David S. Strayer

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Thomas Jefferson University
Thomas Jefferson University Hospital
Pathology, Anatomy And Cell Biol
Thomas Jefferson University
Jefferson Medical College
Department of Pathology, Anatomy & Cell Biology
Professor

Mailing Address

1020 Locust Street
Thomas Jefferson University
Philadelphia, Pennsylvania 19107-5587
United States

Contact Information

Phone: (215) 503-0503
David.Strayer@jefferson.edu

Qualifications

Ph.D..

Keywords

COS Keywords:

Biochemistry, Biophysics, Cell Biology, Complementary DNA, Developmental Biology, Genetics, Human Physiology, Molecular Cloning, Pharmacology, Transfection.

Additional Terms:

Cell Growth Regulation, Complementary Dna, Cyclic Amp, Dna Footprinting, Gene Induction Repression, Gene Mutation, Genetic Promoter Element, Glucocorticoid, Laboratory Rabbit, Molecular Cloning, Nucleic Acid Sequence, Poxviridae, Retinoid, Site Directed Mutagenesis, Tissue Cell Culture, Transcription Factor, Transfection, Tumor Suppressor Gene, Virus Genetics, Virus Protein.

Funding Received

  • National Institutes of Health (NIH), 1 R01 GM53803-01, REGULATION OF P53 EXPRESSION BY C7 TRANSCRIPTION FACTOR, $195109, 1996-1999

