Robert Silbergleit

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University of Michigan
Medical School
Emergency Medicine
Associate ProfessorAppointed: 2006
University of Michigan
Medical School
Emergency Medicine
Assistant ProfessorAppointed: 1997
Professional Headshot of Robert Silbergleit

Mailing Address

UM Department of Emergency Medicine
Neuro Emergencies Research Group
24 Frank Lloyd Wright Dr.
P.O. Box 381
Ann Arbor, Michigan 48106
United States

Contact Information

Phone: (734) 232-2142
Fax: (734) 232-2122
robie@umich.edu

Qualifications

Research Fellow, George Washington University, Brain Resuscitation, 1997.
Residency, Medical College of Pennsylvania, Emergency Medicine, 1995.
M.D., University of Michigan, Medicine, 1992.
S.B., Massachusetts Institute of Technology, Life Sciences, 1988.

Expertise and Research Interests

Neurological emergency clinical trials
Clinical stroke research
Experimental cerebral ischemia
Hyperbaric oxygenation
Fatigue in health care workers
Air medical transport
Resuscitation and hypothermia

Other Expertise

Reviewer and Consulting Editor, Annals of Emergency Medicine

Keywords

COS Keywords:

Brain Injury, Emergency Health Services, Inflammation, Ischemia, Neurology, Stroke, Trauma, Traumatic Brain or Head Injury.

Additional Terms:

Animal Model, Brain Injury, Cerebral Ischemia, Cerebrovascular Disease, Disability, Emergency Medicine, Hyperbaric Oxygen, Inflammation, Ischemia, Neurology, Neuroprotection, Platelet Inhibition, Stroke.

Memberships

Alpha Omega Alpha
American Academy of Emergency Medicine
American Association for the Advancement of Science
National Association of Emergency Medical Services Physicians
Sigma Xi, The Scientific Research Society
Society for Academic Emergency Medicine
Society for Neuroscience

Honors and Awards

2006, Fellow, Stroke Council, American Heart Association (AHA)
2004, "Top Peer Reviewer" Designation, Annals of Emergency Medicine
1996, Fellow, American Academy of Emergency Medicine
1995, Best Resident/Fellow Oral Presentation, Society for Academic Emergency Medicine
1994, Resident Research Grant, MCP Hahnemann University
1993, Member, Alpha Omega Alpha Honor Society
1986, Member, Sigma Xi Research Honor Society

Funding Received

  • St. Joseph Mercy Health System: A Phase-3 Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Hu23F2g (LeukArrest) in Patients with Acute Ischemic Stroke, UM ID# 00-0415, 9/1/99 to 9/1/00.
  • American Heart Association, Midwest Affiliate: Prolongation of Opportunity for Reperfusion or Neuroprotection After Stroke by Enhanced Cerebral Oxygen, UM ID# 99-1514, 7/1/99 to 6/30/02.
  • Lilly Research Laboratories-Elanco Products Company: Abciximab (ReoPro) in Acute Ischemic Stroke, UM ID# 98-2187, 3/1/98 to 3/1/99.
  • National Institutes of Health (NIH): Neurological Emergencies Treatment Trials Network: Clinical Coordinating Center, $7,487,130, 2006 to 2011.
  • AstraZeneca, PLC: CHANT Clinical Trial, UM ID# 05-0774, 2005 to 2006.
  • Michigan Department of Community Health: Safety of Community Delivery of tPA in Acute Stroke, 2005 to 2006.
  • Henry Ford Hospital: Hu23F2G Anti-Adhesion to Limit Cytotoxic in Stroke (HALT Stroke) Trial: Phase 2, UM ID# 98-1978, 1/28/98 to 6/28/98.
  • Foundation for Aeromedical Research: Fatigue in Air Medical Helicopter Pilots on Rotating Shift Schedules: Measurement and Characterization, UM ID# 99-1709, 1/1/99 to 12/31/99.
  • St. Joseph Mercy Hospital: SAINT II Clinical Trial, UM ID# 04-3665, 06/22/2004 to 12/22/2005.

