Fred Hutchinson Cancer Research Center Molecular Diagnostics Public Health Sciences Program HeadAppointed: 2005 Fred Hutchinson Cancer Research Center Public Health Sciences Division Molecular Diagnostics Full Member | |
QualificationsPh.D., University of Michigan, Human Genetics, 1976. M.D., American University of Beirut, 1972. Expertise and Research InterestsDr. Hanash's interests and expertise focus on the development and application of integrated approaches to the molecular profiling of cancer, with particular emphasis on proteomics. Dr. Hanash's Ph.D. training is in Human Genetics and clinical training in Pediatric Oncology. He has been a program principal investigator (PI) for multi-investigator projects funded by the National Cancer Institute (NCI) while at the University of Michigan, including program projects and most recently, PI for an NCI-funded Director's Challenge program, which focuses on molecular profiling of lung, colon and ovarian cancer and PI of an NCI-funded Cancer Biomarker Development program, which focuses on the application of proteomics to the discovery of protein markers for the early diagnosis of lung and GI cancers. Dr. Hanash has organized and participated in several workshops sponsored by the NCI related to cancer diagnostics and molecular profiling. Dr. Hanash relocated from the University of Michigan to the Fred Hutchinson Cancer Research Center in August 2004 to lead a newly developed program in Molecular Diagnostics. Other ExpertiseHuman Proteome Organisation - Founding Member KeywordsCOS Keywords:Cancer Or Carcinogenesis, Pediatrics, Proteomics.Additional Terms:Proteomics.MembershipsAmerican Association for Cancer Research American Society for Cell Biology American Society for Human Genetics American Society for Pediatric Research American Society of Hematology Children's Cancer Study Group Electrophoresis Society Human Proteome Organisation Previous Positions1992-1999, Director,
University of Michigan,
Cancer Center,
Carcinogenesis
1989-2004, Professor,
University of Michigan,
Pediatrics
1984-1989, Associate Professor,
University of Michigan,
Pediatrics
1979-1984, Assistant Professor,
University of Michigan,
Pediatrics
1978-1979, Instructor,
University of Michigan,
Pediatrics
1978-1979, Fellow,
University of Michigan,
Pediatric Hematology
1973-1976, Post-doctoral Fellow,
University of Michigan,
Medical School,
Human Genetics
Publications- States DJ, Omenn GS, Blackwell TW, Fermin D, Eng J, Speicher DW, Hanash S (2006) Challenges in deriving high-confidence protein identifications from data gathered by a HUPO plasma proteome collaborative study, Nature Biotechnology, 3 (24), 333-8
- Rauch A, Bellew M, Eng J, Fitzgibbon M, Holzman T, Hussey P, Igra M, Maclean B (2006) Computational Proteomics Analysis System (CPAS): an extensible, open-source analytic system for evaluating and publishing proteomic data and high throughput biological experiments, Journal of Proteome Research, 5 (1), 112-21
- Faca V, Coram M, Phanstiel D, Glukhova V, Zhang Q, Fitzgibbon M, McIntosh M, Hanash S (2006) Quantitative Analysis of Acrylamide Labeled Serum Proteins by LC-MS/MS, Journal of Proteome Research, In Press
- Giordano TJ, Kuick R, Thomas DG, Misek DE, Vinco M, Sanders D, Zhu Z, Ciampi R, Roh M, Shedden K, Gauger P, Doherty G, Thompson NW, Hanash S, Koenig RJ, Nikiforov YE (Oct 2005) Molecular classification of papillary thyroid carcinoma: distinct BRAF,
RAS, and RET/PTC mutation-specific gene expression profiles discovered by
DNA microarray analysis, Oncogene, 24 (44), 6646-56
- Misek DE, Kuick R, Wang H, Galchev V, Deng B, Zhao R, Tra J, Pisano MR, Amunugama R, Allen D, Walker AK, Strahler JR, Andrews P, Omenn GS, Hanash SM (Aug 2005) A wide range of protein isoforms in serum and plasma uncovered by a
quantitative intact protein analysis system, Proteomics, 5 (13), 3343-52
- Ping P, Vondriska TM, Creighton CJ, Gandhi TK, Yang Z, Menon R, Kwon MS, Cho SY, Drwal G, Kellmann M, Peri S, Suresh S, Gronborg M, Molina H, Chaerkady R, Rekha B, Shet AS, Gerszten RE, Wu H, Raftery M, Wasinger V, Schulz-Knappe P, Hanash SM, Paik YK, Hancock WS, States DJ, Omenn GS, Pandey A (Aug 2005) A functional annotation of subproteomes in human plasma, Proteomics, 5 (13), 3506-19
- Omenn GS, States DJ, Adamski M, Blackwell TW, Menon R, Hermjakob H, Apweiler R, Haab BB, Simpson RJ, Eddes JS, Kapp EA, Moritz RL, Chan DW, Rai AJ, Admon A, Aebersold R, Eng J, Hancock WS, Hefta SA, Meyer H, Paik YK, Yoo JS, Ping P, Pounds J, Adkins J, Qian X, Wang R, Wasinger V, Wu CY, Zhao X, Zeng R, Archakov A, Tsugita A, Beer I, Pandey A, Pisano M, Andrews P, Tammen H, Speicher DW, Hanash SM (Aug 2005) Overview of the HUPO Plasma Proteome Project: results from the pilot phase