Publications

  • Strayer DS, Hoek JB, Thomas AP, White MK, Cellular activation by Ca2+ release from stores in the endoplasmic reticulum but not by increased free Ca2+ in the cytosol., Biochemical Journal, 344 Pt 1, 39-46, 15 Nov 1999 Abstract
  • Wali A, Strayer DS, Infection with vaccinia virus alters regulation of cell cycle progression., DNA and Cell Biology, 18(11), 837-43, November 1999 Abstract
  • BouHamdan M, Duan LX, Pomerantz RJ, Strayer DS, Inhibition of HIV-1 by an anti-integrase single-chain variable fragment \(SFv\): delivery by SV40 provides durable protection against HIV-1 and does not require selection., Gene Therapy, 6(4), 660-6, April 1999 Abstract
  • Wali A, Strayer DS, Comparative effects of virulent and avirulent poxviruses on cell cycle progression., Experimental and Molecular Pathology, 66(1), 31-8, April 1999 Abstract
  • Korutla L, Strayer DS, SP-A as a cytokine: surfactant protein-A-regulated transcription of surfactant proteins and other genes., Journal of Cell Physiology, 178(3), 379-86, March 1999 Abstract
  • Zern MA, Ozaki I, Duan L, Pomerantz R, Liu SL, Strayer DS, A novel SV40-based vector successfully transduces and expresses an alpha 1-antitrypsin ribozyme in a human hepatoma-derived cell line., Gene Therapy, 6(1), 114-20, Jan 1999 Abstract
  • Kondo R, Feitelson MA, Strayer DS, Use of SV40 to immunize against hepatitis B surface antigen: implications for the use of SV40 for gene transduction and its use as an immunizing agent., Gene Therapy, 5(5), 575-82, May 1998 Abstract
  • Milano J Jr, Strayer D S, Effects of overexpression of Ran/TC4 mammalian cells in vitro., Experimental Cell Research, 239(1), 31-9, 25 Feb 1998 Abstract
  • Herting E, Strayer D S, Jarstrand C, Sun B, Robertson B, Lung function and bacterial proliferation in experimental neonatal pneumonia in ventilated rabbits exposed to monoclonal antibody to surfactant protein A., Lung, 176(2), 123-31, 1998 Abstract
  • Strayer D S, Schwarting R, Recognition of normal, neoplastic, and fetal airway epithelial cell membranes by two monoclonal antibodies., Human Pathology, 28(7), 840-6, July 1997 Abstract
  • Strayer D S, Kondo R, Milano J, Duan L X, Use of SV40-based vectors to transduce foreign genes to normal human peripheral blood mononuclear cells., Gene Therapy, 4(3), 219-25, March 1997 Abstract
  • Strayer D S, Duan L X, Ozaki I, Milano J, Bobraski L E, Bagasra O, Titering replication-defective virus for use in gene transfer., Biotechniques, 22(3), 447-50, March 1997 Abstract
  • Strayer D S, Korutla L, Thomas A P, Surfactant protein-A receptor-mediated inhibition of calcium signaling in alveolar type II cells., Receptors and Signal Transduction, 7(2), 111-20, 1997 Abstract
  • Strayer D S, SV40 as an effective gene transfer vector in vivo., Journal of Biological Chemistry, 271(40), 24741-6, 4 Oct 1996 Abstract
  • Wali A, Strayer D S, Regulation of p53 gene expression by a poxviral transcription factor., Virology, 224(1), 63-72, 1 Oct 1996 Abstract
  • Strayer D S, Pinder R, Chander A, Receptor-mediated regulation of pulmonary surfactant secretion., Experimental Cell Research, 226(1), 90-7, 10 Jul 1996 Abstract
  • Strayer D S, Milano J, SV40 mediates stable gene transfer in vivo., Gene Therapy, 3(7), 581-7, July 1996 Abstract
  • Strayer D S, Herting E, Sun B, Robertson B, Antibody to surfactant protein A increases sensitivity of pulmonary surfactant to inactivation by fibrinogen in vivo., American Journal of Respiratory and Critical Care Medicine, 153(3), 1116-22, March 1996 Abstract
  • Luzi P, Anceschi M, Strayer D S, The upstream region of the SP-B gene: intrinsic promoter activity and glucocorticoid responsiveness related to a new DNA-binding protein., Gene, 165(2), 285-90, 20 Nov 1995 Abstract
  • Luzi P, Anceschi M, Strayer D S, Glucocorticoid responsiveness conferred by a cloned DNA binding protein., Receptor, 5(2), 93-103, 1 Jul 1995 Abstract
  • Luzi P, Strayer D S, DNA binding proteins that amplify surfactant protein B gene expression: isolation and characterization., Biochemical and Biophysical Research Communications, 208(1), 153-60, 8 Mar 1995 Abstract
  • Strayer D S, Merritt T A, Hallman M, Levels of SP-A-anti-SP-A immune complexes in neonatal respiratory distress syndrome correlate with subsequent development of bronchopulmonary dysplasia., Acta Paediatrica, 84(2), 128-31, February 1995 Abstract
  • Strayer D S, The viruses don't always read the books: engineered vaccines and gene therapy using viral vectors [editorial], Laboratory Investigation, 71(3), 319-23, September 1994 Abstract
  • Spragg R G, Gilliard N, Richman P, Smith R M, Hite R D, Pappert D, Robertson B, Curstedt T, Strayer D, Acute effects of a single dose of porcine surfactant on patients with the adult respiratory distress syndrome [see comments], Chest, 105(1), 195-202, January 1994 Abstract
  • Strayer D S, Effect of virus infection on levels of transcripts for cellular genes., Virus Research, 30(3), 259-69, December 1993 Abstract
  • Strayer D S, Yang S, Schwartz M S, Epidermal growth factor-like growth factors. I. Breast malignancies and other epithelial proliferations in transgenic mice., Laboratory Investigation, 69(6), 660-73, December 1993 Abstract
  • Strayer D S, Yang S, Jerng H H, Surfactant protein A-binding proteins. Characterization and structures., Journal of Biological Chemistry, 268(25), 18679-84, 5 Sep 1993 Abstract
  • Strayer D S, Mathew J, A 34-kd protein with strong homology to ras-like proteins inhibits epidermal growth factor activity., American Journal of Pathology, 142(4), 1141-53, April 1993 Abstract
  • Strayer D S, Jerng H H, Sequence and analysis of the BamHI "D" fragment of Shope fibroma virus: comparison with similar regions of related poxviruses., Virus Research, 25(1-2), 117-32, 1 Sep 1992 Abstract
  • Strayer D S, Robertson B, Surfactant as an immunogen: implications for therapy of respiratory distress syndrome., Acta Paediatrica, 81(5), 446-7, May 1992 Abstract
  • Robertson B, Curstedt T, Tubman R, Strayer D, Berggren P, Kok J, Koppe J, van Sonderen L, Halliday H, McClure G, et al, A 2-year follow up of babies enrolled in a European multicentre trial of porcine surfactant replacement for severe neonatal respiratory distress syndrome. Collaborative European Multicentre Study Grou, European Journal of Pediatrics, 151(5), 372-6, May 1992 Abstract
  • Strayer D S, Determinants of virus-related suppression of immune responses as observed during infection with an oncogenic poxvirus., Progress In Medical Virology, 39, 228-55, 1992 Abstract
  • Strayer D S, Applications of anti-curosurf antibodies to understanding the biology of alveolar surfactant., Biology of The Neonate, 61 Suppl 1, 2-14, 1992 Abstract
  • Strayer D S, Jerng H H, O'Connor K, Sequence and analysis of a portion of the genomes of Shope fibroma virus and malignant rabbit fibroma virus that is important for viral replication in lymphocytes., Virology, 185(2), 585-95, December 1991 Abstract
  • Eijking E P, Strayer D S, van Daal G J, Tenbrinck R, Merritt T A, Hannappel E, Lachmann B, In vivo and in vitro inactivation of bovine surfactant by an anti-surfactant monoclonal antibody., European Respiratory Journal, 4(10), 1245-50, November 1991 Abstract
  • Strayer D S, Identification of a cell membrane protein that binds alveolar surfactant., American Journal of Pathology, 138(5), 1085-95, May 1991 Abstract
  • Eijking E P, Strayer D S, van Daal G J, Lachmann B, Effects of antisurfactant antibodies on the course of mild respiratory distress syndrome., Pathobiology, 59(2), 96-101, 1991 Abstract
  • Strayer D S, Hallman M, Merritt T A, Immunogenicity of surfactant. II. Porcine and bovine surfactants., Clinical and Experimental Immunology, 83(1), 41-6, January 1991 Abstract
  • Strayer D S, Hallman M, Merritt T A, Immunogenicity of surfactant. I. Human alveolar surfactant., Clinical and Experimental Immunology, 83(1), 35-40, January 1991 Abstract
  • Strayer D S, Laybourn K A, Heard H K, Determinants of the ability of malignant fibroma virus to induce immune dysfunction and tumor dissemination in vivo., Microbial Pathogenesis, 9(3), 173-89, September 1990 Abstract
  • Laybourn K A, Hiserodt J C, Hunt J M, Sell S, Strayer D S, Natural cell-mediated immunity in the rabbit., Cellular Immunology, 129(2), 519-27, September 1990 Abstract
  • Heard H K, O'Connor K, Strayer D S, Molecular analysis of immunosuppression induced by virus replication in lymphocytes., Journal of Immunology, 144(10), 3992-9, 15 May 1990 Abstract

Profile Details

Last Updated: 3/14/2006

COS Expertise ID #544614
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