Clark M. Stanford

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University of Iowa
College of Dentistry
Prosthodontics
ProfessorAppointed: 1992
University of Iowa
College of Dentistry
Dows Institute for Dental Research
ProfessorAppointed: 1992
Professional Headshot of Clark M. Stanford

Mailing Address

N447 DSB
University of Iowa
Iowa City, Iowa 52242
United States

Contact Information

Phone: (319) 335-7381
Fax: (319) 335-8895
clark-stanford@uiowa.edu

Qualifications

Ph.D., University of Iowa, Cell Biology, 1992.
Certificate in Prosthodontics, University of Iowa, 1992.
D.D.S., University of Iowa, Dentistry, 1987.
B.S., University of Iowa, Zoology, 1984.

Expertise and Research Interests

Research interests include: the evaluation of the differential osteoblast response to oxide metal surfaces; characterization of matrix-associated glycoproteins in an in vitro culture system; development of a viable osteoblast culture system for the assay of biomaterial responses; collaborative work on distinguishing various cell responses to a mechanically active environment; isolating and characterizing human osteogenic cells of patients with osteoporotic bone disease; collaborative work exploring both the influences of mechanical forces on the mineralization phenotype of an osteosarcoma cell type, and the manner in which bone-like phenotypic markers are altered when subjects to the mechanical strain parameters of magnitude, frequency, and duration.

Other Expertise

Studies include: studying early biologically-mediated bone mineralization events, which, used as a research tool, clinically explore useful issues, such as HA coating responses of implants, in a cost-efficient manner; creating a linear PCR amplification using a cRNA standards approach; studying the effects of specific growth factors on bone metabolism and mineralization by using the UMR cell culture system to clarify signal transduction cascade mechanisms, which inhibit mineralization.

Keywords

COS Keywords:

Bioengineering, Biomechanics, Biomedical Research Resources, Other, Cell Biology, Clinical Trial, Dentistry, Implants, Molecular Biology, Recombinant Dna.

Additional Terms:

Bioengineering, Biomechanics, Biomedical Research, Cellular Biology, Clinical Trial, Dentistry, Implants, Molecular Biology, Recombinant DNA.

Languages

(Reading, Writing, Speaking)

German: (Basic, Basic, Basic)
Spanish: (Basic, Basic, Basic)

Memberships

Academy of Osseointegration
American Association for Dental Research
American College of Prosthodontics
American Dental Association
American Society for Cell Biology
International Association for Dental Research
Orthopaedic Research Society

Previous Positions

1992-1996, University of Iowa, Assistant Professor
1987-1992, University of Iowa, Research Fellow

