William Sloan Spielman

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Michigan State University
College of Human Medicine
Physiology
ChairAppointed: 1993

Mailing Address

2201 Biomedical Physical Sciences
Michigan State University
East Lansing, Michigan 48824
United States

Contact Information

Phone: (517) 353-4539
Fax: (517) 432-1967
spielman@msu.edu

Qualifications

Ph.D., University of Missouri-Columbia, Physiology, 1974.
B.A., Westminster College, Biology, 1969.

Expertise and Research Interests

My areas of research interest are as follows: signal transduction and g. protein coupled receptors; hormonal control of renal function biology of the renal cells.

Other Expertise

Academic Experience:
Editorial Board, International J. Purine and Pyrimidine research, 1989-present; Editorial Board, Advances in Physiology Education, American Physiological Society, 1988-1992; Chairperson, National Institutes of Health (NIH) Study Section, General Medicine B, 1988- 1992; Research Career Development Award, National Heart Lung and Blood; Institute (NHLBI), Metabolic Control of Renal Function, 1981-1986

Business Experience:
Director, Department of Renal Pharmacology; SmithKline Beecham Pharmaceuticals

Future Research

Future research plan involved receptor dimerization, RAMP molecules in signal transduction

Industrial Relevance

Identification of molecular targets for therapeutic pharmaceuticals.

Keywords

COS Keywords:

Biological Sciences, Cell Biology, Hormones, Human Physiology, Signal Transduction.

Additional Terms:

Adenosine, Adrenomedullin, GPCRs, RAMP, receptor biology.

Languages

(Reading, Writing, Speaking)

German: (Basic, Basic, Functional)

Memberships

American Federation for Medical Research
American Heart Association
American Heart Association of Michigan
American Physiological Society
American Society for Cell Biology
American Society of Nephrology
American Society of Renal Biochemistry and Metabolism
International Society of Nephrology
Midwest Salt and Water Club
National Kidney Foundation of Michigan, Inc.
Sigma Xi, The Scientific Research Society

Previous Positions

1992-1993, SmithKline Beecham Pharmaceuticals, Department of Pharmacology, Director
1990-1992, Michigan State University, Director of Graduate Studies
1988-1989, Pharmakologishes Institut der Universitat Heidelberg, Faculty of Medicine, Guest Professor
1982-1987, Michigan State University, Department of Physiology, Associate Professor

