Elaine M. Smith

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University of Iowa
College of Public Health
Epidemiology
ProfessorAppointed: 2000
University of Iowa
Carver College of Medicine
Obstetrics and Gynecology
ProfessorAppointed: 1999
University of Iowa
Carver College of Medicine
Cancer Center, Holden Comprehensive
Virology Program and Epidemiology Program
MemberAppointed: 1996

Mailing Address

C21-C General Hospital
University of Iowa
Iowa City, Iowa 52242
United States

Contact Information

Phone: (319) 384-5014
Fax: (319) 384-5004
elaine-smith@uiowa.edu
http://www.public-health.uiowa.edu/faculty-staff/faculty/directory/faculty-detail.asp?emailAddress=elaine-smith@uiowa.edu

Qualifications

M.B.A., University of Iowa, Business Administration, 1988.
Ph.D., University at Buffalo, Epidemiology, 1977.
M.P.H., University of Michigan, Epidemiology, 1971.
B.A., Ohio State University, Hygiene Certification-Pre Dentistry, 1968.

Expertise and Research Interests

My research interests include:
  • etiology of oncogenic diseases, focused on molecular epidemiology

  • HPV effects on the development of genital and other cancers; hormones and risk of HPV detection and replication; HPV and perinatal vertical transmission, head and neck cancers and

  • Reproductive diseases: HPV and vestibulitis; prostate cancer risk associated with pesticides and sex steroid hormone alterations.

Other Expertise

I have served as a co-author of the following book.

Anderson B, Smith E. Epidemiology of breast cancer. In Mitchell GW, Bassett LW, eds. The female breast and its disorders. Williams & Wilking, Baltimore, 1990

I have served as author or co-author of the following chapters.
  • Dental Health Education. Region II, DHEW, 1973.
  • Smith EM. "Social Epidemiology," "Morbidity & Mortality Indices," "Hypotheses Testing & Causality," in Epidemiology Programmed Text (medical students, S.U.N.Y.-Buffao), 1976.
  • Smith EM. "Epidemiology of oral and pharyngeal cancers," in Correa P, ed., Epidemiology of Cancer of the Digestive Organs. Nijhoff Pub., The Hague, 1981.
  • Anderson B and Smith E. "Epidemiology of Breast Cancer," in The Female Breast and Its Disorders, edited by GW Mitchel and LW Bassett, Williams and Wilkings, Baltimore, 1990.
  • Dennis LK, Lynch CF and Smith EM. "Cancer" in Maxcy-Rosenau-Last Public Health & Preventive Medicine, Fifteenth Editiion (Wallace RB Editor), McGraw-Hill Companies, Inc., pp 1047-69, 2007.

Keywords

COS Keywords:

Epidemiology, Oncology, Preventive Medicine.

Memberships

American Association for the Advancement of Science
American College of Epidemiology
American Public Health Association
American Society of Preventive Oncology
International Society of Preventive Oncology
Sigma Xi
Society for Epidemiologic Research

Honors and Awards

1994-1997, Shannon Award, National Institutes of Health
1987, DAAD (German scholarship) in Epidemiology,
1977-1979, Postdoctoral National Research Servie Award, National Institutes of Health, University of Washington
1973-1977, Fellowships, New York State
1970-1972, Special Purpose Traineeship, United States Public Health Service, University of Michigan

Previous Positions

1998-1999, Professor, University of Iowa, Preventive Medicine and Community Dentistry
1986-1994, Collaborative Researcher, German Cancer Research Center, Heidelberg, HPV & Cervical Cancer
1985-1997, Associate Professor, University of Iowa, Preventive Medicine and Community Dentistry
1979-1985, Epidemiologist, Iowa SEER
1979-1985, Assistant Professor, University of Iowa, Epidemiology and Community Dentistry
1977-1979, Postdoctoral Fellow, University of Washington, School of Public Health and Community Medicine, Epidemiology

