Dr. Michael H. Smolensky

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University of Texas Health Science Center at Houston
School of Public Health
Environmental Sciences
Professor/ConvenerAppointed: 1988
Herman Hospital
Clinical Chronobiology Center and Clinic
DirectorAppointed: 1991
University of Texas Health Science Center at Houston
Graduate School of Biomedical Sciences
FacultyAppointed: 1978

Mailing Address

University of Texas Health Science Center at Houston
School of Public Health
1200 Herman Pressler Drive, RAS W606
Houston, Texas 77030
United States

Contact Information

Phone: (713) 500-9237
Fax: (713) 500-9221
Michael.H.Smolensky@uth.tmc.edu

Qualifications

Ph.D., University of Illinois, Physiology, 1971.
M.S., University of Illinois, Physiology, 1966.
B.S., University of Illinois, Zoology, 1964.

Expertise and Research Interests

1. Biological Rhythms in Medicine and Public Health;
2. Chronopharmacology (Biological Rhythms and Effects on the Pharmacokinetics and Pharmacodynamics of Medications);
3. Circadian Rhythms of Asthma & Allergy and Treatment;
4. Circadian Rhythms of Blood Pressure/Hypertension and Treatment;
5. Chronotherapeutics (Timing Medications to Biological Rhythms to Optimize Therapeutic Effects and Minimize Side Effects;and
6. Environmental Physiology; Occupational Health (Shiftwork & Industrial Accidents; Safety and Job Performance).

Other Expertise

Consultant:
The Food and Drug Administration, Cardiorenal Division (Since 1994);
Texas Allergy Research Foundation (1972-1992);
United States Navy, San Diego, with Dr. Paul Naitoh (Environmental Physiology). Issues Relating to (1) Shift Work and Performance, and Health Effects of Unusual Work Environments; and
Astronaut Cicadian Shifting Committee, NASA-JSC, (1991-1994).

Editoral Appointments:
Senior-Editor-in-Chief and Co-founder: Chronobiology International (Marcel Dekker, Inc);
Co-Editor-in-Chief Annual Review of Chronopharmacology (Pergamon Press), 1984-1990.

Keywords

COS Keywords:

Allergy, Environmental Health, Human Physiology, Social Sciences.

Additional Terms:

Allergy, Chronopathology-Biological Rhythms in Disease, Chronopharmacology-Biological Rhythms & Medicines, Chronotherapeutics-Timing Medicines to Rhythms in Disease, Chronotoxicology-Rhythms in Vulnerability to Toxins, Environmental Physiology-Air Pollution Health Effects, Human Chronobiology, Human Physiology, Human Reproduction/Woman's Health Issues, Medical Chronobiology/Chronomedicine, Nocturnal Asthma & Circadian Rhythms, Shiftwork Tolerance/intolerance.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Spanish: (Functional, Basic, Basic)
French: (Functional, None, None)

Memberships

Board Member, International Society of Chronobiology, 1991-present
Founding Member; Broad of Directors: Society for Menstrual Cycle Research
Member: Total Allergy Symptom Control (TASC) Force, Aventis Pharmaceutical Company/American College
Vice-President, American Association of Medical Chronobiology & Chronotherapeutics, 1998-2002.

Previous Positions

1980-1988, Faculty, University of Texas Health Science Center at Houston, School of Allied Health Sciences, Program in Respiratory Therapy
1974-1988, Associate Professor, University of Texas Health Science Center at Houston, School of Public Health, Environmental Sciences
1971-1974, Assistant Professor, University of Texas Health Science Center at Houston, School of Public Health, Environmental Sciences

Funding Received

  • National Aeronautics and Space Administration (NASA): Effects of Circadian Rhythm on Decompression Outcome, $297,969, 1998 to 2001.