Funding Received

  • National Science Foundation (NSF): Co-Investigator, Using Force Feedback Devices to Train and Assess Recognition of Force Signals as a Component of Professional Skill, Geb Thomas, PI, $104,210, Sep 15, 2002 to Aug 31, 2005.
  • National Institutes of Health (NIH): Sub-Investigator, Oral Health Research Clinical Core Center, James Wefel, PI, $4,571,326, Sep 15, 1991 to Jul 31, 2002.
  • Dentsply Endodontics: Principal Investigator, Protocol for Evaluation of Radiopacity of Dental Restorative Materials, $4,000, Sep 14, 2000 to Feb 14, 2001.
  • Roy J. Carver Charitable Trust: Principal Investigator, Role of Estrogens in Altering the Responses of Osteoporotic Bone Cells to Mechanical Strain, $154,632, Sep 1, 1998 to Nov 1, 2002.
  • 3M Company: Principal Investigator, Clinical Comparison of Two Luting Cements: An Evaluation of Short-Term Postoperative Complications and Long-Term Retention of Ceramic Dental Inlays and Onlays, $117,344, Oct 15, 2002 to Oct 15, 2003.
  • Talladium, Inc.: Principal Investigator, Evaluation of Mucosal Sensitivity of Dental Casting Alloys, $7,765, Oct 1, 1998 to Mar 31, 1999.
  • Procter & Gamble Company: Co-Investigator, Evaluation of Dentifrice Components In Situ, James Wefel, PI, $134,500, May 7, 2001 to Jun 30, 2002.
  • American Association for Dental Research: Principal Investigator, Fatigue Properties and Joint Stability of Single Tooth Implant Restorations--Fellowship for Daniel Norris, $2,400, May 1, 2001 to Apr 30, 2002.
  • National Institutes of Health (NIH): Co-Investigator, Do Integrins and the Associated Kinase FAK Mediate Mineralization?, Galen Schneider, PI, $147,166, Mar 1, 2002 to Feb 28, 2004.
  • Roy J. Carver Charitable Trust: Principal Investigator, A Multidisciplinary Research Program for Patients with Advanced Oral Facial Bone Loss, $143,239, Mar 1, 2000 to Jun 30, 2001.
  • American Association for Dental Research: Principal Investigator, Fellowships for Bhupinder Khanuja and Scott Hoyer, $1,200, Mar 1, 1998 to Feb 29, 2000.
  • ITI Foundation: Co-Investigator, A Study in the Retention Profile of Ball Attachments Used for Implan-Retained Overdentures, Ali Fakhry, PI, $15,000, Jul 15, 2002 to Jul 14, 2003.
  • American Association for Dental Research: Principal Investigator, Adaptation of Implant-Abutment Interface as a Function of Fatigue Loading, $2,400, Jul 1, 2002 to Jun 30, 2003.
  • American Association for Dental Research: Principal Investigator, Kevlar Fiber Reinforced Acrylic Resin Fractures and Provisional Implant Cantilever, $2,400, Jul 1, 2002 to Jun 30, 2003.
  • ITI Foundation: Principal Investigator, Does Implant Surface Roughness Alter the Regulation of Bone Differentiation?, $16,829, Jul 1, 2001 to Jun 30, 2002.
  • Astra Tech AB: Principal Investigator, An Open, Prospective, Multicenter Study to Evaluate Treatment of Edentulous Upper Jaws with an Implant-Supported Prosthesis Retained by Astra Tech Dental Implants Fixture Micro-Macro in Patients with Poor Bone Quality, $369,410, Feb 25, 1999 to Oct 31, 2005.
  • Astra Tech AB: Co-Investigator, Relationship Between Alveolar Bone Mineral Density Following Placement of Dental Implants and Systemic Bone Mineral Density, Ali Fakhry, PI, $9,375, Dec 5, 2000 to Jan 31, 2006.
  • National Institutes of Health (NIH): Co-Investigator, Institutional Training Program in Oral Health Research, Christopher Squier, PI, $1,974,737, Aug 10, 2002 to Jul 31, 2007.
  • National Institutes of Health (NIH): Co-Investigator, Comprehensive Program for Craniofacial and Dental Anomalies, Jeffrey C. Murray, PI, $10,447,657, Aug 1, 1999 to Jul 31, 2004.
  • American Association for Dental Research: Principal Investigator, The Clinical Evaluation of a Force Measuring Device for Creation of Robotic Simulation of Clinical and Surgical Patient Care (Fellowship for Paul Harris), $2,400, Apr 25, 2000 to Apr 24, 2001.
  • Institut Straumann: Principal Investigator, Field Trial on SLA Tapered Immediate Placement Dental Implants, $56,250, Apr 1, 2002 to Dec 31, 2007.
  • Quantitative RT-PCR of noncollagenous mRNA of Bone., National Institutes of Health (NIH), $72,000, 6/95-5/97
  • Characterization of Bioapaticic Mineral Formation Within a #-D Matrix; a role for TGF-Beta in Regulating an Osteoporotic-like Cellular Phenotype, National Institutes of Health (NIH), $16,000, 3/96-9/96
  • Osteoblast Phenotypic Responses to HA as a Function of Crystallinity, Implant Dentistry Research and Education Foundation, $20,000, 3/95-6/96
  • Clinical Evalution of the Efficacy of a Sonic Toothbrush, Optiva Corporation, $50,000, 6/94-9/96