Publications

  • Bomberger, J.M., N. Parameswaran, C.S. Hall, N. Aiyar, W.S. Spielman, Novel Function for Receptor Activity Modifying Proteins (RAMPs) in Post-Endocytic Trafficking, Journal of Biological Chemistry, JBC Paper of week award, 280(10), 9297-307, 2005
  • Bomberger, J.M., W.S. Spielman, C.S. Hall, N. Parameswaran, RAMP Isoform-Specific Regulation of Adrenomedullin Receptor Trafficking By NHERF-1, Journal of Biological Chemistry, 280(25), 23926-35, 2005
  • Bomberger, J.M., N. Parameswaran, C.S. Hall, W.S. Spielman, Differential Regulation of Adrenomedullin Receptor Desensitization and Internalization By RAMPs, Journal of Biological Chemistry, in Revision, 2005
  • Parameswaran, N., W.S. Spielman, D.P. Brooks, P. Nambi, Okadaic Acid Induces Apoptosis and Stimulates Caspase-Like Activities in Rat Mesangial Cells, Molecular and Cellular Biochemistry, 260(1-2), 7-11, 2004
  • Parameswaran, N., C.S. Hall, J. Bomberger, H.V. Sparks, D.B. Jump, W.S. Spielman, Negative Growth Effects of Ciglitazone on Kidney Mesangial Cells and Interstitial Fibroblasts: Role of PPAR-G, Kidney Blood Press Res, 26(1), 2-9, 2003
  • Parameswaran, N., C.S. Hall, H.V. Sparks, L. McCabe, W.S. Spielman, Adrenomedullin Increases AP-1 Expression and Activity in Rat Mesangial Cells, Cellular Physiology and Biochemistry, 13(6), 367-74, 2003
  • Parameswaran, N., C.S. Hall, J. Bomberger, W.S. Spielman, Regulation of Adrenomedullin Signaling in Kidney Interstitial Fibroblasts, Cellular Physiology and Biochemistry, 13(6), 391-400, 2003
  • Parameswaran, N., C.S. Hall, B.C. Broeck, H.V. Sparks, K.A. Gallo, W.S. Spielman, Mixed Lineage Kinase 3 Inhibits Phorbol Myristoyl Acetate-Induced DNA Synthesis But Not Osteopontin Expression in Rat Mesangial Cells, Molecular Cellular Biochemistry, 241(1-2), 37-43, Dec 2002
  • Nowak, V., N. Parameswaran, C.S. Hall, N. Aiyar, H.V. Sparks, W.S. Spielman, A Novel Regulation of Adrenomedullin Receptor By Pdgf in Mesangial Cells- Role of Receptor Activity Modifying Protein-3, Am. J. of Physiol.:Cell Physiology, 282(6), C1322-31, Jun 2002
  • Parameswaran, N., C.S. Hall, B.C. Broeck, H.V. Sparks, K.A. Gallo, W.S. Spielman, Mixed Lineage Kinase 3 Inhibits Platelet-Derived Growth Factor-Stimulated DNA Synthesis and Matrix MRNA Expression in Mesangial Cells, Cellular Physiology and Biochemistry, 12(5-6), 325-34, 2002
  • Parameswaran, N., W. Nowak, C.S. Hall, H.V. Sparks, W.S. Spielman, Cellular and Molecular Mechanisms of Adrenomedullin Actions in Mesangial Cells., Peptides, 22(11), 1919-1924, Nov 2001
  • Hwang, K.K.,, C.S. Hall, W.S. Spielman, H.V. Sparks, Fk506 Promotes Adenosine Release From Endothelial Cells Via Inhibition of Adenosine Kinase, Eur. J. Pharmacol, 425(2), 85-93, Aug 2001
  • Filippatos, G.S., N. Gangopadhyay, O. Lalude, N. Parameswaran, S.I. Said, W.S. Spielman, B.D. Uhal, Regulation of Apoptosis By Vasoactive Peptides, Am. J. Physiol.:Lung Cell Mol. Physiol., 281, L749-L761, 2001
  • Parameswaran, N., P. Nambi, H. Wu, D.P. Brooks, N. Aiyar, W.S. Spielman, Desensitization and Resensitization of Adrenomedullin-Sensitive Receptor in Rat Mesangial Cells, Eur. J. of Pharmacol, 407(3), 205-210, Nov 2000
  • Parameswaran, N, P. Nambi, C.S. Hall, D.P. Brooks, W.S. Spielman, Adrenomedullin Decreases Extracellular Signal-regulated Kinase Activity Through An Increase in Protein Phosphatase-2a Activity in Mesangial Cells, Euro. J. Pharmacol, 388(2), 133-138, 2000
  • Spielman, W.S., N. Parameswaran, H.V. Sparks, D.W. Seldin, G. Giebisch, Adenosine: An Intrarenal Mediator of Renal Function, The Kidney: Physiology and Pathophysiology, 3rd, Submitted, 2000
  • Parameswaran, N., J. Disa, P. Nambi, D.P. Brooks, W.S. Spielman, N. Aiyar, Activation of Multiple Mitogen-Activated Protein Kinases By Recombinant Calcitonin Gene-Related Peptide Receptor, Euro. J. Pharmacol, 389, 125-130, 2000
  • Hwang, K.K., L.J. Scott, J. Chifamba, J. Mufunda, W.S. Spielman, H.V. Sparks, Microalbuminuria in Urban Zimbabwean Women, J. Hum. Hypertens, 14(9), 587-93, 2000