Publications

  • Noel HC, Saunders E, Smolensky MH, Hypertension, chronotherapy, and patient management, Nurse Practitioner, 25(3 Suppl), 2-10, March 2000 Abstract
  • Parks DK, Yetman RJ, McNeese MC, Burau K, Smolensky MH, Day-night pattern in accidental exposures to blood-borne pathogens among medical students and residents, Chronobiology International, 17(1), 61-70, Jan 2000 Abstract
  • Smolensky MH, Martin RJ, Nocturnal asthma: role of circadian rhythms in its mechanisms and therapy [editorial], Chronobiology International, 16(5), vii-ix, September 1999 Abstract
  • Haus E, Smolensky MH, Biologic rhythms in the immune system, Chronobiology International, 16(5), 581-622, September 1999 Abstract
  • D'Alonzo GE, Crocetti JG, Smolensky MH, Circadian rhythms in the pharmacokinetics and clinical effects of beta-agonist, theophylline, and anticholinergic medications in the treatment of nocturnal asthma, Chronobiology International, 16(5), 663-82, September 1999 Abstract
  • Smolensky MH, Reinberg AE, Martin RJ, Haus E, Clinical chronobiology and chronotherapeutics with applications to asthma, Chronobiology International, 16(5), 539-63, September 1999 Abstract
  • Smolensky MH, Portaluppi F, Chronopharmacology and chronotherapy of cardiovascular medications: relevance to prevention and treatment of coronary heart disease, American Heart Journal, 137(4 Pt 2), S14-S24, April 1999 Abstract
  • Smolensky MH, Knowledge and attitudes of American physicians and public about medical chronobiology and chronotherapeutics. Findings of two 1996 Gallup surveys, Chronobiology International, 15(4), 377-94, July 1998 Abstract
  • Smolensky MH, Portaluppi F, Ambulatory blood pressure monitoring. Application to clinical medicine and antihypertension medication trials, Annals of the New York Academy of Sciences, 783, 278-94, August 1996 Abstract
  • Smolensky MH, Chronobiology and chronotherapeutics. Applications to cardiovascular medicine, American Journal of Hypertension, 9(4 Pt 3), 11S-21S, April 1996 Abstract
  • Black HR, Smolensky MH, Johnstone MT, White WB, The emerging role of chronotherapeutics in managing hypertension. Panel discussion, American Journal of Hypertension, 9(4 Pt 3), 34S-39S, April 1996 Abstract
  • Jaffe M P, Smolensky M H, Wun C C, Sleep quality and physical and social well-being in North American petrochemical shift workers., Southern Medical Journal, 89(3), 305-12, March 1996 Abstract
  • Smolensky MH, Reinberg A, Labrecque G, Twenty-four hour pattern in symptom intensity of viral and allergic rhinitis: treatment implications, Journal of Allergy and Clinical Immunology, 95(5 Pt 2), 1084-96, May 1995 Abstract
  • Langlois PH, Smolensky MH, Glezen WP, Keitel WA, Diurnal variation in responses to influenza vaccine, Chronobiology International, 12(1), 28-36, February 1995 Abstract
  • D'Alonzo GE, Smolensky MH, Feldman S, Gnosspelius Y, Karlsson K, Bambuterol in the treatment of asthma. A placebo-controlled comparison of once-daily morning vs evening administration [see comments], Chest, 107(2), 406-12, February 1995 Abstract
  • Reinberg AE, Bicakova-Rocher A, Gorceix A, Ashkenazi IE, Smolensky MH, Placebo effect on the circadian rhythm period tau of temperature and hand-grip strength rhythms: interindividual and gender-related difference, Chronobiology International, 11(1), 45-53, February 1994 Abstract
