Dr. Edward L. Snyder

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Yale University
School of Medicine
Laboratory Medicine
Blood Bank
Director
Yale University
School of Medicine
Laboratory Medicine
Professor

Mailing Address

Blood Bank, CB-459
Yale-New Haven Hospital
20 York Street
New Haven, Connecticut 06510-3202
United States

Contact Information

Phone: (203) 688-2441
Fax: (203) 688-2748
edward.snyder@yale.edu

Qualifications

Postdoctorate Fellowship, Montefiore Hospital, Hematology/Transfusion Medicine, 1976.
M.D., New York Medical College, 1973.
M.A., SUNY Binghamton, 1969.
B.A., Harpur College, 1967.

Expertise and Research Interests

Current research interests involve evaluation of the platelet storage lesion. This includes metabolic aspects, evaluation of the alterations that occur in the platelet cytoskeleton, platelet membrane, and mitochondria as involves platelet storage. In addition, we are investigating the role of generation of cytokines in blood components during storage. We have shown that interleukin-1, interleukin-6, interleukin-8, and TNF-a, are all generated during storage of platelet concentrates. The effect of leukocyte depletion on the generation of these cytokines in bacterially and non-bacterially contaminated blood components is also being studied. We are also interested in clinical apheresis and evaluation of clinical response of patients to pheresis interventions for a variety of immunologic disorders. Current research includes clinical trials involving pathogen reduction of the blood supply.

Other Expertise

I wish to be contacted by interested students (medical, graduate, or undergraduates) as a potential research mentor/thesis advisor. Anyone wishing to develop expertise in Transfusion Medicine, Transfusion Oncology, or Transfusion Immunobiology may contact my office to discuss.

Future Research

Future research will be in the area of pathogen inactivation, including FDA clinical trials for licensure of psoralen and inactine pathogen reduction technologies. We are also studying use of new apheresis technologies for patient clinical care of immune-mediated disorders. Other research involves the platelet storage lesion and platelet apoptosis.

Industrial Relevance

These research clinical trials relate to apheresis and filtration technologies and include corporate research for Baxter, Cerus, Pall, Terumo, and other Corporations.

Keywords

COS Keywords:

Cytoskeleton, Health and Medicine, Membranes, Metabolism.

Additional Terms:

Apheresis Technology, Pathogen Inactivation, Platelet Apoptosis, Platelet Storage Lesion.

Memberships

Alpha Omega Alpha
American Association of Blood Banks
American College of Physicians
American Society for Apheresis
American Society for Blood and Bone Marrow Transplantation
American Society of Hematology
ISCT - International Society for Cellular Therapy

Publications

  • Benjamin RJ, McCullough J, Mintz P, Snyder EL, et al., Therapeutic Efficacy and Safety of Red Blood Cells Treated With a Chemical Process (S-303) for Pathogen Inactivation: a Phase III Clinical Trial in Cadiac Surgery Patients, Transfusion, In Press, 2005
  • Snyder EL, McCullough J, Slichter SJ, et al., Clinical Safety of Platelets Photochemically Treated With Amotosalin HCl and Ultraviolet "A" Light for Pathogen Inactivation: Results of the SPRINT Trial., Transfusion, In Press, 2005
  • Fisk J, Snyder EL, Therpeutic Use of Blood Components, Conn's Current Therapy 2005, Philadelphia, PA, Elsevier, 2004
  • Snyder EL, Wu YY, Transfusion Therapy, Cancer: Principles and Practice of Oncology, 7th edition, New York, Lippincott-Raven, 2004
  • Paglino JC, Pomper GJ, Fisch GS, Champion MH, Snyder EL, Reduction of Febrile But Not Allergic Reactions to RBCs and Platelets After Converstion to Universal Prestorage Leukoreduction, Transfusion, 44, 16-24, 2004
  • Snyder EL, Raife T, Lin L, et al., Recovery and Life Span of 111-indium Radiolabeled Platelets Treated With Pathogen Inactivation With Amotosalen HCL (S-59) and UV Light, Transfusion, 44, 1732-1740, 2004
  • McCullough J, Vesole DH, Benjamin RJ, Slichter S, Pineda A, Snyder EL, et al., Therapeutic Efficacy and Safety of Platelets Treated With a Phtochemical Process for Pathogen Inactivation: the SPRINT Trial., Blood, 104, 1534-1541, 2004
  • Mechanic SA, Krause D, Proytcheva M, Snyder EL, Mobilization and Collection of Peripheral Blood Progenitor Cells, Apheresis: Principles and Practice, 2nd, Bethesda, MD, AABB Press, 503-543, 2003
  • Perrotta P, Snyder EL, Apoptotic Activity in Stored Human Platelets, Transfusion, 43, 526-535, 2003
  • Snyder EL, Rinder HR, Platelet Storage - Time to Come in From the Cold?, New England Journal of Medicine, 348, 2032-2033, 2003
  • Ringer HM, Snyder EL, Tracey J, Dincecco D, et al., Reversibility of Severe Metabolic Stress in Stored Platelets After in Vitro Plasma Rescue Or in Vivo Transfusion: Restoration of Secretory Function and Maintenance of Platelet Survival, Transfusion, 43, 1230-1237, 2003
  • Perrotta PL, Snyder EL, Blood Transfusion, Oxford Textbook of Medicine, 4th, Oxford University Press, 2002
  • Pomper GJ, Snyder EL, Platelet Transfusion and Alternatives, Principles of Transfusion Medicine, Lippincott, Williams & Wilkins, 2002
  • Snyder EL, et al., Ex vivo evaluation of PBMNC's collected with a new cell separator, Transfusion, 41, 940-9, 2001
  • Snyder EL, et al, In vitro collection and post transfusion engraftment of MNCs obtained using a new separator for autologous PBPC transplantation, Transfusion, 40, 961-7, 2000
  • Perrotta P, Feldman D, Snyder EL, Role of Biological Response Modifiers in Platelet Transfusion, Platelet Therapy: Current Status & Future Trends, Amsterdam, Elsevier Science, 2000
  • Perrotta PL, Baril L, Tead C, Chapman J, Dincecco D, Buchholz DH, Snyder EL, Effects of methylene blue-treated plasma on red cells and stored platelet concentrates., Transfusion, 39(1), 63-9, Jan 1999 Abstract
  • Menitove J E, Snyder E L, Platelet transfusion practice: time for renewed consensus, Transfusion, 38(8), 707-9, August 1998 Abstract
  • Geiger T L, Perrotta P L, Davenport R, Baril L, Snyder E L, Removal of anaphylatoxins C3a and C5a and chemokines interleukin 8 and RANTES by polyester white cell-reduction and plasma filters., Transfusion, 37(11-12), 1156-62, November 1997 Abstract
  • Snyder E L, Mechanic S, Baril L, Davenport R, Removal of soluble biologic response modifiers (complement and chemokines) by a bedside white cell-reduction filter., Transfusion, 36(8), 707-13, August 1996 Abstract
  • Blundell E L, Pamphilon D H, Fraser I D, Menitove J E, Greenwalt T J, Snyder E L, Repucci A J, Hedberg S L, Anderson J K, Buchholz D H, Kagen L R, Aster R H, A prospective, randomized study of the use of platelet concentrates irradiated with ultraviolet-B light in patients with hematologic malignancy., Transfusion, 36(4), 296-302, April 1996 Abstract

Profile Details

Last Updated: 9/7/2005

COS Expertise ID #397142
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