Publications

  • Silbergleit R, Geocadin RG (Feb 2009) Neurological emergencies are a common presentation. Preface., Emergency medicine clinics of North America, 27 (1), xvii-xviii Abstract
  • Uren B, Lowell MJ, Silbergleit R (Feb 2009) Critical care transport of patients who have acute neurological emergencies., Emergency medicine clinics of North America, 27 (1), 17-26, vii Abstract
  • Millikan D, Rice B, Silbergleit R (Feb 2009) Emergency treatment of status epilepticus: current thinking., Emergency medicine clinics of North America, 27 (1), 101-13, ix Abstract
  • Afshar N, Tabas J, Afshar K, Silbergleit R (Feb 2009) Blood cultures for community-acquired pneumonia: are they worthy of two quality measures? A systematic review., Journal of hospital medicine (Online), 4 (2), 112-23 Abstract
  • Silbergleit R, Barsan W (2009) Neurological emergencies., Frontiers of neurology and neuroscience, 25, 163-73 Abstract
  • Majersik JJ, Silbergleit R, Meurer WJ, Brown DL, Lisabeth LD, Morgenstern LB (May 2008) Public health impact of full implementation of therapeutic hypothermia after cardiac arrest., Resuscitation, 77 (2), 189-94 Abstract
  • Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Köhrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S (May 2008) Acute stroke imaging research roadmap., Stroke; a journal of cerebral circulation, 39 (5), 1621-8 Abstract
  • Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Köhrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S (May 2008) Acute stroke imaging research roadmap., AJNR. American journal of neuroradiology, 29 (5), e23-30 Abstract
  • Laniewicz M, Lyn-Kew K, Silbergleit R (Feb 2008) Rapid endovascular warming for profound hypothermia., Annals of emergency medicine, 51 (2), 160-3 Abstract
  • Qin Z, Hua Y, Liu W, Silbergleit R, He Y, Keep RF, Hoff JT, Xi G (2008) Hyperbaric oxygen preconditioning activates ribosomal protein S6 kinases and reduces brain swelling after intracerebral hemorrhage., Acta neurochirurgica. Supplement, 102, 317-20 Abstract
  • Qin Z, Xi G, Keep RF, Silbergleit R, He Y, Hua Y (2008) Hyperbaric oxygen for experimental intracerebral hemorrhage., Acta neurochirurgica. Supplement, 105, 113-7 Abstract
  • Qin Z, Karabiyikoglu M, Hua Y, Silbergleit R, He Y, Keep RF, Xi G (Apr 2007) Hyperbaric oxygen-induced attenuation of hemorrhagic transformation after experimental focal transient cerebral ischemia., Stroke; a journal of cerebral circulation, 38 (4), 1362-7 Abstract
  • Silbergleit R (Apr 2007) Response to Food and Drug Administration draft guidance statement on research into the treatment of life-threatening emergency conditions using exception from informed consent: testimony of the neurological emergencies treatment trials., Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 14 (4), e63-8 Abstract
  • Qin Z, Song S, Xi G, Silbergleit R, Keep RF, Hoff JT, Hua Y (2007) Preconditioning with hyperbaric oxygen attenuates brain edema after experimental intracerebral hemorrhage., Neurosurgical focus, 22 (5), E13 Abstract
  • Mecozzi AC, Brown DL, Lisabeth LD, Barsan WG, Silbergleit R, Hickenbottom SL, Scott PA, Morgenstern LB (2007) Determining intravenous rt-PA eligibility in the Emergency Department., Neurocritical care, 7 (2), 103-8 Abstract
  • DeFlorio PT, Silbergleit R (2006) Mal de debarquement presenting in the Emergency Department, J Emerg Med, 31 (4), 377-9
  • Silbergleit R, Watters D, Sayre MR (2006) What treatments are "satisfactory?" divining regulatory intent and an ethical basis for exception to informed consent for emergency research, Am J Bioeth, 6 (3), 24-6
  • Scott PA, Silbergleit R (2006) Economic benefit of increasing utilization of intravenous tissue plasminogen activator for acute ischemic stroke in the United States (letter), Stroke, 37 (4), 943-4
  • Silbergleit R, Kronick SL, Philpott S, Lowell MJ, Wagner C (2006) Quality of emergency care on the night shift, Acad Emerg Med, 13 (3), 325-30
  • Watters D, Sayre MR, Silbergleit R (2005) Research conditions that qualify for emergency exception from informed consent, Acad Emerg Med, 12 (11), 1040-4
  • Silbergleit R, Scott PA, Thrombolysis for acute stroke: the incontrovertible, the controvertible, and the uncertain, Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine., 12(4), 348-51, Apr 2005
  • Scott PA, Silbergleit R (Nov 2003) Misdiagnosis of stroke in tissue plasminogen activator-treated patients: characteristics and outcomes, Annals of Emergency Medicine, 42 (5), 611-8
  • Silbergleit R, Scott PA, Lowell MJ (Sep 2003) Cost-effectiveness of helicopter transport of stroke patients for thrombolysis, Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine., 10 (9), 966-72