Funding Received

  • National Institutes of Health (NIH): Principal Investigator, Genetic Epidemiology and Mechanisms in Oral Cancer, $2,419,805, Sep 24, 1999 to Aug 31, 2004.
  • NIH/NIDCR/NCI: Principal Investigator, Seroepidemiology Study of HPV and Oral Cancer, $2,825,565, Sep 24, 1999 to Aug 31, 2003.
  • National Institutes of Health (NIH): Principal Investigator, Voice Disorders in Teachers and the General Population, $100,000, Sep 15, 1994 to Sep 14, 1997.
  • National Institutes of Health (NIH): Principal Investigator, HPV Transmission and Risk of Oral Cancer, $955,458, May 1, 1997 to Feb 28, 2002.
  • National Institutes of Health (NIH): Principal Investigator, HPV and Risk of Oral Cancer in the Czech Republic, $120,480, Jun 15, 2001 to May 31, 2004.
  • National Institutes of Health (NIH): Principal Investigator, Research Training in Clinical Trials, $463,636, Jul 1, 1997 to Jun 30, 2004.
  • National Institutes of Health (NIH): Principal Investigator, Voice Disorders in Teachers and the General Population, $788,819, Apr 1, 1997 to Mar 31, 2001.
  • NIH: Principal Investigator, International Collaborative HNC Research, $100,000, 2006 to 2008.
  • VAMC: Co-Investigator, Molecular Epidemiology of Head and Neck, 2005 to 2010.
  • NIH: Principal Investigator, Transcriptional and Genetic Profiles in HNSCCs, $618,800, 2004 to 2009.
  • NIH/NCI: Co-Investigator, Infectious etiology of chronic diseases: Novel approaches to pathogen detection, $1,434,538, 2002 to 2006.