  • Smolensky MH, D'Alonzo GE, Medical chronobiology: concepts and applications, American Review of Respiratory Disease, 147(6 Pt 2), S2-19, June 1993 Abstract
  • Brown AC, Smolensky MH, D'Alonzo GE, Day-night variation of airways status in sympathomimetic- and theophylline-treated asthma patients [see comments], Journal of the American Osteopathic Association, 93(3), 321-4 327-9 332-3, March 1993 Abstract
  • Smolensky MH, [Day-night pattern of bronchial width and dyspnea: basis for selection of optimal dosage schedules for theophylline], Pneumologie, 45 Suppl 4, 819-26, November 1991 Abstract
  • D'Alonzo GE, Smolensky MH, Feldman S, Gianotti LA, Emerson MB, Staudinger HW, Sauter R, Steinijans VW, [24-hour lung function in asthmatic patients: chrono-optimal theophylline therapy as once-daily Euphylong administration vs conventional twice-daily administration], Pneumologie, 45 Suppl 4, 834-41, November 1991 Abstract
  • D'Alonzo GE, Smolensky MH, PEF flow meter plays important role in asthma therapy [editorial], Journal of the American Osteopathic Association, 91(9), 858 860, September 1991 Abstract
  • Smolensky MH, D'Alonzo GE, Rheinberg A, [Chronotherapy of asthma], Internist, 32(7), 411-7, July 1991 Abstract
  • White C, Smolensky MH, Sanders SW, Buchi KN, Moore JG, Day-night and individual differences in response to constant-rate ranitidine infusion, Chronobiology International, 8(1), 56-66, February 1991 Abstract
  • D'Alonzo GE, Smolensky MH, Chronophysiologic determinants of asthma, Annals of the New York Academy of Sciences, 618, 123-39, 1991 Abstract
  • Smolensky MH, D'Alonzo GE, Investigative protocols for chronotherapeutics. Basic requirements and illustrative case histories, Annals of the New York Academy of Sciences, 618, 465-83, 1991 Abstract
  • D'Alonzo GE, Smolensky MH, Feldman S, Gianotti LA, Emerson MB, Staudinger H, Steinijans VW, Twenty-four hour lung function in adult patients with asthma. Chronoptimized theophylline therapy once-daily dosing in the evening versus conventional twice-daily dosing, American Review of Respiratory Disease, 142(1), 84-90, July 1990 Abstract
  • Smolensky MH, Reinberg A, Clinical chronobiology: relevance and applications to the practice of occupational medicine, Occupational Medicine, 5(2), 239-72, 1990 Abstract
  • Novak RD, Smolensky MH, Seasonal and circadian trends in occupational injuries, Progress in Clinical and Biological Research, 341B, 355-62, 1990 Abstract
  • D'Alonzo GE, Smolensky MH, Nocturnal asthma, its pathogenesis and treatment, Progress in Clinical and Biological Research, 341A, 223-33, 1990 Abstract
  • Soulban G, Smolensky MH, Yonovitz A, Gentamicin-induced chronotoxicity: use of body temperature as a circadian marker rhythm, Chronobiology International, 7(5-6), 393-402, 1990 Abstract
  • Novak RD, Smolensky MH, Fairchild EJ, Reves RR, Shiftwork and industrial injuries at a chemical plant in southeast Texas, Chronobiology International, 7(2), 155-64, 1990 Abstract
  • Brown AC, Smolensky MH, D'Alonzo GE, Redman DP, Actigraphy: a means of assessing circadian patterns in human activity, Chronobiology International, 7(2), 125-33, 1990 Abstract
  • Albright DL, Voda AM, Smolensky MH, Hsi BP, Decker M, Seasonal characteristics of and age at menarche, Progress in Clinical and Biological Research, 341A, 709-20, 1990 Abstract
  • Albright DL, Voda AM, Smolensky MH, Hsi B, Decker M, Temporal patterns of hot flashes in natural and surgically-induced menopause, Progress in Clinical and Biological Research, 341A, 731-9, 1990 Abstract