  • Parameswaran N, Nambi P, Brooks DP, Spielman WS, Regulation of glomerular mesangial cell proliferation in culture by adrenomedullin., European Journal of Pharmacology, 372(1), 85-95, 7 May 1999 Abstract
  • Parameswaran N, W.S. Spielman, Brooks DP, Nambi P, SB203580 Reverses Adrenomedullin''s Effect on Proliferation and Apoptosis in Cultured Mesangial Cells., European Journal of Pharmacology, 371(1), 77-86, 23 Apr 1999 Abstract
  • Parameswaran N, Spielman WS, Pullen M, Francis J, Brooks DP, Nambi P, Mechanism of adrenomedullin-stimulated hyaluronic acid release in rat mesangial cells., European Journal of Pharmacology, 370(3), 313-8, 16 Apr 1999 Abstract
  • Burnatowska-Hledin M A, Spielman W S, Smith W L, Shi P, Meyer J M, Dewitt D L, Expression cloning of an AVP-activated, calcium-mobilizing receptor from rabbit kidney medulla., American Journal of Physiology, 268(6 Pt 2), F1198-210, June 1995 Abstract
  • McCoy D E, Schwiebert E M, Karlson K H, Spielman W S, Stanton B A, Identification and function of A1 adenosine receptors in normal and cystic fibrosis human airway epithelial cells., American Journal of Physiology, 268(6 Pt 1), C1520-7, June 1995 Abstract
  • Bhattacharya S, Dewitt D L, Burnatowska-Hledin M, Smith W L, Spielman W S, Cloning of an adenosine A1 receptor-encoding gene from rabbit., Gene, 128(2), 285-8, 30 Jun 1993 Abstract
  • McCoy D E, Bhattacharya S, Olson B A, Levier D G, Arend L J, Spielman W S, The renal adenosine system: structure, function, and regulation., Seminars In Nephrology, 13(1), 31-40, January 1993 Abstract
  • LeVier D G, McCoy D E, Spielman W S, Functional localization of adenosine receptor-mediated pathways in the LLC-PK1 renal cell line., American Journal of Physiology, 263(4 Pt 1), C729-35, October 1992 Abstract
  • Spielman W S, Klotz K N, Arend L J, Olson B A, LeVier D G, Schwabe U, Characterization of adenosine A1 receptor in a cell line (28A) derived from rabbit collecting tubule., American Journal of Physiology, 263(2 Pt 1), C502-8, August 1992 Abstract
  • Schwiebert E M, Karlson K H, Friedman P A, Dietl P, Spielman W S, Stanton B A, Adenosine regulates a chloride channel via protein kinase C and a G protein in a rabbit cortical collecting duct cell line., Journal of Clinical Investigation, 89(3), 834-41, March 1992 Abstract
  • Spielman W S, Arend L J, Adenosine receptors and signaling in the kidney., Hypertension, 17(2), 117-30, February 1991 Abstract
  • Burnatowska-Hledin M A, Spielman W S, Effects of adenosine on cAMP production and cytosolic Ca2+ in cultured rabbit medullary thick limb cells., American Journal of Physiology, 260(1 Pt 1), C143-50, January 1991 Abstract
  • Burnatowska-Hledin M A, Spielman W S, Vasopressin V1 receptors on the principal cells of the rabbit cortical collecting tubule. Stimulation of cytosolic free calcium and inositol phosphate production via coupling to a pertussis toxin subs, Journal of Clinical Investigation, 83(1), 84-9, January 1989 Abstract
  • M.A. Burnatowska-Hledin and W.S. Spielman, Regulation of Hormonal Responses in Rabbit Medullary Thick Ascending Loop Cells by Adenosine. Am. J. Physiol. 260:C143-C150, 1991
  • W.S. Spielman and L.J. Arend. Adenosine Receptors and Signalling in the Kidney. Hypertension 17:117- 130, 1991
  • L.J. Arend, F. Gusovsky, J.H,. Daly, J.S. Handler, J.S. Rhim, and W.S. Spielman. Adenosine-Sensitive Phosphoinositide Turnover in a Newly Established Renal Cell Line. Am. J. Physiol.256:F1067-F1074, 1989
  • M.A. Burnatowska-Hledin, and W.S. Spielman Vasopressin V1 Receptors on the Principal Cells of the Rabbit Cortical Collecting Tubule: Stimulation of Cytosolic Free Calcium and Inositol Phosphate Production Via Coupling to a Pertussis Toxin Substrate. J. Clin. Invest. 83:84-89, 1989
  • M.L. Allen, A. Nakao, W.K. Sonnenberg, M.A. Burnatowska-Hledin, W.S. Spielman and W.L. Smith. Immunodissection of Cortical and Medullary Thick Ascending Limb Cells from Rabbit Kidney. Am. J. Physiol. 255:F704- F710, 1988

Profile Details

Last Updated: 9/7/2005

COS Expertise ID #260372
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