  • Rosenthal RE, Silbergleit R, Hof PR, Haywood Y, Fiskum G, Hyperbaric oxygen reduces neuronal death and improves neurological outcome after canine cardiac arrest, Stroke; a Journal of Cerebral Circulation, 34(5), 1311-6, May 2003
  • Miljkovic-Lolic M, Silbergleit R, Fiskum G, Rosenthal RE, Neuroprotective effects of hyperbaric oxygen treatment in experimental focal cerebral ischemia are associated with reduced brain leukocyte myeloperoxidase activity, Brain Research, 971(1), 90-4, May 2003
  • Scott PA, Silbergleit R, Frederiksen SM, Smith RW, Long Term Mortality in Stroke Patients Treated with TPA: Emergency Physicians vs NINDS Physicians, Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine, 10(5), 433, May 2003
  • Silbergleit R, Frederiksen SM, Smith RW, Scott PA, Higher Diagnostic Imaging Use in tPA-treated Stroke Patients in University Hospital Compared to Matched Community Teaching Hospital, Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine, 10(5), 574, May 2003
  • Silbergleit R, Burney RE, Nelson K, Snyder M, Lowell MJ, Maio RF (Apr-Jun 2003) Long-term air medical services system performance using APACHE-II and mortality benchmarking, Prehospital Emergency Care : Official Journal of the National Association of Ems Physicians and the National Association of State Ems Directors., 7 (2), 195-8
  • Silbergleit R, Shift work and physician performance, Annals of Emergency Medicine, 39(3), 349-51, Mar 2002
  • Marco CA, Larkin GL, Silbergleit R, SAEM Ethics Committee (Mar 2002) Filming of patients in academic emergency departments, Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine., 9 (3), 248-51
  • Lee DC, Chu J, Satz W, Silbergleit R, Low plasma thiamine levels in elder patients admitted through the emergency department, Academic Emergency Medicine, 7(10), 1156-9, October 2000
  • Cunningham R, Silbergleit R, Viral myocarditis presenting with seizure and electrocardiographic findings of acute myocardial infarction in a 14-month-old child, Annals of Emergency Medicine, 35(6), 618-22, June 2000
  • Silbergleit R, Jancis MO, McNamara RM, Management of sickle cell pain crisis in the emergency department at teaching hospitals, Journal of Emergency Medicine, 17(4), 625-30, 1999
  • Silbergleit R, Haywood Y, Fiskum G, Rosenthal RE, Lack of a neuroprotective effect from N-acetylcysteine after cardiac arrest and resuscitation in a canine model, Resuscitation, 40(3), 181-6, 1999
  • Silbergleit R, Silbergleit A, Silbergleit R, Kota RK, Benign pneumoperitoneum associated with pneumomediastinum and pneumoretroperitoneum in ambulatory outpatients, Journal of Emergency Medicine, 17(1), 81-5, 1999
  • Silbergleit R, Walls RM, The trauma airway: Whose responsibility?, Anesthesia and Analgesia, 86(5), 1146-7, May 1998
  • Silbergleit R, Satz W, Lee DC, McNamara RM, Hypothermia from realistic fluid resuscitation in a model of hemorrhagic shock, Annals of Emergency Medicine, 31(3), 339-43, March 1998
  • Silbergleit R, Satz W, McNamara RM, Lee DC, Schoffstall JM, A new model of uncontrolled hemorrhage that allows correlation of blood pressure and hemorrhage, Academic Emergency Medicine, 3(10), 917-21, October 1996
  • Silbergleit R, Satz W, McNamara RM, Lee DC, Schoffstall JM, Effect of permissive hypotension in continuous uncontrolled intra-abdominal hemorrhage, Academic Emergency Medicine, 3(10), 922-6, October 1996
  • Silbergleit R, Lee DC, Blank-Reid C, McNamara RM, Sudden severe barotrauma from self-inflating bag-valve devices, Journal of Trauma, 40(2), 320-2, February 1996
  • Silbergleit R, Blumstein H, Revascularization options: Implications for critical transport, Academic Emergency Medicine, 2(6), 568-9, June 1995
  • Silbergleit R, McNamara RM, Effect of gender on the emergency department evaluation of patients with chest pain, Academic Emergency Medicine, 2(2), 115-9, February 1995
  • Silbergleit R, Lee DC, Bowel obstruction and radiopaque vitamin B12 'pseudobezoar', American Journal of Emergency Medicine, 13(1), 112-3, January 1995
  • Silbergleit R, Silbergleit R, Schistosomal granuloma of the spinal cord: Evaluation with MR imaging and intraoperative sonography, AJR American Journal of Roentgenology, 158(6), 1351-3, June 1992
  • Silbergleit R, Dedrick DK, Pape J, Burney RE, Forces acting during air and ground transport on patients stabilized by standard immobilization techniques, Annals of Emergency Medicine, 20(8), 875-7, August 1991
  • Kenyon RV, Kerschmann R, Silbergleit R, Streptomycin in the chick embryo: Post-hatching vestibular behavior and morphology, Experimental Brain Research, 69(2), 260-71, 1988

Profile Details

Last Updated: 7/12/2009

COS Expertise ID #420689
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