Publications

  • Lindquist TJ, Stanford CM, Mostafavi H, Xie XJ, Abrasion resistance of a resin-impregnated type IV gypsum in comparison to conventional products, Journal of Prosthetic Dentistry, 87(3), 319-22, March 2002 Abstract
  • Wefel JS, Stanford CM, Ament DK, Hogan MM, Harless JD, Pfarrer AM, Ramsey LL, Leusch MS, Biesbrock AR, In situ evaluation of sodium hexametaphosphate-containing dentifrices, Caries Research, 36(2), 122-8, 2002 Abstract
  • Hoyer SA, Stanford CM, Buranadham S, Fridrich T, Wagner J, Gratton D, Dynamic fatigue properties of the dental implant-abutment interface: joint opening in wide-diameter versus standard-diameter hex-type implants, Journal of Prosthetic Dentistry, 85(6), 599-607, June 2001 Abstract
  • Brand RA, Stanford CM, Nicolella DP, Primary adult human bone cells do not respond to tissue (continuum) level strains, Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association, 6(3), 295-301, 2001 Abstract
  • Lindquist TJ, Stanford CM, Development and application of a new abrasion testing device, Journal of Prosthetic Dentistry, 84(6), 635-41, December 2000 Abstract
  • Chang YL, Stanford CM, Keller JC, Calcium and phosphate supplementation promotes bone cell mineralization: implications for hydroxyapatite (HA)-enhanced bone formation, Journal of Biomedical Materials Research, 52(2), 270-8, November 2000 Abstract
  • Stanford CM, Welsch F, Kastner N, Thomas G, Zaharias R, Holtman K, Brand RA, Primary human bone cultures from older patients do not respond at continuum levels of in vivo strain magnitudes., Journal of Biomechanics, 33(1), 63-71, 2000 Abstract
  • Stanford CM, Brand RA, Toward an understanding of implant occlusion and strain adaptive bone modeling and remodeling., Journal of Prosthetic Dentistry, 81(5), 553-61, May 1999 Abstract
  • Hesby RM, Haganman CR, Stanford CM, Effects of radiofrequency glow discharge on impression material surface wettability., Journal of Prosthetic Dentistry, 77(4), 414-22, 1997 Abstract
  • Stanford C M, Srikantha R, Wu C D, Efficacy of the Sonicare toothbrush fluid dynamic action on removal of human supragingival plaque., Journal of Clinical Dentistry, 8(1 Spec No), 10-4, 1997 Abstract
  • Morgan J, Holtman K R, Keller J C, Stanford C M, In vitro mineralization and implant calcium phosphate-hydroxyapatite crystallinity., Implant Dentistry, 5(4), 264-71, 1 Jan 1996 Abstract
  • Stanford C M, Stevens J W, Brand R A, Cellular deformation reversibly depresses RT-PCR detectable levels of bone-related mRNA., Journal of Biomechanics, 28(12), 1419-27, December 1995 Abstract
  • Stanford C M, Morcuende J A, Brand R A, Proliferative and phenotypic responses of bone-like cells to mechanical deformation., Journal of Orthopaedic Research, 13(5), 664-70, September 1995 Abstract
  • Stanford C M, Jacobson P A, Eanes E D, Lembke L A, Midura R J, Rapidly forming apatitic mineral in an osteoblastic cell line (UMR 106-01 BSP)., Journal of Biological Chemistry, 270(16), 9420-8, 21 Apr 1995 Abstract
  • Keller J C, Stanford C M, Wightman J P, Draughn R A, Zaharias R, Characterizations of titanium implant surfaces. III., Journal of Biomedical Materials Research, 28(8), 939-46, August 1994 Abstract
  • Stanford C M, Keller J C, Solursh M, Bone cell expression on titanium surfaces is altered by sterilization treatments., Journal of Dental Research, 73(5), 1061-71, May 1994 Abstract
  • Brand R A, Stanford C M, How connective tissues temporally process mechanical stimuli., Medical Hypotheses, 42(2), 99-104, February 1994 Abstract
  • Swart K M, Keller J C, Wightman J P, Draughn R A, Stanford C M, Michaels C M, Short-term plasma-cleaning treatments enhance in vitro osteoblast attachment to titanium., Journal of Oral Implantology, 18(2), 130-7, 1992 Abstract
  • Stanford C M, Keller J C, The concept of osseointegration and bone matrix expression., Critical Reviews In Oral Biology and Medicine, 2(1), 83-101, 1991 Abstract
  • Michaels C M, Keller J C, Stanford C M, In vitro periodontal ligament fibroblast attachment to plasma-cleaned titanium surfaces., Journal of Oral Implantology, 17(2), 132-9, 1991 Abstract
  • Gorski J P, Griffin D, Dudley G, Stanford C, Thomas R, Huang C, Lai E, Karr B, Solursh M, Bone acidic glycoprotein-75 is a major synthetic product of osteoblastic cells and localized as 75- and/or 50-kDa forms in mineralized phases of bone and growth plate and in serum., Journal of Biological Chemistry, 265(25), 14956-63, 5 Sep 1990 Abstract
  • Stanford, C., Stevens, J. and Brand, R. "Cellular Deformation Reversibly Depresses RT-PCR Detectable Levels of Bone-related mRNA." J. Biomechanics, 28: 1419-1427; 1995
  • Stanford, C., Morcuende, J. and Brand, R. "Proliferative and Phenotypic Responses for Bone-like Cells to Mechanical Deformation." J. Orthopaedic Res. 13: 664-670; 1995
  • Stanford C., Jacobson. P., Eanes, E.D., Lemke, L., Midura, R. "Rapidly Forming Apatitic Mineral in an Osteoblastic Cell Line (UMR 106-01 BSP)" J. Biol. Chem. 270: 9420-9428; 1995
  • Stanford, C.M., Solursh, M. and Keller, J.C. "Osteoblast Expression on cpTi as a Function of Sterilization Treatments." J. Dent. Res.,73:1061-1071; 1994
  • Keller, J.C., Stanford, C.M., Draughn, R.D. and Wightman, J.P. In Vitro Osteoblast Responses to cpTi and Ti 6Al-4V Alloy. Medical Applications of Titanium and its Alloys: The Material and Biological Issues, ASTM STP 1272. S.A. Brown and J.E. Lemons, editors., American Society for Testing and Materials, Philadelphia, (in press)

Profile Details

Last Updated: 6/18/2003

COS Expertise ID #320837
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