • Yang, T., Shadlen, M.N. (2007) Probabilistic reasoning by neurons, Nature, 447 (7148), 1075-1080
  • Shadlen, M.N., Hanks, TD, Churchland, AK, Kiani, R, Yang, T (2007) The speed and accuracy of a simple perceptual decision: a mathematical primer In Doya, K, Ishii, S, Rao,R, Pouget, A (eds), Bayesian Brain: Probabilistic Approaches to Neural Coding, Cambridge, MA, USA, MIT Press, ISBN=026204238X (bookchapter)
  • Shadlen, M.N. (2007) Neurology: an awakening, Nature (448), 539-540
  • Gold, J.I., Shadlen, M.N. (2007) The Neural Basis of Decision Making, Annual Review of Neuroscience, 30, 535-574
  • Kiani, R., Hanks, T.D., Shadlen, M.N. (2006) When is enough enough?, Nature Neuroscience, 9, 861-863
  • Hanks, T.D., Ditterich, J., Shadlen, M.N. (2006) Microstimulation of macaque area LIP affects decision-making in a motion discrimination task, Nature Neuroscience, 9, 682-689
  • Palmer, J, Huk, AC, Shadlen, MN, The Effect of Stimulus Strength on the Speed and Accuracy of a Perceptual Decision, J Vision, 5(5), 376-404, 2005
  • Janssen, P and Shadlen, MN, A Representation of the Hazard Rate of Elapsed Time in Macaque Area LIP, Nat Neurosci, 8(2), 234-241, 2005
  • Huk, A.C., Shadlen, M.N. (2005) Neural activity in macaque parietal cortex reflects temporal integration of visual motion signals during perceptual decision making, J Neuroscience, 25 (45), 10420-10436
  • Leon M and Shadlen MN, Representation of Time by Neurons in the Posterior Parietal Cortex of the Macaque, Neuron, 38, 317-327, 24 Apr 2003
  • Gold, JI and Shadlen, MN, The influence of behavioral context on the representation of a perceptual decision in developing oculomotor commands, Journal of Neuroscience, 23(2), 632-651, 15 Jan 2003
  • Ditterich, J., Mazurek, M., and Shadlen, MN, Microstimulation of Visual Cortex Affects Speed of Perceptual Decisions, Nature Neuroscience, 891-898, 2003
  • Mazurek, ME., Roitman, JD., Ditterich, J. and Shadlen, MN, A Role for Neural Integrators in Perceptual Decision-making, Cereb Cortex, 13, 1257-1269, 2003
  • Gold JI, Shadlen MN, Banburismus and the brain: decoding the relationship between sensory stimuli, decisions, and reward, Neuron, 36, 299 - 308, 2002
  • Shadlen MN, Pursuing commitments, Nat. Neurosci., 5, 819 - 821, 2002
  • Roitman, JD, Shadlen, MN, Response of neurons in the lateral intraparietal area during a combined visual discrimination reaction time task, Journal of Neuroscience, 9475-9489, 01 Jan 2002
  • Mazurek, ME, Shadlen, MN, Limits to the Temporal Fidelity of Cortical Spike Rate Signals, Nature Neuroscience, 5, 463 - 471, 2002
  • Shadlen MN, Newsome WT, Neural basis of a perceptual decision in the parietal cortex (area lip) of the rhesus monkey, Journal of Neurophysiology, 86, 1916-1936, October 2001
  • Gold, JI, Shadlen, MN, Neural computations that underlie decisions about sensory stimuli, Trends in Cognitive Sciences, 5(1), 10-16, Jan 2001
  • Gold JI, Shadlen MN, Representation of a perceptual decision in developing oculomotor commands, Nature, 404(6776), 390-4, March 2000 Abstract
  • Leon MI, Shadlen MN, Effect of expected reward magnitude on the response of neurons in the dorsolateral prefrontal cortex of the macaque, Neuron, 24(2), 415-25, October 1999 Abstract
  • Shadlen MN, Movshon JA, Synchrony unbound: a critical evaluation of the temporal binding hypothesis., Neuron, 24(1), 67-77, 111-25, 1999 Abstract
  • Kim JN, Shadlen MN, Neural correlates of a decision in the dorsolateral prefrontal cortex of the macaque, Nat. Neurosci., 2(2), 176-85, February 1999 Abstract
  • Shadlen, MN and Movshon, JA, Synchrony unbound: a critical evaluation of the temporal binding hypothesis, Neuron, 24, 67 - 77, 1999