  • White CA, Smolensky MH, Sanders S, Buchi K, Moore J, Circadian rhythm of gastric pH in patients with healed ulcer under placebo and constant-rate ranitidine infusions, Progress in Clinical and Biological Research, 341B, 203-8, 1990 Abstract
  • Gillooly PB, Smolensky MH, Albright DL, Hsi B, Thorne DR, Circadian variation in human performance evaluated by the Walter Reed performance assessment battery, Chronobiology International, 7(2), 143-53, 1990 Abstract
  • Albright DL, Voda AM, Smolensky MH, Hsi BP, Decker M, Seasonal characteristics of and age at menarche, Chronobiology International, 7(3), 251-8, 1990 Abstract
  • Meltzer AA, Smolensky MH, D'Alonzo GE, Harrist RB, Scott PH, An assessment of peak expiratory flow as a surrogate measurement of FEV1 in stable asthmatic children, Chest, 96(2), 329-33, August 1989 Abstract
  • Albright DL, Voda AM, Smolensky MH, Hsi B, Decker M, Circadian rhythms in hot flashes in natural and surgically-induced menopause, Chronobiology International, 6(3), 279-84, 1989 Abstract
  • Scott PH, Kramer WG, Smolensky MH, Harrist RB, Hiatt PW, Baenziger JC, Klank BJ, Eigen H, Day-night differences in steady-state theophylline pharmacokinetics in asthmatic children, Chronobiology International, 6(2), 163-71, 1989 Abstract
  • Smolensky MH, D'Alonzo GE, Biologic rhythms and medicine, American Journal of Medicine, 85(1B), 34-46, July 1988 Abstract
  • Reinberg A, Smolensky MH, Hallek M, Smith KD, Steinberger E, Annual variation in semen characteristics and plasma hormone levels in men undergoing vasectomy, Fertility and Sterility, 49(2), 309-15, February 1988 Abstract
  • Reinberg A, Smolensky MH, D'Alonzo GE, McGovern JP, Chronobiology and asthma. III. Timing corticotherapy to biological rhythms to optimize treatment goals, Journal of Asthma, 25(4), 219-48, 1988 Abstract
  • Smolensky MH, Chronobiology and epidemiology, Pathologie Biologie, 35(6), 991-1004, June 1987 Abstract
  • Smolensky MH, Scott PH, McGovern JP, Clinical relevance of theophylline chronokinetics for asthmatic children, Progress in Clinical and Biological Research, 227B, 259-70, 1987 Abstract
  • Smolensky MH, McGovern JP, Scott PH, Reinberg A, Chronobiology and asthma. II. Body-time-dependent differences in the kinetics and effects of bronchodilator medications, Journal of Asthma, 24(2), 91-134, 1987 Abstract
  • Smolensky MH, D'Alonzo GE, Kunkel G, Barnes PJ, Day-night patterns in bronchial patency and dyspnea: basis for once-daily and unequally divided twice-daily theophylline dosing schedules, Chronobiology International, 4(3), 303-17, 1987 Abstract
  • Smolensky MH, D'Alonzo GE, Kunkel G, Barnes PJ, Sustained-release theophylline and nocturnal asthma, once-daily and unequal dosing schedules, Chronobiology International, 4(3), 459-66, 1987 Abstract
  • Randem B, Smolensky MH, Hsi B, Albright D, Burge S, Field survey of circadian rhythm in PEF of electronics workers suffering from colophony-induced asthma, Chronobiology International, 4(2), 263-71, 1987 Abstract
  • Frankoff HM, Smolensky MH, D'Alonzo GE, Gianotti L, Hsi B, McGovern JP, Comparison of sustained-release theophylline scheduled conventionally (twice-daily, equal interval in equal amount) versus once-daily mornings or evenings on circadian pattern of bronchial patency in, Chronobiology International, 4(3), 421-33, 1987 Abstract