Publications

  • Smith EM, Rubenstein LM, Ritchie JM, Lee JH, Haugen TH, Hamsikova E, Turek LP (Aug 2008) Does pretreatment seropositivity to human papillomavirus have prognostic significance for head and neck cancers?, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17 (8), 2087-96 Abstract
  • Beining RM, Dennis LK, Smith EM, Dokras A (2008) Meta-Analysis of Intrauterine Device Use and Risk of endometrial Cancer., Annals of epidemiology, 18 (6), 492-9 Abstract
  • Smith EM, Wang D, Rubenstein LM, Morris WA, Turek LP, Haugen TH (Feb 2008) Association between p53 and Human Papillomavirus in Head and Neck Cancer Survival., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17 (2), 421-7 Abstract
  • Smith EM, Wang D, Kim Y, Rubenstein LM, Lee JH, Haugen TH, Turek LP (Feb 2008) P16INK4a expression, human papillomavirus, and survival in head and neck cancer., Oral oncology, 44 (2), 133-42 Abstract
  • Smith EM, Ritchie JM, Lee JH, Ludvikova V, Haugen TH, Turek LP, Hamsikova E (2008) Prognostic significance of human papillomavirus seropositiveity in cancers of the oral cavity and oropharynx, Int J Cancer, In Press
  • Smith EM, Swarnaval S, Ritchie JM, Wang D, Haugen TH, Turek LP (2007) Prevalence of Human Papillomavirus in the Oral Cavity/Oropharynx in a Large Population of Children and Adolescents, Pediatr Infect Dis J, 26 (9), 836-40
  • Smith EM, Ritchie JM, Pawlita M, Rubenstein LM, Haugen TH, Turek LP, Hamsikova E (2007) Human papillomavirus seropositivity and risks of head and neck cancer, Int J Cancer, 120 (4), 825-32
  • Pyeon D, Newton MA, Lambert PF, den Boon JA, Sengupta S, Marsit CJ, Woodworth CD, Connor JP, Haugen TH, Smith EM, Kelsey KT, Turek LP, Ahlquist P (2007) Differences in cell-cycle deregulation in human papillomavirus-positive and -negative head/neck and cervical cancers, Cancer Res, 67, 4605-19
  • Hashibe M, Brennan P, Benhamou S, Castellsague X, Chen C, Cuardo MP, Dal Maso L, Daudt AW, Fabianova E, Wünsch-Filho V, Franceschi S, Hayes RB, Herrero R, Koifman S, La Vecchia C, Lazarus P, Levi F, Mates D, Matos E, Menezes A, Muscat J, Eluf-Neto J, Olshan AW, Rudnai P, Schwartz SM, Smith E, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Wei Q, Winn DM, Zaridze D, Zatonski W, Zhang Z-F, Berthiller J, Boffetta P (2007) Muscat J; Eluf-Neto J; Olshan AW; Rudnai P; Schwartz SM; Smith E, epidemiology; Sturgis EM; Szeszenia-Dabrowska N; Talamini R; Wei Q; Winn DM; Zaridze D; Zatonski W; Zhang Z-F; Berthiller J; Boffetta P Alcohol drinking in never users of tobacco, cigarette, J Natl Cancer Inst, 99, 777-89
  • Parker TM, Smith EM, Ritchie JM, Haugen TH, Vonka V, Turek LP, Hamsikova E (2006) Head and neck cancer associated with herpes simplex virus 1 and 2 and other risk factors, J Oral Oncol, 42, 288-96
  • Roy N, Merrill RM, Smith EM (2005) Voice disorders in the general population: Prevalence, risk factors, and occupational impact, Laryngoscope, 115 (11), 1988-95
  • Einwalter LA, Ritchie JM, Ault KA, Smith EM (2005) Gonorrhea and chlamydia infection among women visiting family planning clinics: Racial variation in prevalence and predictors, Perspectives on Sexual & Reproductive Health, 37 (3), 135-40
  • Ritchie JM, Vial SL, Fuortes LJ, Robertson LW, Guo H, Reedy VE, Smith EM, Comparison of Proposed Frameworks for Grouping Polychlorinated Biphenyl Congener Data Applied to a Case–control Pilot Study of Prostate Cancer, Environmental Research, 98(1), 104-113, May 2005
  • Tachezy R, Klozar J, Salakova M, Smith E, Turek L, Betka J, Kodet R, Hamsikova E, HPV and Other Risk Factors of Oral Cavity/oropharyngeal Cancer in The Czech Republic., Oral Diseases, 11(3), 181-5, May 2005 Abstract
  • Wang D, Ritchie JM, Smith EM, Zhang Z, Turek LP, Haugen TH, Alcohol Dehydrogenase 3 (ADH3) and Risk of Squamous Cell Carcinomas of the Head and Neck (HNSCC), Cancer Epidemiol Biomark Prev, 14(3), 626-32, Mar 2005
  • Smith EM, Haugen TH, Turek LP, Human papillomavirus in oral exfoliated cells and risk of head and neck cancer – Response [Letter], Journal of the National Cancer Institute, 96(15), 1182-3, 3 Aug 2004
  • Smith EM, Ritchie JM, Summersgill KF, Hoffman HT, Wang DH, Haugen TH, Turek LP, Human papillomavirus in oral exfoliated cells and risk of head and neck cancer, Journal of the National Cancer Institute, 96(6), 449-455, 17 Mar 2004