  • Leon MI, Shadlen MN, Exploring the neurophysiology of decisions, Neuron, 21(4), 669-72, October 1998 Abstract
  • Shadlen MN, Newsome WT, The variable discharge of cortical neurons: implications for connectivity, computation, and information coding., Journal of Neuroscience, 18(10), 3870-96, 15 1998 Abstract
  • Shadlen, MN, Look but don't touch, or vice versa, Nature, 386, 122 - 123, 1997
  • Olshen, RA and Shadlen, MN, Discussion of 'Non-linear Fourier time series analysis for human brain mapping' by N. Lange and S.L. Zeger, Applied Statistics, Journal of the Royal Statistical Society (Series C), 46, 22, 1997
  • Shadlen MN, Britten KH, Newsome WT, Movshon JA, A computational analysis of the relationship between neuronal and behavioral responses to visual motion, Journal of Neuroscience, 16(4), 1486-510, February 1996 Abstract
  • Shadlen MN, Newsome WT, Motion perception: seeing and deciding, Proceedings of the National Academy of Sciences (USA), 93(2), 628-33, January 1996 Abstract
  • Britten KH, Newsome WT, Shadlen MN, Celebrini S, Movshon JA, A relationship between behavioral choice and the visual responses of neurons in macaque MT, Visual Neuroscience, 13(1), 87-100, 1996 Abstract
  • Shadlen MN, Newsome WT, Is There a Signal in the Noise?, Current Opinion in Neurobiology, 5(2), 248-50, April 1995
  • Zohary E, Shadlen MN, Newsome WT, Correlated neuronal discharge rate and its implications for psychophysical performance [published erratum appears in Nature 1994 Sep 22, Nature, 370(6485), 140-3, July 1994 Abstract
  • Engel SA, Rumelhart DE, Wandell BA, Lee AT, Glover GH, Chichilnisky EJ, Shadlen MN, fMRI of human visual cortex [letter] [published erratum appears in Nature 1994 Jul 14, Nature, 369(6481), 525, June 1994 Abstract
  • Shadlen, MN and Newsome, WT, Noise, neural codes and cortical organization, Current Opinion in Neurobiology, 4, 569 - 579, 1994
  • Britten KH, Shadlen MN, Newsome WT, Movshon JA, Responses of neurons in macaque MT to stochastic motion signals, Visual Neuroscience, 10(6), 1157-69, 1993 Abstract
  • Carney T, Shadlen MN, Dichoptic activation of the early motion system, Vision Research, 33(14), 1977-95, September 1993 Abstract
  • Britten KH, Shadlen MN, Newsome WT, Movshon JA, The analysis of visual motion: a comparison of neuronal and psychophysical performance, Journal of Neuroscience, 12(12), 4745-65, December 1992 Abstract
  • Carney T, Shadlen MN, Binocularity of early motion mechanisms: comments on Georgeson and Shackleton [letter], Vision Research, 32(1), 187-91, January 1992 Abstract
  • Carney T, Shadlen M, Switkes E, Parallel processing of motion and colour information, Nature, 328(6131), 647-9, August 1987 Abstract
  • Ramoa AS, Shadlen M, Freeman RD, Dark-reared cats: unresponsive cells become visually responsive with microiontophoresis of an excitatory amino acid, Experimental Brain Research, 65(3), 658-65, 1987 Abstract
  • Ramoa AS, Shadlen M, Skottun BC, Freeman RD, A comparison of inhibition in orientation and spatial frequency selectivity of cat visual cortex, Nature, 321(6067), 237-9, May 1986 Abstract
  • Shadlen M, Carney T, Mechanisms of human motion perception revealed by a new cyclopean illusion, Science, 232(4746), 95-7, April 1986 Abstract
  • Shadlen, MN, Refugees of El Salvador: a firsthand account of their precarious health and safety, The New Physician, 5, 24 - 29, 1982
  • Palmer, J., Huk, A.C. and Shadlen, M.N., The effect of stimulus strength on the speed and accuracy of a perceptual decision, J Vision, in press

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Last Updated: 9/11/2009

COS Expertise ID #543698
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