  • Smolensky MH, Scott PH, Harrist RB, Hiatt PH, Wong TK, Baenziger JC, Klank BJ, Marbella A, Meltzer A, Administration-time-dependency of the pharmacokinetic behavior and therapeutic effect of a once-a-day theophylline in asthmatic children, Chronobiology International, 4(3), 435-47, 1987 Abstract
  • Reinberg A, Pauchet F, Ruff F, Gervais A, Smolensky MH, Levi F, Gervais P, Chaouat D, Abella ML, Zidani R, Comparison of once-daily evening versus morning sustained-release theophylline dosing for nocturnal asthma, Chronobiology International, 4(3), 409-19, 1987 Abstract
  • Smolensky MH, Scott PH, Kramer WG, Clinical significance of day-night differences in serum theophylline concentration with special reference to Theo-Dur, Journal of Allergy and Clinical Immunology, 78(4 Pt 2), 716-22, October 1986 Abstract
  • Smolensky MH, Barnes PJ, Reinberg A, McGovern JP, Chronobiology and asthma. I. Day-night differences in bronchial patency and dyspnea and circadian rhythm dependencies, Journal of Asthma, 23(6), 321-43, 1986 Abstract
  • Smolensky MH, Jonkman JH, Scott PH, Circadian variation in theophylline 'trough' serum concentrations [letter], British Journal of Clinical Pharmacology, 20(6), 718-20, December 1985 Abstract
  • Smolensky MH, Reinberg A, Chronobiology and biometeorology, International Journal of Biometeorology, 29 Suppl 2, 149-64, 1985 Abstract
  • Langlois PH, Smolensky MH, Hsi BP, Weir FW, Temporal patterns of reported single-vehicle car and truck accidents in Texas, U.S.A. during 1980-1983, Chronobiology International, 2(2), 131-40, 1985 Abstract
  • Flannigan SA, Smolensky MH, Harrist R, Brown RL, Menon VK, McGovern JP, Scapular reactivity to contact irritants: application-time and area variations, Chronobiologia, 11(2), 93-107, 1984 Abstract
  • Scott PH, Kramer WG, Smolensky MH, Harrist R, Circadian rhythms in theophylline pharmacokinetics and pharmacodynamics in asthmatic children, British Journal of Clinical Practice. Symposium Supplement, 35, 57-63, 1984 Abstract
  • Flannigan SA, Smolensky MH, Harrist R, Machinski G, McGovern JP, Time considerations in scoring contact irritant patch test sites, Contact Dermatitis, 9(6), 519-20, November 1983 Abstract
  • D'Eramo JE, DuPont HL, Preston GA, Smolensky MH, Roht LH, The short- and long-term effects of a handbook on antimicrobial prescribing patterns of hospital physicians, Infection Control, 4(4), 209-14, 1983 Abstract
  • Tjoa WS, Smolensky MH, Hsi BP, Steinberger E, Smith KD, Circannual rhythm in human sperm count revealed by serially independent sampling, Fertility and Sterility, 38(4), 454-9, October 1982 Abstract
  • Reinberg A, Smolensky MH, Circadian changes of drug disposition in man, Clinical Pharmacokinetics, 7(5), 401-20, 1982 Abstract
  • Smolensky MH, Lee E, Mott D, Colligan M, A health profile of American flight attendants (FA), Journal of Human Ergology, 11 Suppl, 103-19, 1982 Abstract
  • Smolensky MH, Reinberg A, Queng JT, The chronobiology and chronopharmacology of allergy, Annals of Allergy, 47(4), 234-52, October 1981 Abstract
  • Smolensky MH, Reinberg A, Bicakova-Rocher A, Sanford J, Chronoepidemiological search for circannual changes in the sexual activity of human males, Chronobiologia, 8(3), 217-30, 1981 Abstract
  • Snyder NK, Smolensky MH, Hsi BP, Circadian variation in the susceptibility of male Balb/C mice to ifosfamide, Chronobiologia, 8(1), 33-44, 1981 Abstract