with 35 collaborating laboratories and multiple analytical groups,
generating a core dataset of 3020 proteins and a publicly-available
database, Proteomics, 5 (13), 3226-45
- Gao WM, Kuick R, Orchekowski RP, Misek DE, Qiu J, Greenberg AK, Rom WN, Brenner DE, Omenn GS, Haab BB, Hanash SM (Aug 2005) Distinctive serum protein profiles involving abundant proteins in lung
cancer patients based upon antibody microarray analysis, Bmc Cancer [electronic Resource], 5, 110
- Rozek LS, Lipkin SM, Fearon ER, Hanash S, Giordano TJ, Greenson JK, Kuick R, Misek DE, Taylor JM, Douglas JA, Rennert G, Gruber SB (Jul 2005) CDX2 polymorphisms, RNA expression, and risk of colorectal cancer, Cancer Research, 65 (13), 5488-92
- Li JY, Kuick R, Thompson RC, Misek DE, Lai YM, Liu YQ, Chai BX, Hanash SM, Gantz I (Jun 2005) Arcuate nucleus transcriptome profiling identifies ankyrin repeat and
suppressor of cytokine signalling box-containing protein 4 as a gene
regulated by fasting in central nervous system feeding
circuits, Journal of Neuroendocrinology, 17 (6), 394-404
- Wang H, Clouthier SG, Galchev V, Misek DE, Duffner U, Min CK, Zhao R, Tra J, Omenn GS, Ferrara JL, Hanash SM (May 2005) Intact-protein-based high-resolution three-dimensional quantitative
analysis system for proteome profiling of biological
fluids, Molecular & Cellular Proteomics : Mcp, 4 (5), 618-25
- Hinoi T, Gesina G, Akyol A, Kuick R, Hanash S, Giordano TJ, Gruber SB, Fearon ER (Apr 2005) CDX2-regulated expression of iron transport protein hephaestin in
intestinal and colonic epithelium, Gastroenterology, 128 (4), 946-61
- Nam MJ, Kee MK, Kuick R, Hanash SM (Mar 2005) Identification of defensin alpha6 as a potential biomarker in colon
adenocarcinoma, The Journal of Biological Chemistry, 280 (9), 8260-5
- Shedden KA, Kshirsagar MP, Schwartz DR, Wu R, Yu H, Misek DE, Hanash S, Katabuchi H, Ellenson LH, Fearon ER, Cho KR (Mar 2005) Histologic type, organ of origin, and Wnt pathway status: effect on gene
expression in ovarian and uterine carcinomas, Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 11 (6), 2123-31
- Creighton CJ, Bromberg-White JL, Misek DE, Monsma DJ, Brichory F, Kuick R, Giordano TJ, Gao W, Omenn GS, Webb CP, Hanash SM (Mar 2005) Analysis of tumor-host interactions by gene expression profiling of lung
adenocarcinoma xenografts identifies genes involved in tumor
formation, Molecular Cancer Research : Mcr, 3 (3), 119-29
- Williams TM, Williams ME, Kuick R, Misek D, McDonagh K, Hanash S, Innis JW (Mar 2005) Candidate downstream regulated genes of HOX group 13 transcription factors
with and without monomeric DNA binding capability, Developmental Biology, 279 (2), 462-80
- Steel LF, Haab BB, Hanash SM (Feb 2005) Methods of comparative proteomic profiling for disease diagnostics, Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 815 (1-2), 275-84
- Shedden K, Chen W, Kuick R, Ghosh D, Macdonald J, Cho KR, Giordano TJ, Gruber SB, Fearon ER, Taylor JM, Hanash S (Feb 2005) Comparison of seven methods for producing Affymetrix expression scores
based on False Discovery Rates in disease profiling
data, Bmc Bioinformatics [electronic Resource], 6 (1), 26
- Misek DE, Kuick R, Hanash SM, Logsdon CD (2005) Oligonucleotide-directed microarray gene profiling of pancreatic
adenocarcinoma, Methods in Molecular Medicine, 103, 175-87
- Dobbin KK, Beer DG, Meyerson M, Yeatman TJ, Gerald WL, Jacobson JW, Conley B, Buetow KH, Heiskanen M, Simon RM, Minna JD, Girard L, Misek DE, Taylor JM, Hanash S, Naoki K, Hayes DN, Ladd-Acosta C, Enkemann SA, Viale A, Giordano TJ (Jan 2005) Interlaboratory comparability study of cancer gene expression analysis
using oligonucleotide microarrays, Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 11 (2 Pt 1), 565-72
- Wang H, Hanash S (May-Jun 2005) Intact-protein based sample preparation strategies for proteome analysis
in combination with mass spectrometry, Mass Spectrometry Reviews, 24 (3), 413-26
- Hanash SM (2004) The role of proteomic analyses in breast cancer In Harris JR, Lippman ME, Morrow M, Osborne CK (eds), Diseases of the Breast, 3rd Edition, Lippincott, Williams & Wilkins, 427-431 pages (bookchapter)
- Hanash SH (2004) Clinical applications of proteomics In Speicher DW (eds), Proteome Analysis: Interpreting the Genome, Elsevier Science B.V., 225-237 pages (bookchapter)
- Endler T, Hanash S (1989) Progress in Two-Dimensional Electrophoresis, VCH Publishers, Verlag Chemie
- Hanash SM, Brewer GJ (1981) Advances in Hemoglobin Analysis, Vol. 60, Progress in Clinical and Biological Research, New York, NY, Alan R. Liss, Inc.
Profile DetailsCOS Expertise ID #1234725 Individual Expertise profile of Samir Hanash, Copyright Samir Hanash. © COS Expertise TM, 2008, ProQuest LLC All rights reserved. |