  • Klussmann JP, Dinh S, Guntinas-Lichius O, Wittekindt C, Weissenborn S, Wieland U, Dienes HP, Hoffmann T, Smith E, Turek L, Speel EJ, Pfister HJ, [HPV-associated tonsillar cancer. An update], Hno, 52(3), 208-18, 2004 Abstract
  • Smith EM, Ritchie JM, Summersgill KF, Klussmann JP, Lee JH, Wang DH, Haugen TH, Turek LP, Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers, International Journal of Cancer, 108(5), 766-72, 22 Feb 2004
  • Smith EM, Ritchie JM, Yankowitz J, Swarnavel S, Wang DH, Haugen TH, Turek LP, Human papillomavirus prevalence and types in newborns and parents – concordance and models of transmission, Sexually Transmitted Diseases, 31(1), 57-62, January 2004
  • Thibault SL, Merrill RM, Roy N, Gray SD, Smith EM, Occupational risk factors associated with voice disorders among teachers, Ann Epidemiol, 14, 786-92, 2004
  • Smith EM, Johnson SR, Ritchie RM, Wang DH, Turek LP, Haugen TH, Persistent HPV infection in postmenopausal age women. Int J Obstet Gynec, Int J Obstet Gynec, 87, 131-7, 2004
  • Smith EM, Ritchie J, Yankowitz J, Wang D, Turek LP, Haugen TH (2004) HPV prevalence and concordance in the cervix and oral cavity of pregnant women, Infec Dis Obstet Gynecol, 12, 45-56
  • Ritchie JM, Vial SL, Fuortes LJ, Guo H, Reedy VE, Smith EM, Organochlorines and risk of prostate cancer, Journal of Occupational and Environmental Medicine / American College of Occupational and Environmental Medicine., 45(7), 692-702, July 2003 Abstract
  • Levy BT, Ritchie JM, Smith E, Gray T, Zhang W, Physician specialty is significantly associated with hormone replacement therapy use, Obstetrics and Gynecology, 101(1), 114-22, January 2003 Abstract
  • Ritchie JM, Smith EM, Summersgill KF, Hoffman HT, Wang D, Klussmann JP, Turek LP, Haugen TH, Human Papillomavirus Infection as a Prognostic Factor in Carcinomas of the Oral Cavity and Oropharynx, International Journal of Cancer, 104, 336-44, 2003
  • Smith EM, Levy B, Ritchie J, Zhang W, Wang D, Haugen TH, Turek LP, Use of hormone replacement therapy and detection of human papillomavirus in postmenopausal women, Cancer Prev Detec, 2003
  • Smith EM, Ritchie JM, Levy BT, Zhang W, Wang DH, Haugen TH, Turek LP, Prevalence and persistence of human papillomavirus in postmenopausal age women, Cancer Detection and Prevention, 27(6), 472-80, 2003
  • Smith EM, Levy BT, Ritchie JM, Jia J, Wang D, Haugen TH, Turek LP, Is use of hormone replacement therapy associated with increased detection of human papillomavirus and potential risk of HPV-related genital cancers?, European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ecp)., 11(3), 295-305, June 2002 Abstract
  • Ritchie JM, Smith EM, Summersgill KF, Hoffman HT, Turek LP, Haugen TH, Human papillomavirus in oral cancers: Association with survival, International Journal of Cancer, 2002
  • Smith EM, Ritchie JM, Jian J, Pugh EE, Galask R, Ricks-McGillan J, Risk of vulvar vestibulitis associated with genitourinary infections, Infectious Diseases in Obstetrics and Gynecology, 10, 2002
  • Hilger TM, Smith EM, Ault K, Predictors of Chlamydia trachomatis infection among women attending rural Midwest family planning clinics, Infectious Diseases in Obstetrics and Gynecology, 9(1), 3-8, 2001 Abstract
  • Summersgill KF, Smith EM, Levy BT, Allen JM, Haugen TH, Turek LP, Human papillomavirus in the oral cavities of children and adolescents, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, 91(1), 62-9, Jan 2001 Abstract
  • Smith EM, Summersgill KF, Allen J, Hoffman HT, McCulloch T, Turek LP, Haugen TH, Human papillomavirus and risk of laryngeal cancer, The Annals of Otology, Rhinology, and Laryngology, 109(11), 1069-76, November 2000 Abstract
  • Summersgill KF, Smith EM, Kirchner HL, Haugen TH, Turek LP, p53 polymorphism, human papillomavirus infection in the oral cavity, and oral cancer, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, 90(3), 334-9, September 2000 Abstract
  • Smith EM, Hoffman HT, Summersgill KS, Kirchner HL, Turek LP, Haugen TH, Human papillomavirus and risk of oral cancer, Laryngoscope, 108(7), 1098-103, July 1998 Abstract