  • Gombeski WR Jr, Smolensky MH, Non-emergency health transportation needs of the rural Texas elderly, Gerontologist, 20(4), 452-6, August 1980 Abstract
  • Emery JC, Furry DE, Sacks EJ, Kapadia AS, Smolensky MH, Medical barofunction testing of aviators with otorhinolaryngologic disease, Aviation Space and Environmental Medicine, 50(10), 1062-6, October 1979 Abstract
  • Cech I, Smolensky MH, Gonzales EA, Excessive sodium in drinking water [editorial], Southern Medical Journal, 72(6), 639-41, June 1979 Abstract
  • Gonzales EA, Cech I, Smolensky MH, Sodium in drinking water: information for clinical application, Southern Medical Journal, 72(6), 753-5, June 1979 Abstract
  • Cech I, Youngs K, Smolensky MH, Sargent F, Day-to-day and seasonal fluctuations of urban mortality in Houston, Texas, International Journal of Biometeorology, 23(2), 77-87, June 1979 Abstract
  • Cech I, Smolensky MH, Lane R, Nagata H, Takahashi Y, Morimoto T, Day-to-day and seasonal fluctuations of urban mortality in Kyoto, Japan, International Journal of Biometeorology, 23(2), 89-105, June 1979 Abstract
  • Bafitis H, Smolensky MH, Hsi BP, Mahoney S, Schectman T, Kresse H, Powel S, Dutton L, A circadian susceptibility/resistance rhythm for potassium cyanide in male BALB/cCr mice, Toxicology, 11(3), 251-258, November 1978 Abstract
  • Hartung GH, Smolensky MH, Harrist RB, Rangel R, Skrovan C, Effects of varied durations of training on improvement in cardiorespiratory endurance, Journal of Human Ergology, 6(1), 61-8, September 1977 Abstract
  • Smolensky MH, Bergman SA Jr, Bernard CN, Beck W, Kraft IA, Functional independence of donor and recipient cardiac tissues of single and double heart transplant patients revealed by chronobiology, European Journal of Cardiology, 5(2), 119-37, March 1977 Abstract
  • Smolensky MH, Reinberg A, The chronotherapy of corticosteroids: practical application of chronobiologic findings to nursing, Nursing Clinics of North America, 11(4), 609-19, December 1976 Abstract
  • Smolensky MH, Tatar SE, Bergman SA, Losman JG, Barnard CN, Dacso CC, Kraft IA, Circadian rhythmic aspects of human cardiovascular function: a review by chronobiologic statistical methods, Chronobiologia, 3(4), 337-71, 1976 Abstract
  • McHugh RB, Smolensky MH, Halberg F, Biological rhythm experimentation: a longitudinal design and analysis, Chronobiologia, 2(1), 1-12, 1975 Abstract
  • Smolensky MH, Kraft IA, Sothern RB, Downs TD, Eifler CW, Mealy EA, Circadian rhythmicity in heart rate and duration of cardiac cycle (P-P interval) in donor and recipient cardiac tissue of heart homograft patients, Texas Reports On Biology and Medicine, 33(4), 533-48, 1975 Abstract
  • Reinberg A, Smolensky MH, Ghata J, Gervais A, Gervais P, [Chronobiological approach to monthly rhythms of healthy women, with spontaneous menses (author's transl)], Annales D Endocrinologie, 35(3), 309-10, 1974 Abstract
  • D'Alonzo, G.E., SMOLENSKY, M.H. (GE) Nocturnal asthma and its mechanisms. Internist 32(7):402-410, Jul 1991
  • Reinberg A, Smolensky MH, Circatrigintan secondary rhythms related to hormonal changes in the menstrual cycle: general considerations. pp. 241-58, Monograph
  • Smolensky MH, Reinberg A, Lee RE, McGovern JP, Secondary rhythms related to hormonal changes in the menstrual cycle: special reference to allergology. pp. 287-306, Monograph

Profile Details

Last Updated: 2/11/2003

COS Expertise ID #303902
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