  • Funk GF, Hoffman HT, Karnell LH, Ricks JM, Zimmerman MB, Corbae DP, Hussey DH, McCulloch TM, Graham SM, Dawson CJ, Means ME, Colwill ML, Titler MG, Smith EM, Cost-identification analysis in oral cavity cancer management, Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-head and Neck Surgery., 118(2), 211-20, February 1998 Abstract
  • Sethi S, Muller M, Schneider A, Bletter M, Smith E, Turek L, Wahrendorf J, Gissmann L, Claude-Dhang J, Serological response to HPV 16 synthetic peptides in pregnant women, American Journal of Obstetrics and Gynecology, 178, 360-364, 1998
  • Smith EM, Kirchner HL, Taylor M, Lemke J, Hoffman H, Voice problems among teachers: Differences by gender and teaching characteristics, Journal of Voice, 12, 328-334, 1998
  • Smith EM, Lemke J, Taylor M, Kirchner HL, Hoffman H, Frequency of vocie problems among teachers and other occupations, Journal of Voice, 12, 480-488, 1998
  • Smith EM, Taylor M, Mendoza M, Lemke J, Hoffman H, Functional impact of nodules: A case-comparison study, Journal of Voice, 12, 551-558, 1998
  • Smith EM, Taylor MH, Mendoza M, Barkmeier J, Lemke J, Hoffman HH, Spasmodic dysphonia and vocal fold paralysis: Outcomes on work-related functioning, Journal of Voice, 12, 223-232, 1998
  • Smith EM, Johnson SR, Figuerres EJ, Mendoza M, Fedderson D, Haugen TH, Turek LP, The frequency of human papillomavirus detection in postmenopausal women on hormone replacement therapy, Gynecologic Oncology, 65(3), 441-6, June 1997 Abstract
  • Fuortes L, Clark MK, Kirchner HL, Smith EM, Association between female infertility and agricultural work history., American Journal of Industrial Medicine, 31(4), 445-51, 1997 Abstract
  • Tomblin JB, Records NL, Buckwalter P, Zhang X, Smith EM, O'Brien M, The prevalence of specific language impairment in kindergarten children, JSHR, 40, 1245-1260, 1997
  • Tomblin JB, Smith EM, X Zhang, O'Brien M, Risk factors for specific language impairment, Journal of Comm, 30, 325-44, 1997
  • Smith EM, Gray SK, Dove H, Kirchner HL, Heras H, Frequency and effects of teachers' voice problems, Journal of Voice, 11, 81-87, 1997
  • Smith EM, Hammonds-Ehlers M, Clark MK, Kirchner HL, Fuortes L, Occupational exposures and risk of female infertility, Journal of Occupational and Environmental Medicine, 39(2), 138-47, 1997 Abstract
  • Turek LP, Smith EM, The genetic program of genital human papillomaviruses in infection and cancer, Obstetrics and Gynecology Clinics of North America, 23(4), 735-58, December 1996 Abstract
  • Claude-Chang J, Schneider A, Smith E, Blettner M, Wahrendorf J, Turek L, Longitudinal study of the effects of pregnancy and other factors on detection of HPV, Journal of Gynecol Oncol, 60, 355-362, 1996
  • Smith E, Verdolini K, Gray S, et al, Effect of voice disorders on quality of life, Journal of Medical Speech-Language Pathology, 4, 223-244, 1996
  • Smith EM, Johnson SR, Cripe T, Perlman S, McGuinness G, Jiang D, Cripe L, Turek LP, Perinatal transmission and maternal risks of human papillomavirus infection, Cancer Detection and Prevention, 19(2), 196-205, 1995 Abstract
  • Smith EM, Pignatari SS, Gray SD, Haugen TH, Turek LP, Human papillomavirus infection in papillomas and nondiseased respiratory sites of patients with recurrent respiratory papillomatosis using the polymerase chain reaction, Archives of Otolaryngology -- Head and Neck Surgery, 119(5), 554-7, May 1993 Abstract
  • Pignatari SSN, Smith EM, Gray SD, Turek LP, Detection of HPV infection in diseased and nondiseased sites of the respiratory tract in recurrent respiratory papillomatosis patients by DNA hybridization, Annals of Otology, Rhinology, & Laryngology, 101, 408-412, 1992
  • Smith EM, Johnson SR, Cripe TP, Pignatari S, Turek L, Perinatal vertical transmission of human papillomavirus and subsequent development of respiratory tract papillomatosis, The Annals of Otology, Rhinology, and Laryngology, 100(6), 479-83, June 1991 Abstract
  • Smith EM, Johnson SR, Jiang D, Zaleski S, Lynch CF, Brundage S, Anderson RD, Turek LP, The association between pregnancy and human papilloma virus prevalence, Cancer Detection and Prevention, 15(5), 397-402, 1991 Abstract

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Last Updated: 9/12/2008

COS Expertise ID #323390
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